13/04/2017 Torasemide:Indication,Dosage,SideEffect,Precaution|MIMS.

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Torasemide
>Indications >Contraindications >DrugInteractions NewBrands
>Dosage >SpecialPrecaution >MechanismofAction OtherKnownBrands RespimerNormal... Hidrasec
>DosageDetails >AdverseDrugReactions >MIMSClass
Toral Unat Furamin Interkrill
>Administration >PregnancyCategory(USFDA)
>Overdosage RespimerHyperto... RespimerBabyNa...

Indications ListedinDosage.
Dosage Adult:POHTN2.55mgoncedaily.Max:5mg/day.Oedema5mgoncedaily,upto20mgoncedailyif
needed.Max:40mg/day.Oedemainpatientsw/hepaticcirrhosisInitial:510mgoncedaily,w/an
aldosteroneantagonistoraKsparingdiuretic,titrateupwardstilldesireddiureticresponse.Max:40
mg/day.IVOedema1020mg/day.Max:200mg/day.
DosageDetails Intravenous
Oedema
Adult:1020mgdailyasIVinjslowlyover2min.Max:200mgdaily.

Oral
Oedemainpatientswithhepaticcirrhosis
Adult:Initially,510mgoncedaily,giventogetherwithanaldosteroneantagonistorapotassium
sparingdiuretic,titratedupwardsuntilthedesireddiureticresponseisobtained.Max:40mgdaily.

Oral
Hypertension
Adult:2.55mgoncedaily.Max:5mgdaily.

Administration
Contraindications
SpecialPrecautions
AdverseDrugReactions
PregnancyCategory(US
FDA)
Oral
MostReadArticles
Oedema
Adult:5mgoncedaily,increasedto20mgoncedailyifnecessary.Max:40mg/day.
Maybetakenwithorwithoutfood. 1. 4"MalaikatKematian"lain
dalamduniakesehatan
Hypersensitivitytosulfonylureas,renalfailurewithanuria,hepaticcomaandprecoma,hypotension,
cardiacarrhythmias.Pregnancyandlactation.
Riskofhyperuricaemia,goutandDM.Correctelectrolytedistubancesanddisordersofmicturitionbefore
treatment.Monitorelectrolytebalance,glucose,uricacid,creatinineandlipidsregularly.Mayimpair
2. WHOinginmengubahterapi
STDkarenatingginyaangka
abilitytodriveoroperatemachinery.
kejadianresistensia...
Electrolytedisturbancese.g.hypokalaemia,dehydration,drymouth,headache,dizziness,hypotension,
weakness,drowsiness,confusionalstates,lossofappetite,cramps,increasedserumuricacid,glucose,
lipids,ureaandcreatinine,increaseinLFT,metabolicalkalosis,tinnitusandhearingloss. 3. BARU:MIMSKariruntuk
Apotekerdantenaga
ROUTE(S):Parenteral/PO kesehatanlain

4. Zikaditetapkansebagai
CategoryB:Eitheranimalreproductionstudieshavenotdemonstratedafoetalriskbutthereareno PenyakitMenularSeksual
controlledstudiesinpregnantwomenoranimalreproductionstudieshaveshownanadverseeffect
(otherthanadecreaseinfertility)thatwasnotconfirmedincontrolledstudiesinwomeninthe1st
trimester(andthereisnoevidenceofariskinlatertrimesters). 5. Mengapaobatitupahit?
Overdosage Symptoms:Markeddiuresiswithseveredehydrationandelectrolytesdisturbances.Somnolence,
confusion,hypotension,circulatorycollapseandGIdisturbances.Management:Reduceorstop
torasemide.Thereisnoantidoteandtreatmentinvolvessimultaneousreplacementoffluidand
electrolytes.Haemodialysisunlikelytobeuseful.
DrugInteractions IncreasedriskofseverehypokalaemiawithamphotercinB,corticosteroids,carbenoxolone,
hypokalaemiacausingmedications.Increasedriskoflithiumtoxicity.Increasedpotentialforototoxicity
Agrelano(clopidogrel)
andnephrotoxicitywithnephrotoxicorototoxicmedicationse.g.aminoglycosides.Highdosesalicylates
mayincreasetheriskofsalicylatetoxicity.Increasedriskoftoxicitywithdigoxin.Reduceddiureticeffect
withNSAIDs.Increasedriskofhypotensionwithantihypertensives.
CounterpainPatchHot
(glycolsalicylate,
MechanismofAction Description:Torasemide,asulfonylurealoopdiuretic,actsfromwithinthelumenofthethickascending levomenthol,...)
portionoftheloopofHenle,whereitinhibitstheNa+/K+/2CIcarriersystem.
Onset:Diuresis:Oral:Within1hrIV:Within10min. InfanrixHexa(Haemophilus
Duration:Diuresis:OralandIV:8hr. influenzaetypebcapsular
Pharmacokinetics: polysaccharide,diphtheria
toxo..
Absorption:Absorbedrapidlyandalmostcompletely(oral).Peakserumlevelsafter12hr.Food
decreasesratebutnotextentofabsorption.
NitrokafRetard/Nitrokaf
Distribution:Proteinbinding:>99%.Apparentdistributionvolume:16L. RetardForte(glyceryl
Metabolism:MetabolisedbythecytochromeP450isoenzymeCYP2C9.Eliminationhalflife:3.5hr. trinitrate)
Excretion:Excretedbyurineasunchangeddrug(24%)andmetabolites.
MIMSClass Diuretics Proten(vitaminC,calcium,
...)


Rytmonorm(propafenone
Disclaimer:ThisinformationisindependentlydevelopedbyMIMSbasedonTorasemidefromvariousreferencesandisprovidedforyourreferenceonly. hydrochloride)
Therapeuticusesandprescribinginformationmayvarybetweencountries.PleaserefertoMIMSProductMonographsforspecificandlocallyapproved
prescribinginformation.Althoughgreatefforthasbeenmadetoensurecontentaccuracy,MIMSshallnotbeheldresponsibleorliableforanyclaimsor Susuformulalanjutanutk
bayiusia6bln1thn.
damagesarisingfromtheuseormisuseoftheinformationcontainedherein,itscontentsoromissions,orotherwise.Copyright2017MIMS.Allrights
reserved.PoweredbyMIMS.com

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