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DIURETICS ANTIBIOTICS
Decrease urates excretion by increase net urates Penicillin, Cephalosporins, Fluoroquinolones,
reabsorption Aminoglycosides
Dose dependent Metabolism is primarily in the kidneys
EFFECT: - Hyperuricemia EFFECTS: May aggrevate existing kidney
-Acute Kidney Injury from Dehydration disease
MONITOR: - UA, BUN, CREATININE MONITOR: BUN, CREA, Creatinine Clearance
WARFARIN INSULIN
Vitamin K Antagonist Insulin is a protein chain or peptide hormone
-Blocks Vitamin K dependent factors Insulin is produced in the islets of Langerhans
Narrow therapeutic range in the pancreas
EFFECTS: - Risk of bleeding, Nepropathy Allows glucose utilization by the tissues
MONITOR: -PT/INR, BUN/CREATININE/Liver EFFECTS: Hypoglycemia
Function Tesr MONITOR: CBG
SUMMARY
Physiologic changes in the elderly affect
the drugs pharmacodynamics ang
pharmacokinetics
Medication therapy is highly valuable
We need to monitor not only the beneficial
effect but the possible adverse effect as
well
Even herbal medications and supplements
have potential harmful effect if
unmonitered