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-1-5 ......................................
-1-6 ..............................................................
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-1-8 ..............................................
-1-9 .....................................
-1-10 ...................................................................................
-2 .............................................................................
-2-1 ...........................................
-2-2 ....................................................................
-2-3 ..............................
-2-4 .............................................
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Streptomyces fradiae .

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: %10 100
%25 250
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MG MS
: CRD: 8/811
%10 3/5 4/4 %25 .
%10 10 4 %25
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(%25 3 5 10 ) (%10 4
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100 107300 :
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: 50

50 6400 :
-1-6
TYLOSIN
)Solution for injection : 5% and 20% (as Base

)Tyrosine Tart ate: Water-Soluble Powder (100% Tylosin Base
Tylosin Phosphate Premix: 250g Tylosin Base Activity per kg
50S
) (CFS 8 . 4
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) (
: .
CRD CRD )
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) (.
CRD
: mg/kg 5

: mg/kg 5
: 10-20mg/kg
-1-7 :

) VAXSAFE MG (ts- .
-1-8 :

. .
Mycoplasma gallisepticum.
PPLO 0/5
Borrelia anserine
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)(
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)(
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6005 2
495000 3
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1%-50% 50%-100%

-2-3 :
85 87
) 85(
150,000
100,000
50,000
) 85(
40,000
30,000
20,000
10,000

) 86(
200,000
150,000
100,000
50,000
) 86(
20,000
15,000
10,000
5,000

) 87(
500,000
400,000
300,000
200,000
100,000
) 87(
40,000
30,000
20,000
10,000

:

30 1
31 2
32 3
33 4
34 5
35 6
36 7
37 8
38 9
39 10
40 11
41 12
42 13
) 43 .. . 14
44 15
45 16
46 17
47 18
48 19
49 20
50 21
51 22
52 23
53 24
54 25
55 26
56 27
57 28
58 29
59 30

60 31
62 32
63 33
:

-2-4 :

)( )( )( )( )( )(
)(
11024.4 36748 25723.6 0 0 0 0 1384 1
15359.4 51443 36083.6 1,981,419 168 514,528 63 1385 2
16176.9 53923 37746.1 665,340 39 665,340 39 1386 3
16237.9 53984 37746.1 0 0 890,986 61 1387 4
16968.4 56377 39408.6 0 0 1,158,282 79 1388 5
)(
60,000
55,000
50,000

45,000
40,000
35,000
30,000
25,000
20,000
15,000
10,000
5,000
0
1 2 3 4 5
-2-5 :
24

) 85(
2,000,000
1,500,000
1,000,000
500,000
) 85(
150,000
100,000
50,000

) 86(
200,000
150,000
100,000
50,000
) 86(
20,000
15,000
10,000
5,000
-2-6 :

2 ) 50 ( 2
10 15
4 5
-3 :

10 60
) (Multi-enzyme coplex ) fatty
(acid synthase .
50 s
" "
) RNA ( methylation TYLOSIN

) (Cross-resistant strains
Streptomyces fradiae g/l 72 72 .
) (Extracellular
* : Streptomyces fradiae
> 120m 0.2
0.5% 33 70-120
* :
* 72
-3-1 :
Hi tech
-4

-5

-5 :
)(
505000 1-1
883750 2-1
2685000 3-1
26000000 4-1
1978000 5-1
120000 6-1
46875 7-1 ) 20 30 (
3221863 9-1 ) 10 (
35440488
328000 8-1
35768488
) ( ) (
505000 202000 2500
505000 0 2500

)(

625000 250000 2500
40000 250000 160
93750 250000 375

125000 250000 500

883750

)(
1800000 1800000 1000
180000 1800000 100 ) (
180000 1800000 100 ) (
187500 2500000 75
37500 1500000 25
50000 2000000 25
62500 2500000 25
187500 2500000 75
2685000

- :
) ( )-(
25000000 2500000 1 1
1000000 1 ) (.... 2
26000000

)(
10000
70000 1
70000
400000 KW 300
70000
55000
103000
200000
1000000
1978000
)(
120000 1
120000
46875

)(
1000 ----------------------
10000 ----------------------
100000 ----------------------
10000 ----------------------
2000 ----------------------
4000 ----------------------
1000 ----------------------
40000 ----------------------
0
150000
10000
328000

)(

1
Streptomyces 2
fradia
3
4
5
6

7

9

25000000

71200 71200000 4000000 1 1
44500 44500000 2500000 1 2
44500 44500000 2500000 1 3
44500 44500000 2500000 1 4
4
284800

178000 178000000 10000000 1 1
106800 106800000 6000000 1 ) ( 2
231400 115700000 6500000 2 3
133500 133500000 7500000 1 4
352440 39160000 2200000 9 5
133500 133500000 7500000 1 )( 6
15
1135640
1295840 19
:
17,8 ) 12 20 (

16200 1200 13500 45

37500 500 75000 250

0 220 0 0
12420 138 90000 300

9000 1000 9000 30
0 165 0 0
75120
300

)(

17675 2 883750
53700 2 2685000

1300000 5 26000000

197800 10 1978000
12000 10 120000
653748 20 3268738
2234923

)( )(
70700 8 883750
214800 8 2685000
2600000 10 26000000
158240 8 1978000
24000 20 120000
9375 20 46875
386623,5 12 3221862,5
3463738,5
)(
25000000 1-3
1295840 2-3
75120 3-3
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300362
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70881 2
3463739 6-3
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33936758

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25000000 0 0 100 25000000
1295840 65 842296 35 453544
75120 20 15024 80 60096
2234923 20 446984,5 80 1787938
1430294 15 214544,1 85 1215750,006
300362 0 0 100 300361,7663
0 100 0 0 0
70881 100 70880,98 0 0
3463739 100 3463739 0 0
65600 100 65600 0 0
33936758 5119068 28817689,77
36651698

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) (

%10 3/5 4/4 %25 .

: 500 : %10 200

. 0/6 0/9 %10

: 8/8 %10 3/5 %25

)Solution for injection : 5% and 20% (as Base

11024.4 36748 25723.6 0 0 0 0 1384 1

15359.4 51443 36083.6 1,981,419 168 514,528 63 1385 2

16176.9 53923 37746.1 665,340 39 665,340 39 1386 3

16237.9 53984 37746.1 0 0 890,986 61 1387 4

16968.4 56377 39408.6 0 0 1,158,282 79 1388 5

) (Multi-enzyme coplex ) fatty

) RNA ( methylation TYLOSIN

Streptomyces fradiae g/l 72 72 .

> 120m 0.2

505000 202000 2500

1295840 65 842296 35 453544

75120 20 15024 80 60096

2234923 20 446984,5 80 1787938

1430294 15 214544,1 85 1215750,006

300362 0 0 100 300361,7663

70881 100 70880,98 0 0

3463739 100 3463739 0 0

65600 100 65600 0 0

33936758 5119068 28817689,77

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