Screening Non-

Diseased
Results diseased Total
Test positive 40 190 230 Number of animals tested

Test negative 10 760 770

Total 50 950 1000 Sensitivity
Specificity

Sensitivity 0.80 True prevalence

Specificity 0.80
Screening
PPV 0.17 Results
NPV 0.99 Test positive
App Prev 0.23 Test negative
True Prev 0.05 Total
Accuracy 0.80
Apparent Prev
PPV
NPV
 Values

Number of animals tested 1800

Screening Diseased Non-diseased
Results

Sensitivity 0.80 Test positive 0.2375 0.0375

Specificity 0.95 Test negative 0.0125 0.7125
Total 0.2500 0.7500
True prevalence 0.25

Diseased Non- Total Screening Diseased Non-diseased

diseased Results

360 68 428 Test positive 428 68

90 1283 1373 Test negative 23 1283

450 1350 1800 Total 450 1350

0.2375
0.84 PPV 0.86
0.93 NPV 0.98
Total

0.2375
0.7625
1.0000

Total

495

1305
1800
Sensitivity 0.9
Specificity 0.75
N 1000
AP 0.35

Diseased Healthy
Test + 138 212 350
Test - 15 635 650
154 846 1000

TP 0.1538 se 0.95
PPV 0.3956 sp 0.85
NPV 0.9763
AP PPV NPV
0 0
0.1 -0.59 1
0.2 0.3 1
0.3 0.59 0.99
0.4 0.74 0.97
0.5 0.83 0.96
Apparent Prevalence 0.5 0.5 0.5 0.5 0.5
Sensitivity 0.95 0.95 0.95 0.95 0.95
Specificity 0.95 0.80 0.70 0.60 0.50

True prevalence 0.50 0.40 0.31 0.18 0.00

Apparent Prevalence 50 50 50 50 50
Sensitivity 95 95 95 95 95
Specificity 95 80 70 60 50
0 0 0 0 0
True prevalence 50 40 31 18 0
Screening Non-
Diseased
Results diseased Total
Test positive 380 20 400
Test negative 90 510 600
Total 470 530 1000
if SE, Sp and AP given
Sensitivity 0.81 Sensitivity 0.95 n 1000

Specificity 0.96 Specificity 0.85

PPV 0.95 PPV 0.74 0.7421875 Test pos
NPV 0.85 NPV 0.97 37.984375 Test ne
App Prev 0.40 App Prev 0.40 Total
True Prev 0.47 True Prev 0.31 0.3125
Accuracy 0.89 Accuracy 0.88

KAPPA
OP Obsrvd prpn (a+d)/n 0.89

EP Expctd prpn (a+b)/n * (a+c)/n + (c+d)/n * (b+d)/n

0.4 0.47 + 0.6 0.53
0.188 0.318
0.506
Kappa (OP-EP)/(1-EP)
0.384 0.494
0.7773279
Diseased Non- Total
diseased

297 103 400

16 584 600
313 688 1000
Screening Non-
Diseased
Results diseased Total fnr

Test positive 94 1 95 J
J= 1 - ( + ) =

Test negative 1 241 242

Total 95 242 337

Sensitivity 0.99 J= 0.99

Specificity 1.00
PPV 0.99
NPV 1.00
App Prev 0.28
True Prev 0.28
Accuracy 0.99

KAPPA
OP Obsrvd prpn (a+d)/n 0.99407

EP Expctd prpn (a+b)/n * (a+c)/n + (c+d)/n * (b+d)/n

0.28189911 0.2819 + 0.718101 0.718101
0.07947 0.515669
0.595136
Kappa (OP-EP)/(1-EP)
0.398929285 0.40486
0.9853
0.010526 fpr 0.004132
J= 1 - ( + ) = (1 - ) + (1 - ) - 1

0.985341