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FORMAT FOR SUBMISSION OF PROPOSAL

101. Project Title :

Synthesis and Pharmacological Evaluation of Biologically Active Phenothiazine


Fused Isoxazole, Triazole and Pyrazole Systems

102. Name and Address of the Institute/organisation where the project will be
implemented.

PBR Visvodaya Institute of Technology and Science, Udayagiri Road,


Kavali - 524 201, SPSR Nellore (District), Andhra Pradesh.

103. Principal Investigator (PI) : Dr. S. V. Subba Rao


104. Designation : Professor
105. Category : General
106. Institute Name : PBR Visvodaya Institute of
Technology and Science
Address :

City : Kavali
Pin Code : 524201
State : Andhra Pradesh
Telephone No : 08626 -243930
Fax : 08626 -243930
E-mail : vitsaim1998@gmail.com
Mobile No : 9849172028
107. Co-Investigator : Dr. D. Prathyusha Reddi
Designation : Professor
Category : General
Institute Name : PBR Visvodaya Institute of
Technology and Science
Address :

City : Kavali
Pin Code : 524201
State : Andhra Pradesh
Telephone No : 08626 -243930
Fax : 08626 -243930
E-mail : vitsaim1998@gmail.com
Mobile No : 9849172028

108. Total Cost (In Rupees) : 94,51,440.00 /-

109. Duration (in months) : 36 months


110. Ideation of the study (give brief elaboration under select option (s))
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Cancer, a catastrophic disease, is one of the major causes of death


irrespective of age and sex. To date, safe treatment for cancer is not yet
available. Microtubules are ubiquitous, cytoskeletal components of eukaryotic
cells. They serve as the primary structural substrates for cellular processes such
as mitosis, cytoplasmic transport, and flagellar and cilia-based motility.
The central role of microtubules in the process of separating duplicated
chromosomes before cell division makes them an important target for anticancer
drugs. Thus, molecules that target tubulin halt the characteristic rapid division
of cancer cells. This therapeutic strategy has been validated by the clinical
success of antimicrotubule drugs such as paclitaxel, docetaxel, vincristine, and
vinblastine. Nonetheless, neurotoxicity and P-glycoproteinmediated drug
resistance limit the clinical utility of these drugs.
The continuation of research work towards the invention of potent drugs
to the both anticancer and anti-tuberculosis diseases, we proposed the indole
and phenothiazine active scaffolds with new derivatives as mentioned
schematically. The future plans investigate to identify the high active isoxazole,
triazole and pyrazole analogues and further performed the mechanical studies
in both invitro and invivo.

201. Introduction
The proposal originates from the recent reports and the necessity of the
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development of efficient drugs for cancer and tuberculosis diseases. Cancer, a


catastrophic disease, is one of the major causes of death irrespective of age and sex. To
date, safe treatment for cancer is not yet available. Microtubules are ubiquitous,
cytoskeletal components of eukaryotic cells. They serve as the primary structural
substrates for cellular processes such as mitosis, cytoplasmic transport, and flagellar
and cilia-based motility.1 The central role of microtubules in the process of separating
duplicated chromosomes before cell division makes them an important target for
anticancer drugs. Thus, molecules that target tubulin halt the characteristic rapid
division of cancer cells. This therapeutic strategy has been validated by the clinical
success of antimicrotubule drugs such as paclitaxel, docetaxel, vincristine, and
vinblastine. Nonetheless, neurotoxicity and P-glycoprotein mediated drug resistance
limit the clinical utility of these drugs.2

202. Review of Literature (Both National & International Status)

Cancer is the second leading cause of mortality in developed countries after cardiovascular
disease. .
3

Currently, chemotherapy is the most important treatment for cancer and the ultimate goal
is to destroy the cancer cells without any harmful effect on the normal cells. Within the
past decade, advances in our understanding of the cell cycle have presented new targets
that may allow for the development of more selective chemotherapeutic agents agents
that target only cancer cells. Cancer chemotherapy has achieved significant success
through the discovery of various new drugs. However these drugs cannot completely
eliminate tumours in the human body and also show side effects and toxicity. Despite this,
the discovery of most potent anticancer agents had challenging issue in cancer
chemotherapy for the future generations.
In phenothiazines, the proton on the nitrogen atom was acidic. So large number of
phenothiazine analogues (Figure1) are expected through nitrogen atom either aliphatic
chain or hetero atoms cyclic chain. Some of the phenothiazines bearing pyrazole unit
and benzoyl unit (partial analogues of phenstatin with a phenothiazine) on the
nitrogen atom exhibit in vitro cytotoxic activity inhibiting the growth of HCT-116, LOX

IMVI, SK-MEL-5 cell lines and COLO-205, A498, and MCF7 cell lines.4- 6

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The Indole nucleus is a privileged scaffold that is highly prevalent in natural


and synthetic compounds of medicinal interest. 7 In particular, indole-based alkaloids
play a versatile role in imparting cytotoxicity to many naturally occurring anticancer
agents.8-10 1A variety and large number of Indole analogues are widely featured in
nature and evaluated their antitumor activity against a panel of different cancer cell
lines like A549, MCF 7, A375, Colon 205, HeLa and MDAMB231. 11-12 Mycobacterium
tuberculosis (MTB), the causative agent of tuberculosis (TB), infects one-third of the
worlds population, and 510% of those infected will eventually develop active disease
in their lifetime.12, 13 Currently, drug-susceptible TB is treated using drugs discovered
more than 50 years ago. There are increasing reports on multidrug resistant (MDR) and
extensively drug resistant (XDR) tuberculosis in recent years. 14 Some strains of Mtb are
becoming resistant to most of the currently available antimycobacterial drugs,
rendering them totally drug resistant (TDR).15
Hence, there is an urgent need to develop novel drugs with new modes of
action to fight all of the different forms of TB: MDR, XDR, and TDR. Recently, drug
discovery initiatives have yielded a few new interesting compounds that are being
evaluated for the treatment of TB, namely, TMC207 (42),14 OPC-67683 (43),15 and PA-
824 (44).17
A large number of the analogues of both phenothiazine and indoles represent a
promising new class of antituberculosis agents against Mycobacterium tuberculosis
(Mtb).19-22

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203. Objectives
Our objectives of the proposed project are:

1. Design and development of new small molecule antimitotic agents with


increased potency and specificity for cancer therapy by inducing DNA
damage and tubulin polymerization inhibition.
2. To develop an efficient new synthetic routes for the development of
Isoxazole, Triazole and Pyrazole moieties.
3. To Synthesize and evaluation of new analogues of antitumor and
antituberculosis drugs.
4. The proposal aims at developing high efficient drugs to minimize the
genotoxic impurities for the next generation

204. Methodology:
1. Target population and sample size to be covered

NA

2. Method of data collection

p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor


protein that in humans is encoded by the TP53 gene. The tumor suppressor
protein p53 is a transcription factor that plays a key role in the prevention of
cancer development. p53 is important in multicellular organisms, where it
regulates the cell cycle and, thus, functions as a tumor suppressor that is
involved in preventing cancer. Human p53 is 393 amino acids long and has
seven domains.

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3. Sources of the data

The tumor suppressor protein p53 is a transcription factor that plays a


key role in the prevention of cancer development. The p53 cancer mutation
Y220C induces formation of a cavity on the protein's surface that can
accommodate stabilizing small molecules. Researchers have attempted with the
help of virtual screening and molecular docking approach using Lamarckian
Genetic Algorithm to elucidate the extent of specificity of p53 cancer mutation
Y220C towards different class of Phenothiazines (an anti-cancer agent).

4. Reference period of the data to be covered

NA

5. Method of processing and analyzing

The continuation of research work towards the invention of potent drugs


to the both anticancer and anti-tuberculosis diseases, we proposed the indole
and phenothiazine active scaffolds with new derivatives as mentioned below
schematically.
Synthesis of biologically active Phenothiazine based Isoxazole derivatives:

Synthesis of biologically active Indole based 1, 2, 4-Triazole derivatives:

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Synthesis of biologically active Phenothiazine-Indole based Pyrazole derivatives:

Biological Evaluation Studies: All the synthesized novel derivatives are


evaluated for antitumor andanti tuberculosis activities against a panel of different
cancer cell lines like A549, MCF 7, A375, Colon 205, HeLa and MDAMB231 and
Mycobacterium tuberculosis.

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6. Time schedule of activities giving milestones (append a bar diagram)

Quarter in Quarter in Quarter in


S.No. Deliverables
1st year 2nd year 3rd year
Literature survey &
Procurement of
1
Chemicals &
Glassware
Synthesis of
biologically active
2 Phenothiazine based
Isoxazole
derivatives
Synthesis of
biologically active
3
Indole based 1, 2, 4-
Triazole derivatives
Synthesis of
biologically active
Phenothiazine-
4
Indole based
Pyrazole
derivatives
1st year report
5
submission
2nd year report
6
submission
Final report
7
submission

205. Expected Benefits :

From the present work, we will be engaged with development of biologically active
new heterocyclic systems such as isoxazoles, triazoles, and pyrazoles. Further all the
synthesized molecules are screened for different pharmacological activities including
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antitumor and anti tuberculosis activities. All the synthesized compounds will have
the commercialization capabilities.

206. Limitations of the study :

NA

207. Name of the experts(s) in the related field :

1. Dr. Parthasarathi Das


Principal Scientist,
Medicinal Chemistry Division,
Indian Institute of Integrative Medicine
CSIR-IIIM), Jammu-180001,
Jammu & Kashmir, India,
Phone: +91-9419227993
Email: partha@iiim.res.in

2. Dr. P. Venkateswara Rao


Professor of Chemistry,
Osmania University, Tarnaka
Hyderabad-500076,
Telangana State, India
Phone: +91-9491884508
Email: venkateswararao.pallapothula@gmail.com

3. Dr. Manojit Pal


Professor of Chemical Biology,
Medicinal Chemistry Division,
Dr. Reddy;s Institute of Lifesciences, HCU Campus,
Gachibowli, Hyderabad, Telangana State,
Phone: 9000015358
Email: manojitp@drils.org, manojitpal@rediffmail.com

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301. Budget Estimate : (Rupees)

Amount requested in Rs.


Budget items Total (Rs.)
1st year 2nd year 3rd year
A Recurring
Staff
1 RA@Rs.46,500PM + 7,25,400 7, 25,400 7, 25,400 21, 76,200
HRA 30%
2 Contingency 2,00,000 2,00,000 2,00,000 6,00,000
4,00,000 4,00,000 4,00,000 12,00,000
3 Chemicals & Glassware
2,00,000 2,00,000 2,00,000 6,00,000
4 Travel 1,00,000 1,00,000 1,00,000 3,00,000
B.Permanent equipment
i) ) Parallel Synthesizer 20,00,000 00 00 20,00,000
ii) Rotary Evaporator 10,00,000 00 00 10,00,000
Total (A+B) 46,25,400 16,25,400 16,25,400 78,76,200
Overhead charges (@
C 9,25,080 3,25,080 3,25,080 15,75,240
20% of project cost)
Grand Total (A+B+C) 55,50,480 19,50,480 19,50,480 94,51,440
Rupees : Ninety Four Lakhs Fifty One Thousand Four Hundred And Forty Only

A. Recurring
1) BUDGET FOR SALARIES/WAGES

Budget In Rupees
Designation& Monthly 1 year
st
2 year
nd
3 year
rd
Total
number of emoluments
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persons
Research 6,00,000 6,00,000 6,00,000 18,00,000
25,000
Associate Two (24) (24) (24) (72)
1,80,000 1,80,000 1,80,000
JRF- One 15,000 5,40,000
(12) (24) (24)
Lab Assistant- 1,20,000 1,20,000 1,20,000
10,000 1,20,000
One (12) (12) (12)
Total 3,00,000 3,00,000 3,00,000 9,00,000

Justification for the manpower requirement

Two persons (Senior Research Associates) with M.Tech (experience in RF and


microwaves) are required to work on the design and simulation of micro strip patch
antennas, feeder network and TR modules. The same persons have to work on the
realization of digital receiver and data processing systems. They need to be offered a
pay of Rs.20, 000/- per month including all allowances. Since we need the experienced
persons the pay and allowances need to be with some additional increments which will
be negotiable.
Similarly one Junior Research Fellow with B.Tech (ECE) is required work along
with above two Senior Research Associates, mainly to conduct the experiments as
suggested by them and also to coordinate with Industry during fabrication, realization
and testing of the Antennas and TR modules.
One Lab Asst (Electronic Mechanic with ITI qualification) is required to work in
the Laboratory to prepare the experimental setup and carry out the integration
activities of the total system. He is essential from the beginning as the proto type model
wiring and testing shall be done at the institute before gving clearance for production
of the subsystems.

2) Consumables

a) BUDGET FOR THE MATERIAL (SUBSYSTEMS OF THE ALTIMETER)

Budget In Rupees
Item Quantity 1st year 2nd year 3rd year Total
Microstrip patch 1No
1,50,000 1,50,000 57,000 3,57,000
antenna (10x10)
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110Nos
TR modules @Rs.
per
2,31,000/-
one TR
1,00,00,000 1,00,00,000 54,10,000 2,54,10,000
module

Feeder network 1 lot 1,00,000 1,00,000 2,00,000


Mechanical
1 No. 1,00,000 2,00,000 1,00,000 4,00,000
structure
Digital Receiver
with radar 1 No. 50,00,000 50,00,000 52,00,000 1,52,00,000
controller
Power supplies 1 lot 1,00,000 1,00,000 -- 2,00,000
Cables,
Connectors, PCs,
1 lot 1,00,000 1,00,000 1,00,000 3,00,000
integration
panels etc.
Total 1,55,50,000 1,56,50,000 1,08,67,000 4,20,67,000,

Justification for material (sub systems for the altimeter)


As per the configuration of the Radar Altimeter the sub systems lists as items in
the table 320 need to be procured form the Indian industry. All the sub systems will be
realized indigenously and hence no imported item shown. Based on the similar items
being supplied by the industries the budget is estimated. The Rs.1,55,50,000 shown in
the 1st year will be used mainly towards advance to be paid to the suppliers for
fabrication of the subsystems. The 2nd year budget will be paid as per milestone
payments indicated in the purchase orders. The above cost includes taxes, insurance,
packing and forwarding charges also.

b) BUDGET FOR TEST EQUIPMENT AND SOFTWARE

Item Budget In Rupees


1st year 2nd year 3rd year Total
ADS & HFSS
1 10,00,000 ---------- ------------- 10,00,000
software
Network
analyzer/ 10,00,000
2 ------------ 10,00,000
Spectrum (FE)
analyzer
Total 10,00,000 10,00,000 20,00,000

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Justification for the test equipment and software

In order to carry out the design and simulations of antenna and feeder network
a tailored versions of the RF software will be procured. This will be used during 1 st
year and later it can be used by the institute for future projects. Further, a network
analyzer/ a spectrum analyzer is required in the 2nd year to carry out the pattern/
spectrum measurements on the antenna, feeder network and TR modules. This need to
be imported and these instruments are not being manufactured in India.

3) BUDGET FOR TRAVEL

Item Budget In Rupees


1st year 2nd year 3rd year Total
1 Travel 2,00,000 2,00,000 2,00,000 6,00,000

Justification for travel

It is essential to travel to the industries to assess their performance for


manufacturing the antennas and TR modules which are the critical sub systems of the
Radar Altimeter. Further, it is also required to constitute the design review committees,
who will thoroughly review the design and clear for implementation. The experts will
be from other organizations and industries. If required, their travel expenditure shall
be met from this budget. In order to have the follow up with the industry during
production of our sub systems, the research team need to travel which will be from this
budget.

1. BUDGET FOR MSCELLANEOUS ITEMS

Item Budget In Rupees


1st year 2nd year 3rd year Total
1 Miscellaneous 1,00,000 1,00,000 1,00,000 3,00,000

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Justification for Miscellaneous Items

The miscellaneous expenditure includes the consumables like paper, printer


cartridges, batteries, electronic components which are unaccounted during
procurements along with other systems, expenses during the review committee
meetings etc.

Check list for New Projects (To be filled by the PI)

1. Date of Birth of the PI : 15.08.1955


2. Date of Birth of the Co-PI : 15.06.1965
3. Whether PI would retire during the currency of the project
No
4. Whether PI is having ongoing project; If, so, when it is to be completed.
Yes, DST-FIST
5. Whether PI has completed any project, If, so, : Not applicable
i. Equipment purchased under that project and
ii. Whether A/Cs have been settled.

6. Whether PI would avail sabbatical leave for more than 6 months during the
project.If so, the name of the Co-PI.
No

7. Whether PI is retired scientist; If so, amount of honorarium proposed along-


with last pay certificate/pension drawn by PI.
Yes. PI is the amount of honorarium will be as per the norms.

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8. Whether staff salary as per DST/Host Institute norms; If salary as per norms of
host institute, certificate from host institute to be attached

Not Applicable

9. Whether quotations for equipment received.


No

10. List of equipment already available with host institute.

S.No. Equipment Make & Model Cost (Rs.) Quantity

1 Spectrum Analyzer (25 MHz ) Hameg & HMS-X 178,500 1

2 Digital Storage Oscilloscope (30 MHz) Scientific & SM0502 1,40,000 7

Akadamika & AMS-


3 Antenna Trainer Kits 1,53,000 2
B
SICO
4 Microwave benches 4,00,000 8
Pvt.ltd & SX-9000

5 Fiber optical communications Trainers FALCON & AL-01 1,20,000 4

Cranes software &


6 DSP kits 1,20,000 4
TMS20C6713
ENT Technologies
7 Multisim software 1,21,680 1
Labs

8 Xilinx software Edge Technologies 1,95,712 5

9 Spartan 3E FPGA Starter Kit Corel & FPGA01 50,000 5

10 Cool Runner - II CPLD Starter Kit Corel Technologies 27,500 5

Mentor Graphics EDA Tools Mentor Graphics &


11 3,00,000 1
( 3 years licence) 30 user floating licence HEP 1 and 2

XILINX ISE System Edition 12 Software


12 (Version 12, perpetual type, 25-users Corel Technologies 96,100 1
Licence)

National
13 LabVIEW software (10-users Licence ) 6,00,000 1
Instruments

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11. Whether institute is private/society, registration certificate along-with annual


accounts/annual reports for last 3 years are to be enclosed.
Registration certificate along-with annual accounts/annual reports for last 3 years
are enclosed (Annexure-2)
12. If funded institute is private, whether agreement/bond has been signed.
Not Applicable

ANNEXURE: 1

PROFILE OF THE PRINCIPLE INVESTIGATOR

Name : Dr. Subba Rao SV

Address : Associate Director (Retd.), SDSC SHAR, ISRO


Flat No: 103, SIRI Residency Pulla R eddy Nagar,
Kavali -524 201, SPS Nellore (Dist), A.P.
Phone: 08626-251 252 (R), 94414 90853(M)
Email: svsrao55@gmail.com

Date of Birth : August 15, 1955

Institutional Address : Department of Electronics and communication


Engineering, PBR Visvodaya Institute of Technology
and Science, Kavali 524 201, SPSR Nellore .Dist., A.P
Academic Qualifications:

Degr Yea University/


Specialization
ee r Institution
200 S.V.Univesity,
Ph.D Signal Processing
8 Tirupati
M.Tec 198 S.V.Univesity,
Instrumentation& Control systems
h 0 Tirupati
197 S.V.Univesity, Electronics &Communication
B.Tech
8 Tirupati Engineering.

Experience:

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Duration from Organisation Position Responsibility


6 months Sep 2016 PBR VITS, Kavali Professor Teaching/ Research
ISRO, Dept. Of Scientist/ Research/
35 years Dec1981
Space Engineer Supervision
ER&DC, Dept of Project
11 months Jan1981 Research
Electronics Engineer

Professional achievements:

General Manager, Range Instrumentation Systems


Dy. Director, Vehicle Assembly and Static Test facilities
Dy. Director, Range Operations
Project Director, Multi Object Tracking Radar Project
Project Director of Digital Work Flow Systems Project
Range Operations Director for PSLV, GSLV and GSLV-X Missions
Superannuated as Associate Director, SDSC SHAR

Honours:

Best paper awards in three international conferences


National award for system Innovation in Instrumentation in 2006
ISRO team Excellence award for the year 2011
ISRO Individual merit award for the year 2012
ISRO team Excellence award for the year 2013
ISRO team excellece award for the year 2014

Professional Society(s) Membership:

Fellow of Indian Socity for Non-Destructuvive Testing


Life Member, AstronauticalSocity of India
Life Member, Acoustic Emission working Group
Member, Institution Of Engineers

Specific Contributions:

Lead the team for preparing the study report on realisation of Multi
Object Tracking Radar (MOTR)
A subscale version of Multi Object Tracking Radar was realised and
successfully commissioned.
Realised and commissioned C-band and S-band radars.

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Developed the abort and acceptance criteria and implemented the same
for Acoustic Emission monitoring during proof pressure testing of rocket
motor cases.
Developed a two-channel Acoustic Emission Monitoring system, which
can be used for weld monitoring.
Developed a source location algorithm to detect cracks in metallic
structures using acoustic emission technique.
Realized and commissioned state of the art Instrumentation systems for
performance testing of rockets and subsystems.
As Project Director, MOTR contributed significantly in realizing
Indigenous Multi Object Tracking Radar first time in India. The Radar is
commissioned and made successfully operational.

Publications List (39):

[1].Subba Rao SV, Subramanyam B, Program mode of antenna position control


using microcomputer, Journal of Institution of Engineers(India), Vol.5,
November 1984,pp 43-45

[2].Subba Rao S.V, Srinivasan K.V, Annamalai .M" Instrumentation for high
frequency signals form Acoustic Emission sources", National Symposium on
Instrumentation (NSI-11), Hyderabad, October 1-4, 1986.

[3].Subba Rao S.V,Srinivasan K.V, Annamalai .M "A Simple Weld Monitoring


System", International Welding conference (IWC-87), New Delhi, January 12-
14, 1987.

[4].Subba Rao S.V,Srinivasan K.V, Annamalai .M "NDE of rocket motor cases


using AE technique", Seminar on NDE of solid propellants and components,
SHAR centre, Sriharikota, August 18, 1988.

[5].Subba Rao S.V,Srinivasan K.V, Annamalai .M "Time-Frequency domain


Analysis of AE signals using simple Instrumentation techniques", World
meeting on Acoustic Emission, Charlotte, North Carolina, USA, March 20-23,
1989. (Journal of Acoustic Emission, Vol.8, No 1-2, January-June, 1989, pp-S8-
S11.

[6].Subba Rao S.V,Srinivasan K.V, Annamalai .M, Devaraju K.V.M,


"Instrumentation for processing of Acoustic Emission Signals using parallel
processing concepts", National symposium on instrumentation (NSI-14),
Bangalore, October 3-6, 1989.

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[7].Subba Rao S.V,"Acoustic Emission-Signal Processing", First National


workshop on Acoustic Emission (NAWACE-90), SHAR centre, Sriharikota,
June 28-29, 1990.

[8].Subba Rao S.V,Srinivasan K.V, Annamalai .M and Devaraju K.V.M, "A Real
Time Token Ring LAN for AE monitoring", 10 th International Acoustic
Emission symposium, Sendai, Japan, October 22-25, 1990.

[9].Subba Rao S.V, Muralidharan. D, "Automatic Pressurization system for


testing pressure of vessels", Journal institution of Engineers (I), Vol.71,
March 1991, pp.37-38.

[10]. Subba Rao S.V, Srinivasan K.V, Visvanathan. K "Acoustic Emission-


Instrumentation and signal processing", Second National workshop on
Acoustic Emission (NAWACE-92), Hyderabad, September 17-18, 1992.

[11]. Subba Rao S.V,Srinivasan K.V, Visvanathan. K "Acoustic Emission


Monitoring of Rocket Motor Cases", Second National workshop on Acoustic
Emission (NAWACE-92), Hyderabad, September 17-18, 1992.

[12]. Subba Rao S.V,Devaraju K.V.M, Visvanathan. K, "PC based Acoustic


Emission Measurement system An Indigenization Concept", National
seminar on NDE (NDE-92), Tiruchirapalli, December 3-5, 1992.

[13]. Subba Rao S.V, Bhat M.R, Jayakumar.T. Guide To Non-Destructive Testing,
Publications of Indian Society for Nondestructive testing, 1994.

[14]. Subba Rao S.V, Srinivasan K.V, Visvanathan K,Devaraju K.V.M


"Multichannel Real-Time Data Acquisition system using Dual Ported FIFO
buffers", Journal of Microprocessors and Microsystems, Vol.18, No.s, March
1994,pp.101-108.

[15]. Subba Rao S.V, N. Satyanarayana, Visvanathan.K "Qualification of long


stored Rocket Motor Cases using Acoustic Emission technique", National
symposium on Acoustics (NSA-94), IGCAR, Kalpakkam, December 15-16,
1994. (Journal of the acoustical society of India, Vol. XXII, No.2, December
1994.pp.125-127.

[16]. SubbaRao S V, Chelladurai T, Satyanarayana N, Visvanathan K, "Integrity


Evaluation of Rocket Motor Cases using Acoustic Emission technique",
National seminar on Advances in Non-Destructive Testing (NDE-95), New
Delhi, November 9-10, 1995.

[17]. Subba Rao S.V, Jayaseelan D, Satyanarayana .N, Visvanathan. K "Analysis of


Acoustic Emission data obtained during proof pressure testing of M250
Maraging steel Rocket Motor Cases", 14th World Conference on NDT (14th
WCNDT), New Delhi, December 22-28, 1996.

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[18]. Subba Rao S.V, Jayaseelan D., Satyanarayana. N, Visvanathan .K, "Acoustic
Emission monitoring of a long stored Rocket Motor Case", 14 th World
conference on NDT (14th WCNDT), New Delhi, December 22-28, 1996.

[19]. Subba Rao S.V, Chelladurai. T, Sankaranarayanan A.S, Sarama.AVSSSR,


Acharya A.R., and Krishnamurthy R., "Acoustic Emission Technique-An
effective tool for the integrity Evaluation of M250 Maraging Steel Aerospace
pressure Chambers", 14th World Conference on DT (14th WCNDT), New
Delhi, December 22-28, 1996.

[20]. Subba Rao S.V, Jayaseelan .D,Madhusudhana Rao K., Murthy CRL,
"Modern Trends in AE Instrumentation", Fourth National Workshop on
Acoustic Emission (NAWACE-97), Mumbai, August 22-23, 1997.

[21]. Subba Rao S.V, "Standardization of Acoustic Emission test procedure to


qualify M250 Maraging Steel pressure vessels", Proceedings of seminar on
NDE for life extension (NDE-97), Hyderabad, December 11-13, 1997.

[22]. Subba Rao SV, Proof Pressure Testing of PSLV/GSLV rocket motor
hardware- a review, ISRO Technical symposium, Bangalore, September
13,2001

[23]. Subba Rao S.V, Sensors, Signals conditioning and data Acquisition for
Acoustic Emission testing", Proceedings of fifth National workshop on
Acoustic Emission (NAWACE-2002), Hyderabad, October 18-19, 2002.

[24]. Subba Rao S.V, "Attenuation of Acoustic Emission signals in Maraging steel
hardware", National seminar on NDE-2003, Thiruvananthapuram, December
11-13, 2003.

[25]. Subba Rao S.V, Signals and Data acquisition for NDE, National Seminar
on NDE-2005, Kolkata, December 30-31, 2005.

[26]. Subba Rao S.V, Mukhopadhyay C.K, Kalyanasunderam P. "Practical


Acoustic Emission, Narosa Publishing house, New Delhi, Nov 2007.

[27]. Subba Rao S.V, Subramanyam. B, "Analysis of Acoustic Emission signals


using Wavelet Transformation Technique, Defence Science Journal, July -
Sept 2008.

[28]. Subba Rao S.V, Subramanyam B, "Signature Identification of Hydraulic leak


Signals in Pressure Vessels Using Wavelet Transformation Technique,
journal of non-destructive evaluation, ISNT, 2009.

[29]. Veerraju A, Anandaraj J, RamanappaTV ,Sankaran S, Jopaul.K. Ignatius, Rao


JV, Suryanarayana E, Subba Rao SV Development of high frequency
instrumentation system for studying aero acoustic characteristics related to

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launch vehicle lift off, National symposium on Acoustics (NSA-2009),


Hyderabad, November 26-28, 2009,

[30]. Subba Rao BV, Gopala Krishna J, SrinivasaBabu M, Subba Rao SV, Seshagiri
Rao V, Prasad MYS, Design considerations for realization of Multi Object
Trcking Radar (MOTR) for space applications Proceedings of Second IEEE
International conference on RF and signal processing systems (RSPS 2010),
KL University, Guntur, January 7-9, 2010.

[31]. SaralaPatchala, GnanaPrakash T, KPadamRaju K, Subba Rao SV, Time


Domain Signal Detection for MIMO OFDM systems ,Special Issue of IJCCT
Vol.1 Issue 2, 3, 4 August 2010, PP 103-110.

[32]. Prasad MYS, Seshagiri Rao V, Subba Rao SV, Subba Rao BV, Requirements
of Indian Space Research Organisation for a Multi Object Tracking Radar
61st International Astronautical Congress(IAC 2010), Prague, Czech
Republic, 27 September-1 October, 2010.

[33]. Naga Prasanna B, PhaniSrinivas M, Subba Rao SV, Subba Rao BV, Design
of1X4 Microstrip Patch Antenna and evaluation of its Performance,
National Conference on signal processing and communications (SPCOMs
2011),Guntur, 1-2 April, 2011.

[34]. Subba Rao SV, Subba Rao BV, Prasad MYS, Seshagiri Rao V,
Configuration and design options to monitor GSO space debris by Multi
Object Tracking Radar of ISRO, 63rd International Astronautical
Congress(IAC 2012), Naples, Italy, 1-5 October, 2012.

[35]. Vaidhyanathan A, Muhammad Suhail M, SrinivasaBabu M, Subba Rao SV,


Seshagiri Rao V, Desigh and Evaluation of Tracking filters for a special
Radar application Proceedings of International conference on
communications, Devices and Intelligent systems (CODIS 2012), 978-1-4673-
4700-6/12, PP 69-72.

[36]. Subba Rao BV, Gopala Krishna J, SrinivasaBabu M, Subba Rao SV, Seshagiri
Rao V, Prasad MYS, Design, development and qualification of MOTR
subscale system Proceedings of National conference on space debris
management and mitigation techniques, Bangalore, February 27-28,2014.

[37]. VenkataRamana P, Malini K, Rajkumar S, SrinivasaBabu M, Subba Rao SV,


Seshagiri Rao V, Tracking of Multiple Targets using MOTR Proceedings
of National conference on space debris management and mitigation
techniques, Bangalore, February 27-28,2014.

[38]. Venkatraman R, Sankaran S, Subba Rao SV, Krishnaiah P and Sundararajan


T, Investigation on the Ignition Over Pressure Related to Launch Vehicle
Lift-off, Indian Journal of Science and Technology, Volume 7(1), January
2015, PP 86-94.
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[39]. Raghu Kumar S, Velayudham K, Subba Rao SV, Seshagiri Rao V, Digital
Workflow Systems for ISRO A Systems Approach for e-Governance ISRO
seminar on computers and Information Technology (ISCIT-2015),
Thiruvananthapuram, March 19,2015.

List of Projects implemented:

1. Design and development of Indigenous Multi Object Tracking Radar first


time in India. The Radar is commissioned and made successfully
operational.
2. Realized and commissioned state of the art Instrumentation systems for
performance testing of rockets and subsystems.

PROFILE OF THE CO-INVESTIGATOR

Name : Dr. D.Prathyusha Reddi

Address : Professor, Dept of ECE,PBRVITS,Kavali-524201


SPSR Nellore district, AP

Date of birth : June 05, 1965

Institutions address : Department of Electronics and communication


Engineering, PBR Visvodaya Institute of Technology
and Science, Kavali 524 201, SPSR Nellore .Dist., A.P
Email:prathyu65@yahoo.co.in

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Academic Qualifications:

Degree Year University/ Institution Specialization

Ph.D Dec 2014 JNTU Anantapuramu Image Processing.

Digital Systems &Computer


M.Tech 2004 JNTU Hyderabad
Electronics
Electronics &Communication
B.Tech 1998 S.V.Univesity, Tirupati
Engineering

Experience

Duration From Organisation Position Responsibility

15 years Oct 1999 PBR VITS, Kavali Professor Teaching/ Research

Publications List

[1].D.Prathyusha Reddi,Dr S.Varadarajan& Dr M.N.Giri Prasad, Visual Signal


Content Based Image Compression, National Conference on Emerging trends
in Communications and Signal Processing Techniques (Sanketa-2012), Jan2012.
(Proceedings published in Journal of Innovation in Electronics&
Communication, a special issue on Signal Processing & Communication
Techniques, Vol.2,Issue2,Jan2012,Page104-109.
[2].D.Prathyusha Reddi,Dr M.N.Giri Prasad&Dr S.Varadarajan,A New image
compression scheme using Hyper analytic Wavelet Transform and
SPIHT,Contemparary Enginering Sciences,2013, Vol.6,No.6,Page 87-89.
[3].D.Prathyusha Reddi, Dr M.N.Giri Prasad&Dr S.Varadarajan,A comparative
study of image compression using Adaptive DCT and JPEG,Proceedings of
2013 National conference on Innovations in IT & Engineering(IITE2k13),SV
University,Tirupati,April20-22,2013,Page 214-216.
[4].D.Prathyusha Reddi,Dr M.N.Giri Prasad&Dr S.Varadarajan, Image
compression using multi-rate sampling, International journal of Computers
and Technology, July 2013,Vol.10(1),Page 1230-1235.
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[5].D.Prathyusha Reddi, Dr M. N. Giri Prasad & Dr S.Varadarajan, Image


independent compression scheme using Adslets, International Journal of
Advanced computer Research (IJACR), Sept 2013, Vol.No3(3),Issue 12, Page 1-
10.

ANNEXURE: 2

SOCIETY REGISTRATION CERTIFICATE

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