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This section provides brief reviews of articles from many journals that relate to the interests of individuals seeking
information on research and teaching in developmental and behavioral pediatrics. The reviews will not provide critical
comments, but the articles have been selected from peer-reviewed journals.
Readers are invited to recommend articles for inclusion in this section. If you read or author an article you believe would
interest our readers, please send a copy to Mary F. Sharkey, Journal of Developmental and Behavioral Pediatrics, 345 West
70th Street, #6F, New York, NY 10023.
448
Journal Article Reviews 449
mothers and their offspring at considerable financial and received each medication for 7 days. Teachers completed a daily
educational disadvantage. M.I.R. report card, and parents and teachers completed a weekly
behavior rating scale. To evaluate the time course of medication
effects, children spent 12 hours on Saturdays in a laboratory
ATTENTION-DEFICIT HYPERACTIVITY classroom setting. Reports of adverse events were collected. On
DISORDER: SENSORY DYSFUNCTIONS virtually all measures and in all settings, both drug conditions
were significantly different from placebo, and the two drugs
Mangeot SD, Miller LJ, McIntosh DN, et al: Sensory modulation
were not different from each other. In the lab setting, effects of
dysfunction in children with attention-deficit hyperactivity
Concerta were comparable to t.i.d. methylphenidate and lasted at
disorder. Dev Med Child Neurol 43:399, 2001. Sensory
least through 12 hours. Effects were evident for academic
modulation is the capacity to regulate and organize the degree,
performance and social behavior with peers. This study provides
intensity, and nature of responses to sensory input. Sensory
a model for clinical trials of new psychoactive drugs in children,
modulation dysfunction (SMD) presents with two opposite
with multiple raters, in natural and lab settings, and across a
behavioral patterns: sensation seeking and sensation avoiding.
range of domains of impairment. A.D.S.
Emotional responses associated with sensory avoiding are
Thiruchelvam D, Charach A, Schachar RJ: Moderators and
typically explosive, aggressive, and hostile behaviors. Emo-
mediators of long-term adherence to stimulant treatment in
tional responses associated with sensation seeking include
children with ADHD. J Am Acad Child Adolesc Psychiatry
disregard for others, inability to regulate intensity and duration
40:922, 2001. Numerous short-term studies have shown that
of interaction with others, and mania. A high percentage of
stimulant medications are effective in treating symptoms of
children with attention disorders are noted to have sensory
restlessness, inattentiveness, and impulsivity in children with
processing problems and/or to show difficulty modulating
attention-deficit hyperactivity disorder (ADHD). There are a
sensory responses. This study investigated the presence of SMD
limited number of studies that provide information about long-
among children with attention-deficit hyperactivity disorder
term adherence to stimulant medication. The objective of this
(ADHD). Twenty-six children with ADHD (18 boys, 8 girls),
study was to identify and investigate moderators and mediators
ages 5 to 13 years (mean age 8.2 years), and 30 typically
of adherence to stimulant medication. This knowledge would
developing children of similar age and gender were tested using
help to customize treatment programs to assist those children
electrodermal responses (EDR), which are changes in electrical
most likely to need help with continuing a regimen of stimulant
conductance of the skin. Experimenters, blind to participants
medication. Seventy-one children, diagnosed with ADHD and
groups, administered stimuli in five sensory domains: olfactory,
taking methylphenidate, were followed prospectively on an
auditory, visual, tactile, and vestibular. Medications were
annual basis for a 3-year period. Medication adherence was
discontinued 24 to 48 hours before the physiologic testing.
measured, along with moderators and mediators. Moderators
Parental report measures of sensory, emotional, and attentional
(baseline characteristics specific to the child) included symp-
problems were administered, including the Short Sensory
toms of ADHD, oppositional and defiant disorder (ODD),
Profile and the Child Behavior Checklist. Compared with the
conduct disorder (CD), learning disabilities, anxiety, age,
typical sample, children in the ADHD group displayed greater
psychosocial adversity, and family dysfunction. Response to
abnormalities in sensory modulation on both physiologic and
treatment in school was used to assess mediators (factors that
parent-report measures. The group with ADHD showed greater
arise after initiation of treatment and affect whether a child
reactivity to sensory stimuli, with larger initial reactions and
continues to take stimulant medication). Eighty-one percent of
subsequent habituation. Twenty-four percent of children with
subjects continued to use stimulant medication at 12 months,
ADHD scored within normal limits on the Short Sensory
and 52% of subjects adhered to stimulants for the 3 years of the
Profile, whereas 29 of 30 typically developing children scored
study. Some of the children who discontinued stimulants
within normal limits. The children with ADHD also displayed
subsequently returned to using them at later points in time.
more variability in responses. Within the ADHD group, levels
The most salient moderating factor influencing stimulant
of SMD were highly correlated with measures of psychopathol-
treatment adherence was the absence of ODD at school
ogy on the Child Behavior Checklist. The findings suggest that
(children discontinuing medication were 11 times more likely
sensory processing abilities may be impaired in a subgroup of
to have ODD). Adherents to the medication regime were also
children with ADHD and that such impairment may have
more likely than nonadherents to be younger and to have more
behavioral significance. A.D.S.
teacher-rated ADHD symptoms at school. The authors suggest
that oppositional defiant symptoms at school, especially in the
ATTENTION-DEFICIT HYPERACTIVITY presence of lower levels of ADHD symptoms, are a strong
DISORDER: TREATMENT ISSUES indicator that a child will have difficulty continuing to take
medication continuously for 3 years and that targeting these
Pelham WE, Gnagy EM, Burrows-Maclean L, et al: Once-a-day children with resources designed to improve stimulant medi-
Concerta methylphenidate versus three-times-daily methylphe- cation adherence may be particularly important, especially as
nidate in laboratory and natural settings. Pediatrics 107, they approach adolescence. M.I.R.
2001. URL: http://www.pediatrics.org/cgi/content/full/107/6/
e105 This study assesses the efficacy and duration of action of AUTISM: AMANTADINE TREATMENT
Concerta, an extended-release preparation of methylphenidate
(MPH). Sixty eight children with attention-deficit hyperactivity King BH, Wright DM, Handen BL, et al: Double-blind, placebo-
disorder (ADHD), ages 6 to 12 years, participated in a within- controlled study of amantadine hydrochloride in the treatment of
subject, double-blind comparison of placebo, short acting MPH children with autistic disorder. J Am Acad Child Adolesc
administered three times a day, and Concerta given once a day. Psychiatry 40:658, 2001. Excitatory amino acids are involved
Each childs dose was based on his maintenance dose before the in neuronal regulation. Areas of the brain found to exhibit
study: children on MPH 5 mg three times daily (t.i.d.) took cellular abnormalities in autism show a high degree of N-methyl-
Concerta 18 mg, those on MPH 10 mg t.i.d. took Concerta 36 D-aspartate (NMDA) receptors. Amantadine hydrochloride has
mg, and those on 15 mg t.i.d. took Concerta 54 mg. Children been found to have noncompetitive NMDA antagonist activity.
450 Journal Article Reviews JDBP/December, Vol. 22, No. 6
There are limited data suggesting amantadine may decrease outcomes of a support intervention for families of children with
behaviors such as aggression and hyperactivity. Thirty-nine specific chronic illnesses. A population-based sample of 193
subjects with autism, ages 5 to 19 years, were recruited and mothers of children ages 7 to 11 years with diabetes, sickle cell
enrolled in this multicenter study. Subjects all had a high degree disease, cystic fibrosis, or moderate-to-severe asthma was
of irritability and hyperactivity and an IQ greater than 35. The included. About 15% of those contacted refused to participate,
Aberrant Behavior Checklist (ABC) and Clinical Global and 14% of the families were lost to follow-up. The 15-month
Impressions (CGI) scales were used as primary outcomes. intervention, the Family-to-Family Network, was designed to
Nineteen subjects were randomly assigned to receive amantadine enhance mothers mental health by linking mothers of school-
and 20 to receive placebo. The treatment phase was 4 weeks. The age children with mothers of older children with the same
dosing regimen was once a day for the first week and twice a day condition. The program was community-based and included
thereafter, with a dose of 5 mg/kg per day. The mean placebo telephone contacts, face-to-face visits, and special family
response rate was 37% versus amantadine at 47% (not events. The veteran Network Mothers aimed to identify
significant). When assessed on parent-rated ABC scales of naturally occurring sources of support, point out examples of
irritability and hyperactivity, there were no significant differ- effective parenting by the mothers, and point out opportunities
ences between groups. Analysis of blinded investigator-rated for strengthening these sources of support and existing
ABC scores at baseline and again at 5 weeks showed statistically parenting skills. The main outcome measures were the Beck
significant improvement in absolute change from baseline Depression Inventory and the Psychiatric Symptom Index.
scores of hyperactivity and inappropriate speech. CGI ratings Maternal anxiety scores for participants in the experimental
were higher in the amantadine group: 53% showed global group decreased during the intervention period for all diagnos-
improvement versus 25% in the placebo group ( p = .076). tic groups, whereas scores for the control group increased
Amantadine was well tolerated. Although the findings are (F = 5.07, p = .03). In a multiple regression analysis, the
inconclusive, they suggest that further studies of this medication intervention was a significant predictor of posttest anxiety
are warranted. A.D.S. scores. Effects were greater for mothers with higher baseline
anxiety ( p < .001) and for those who were themselves in poor
CHRONIC ILLNESS health ( p < .01). The study provides solid empiric evidence for
the beneficial effect of a parent-to-parent family support
Spieth LE, Stark LJ, Mitchell MJ, et al: Observational assessment intervention on the mental health status of mothers of children
of family functioning at mealtime in preschool children with with chronic illnesses. A.D.S.
cystic fibrosis. J Pediatr Psychol 26:215, 2001. The authors
of this study investigated family functioning during mealtimes
in families of children with and without cystic fibrosis (CF). IRON DEFICIENCY AND COGNITIVE
Groups were matched for age of child, gender, number of DEVELOPMENT
parents and siblings present at the meal, and SES. Ages of the
Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi
children ranged from 2 years to 5 years, 11 months. Families
PG: Iron deficiency and cognitive achievement among school-
were videotaped during mealtimes, and meals were coded for
aged children and adolescents in the United States. Pediatrics
the presence of certain behaviors. Differences were noted
107:1381, 2001. The relationship between iron status and
between the groups, with families of children with CF rated as
cognitive achievement in older children is unclear. The National
lower on an overall measure of family functioning, as well as in
Health and Nutrition examination Survey III 19881994
the areas of communication, interpersonal involvement, affect
provides cross-sectional data on children 6 to 16 years of age
management, behavior control, and roles. Scores on all scales
and contains measures of iron status, including transferrin
fell into the unhealthy range for families with a child with
saturation, free erythrocyte protoporphyrin, and serum ferritin.
CF. However, the weight-for-age percentile was not associated
Children were considered iron-deficient if any two of these
with overall ratings of family functioning. Results appeared to
measures were below age and gender norms. Anemia was
indicate that having a child with CF poses specific challenges
defined using norms for standard hemoglobin measures. Scores
for the family. C.L.G.
on standardized tests of academic achievement were compared
Special Series: Empirically supported treatments in pediatric
among children with normal iron status, iron deficiency without
psychology. J Pediatr Psychol 26:253, 2001. This special
anemia, and iron deficiency with anemia. Logistic regression
series includes a review article of empirically supported
was used to estimate the association of iron status with
treatments for regimen adherence, two commentaries on this
achievement, controlling for confounding factors. Among
article, and reviews of two books on treatment adherence. The
5938 children in the sample, 3% were iron deficient. The
review article addresses intervention studies that target non-
prevalence of iron deficiency was highest among adolescent
adherence to regimens for asthma, juvenile rheumatoid arthritis,
girls (8.7%). Compared with children with normal iron status,
and type 1 diabetes. The prevalence and correlates of non-
children with iron deficiency, with or without anemia, had lower
adherence, possible intervention strategies, and an overview of
math achievement (93.7, 86.4, and 87.4 respectively). Children
the medical characteristics and treatments for each of these
with iron deficiency had twice the risk of scoring below average
diseases are presented. Intervention studies for each illness are
in math than children with normal iron status (odds ratio 2.3;
examined according to criteria developed by a task force from
95% confidence interval: 1.14.4). Although causality cannot
the American Psychological Association (Chambless criteria) to
be inferred, the association raises questions about screening and
assess their efficacy. C.L.G.
therapy. A.D.S.
Ireys HT, Chernoff R, DeVet KA, Kim Y: Maternal outcomes of a
randomized controlled trial of a community-based support
program for families of children with chronic illness. Arch NEGLECT AND COGNITIVE DEVELOPMENT
Pediatr Adolesc Med 155:771, 2001. Parents of children with
chronic illness are at high risk for mental health problems such Strathearn L, Gray PH, OCallaghan MJ, Wood DO: Childhood
as anxiety and depression. This randomized controlled clinical neglect and cognitive development in extremely low birth weight
trial with repeated measures 1 year apart examined maternal infants: A prospective study. Pediatrics 108:142, 2001. This
Journal Article Reviews 451
study from Brisbane, Australia, examines the relationship moderate-level) physical activity was associated with improved
between child maltreatment and cognitive development in scores on self-esteem measures. No relationship was observed
extremely low birth weight infants, adjusting for perinatal and between physical activity levels and anxiety. The authors
parental risk factors. A total of 352 infants with birth weight less conclude that, although high-level physical activity is an
than 100 g were followed prospectively for 4 years. At 4 years, important element in the development of childrens self-esteem,
269 (76%) of these children were cognitively assessed, using the healthy children rarely engage in vigorous physical activity. To
McCarthy general cognitive index. Perinatal risk factors and be most effective, intervention efforts should primarily target
parental risk factors were measured prospectively. Cognitive decreasing television and computer time and increasing self-
z scores were calculated at 1, 2, and 4 years, and head circ- efficacy. M.I.R.
umference z scores at birth, 2 years, and 4 years. Fifty-two (15%)
of the children were referred to child protective services for PLAY AND EMOTIONAL ADJUSTMENT
suspected maltreatment; 32 (11.9%) were referred before the
4-year assessment. Fifty percent of these 32 infants were referred Coplan RJ, Gavinski-Molina M, Lagace-Seguin DG, Wichmann
before the age of 5.5 months. Thirty-one children (60% of those C: When girls versus boys play alone: Nonsocial play and
referred) had one or more substantiated report, including 19 adjustment in kindergarten. Dev Psychol 37:464, 2001. The
children with substantiated neglect. Those cognitively assessed authors investigated the relationship between nonsocial play and
at 4 years included 32 of the 52 referred infants. The adjusted adjustment outcomes. Participants were 77 children attending
general cognitive index at 4 years was significantly reduced in kindergarten who were studied over the course of the school
infants referred for neglect (cognitive z score: 17.6; 95% year. Reticent behavior, in both boys and girls, was associated
confidence interval: 3.3, 31.9). Infants whose neglect was with shyness and negatively associated with social and
substantiated had a progressive decline in their cognitive academic competence. Solitary-passive play was positively
function over time (cognitive z scores: .97, 1.37, and associated with measures of adjustment, whereas for boys this
2.05 standard deviations at 1, 2, and 4 years, respectively), association was negative. The presence of solitary-active play
compared with nonneglected infants. They had significantly was related to parent ratings of greater emotional dysregulation
smaller head circumference at 2 and 4 years, but not at birth and teacher ratings of lower social competence and greater
(adjusted z score at 4 years: .81; 95% confidence interval: internalizing problems. Girls who engaged in at least one
.17, 1.46). Perinatal risk factors and physical disability were episode of solitary-active play had significantly more external-
not related to maltreatment referral; only parental factors were izing problems than girls who did not. The authors conclude that
independent predictors. The findings indicate that childhood these results represent a beginning in the understanding of
neglect is associated with delayed cognitive development and potential gender differences in nonsocial play behaviors in
head growth in this high-risk population. A.D.S. young children. C.L.G.