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CASE: GIANT CELL TUMOR OF BONE

DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
IBUPROFEN 800mg Exact I: Relief of pain CNS: Use drug only as suggested
Tablet mechanism not C: hypersensitivity Headache, Avoid overdose
Class: Oral known. Anti- dizziness, Take with food or after
NSAID Every 6 inflammatory somnolence, meals
hours insomnia
PRN Derm:
Rash

GI:
Nausea,
dyspepsia, GI pain

DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
ACETAMINO 500mg May block pain I: Muscle Spasm GI: Nausea, Asssess VS plus pain
PHEN tablet impulses C: hypersensitivity vomiting, abdominal
PO peripherally that pain; hepa-
Twice a day occur in response totoxicity
to inhibition of Inform patient that toxicity may
prostaglandin INTEG: Rash, occur when used with other
synthesis urticaria combination products

SYST: Advise patient not to use with


Hypersensitivity alcohol, OTC products, or herbals
without prescriber approval
TOXICITY:
Cyanosis, anemia, Watch out for toxicity
neu- tropenia,
jaundice,
pancytopenia, CNS
stimulation,
delirium followed
by vascular
collapse, seizures,
coma, death

DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
HYDROCODO 10 mg Acts as agonist Indication: CNS: Assess temperature, skin
NE Capsule at specific opioid Pain severe enough Dizziness, color, texture lesions;
Oral receptors; to require a sedation, impaired orientation, reflexes,
Class: Every 12 producing continuous around mental ability, bilateral grip strength,
Opioid hours analgesia, the clock analgesic somnolence, affect, pupil size
agonist euphoria, tremor, fatigue auscultation, pulse,
analgesic sedation Contraindication: perfusion respiration,
hypersensitivity CV: peripheral adventitious sound, bowel
edema sounds, normaloutput LFTs
Do not crush, break or
Derm: allow to chew capsule
Pruritus Be aware this is not
intended for PRN
GI: Monitor for addiction and
N/V, dry mouth abuse
constipation Avoid using with alcohol

GU
UTI

Resp:
Respiratory
distress
DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
ZOLEDRONIC 4mg/5ml Inhibits bone I: Treatment of bone CNS: insomnia
ACID Injection resorption, metastases in CV: hypotension Assess vital signs, orientation
IV infusion possibly by conjunction with GI: nausea, affect CBC, electrolytes
Class Three inhibiting antineoplastic constipation
Calcium times a osteoclast therapy Respiratory: Arrange dental exam and
regulator month dyspnea complete any needed treatment
C: allergy before staring this drug

Take Vitamin D and calcium


supplements

DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
INTERFERON 3 million Inhibits growth I: Giant Cell Tumor CNS: Assess Weight,; vital signs,
ALFA-2B units of tumor cell C:Allergy Dizziness, liver evaluation, CBC., CBG
Injection confusion Renal function, urinalysis
Class: IM Mechanism of Use bacteriostatic water for
Interferon Three action is not Derm injection as diluent
Antineoplasti times a clearly Rash, dry skin, Ensure patient is well
c week understood pruritus hydrated
GI:
anorexia, nausea

Others:
Flulike symptoms

DRUG NAME DOSAGE MECHANISM OF INDICATIONS AND SIDE EFFECTS NURSING CONSIDERATION
ACTION CONTRAINDICATION
DENOSUMAB 120mg Human I: giant cell bone CNS: vertigo Obtain baseline serum
Injection monoclonal tumor CV: angina calcium before beginning
Class SQ antibody that GU: cystitis therapy
RANKL Every 4 prevents C:hypersensitivity Other: Administer SQ into
inhibitor weeks RANKL; inhibits hypocalcemia, abdomen/upperthigh/
osteoclast back pain,, upper arm
formation and musculoskeletal Take Ca and Vit D
survival, pain,
decreasing bone hypercholesterole
resorption mia
increasing bone
mass and
strenght