Book of Abstracts - National Symposium On Nanotechnology: From Materials To Medicines and Their Social Impact

One Day National Symposium on
NANOTECHNOLOGY :
From Materials to Medicines and
Their Social Impact
BOOK OF ABSTRACTS
Organized by
Centre for Interdisciplinary Research and Education
Birla Industrial and Technological Museum
West Bengal Academy of Science and Technology (Sec XI)
Adamas University
25th March, 2017

at the Birla Industrial and Technological Museum, Kolkata
Nanotechnology: From Materials to Medicines and Their Social Impact
25th March 2017
The Committees
Board of Advisers
Prof Siddharta Roy, Dir, Bose Instt Dr K Muraleedharan, Dir, CGCRI

Prof S Bhattacharya, Dir., IACS Prof Samit Roy, Chancellor, Adamas Univ
Prof D. Chatterjee, VC Amity U, WAST Prof P Mazumdar, President, WAST
Prof. S.C. Sarkar, President, CIRE, WAST Sk. E Islam, Director, BITM, WAST
Mr D Chatterjee, CIRE Mr G S Rautela, CIRE
Organising Committee
Prof Parimal Sen, Bose Instt Prof Sukhen Das, Jadavpur Univ. & CIRE
Prof Papiya Nandy, CIRE, WAST Dr. Ruma Basu, Jogamaya D. Coll & CIRE
Dr. Ashesh Nandy, Secretary, CIRE Dr. Manas P. Das, AIR & CIRE
Dr. Smarajit Manna, JBNSTS & CIRE Dr. Avijit Kar, JBNSTS & CIRE
Dr. Achintya SIngha, Bose Inst & CIRE Dr. Biplab Paul, Jadavpur Univ, CIRE
Smt. Poonam Das, Jadavpur Univ, CIRE
TABLE OF CONTENTS
Page No
PROGRAM SCHEDULE 7
ABOUT THE SYMPOSIUM 8
COLLABORATORS & SPONSORS 9
INVITED LECTURES
KNA Keynote Address by Dr. D. Chakravorty: New Functionalities in Materials by 15
Nanotechnology
IL01 Dr. G. P. Das: Nano-Science & Technology : Promises, Expectations and 16
Challenges
IL02 Prof. A. Mukherjee: Soft Matter Nanochemistry in Guar Gum for 17
Applications
IL03 Dr. M. Pradhan: Synthesis of Anisotropic Nanostructures for 18
Surface-Enhanced Raman Scattering (SERS) Based Sensing
IL04 Dr. M Ghosh: Nanotechnology Application in Glioma Therapy: 19
Targeted Drug Delivery through Blood Brain Barrier
IL05 Dr. S. Arora: Ultrahigh Dilutions as Nanomedicine 20
IL06 Prof. N. C. Sukul: DSC reveals variation in enthalpy associated with 21
free water molecules in water ethanol solution exposed to x-rays and
magnetic field
IL07 Prof. C. R. Mahata: Nanoparticles of Homeopathy: Their Possible Identities 22
ORAL PRESENTATIONS
OP01 Dr. S Banerjee: Studies on Multifunctional Nanostructured Materials 23
OP02 Dr. Suvadra Das: Phytochemical Stabilized Metal Nanoparticle : 24
A Newer Solution to Neglected Tropical Disease, Visceral Leishmaniasis
OP03 Dr. S. Naskar: Health impact of engineered nanoparticle and their risk 25
assessment study by different models
OP04 Dr. P. Roy: Nanotherapeutics of plant-bioactives: Improved and 26
safer arsenals in present day therapy
OP05 Dr. A. Adhikary: Strategic management of breast cancer by novel nano- 27
therapeutics through regulation of the miRNA circuitry
OP06 Dr. J. Das: Role of nanoparticles in therapeutic gene delivery applications 28
OP07 Dr. P. K. De: Nanosponges: A Modern Tool in Drug Delivery System 29
OP08 Dr. K. C. Paul: Experimental and clinical Assessment of Hepato-protective 31
Activity of Bangladesh plants
Book of Abstracts
OP09 Dr. S. Bhandary: Bioavailability, biodistribution and drug delivery 32
efficiency of nifetepimine-loaded folic acid functionalized pH
responsive highly uniform mesoporous silica nanoparticles for
improved breast cancer therapy
OP10 Dr. A. Ghosh: Antitumorigenic activities of nanoencapsulated 33
nifetepimine: A possible breakthrough in the therapeutic
intervention of triple negative breast cancer
POSTER PRESENTATIONS
PP01 Souravi Bardhan: A Study on Microbial Properties of some 34
Commonly Occurring Minerals
PP02 Atheni Konar: Homoeopathic drugs complementary, antidotal and 35
inimical to Nux vomica produce stronger anti-alcoholic effect on toads
than Nux.
PP03 Tandra Sarkar: High dilution of Mercuric Chloride increases water 36
permeation, chlorophyll content and growth in germinating seeds of
cowpea Vigna unguiculata (L) Walp
PP04 Mou Saha: Influence of nano clay on Structure and Electrical 37
properties of Poly (Ethylene) Oxide based Solid electrolytes
PP05 Antara De: In search of epitopes on nanomedicines - 38
From proteomics to vaccinomics
PP06 Ruma Basu: Photo voltage generation by using mixed dye with 39
oxidized multiwall carbon nanotube and also with potentised
ZnO nanoparticle
PP07 K. Das: Extraction of electrical energy from a system without 40
any source of ion
PP08 P. Bandyopadhyay: Succussion enhances voltage and power 41
generation in polar liquids due to domain formation as predicted
by QED
PP09 P. Maitra: Effect of vigorous shaking on Raman Spectra of 91 % 42
ethanol, a vehicle for homeopathic medicine
PP10 Manisha Ahir: Anticancer effect of Folate-decorated-CuO-Nanowire in 43
human triple negative breast carcinoma cells via mitochondrial-ROS
generation and NF-B-miR425-PTEN pathway
PP11 Tara Shankar Bhattacharya: Extraordinary photoluminescence 44
enhancement in Au decorated few-layer WS2
PP12 Sreyan Raha: Enhanced Raman Scattering from Individual Ge nanowire 45
PP13 Shatadal Ghosh: Assessing the efficiency of the Mesoporous Silica 46
Nanoparticle for the delivery of Curcumin and improving its bioavailability
4
One Day National Symposium on Nanotechnology : From Materials to Medicines
PP14 Ankita Paul: Network Analysis of Crack Patterns in Laponite Clay 47

in presence of DC Electric Field
PP15 A. L. Gayen: Enhanced dielectric properties and conductivity 49
of triturated copper and cobalt nanoparticle doped PVDF-HFP film
and their possible use in electronic industry
PP16 Anindita Dey: Role of multiwalled carbon nano tube as nanofertilizer 50
PP17 Debbethi Bera: Effect of Homeopathy Medicine Aurum metallicum 51
on Anisotropy of Liposomal Membrane
PP18 M. Chakraborty: Phytoreduction of copper nanoparticles from Vigna 52
radiata and its antibacterial activity
PP19 Somasri Hazra: Wavy cracks in Laponite gels: mode selection in a 53
static electric field
PP20 Supriyo Bera: Structure and activity of lysozyme immobilized on 54
graphene oxide
PP21 S. K. Patla: Effect of insulating nano filler on conductivity and 55
morphology of PEO PVDF based blend Solid Polymer Electrolytes
PP22 Shamila Sarwar: Anti-cholera activity of ZnO Nanoparticles 56
PP23 Farha Khatun: Improvement of electroactive phase nucleation, 57
dielectric and optical properties of chalcone modified poly
(vinylidene fluoride) thin films
PP24 Prosenjit Biswas: Synthesis of different WO3 nanostructures: 58
A temperature dependent study
PP25 Swagata Roy: Enhancement of electroactive -phase crystallization 59
and dielectric constant of NiO nanoparticle and CNiO nanocomposite
incorporated poly(vinylidenefluoride) thin films
PP26 Arpan Kool: Development of Copper (Cu0) Nanoparticles 60
Impregnated Mullite Replica of Sacrificial Cotton Wool:
An antimicrobial nanocomposite for biomedical application
PP27 Somtirtha Banerjee: Formulation of gold nanoparticles 61
impregnated hydroxyapatite: An antimicrobially active system
for biomedical application
PP28 Priyanka De: Role of nanotechnology in excavating the 62
enigma of cardiac dysfunction
PP29 Saurav Bhattacharya: Anti-migratory effect of Pegylated- 63
thymoquinone nanoparticles on breast carcinoma cells targeting
p53-miR-34a axis
PP30 Siddheswar Rudra: Redox Mediated Synthesis of Stable and 65
Biocompatible Au@Fe2O3 Nanomaterial for Efficient
Electrocatalytic Hydrogen Evolution
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Book of Abstracts
PP31 Iman Ehsan: Antibody Tagged Nanoparticles Containing Paclitaxel 66

for Prostate Cancer Therapy
PP32 Leena Kumari: Development, Characterization and Investigation of 67
Docetaxel loaded Nanoliposomes to cross Blood Brain Barrier in Rats
PP33 Paramita Paul: Chitosan coating on PLGA nanoparticles: a technology 68
to enhance bioadhesion in murine lungs
PP34 Soma Sengupta: Ribavirin nanoliposome for targeting peripheral 69
nervous system (PNS)
PP35 Dheeraj Mondal: Preparation, Characterization and Electronic 70
Application of Xcuo-(1-X)MnO2 Nanocomposite by Modified
Chemical Synthesis Technique
PP36 Monalisa Char: Effect of Transient Liquid Phase Soldering Technique 71
on Lead Free Solder Joint Interface for Consumable Electronic
Applications
PP37 Laboni Mondal: Targeting of breast cancer cells by ligand 72
conjugated polymeric nanoparticles containing Doxorubicin
PP38 Shib Shankar Singha: Few-layer MoS2 decoration with gold 73
nanoparticles: Tuning the photoluminescence and ultrasensitive
trace detection of bio-molecule
PP39 Biplab Kumar Paul: MnO2-CoO Nanocomposite: Preparation, 74
Characterization and Application in Supercapacitor
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One-Day National Symposium on

Nanotechnology: From Materials to
Medicines and Their Social Impact
25th March 2017
PROGRAM SCHEDULE
From To Code Program

09:00 09:30 Registration and High Tea
09:30 10:00 Inauguration
Session 1 - Nanoparticles Chairman: Prof Parimal Sen

10:00 10:30 KNA Prof Dipankar Chakravorty
10:30 10:50 IL01 Dr G P Das
10:50 11:10 IL02 Prof Arup Mukherjee
11:10 11:30 IL03 Dr Mukul Pradhan
11:30 11:45 OP01 Dr Sujit Banerjee
11:45 12:00 OP02 Dr Suvadra Das
12:00 12:15 OP03 Dr Sagar Naskar
12:15 12:30 OP04 Dr Partha Roy
12:30 13:30 Poster Session

13:30 14:00 Lunch
Session 2 - Nanomedicines & Homeopathy Chairman: Prof. Parames C Sil

Dedicated to the memory of Dr. Bholonath Chakravarty
14:00 14:20 IL04 Dr Mrinal Ghosh
14:20 14:40 IL05 Dr Sourav Arora
14:40 15:00 IL06 Prof N C Sukul
15:00 15:20 IL07 Prof C R Mahata
15:20 15:35 OP05 Dr Arghya Adhikary
15:35 15:50 OP06 Dr Joydeep Das
15:50 16:05 OP07 Dr Pintu K. De
16:05 16:20 OP08 Dr K C Paul
16:20 16:35 OP09 Dr Suman Bhandary
16:35 16:50 OP10 Dr Aparajita Ghosh
16:50 17:15 Summing Up and Vote of Thanks
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Book of Abstracts
A brief note on the

NANOTECHNOLOGY: From Materials to Medicines and Their Social Impact
25th March 2017
Venue: Birla Industrial and Technological Museum, Kolkata
Nanotechnology aims at manipulations of materials in the nanoscale about 1 to 100

nanometers. Nanotechnology may be able to create many new materials and devices with a vast
range of applications, such as in nanomedicine, nanoelectronics, biomaterials, energy production,
and consumer products. On the other hand, nanotechnology raises many of the same issues as
any new technology, including concerns about toxicity and environmental and social impact of
nanomaterials.
The Centre for Interdisciplinary Research and Education, along with its collaborators, the
West Bengal Academy of Science and Technoology, Birla Industrial and Technological Museum
and Adamas University, are jointly organizing a One Day Symposium on Nanotechnology: From
Materials to Medicines and Their Social Impact to bring the world of nanotechnology to the
forefront of consciousness of the technical and lay public. Renowned scientists will provide brief
but illuminating overviews of the topics and their research findings through lectures and oral and
poster presentations.
Target audience for the symposium will be scientists and technologists from academia and
technical institutes and firms, and undergraduate and post-graduate students and research
scholars. We are expecting a good turnout for the symposium, for expenses of which we will need
donations from research institutes, commercial establishments and others.
We had organized a one day symposium on Genetically Modified Crops in 2015 and another
symposium, on Science Behind Homeopathy, in 2016. Both were very well attended with
enthusiastic participation. This year also we expect the event to be well attended. Target audience
for this symposium is intended to include scientists and technologists from academia and technical
institutes and firms, and undergraduate and post-graduate students and research scholars.
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CIRE
CENTRE FOR INTERDISCIPLINARY RESEARCH AND EDUCATION
404B Jodhpur Park, Kolkata 700068
Email: ciresedu@yahoo.in Website: http://cire.co.in
The Centre for Interdisciplinary Research and Education is a non-profit organization registered
(Reg No 75637, 2010-11) under the West Bengal Registration of Societies Act XXVI of 1961. Our
vision is to foster interdisciplinary research and bridge the cultural divide between the arts and
sciences, between the lay person and the academician. People from different disciplines of science
and humanities in India and abroad are our members. Our activities include:
Research: Our members have published scholarly works in Physical Review, Current
Computer Aided Drug Design, PLoS ONE, Chemical Physics Letters, Homeopathy,
Energy and other top ranking journals. Funded research has also started with one
of our members securing a grant for research on homeopathy at our centre.
Seminars and Lectures: The Centre has held Seminars on current research of its
members and associates, and Lectures have been given by them on topics of
scientific and societal importance in various fora. The Centre also organizes special
symposia on scientific topics of interest to the academia and lay public. In 2015 we
organized a One Day Symposium on Genetically Modified Crops and in 2016 on
Science Behind Homeopathy that saw enthusiastic participation by researchers,
students and general public. In 2017 it is organizing, jointly with several other
institutions, a Symposium on Nanotechnology : From Materials to Medicines and
their Social Impact which aims to unravel some of the myths and misperceptions
surrounding this branch of science.
Book Writing: As part of our encouragement to members to write books on

interdisciplinary topics, a project under the sponsorship of INSA was taken up by
one of our members.
Science Workshops for School Students: A special series of annual Workshops on

Science for School Students aimed towards under-privileged students of Classes
VIII and IX have been organized in three years in collaboration with Indian Science
Academy, Kolkata Chapter. For the 4th Workshop in this series, in 2016, Luxmi
Charitable Trust had come forward to support this activity.
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Book of Abstracts
WEST BENGAL ACADEMY OF SCIENCE AND TECHNOLOGY

Regd Office : CSIR-Indian Institute of Chemical Biology
4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032
A convention of scientists and technologists of West Bengal was held on 29 April 1986 in the
auditorium of Indian Institute of Chemical Biology (IICB), Kolkata, to consider the question of
forming an Academy of Science in West Bengal. After a prolonged discussion, the house decided
to form such an Academy and constituted an ad-hoc committee to take necessary steps to give
effect to this decision. In a general meeting on 20th January 1989 in the auditorium of IICB, the
formation of the West Bengal Academy of Science and Technology with 136 Founder Fellows as
per the recommendation as well as the Memorandum of Association and Rules and Regulations
prepared by the ad-hoc committee were approved. The house empowered the ad-hoc committee
to continue till the Council and Officebearers were constitutionally elected. The ad-hoc committee
then convened a General Meeting of the Founder Fellows on 16th August 1989 in the auditorium
of IICB to elect the Council. The first elected council of the Academy met on 24 August 1989 in the
conference room of IICB and elected the office-bearers. The Academy then was registered as a
Society (S/65001 to 1990-91) according to the West Bengal Societies Registration Act 1961. Thus,
a new Academy entitled West Bengal Academy of Science and Technology was born having its
registered office at IICB, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032.
Aims and Objectives of WAST (from their MOA):
1 to promote and apply science and technology for the welfare of the state of West Bengal and
its people.
2 to coordinate activities of various agencies and institutions, governmental as well as non-
governmental, engaged in research and development;
3 to promote cooperation and excellence in scientific seminars, conferences, workshops, symposia,
popular lectures etc. and through publication of scientific and technological journals, books,
monographs, research papers, newsletters, etc.
4 to promote understanding among the basic and applied sciences and technology on the one
hand and letters on the other;
5 to establish, maintain and upgrade scientific and technological library and documentation
facilities; and
6 to do and perform all other acts, matters and things that may assisting, conduce to or be
necessary for the fulfillment of the above mentioned aims and objectives;
7 the income and the properties of the Society shall be applied solely towards the promotion and
objects of the Society and no portion shall be given to any member by way of profits, etc.
10
(National Council of Science Museums, Ministry of Culture, Govt. of India)
In 1956, Dr. B.C. Roy, the then Chief Minister of West Bengal, foresaw a big role [for] Museums
of Science, Technology & Industry in a developing country. This idea also matched with that of
Shri G.D. Birla and the magnanimous Birla Park with its imposing building and five bighas
surrounding space was handed over by him to Pundit Jawaharlal Nehru, the then Prime Minister
of India for setting up a science museum in Kolkata. Three years later the Museum was thrown
open to the public on 2nd May 1959 by Union Minister Prof. Humayun Kabir, in presence of Dr. B.
C. Roy, Sri B. M. Birla and Prof. M. S. Thacker, the then Director General of CSIR.
During the first few years of its inception, BITM opened galleries on a) Iron & Steel b) Copper c)
Petroleum d) Electricity e) Nuclear Physics and f) Motive Power. Then, one by one, Communication
(1963), Mining (1964), Popular Science (1965), Electronics & T.V (1966), Transport (1973) galleries
were added subsequently. Mock-up Coal Mine was inaugurated in 1983.
From the very beginning Popular Lectures and Film Shows got underway. Science Demonstration
Lectures for students became a feature of BITM from 1965. The same year also saw the pioneering
effort of BITM - the Mobile Science Exhibition (MSE). The first exhibition on wheels through MSE
was Our Familiar Electricity. The concept of Model Making Competition, popularly known as
Science Fair can be traced back to 1967 and the very next year, the first Teachers Training
Programme was launched. Gaining a strong foothold in the city, BITM thought of going to the
rural Bengal to spread the message of Science. In 1982, the first satellite unit of BITM, the District
Science Centre at Purulia was opened. From then on till date, Birla Industrial & Technological
Museum, the first Scientific and Industrial Museum in this country have come a long way. With its
various galleries, multifarious activities and ever increasing chains of satellite centres, it has become
a place where Science happens in front of ones eyes through animated and interactive models.
Side by side, the history of Technology and Industry rejuvenates itself to the visitors through real
or scale down replicas.
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Book of Abstracts
ADAMAS UNIVERSITY
Adamas Knowledge City
Barasat - Barrackpore Road
P.O. - Jagannathpur, District - 24 Parganas (North)
Kolkata - 700 126
Adamas University (under West Bengal Act IV of 2014) with an sprawling green campus
extending over 100 acres nestled in Barasat (13 kms away from the Subash Chandra Bose
International Airport Kolkata), and in its 2nd year of operation, aspires to impart finest quality
education to the young minds of West Bengal, with an already established high quality research
facility and a powerful team of teachers. The University has many international initiatives
collaborating with the industries and educational institutes from Europe to the Far East to facilitate
projects, research and student exchange programs. Currently, in its 2nd year, the campus has
1500+ current students and more than 800 resident students & faculties. The University has been
established with the vision of providing quality education to students to help them become
professionally competent as well as academically knowledgeable under the seven Schools of
Studies, like
school of engineering and technology
school of science
school of social science
school of law and justice
school of economics and commerce
school of management
school of biotechnology
school of pharmaceutical technology
Meanwhile the system of imparting the education will be flexible and multidisciplinary with
state-of the-art and interactive pedagogy. The University is expected to gradually grow to
accommodate other areas of study, such as Biological Sciences, Earth Sciences, Fine & Visual Arts
and different branches of Medical Sciences.
The Adamas University has been established by Sachis Kiran Roy Memorial Trust (SKRMT)
(under the West Bengal Act IV of 2014) passed by The West Bengal Legislature and approved by
The Governor. The provisions of The Adamas University Act, 2014, have come into effect on 11th
April 2014, through a notification issued by The Govt. of West Bengal on the same day.
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LUXMI CHARITABLE TRUST

17 R N Mukherjee Road
Kolkata 700001, India
Luxmi Charitable Trust is a Registered Body and is approved as a Public Charitable Trust
under the Income Tax Act. It was set up by Shri Dipankar Chatterjee in 2007. The primary objective
is to create a trust for appropriate and adequate facilities for all round development of young
persons. The Trust aims to provide opportunities to young persons to realize their potential for
growing into active, alert and socially useful citizens. Luxmi Charitable Trust helps them to uplift
their own well being and afford them opportunities to do so.
Luxmi Charitable Trust supports directly or as a contributing member to such relevant

organisations or institutions that are perceived to be enhancing similar values in areas of education
amongst the needy. Similarly the trust operates in areas involving cultural and other socially relevant
areas like research, promotion of well being, food and shelter for needy young people to grow up
in an appropriate environment fostering social well being. The trust also organises medical camps
to provide medical facilities or supports running medical camps.
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Book of Abstracts
Dr. Bholanath Chakravarty Memorial Trust

30 Chowringhee Road
Kolkata 700016, West Bengal, India
Dr Bholanath Chakravarty Memorial Trust Fund was set up to commemorate the name of a
great homeopathic physician and a benefactor of the masses who was interested in and encouraged
the pursuit of science. The Trust Fund has set up a Molecular Homeopathic Research Unit that
provides infrastructure and partial financial support for undertaking research in homeopathy. The
Trust also encourages seminars and symposia, research and education in all aspects of homeopathic
medicine and treatment.
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Keynote Address
NEW FUNCTIONALITIES IN MATERIALS BY NANOTECHNOLOGY

D. Chakravorty
Indian Association for the Cultivation of Science Kolkata
Nanotechnology is the art of synthesizing materials in nanodimensions with different phases
present in the composite structure. This has therefore opened up enormous possibilities to fabricate
materials with new properties.In this presentation a few examples will be discussed.Graphene/
PVA nanocomposites showed magnetodielectric behaviour in which the dielectric constant changed
by about 1.8% at an applied magnetic field of 1 tesla. Similarly, Magneto-dielectric parameter
exhibited a change of upto 51% in nanoglass/mesoporous silica composites. These properties
arise due to space charge polarization resulting from the difference in electrical conductivities of
the two phases and also the phenomenon of magnetoresistance observed in one of the phases.
Multiferroic characteristics have been reported in the case of systems like mesoporous
LiNbO3.These showed both ferroelectric and ferromagnetic behaviour. The latter arises due to
uncompensated spins present at the surfaces of the nanoparticles of LiNbO3. Nanodimensional
silica based glasses were grown within suitable templates like compacted ZnO nanoparticles or
mesoporous silica. These exhibited high ionic conductivity and in some cases fast ion conduction
of Li+ ions was found.
References
1. S. Mitra et al J. Phys. Chem. C 115 (2011)

2. D.R. Saha et al Solid State Ionics 186 (2011) 14
3. S. Banerjee et al J. Appl. Phys. 111 (2012) 054310
4. D.R. Saha et al J. Non-Cryst.Solids 376 (2013) 2
5. D.R. Saha et al J. Phys. Chem. C 116 (2012) 21679
6. S. Chatterjee et al J. Phys. D: Appl. Phys. 49 (2016) 255001
7. S. Chatterjee et al J. Phys. Chem. C 120 (2016) 431
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IL01
NANO-SCIENCE & TECHNOLOGY :

PROMISES, EXPECTATIONS AND CHALLENGES
G.P. Das
Department of Materials Science
Indian Association for the Cultivation of Science
Jadavpur, Kolkata-700032, Email: msgpd@iacs.res.in
Abstract
The advancement achieved in nanoscience in the later half of twentieth century has resulted
in technologies that is leading to nothing less than a revolution in the twenty first century. We
have already experienced the information revolution that puts an ever increasing demand for
miniaturization of active devices, which in turn acts as a driving force for the development of
nano-science and nano-technology. The areas that are being engulfed by this advance are
Automotive industry, Aerospace industry, Medicine, Healthcare, Food and the list is continuously
increasing. For example, nano materials are applied to the surfaces of already existing products,
e.g. painting, plating, pigmented coating, anti-corrosive ceramic coating of automobiles, while
nano-filters are used as membranes for reverse osmosis technology. In this talk I shall give an
overview of this exciting field from a materials scientists point of view, underscoring how this
field of nano-science and technology has emerged from hype to reality. I shall touch upon some
of the application areas, such as Carbon Nanotubes, NEMS, nano-spintronics materials, fuel cells
etc. I shall also highlight the role of computer simulation in designing these novel materials.
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IL02
SOFT MATTER NANOCHEMISTRY IN GUAR GUM FOR APPLICATIONS

Professor Arup Mukherjee
Department of Chemical Technology
University of Calcutta, E mail: arupm1234@gmail.com
Abstract
Vast array of properties are often preserved more easily in a chaos. Nature presents a great
display of that in soft matter dynamics. Molecular memory of life for example is protected
excellently in nanoscale DNA assembly. Dynamics of cell membrane is another great example of
soft matter characteristics expressed in micro and nanoscale. Molecular manipulations in
biopolymers are currently used to develop newer nano-dimensional materials for human
applications.
Guar gum is a large molecular weight plant galactomannan. Guar gum chemistry in water
environment is very intriguing. The biopolymer hydrates hugely in water and form thixotropic gel
in protein and salts environment. This biopolymer is widely used in petroleum oil drilling, minerals
processing, pharmaceuticals, cosmetics, in ice creams to prevent water crystallization and in food
as cholesterol lowing agent. Nanochemistry in guar gum is used to develop newer sustainable
materials and assemblies for new generation applications. Cationic modified guar gum presents
one excellent template for antibacterial silver nanoparticle assemblies useful in water treatment.
Guar gum propionate esters form self assembly nanoparticles for applications in cattle feed
preservation. Maglev guar gum benzoate film assemblies are used for water cleaning. A range of
similar developments using guar gum as a template will be discussed.
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IL03
SYNTHESIS OF ANISOTROPIC NANOSTRUCTURES FOR SURFACE ENHANCED

RAMAN SCATTERING (SERS) BASED SENSING
Mukul Pradhan
Department of Chemistry
National Institute of TechnologyMeghalaya
Shillong-793003, E-mail address: mukulchem@gmail.com
Abstract
Nanocrystals exhibit interesting size dependent electrical, optical, magnetic and chemical
properties where the boundaries between chemistry, molecular biology, materials science and
solid-state physics disappear and new and unexpected properties appear in comparison to their
bulk complements. Recent developments in biomedical science established Raman scattering as
a promising tool for in vivo cancer detection within the near-infrared optical window (700900
nm), where endogenous tissue absorption coefficients are more than two orders lower in
magnitude compared to blue and ultra-violet light. Synthesis of NIR active SERS substrate/NIR
Raman reporter is very important for biosensing. In our recent work, we observed the effect of
composite Ag-FeOOH/Au-MnOOH/Ag-MnO2 (dendrite/nanoflower/nanowire) for the giant SERS
enhancement with the probe molecule down to the single molecular level (EF >1011) due to the
charge transfer as well as electromagnetic enhancement. The marked increase in the Raman activity
of molecules adsorbed on substrates like Au-SiO2, Au-TiO2, Ag-CuO etc. Proteins have their distinct
isoelectric pH. Above and below the isoelectric pH they become positive or negative. Then a
particular protein can be attached onto the nanocomposites as a guest (depending on the charge
of the noble metal in the nanocomposite) with the newly formed hybrid-nanocomposites that
help sensing particular protein molecule using SERS. This idea can be applied even to charged
toxic species. Literature study as well as our experimental observation confers that such composite
nanomaterial would be used as promising SERS sensor.
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IL04
NANOTECHNOLOGY APPLICATION IN GLIOMA THERAPY : TARGETED

DRUG DELIVERY THROUGH BLOOD BRAIN BARRIER (BBB)
Mrinal K. Ghosh
Affiliation & Address:
Dr. Mrinal K. Ghosh, Ph.D., FNASc, FAScT, Principal Scientist
CSIR-Indian Institute of Chemical Biology, TRUE Campus, CN-6, Salt Lake,
Kolkata- 700 091, E-mail: mrinal.res@gmail.com
Abstract
The major cause behind failure of glioma treatment is the presence of blood brain barrier
(BBB) which prevents efficient passage of therapeutics. Other than this, lack of significant
advancement in the field of targeted drug delivery approach impairs the efficacy of many drugs.
To resolve this issue indole derivative 3,3-diindolylmethane (DIM) was encapsulated in PLGA
nanoparticle and tagged with novel peptide designed against SSTR2 receptor on its surface for
targeted delivery. The precision of the peptide binding to the receptor was determined by several
in silico methods like Docking, Molecular dynamics membrane simulation and in vitro techniques
like immunoprecipitation, colocalization study etc. XPS analysis substantiated the coupling of
peptides on the surface of nanoparticles. Accordingly, this formulation not only helped DIM in
crossing BBB, but also made it target specific to the glioma cells overexpressing SSTR2. Furthermore,
our, in vivo studies also validated the in vitro findings and provided improved delivery of DIM
which in turn caused abrogation of EGFR pathway. In due course, induction of apoptosis in treated
glioma cells was noticed. Therefore, this advantageous approach of nanoformulated DIM treatment
can help to expose the whole tumor to the therapeutics and draw deserving explicit attention
towards the generation of effective drug delivery.
*This work was supported by grants provided by CSIR (EMPOWER: OLP-2, MEDCHEM: BSC 0108), CSIR-MAYO Clinic
Collaborative Program: MLP0017) and DST (SR/SO/HS-0150/2010) to Dr. Mrinal K. Ghosh.
19
Book of Abstracts
IL05
ULTRAHIGH DILUTIONS AS NANOMEDICINE

Dr. Saurav Arora
Editor-in-chief: International Journal of High Dilution Research
Founder: Initiative to Promote Research in Homeopathy
email@sauravarora.com / +919811425216
Abstract
The medical science is emerging from simpler applications of techniques and analytical mind
to use of sophisticated equipment, deeper penetrations and complex therapeutics. The discovery
of homeopathy in 1796 changed the outlook of medical science from being crude to philosophical,
deeper and subtle science, but it lost the pace with conventional science due to use of Ultra High
Dilutions(UHDs) whose existence and therapeutic use seems implausible from conventional
scientific point of view. For modern medicine too, it was difficult to define the exact paths from
medicine to biology, then to chemistry and physics, for decades, but conventional science took an
edge over it.There has been a methodical use of UHDs in homeopathy, as well as in allied areassuch
as agronomy, veterinary, dentistry and more recently in physical sciences.The presence and actions
(physical and biological) of UHDs cant be ignored, but it still struggles for established facts,
physicochemical answers and reproducible evidences.
Amidst dealing issues such as existence of UHDs, their biological action, physicochemical
properties, applications beyond clinical use etc., an important aspect which has been discovered
in the recent past is the presence of Nanoparticles (NP) in UHD. This discovery has been used to
term UHDs as Nanomedicine (NM).The nomenclature of UHDs/NP as NM needs rigrourous research.
There is an equal scope to accept or reject the consideration of UHDs as NM. Since it is a challenge,
before claiming UHDs as NM we need to rethink all positive and negative facts.
20
IL06
DSC REVEALS VARIATION IN ENTHALPY ASSOCIATED WITH FREE

WATER MOLECULES IN WATER ETHANOL SOLUTION EXPOSED
TO X-RAYS AND MAGNETIC FIELD
Nirmal Chandra Sukul 1,2, Tandra Sarkar 1, 3; Atheni Konar 1,3; Md Amir Sohel 4;
Asmita Sengupta4; Anirban Sukul1
1
Sukul Institute of Homeopathic Research, Santiniketan, W.B, India.
2
Department of Zoology, Visva-Bharati University, Santiniketan, W.B,India
3
Centre for Healthcare Science and Technology, IIEST, Shibpur, W.B, India
4
Department of Physics, Visva-Bharati University, Santiniketan, W. B, India
Abstract
Preparation of homeopathic potencies from solid substances involves initial trituration of
the substance. The process results in breaking down of solid into fine particles. A growth retardant
substance CCC was trituated with Cu nanoparticles initially and then dynamised in 30 steps to
produce CCC 30cH (nano). CCC 30cH produced by standard process of dynamisation was less
effective than CCC 30 (nano) in promoting growth of pigeon pea. In a series of studies using
vibrational and Raman spectroscopy we demonstrated that potentised drugs have specific water
structures which relate to free water molecules and hydrogen bond strength. Here the nano
particles simply promoted water structures induced by CCC. In the present study we used two
homeopathic drugs, X-ray and magnetis poli ambo which do not originate from any substance.
Aqueous ethanol is the standard medium of all drugs used in homeopathy. X-ray and
Magnetis Poli Ambo are two homeopathic drugs prepared by exposure of aqueous ethanol to X-
radiation and static magnetic field, respectively to produce their mother tinctures (MTs). These
MTs were successively diluted with the solvent 1:100 and succussed in several steps to prepare
their centesimal potencies like 8 cH, 14 cH and 32 cH. The solvent is also processed in the same
way to produce its 3 potencies. All of them, though identical in chemical composition (0.03 molar
ethanol) and water content (96%), produce different therapeutic effects. One of the potencies
8cH of each was diluted with water so that it had 4, 20, 40 and 80% ethanol. The objective is to
see whether these potencies show variation in free water molecules. DSC of the MTs and the
potencies of each drug have revealed almost similar freezing and melting points. But they differ
markedly from each other with respect to their freezing and melting enthalpies as well as free
water molecules. Different dilutions of the 8th potency show variation in enthalpies and free
water molecules, and this variation in independent of the amount of water added. It is concluded
that exposure of aqueous ethanol to x-ray and magnetic field and its subsequent dilution and
succussion induce changes in the solvent involving free water molecules.
21
Book of Abstracts
IL07
NANOPARTICLES OF HOMEOPATHY: THEIR POSSIBLE IDENTITIES

Prof. C. R. Mahata
IIEST Shibpur, Howrah
Email: crmahata@gmail.com
Abstract
Nano-particles are observed in serially diluted homeopathic solutions of potencies even
beyond Avogadro limit of 12c. It is an experimentally established fact. These microscopic particles
of 1 100 nm in size are effectively a bridge between bulk materials and atomic or molecular
structures. But, what are the chemical identities of these particles?
In a certain amount of solute the number of nano-particles will be less than the number of
atoms or molecules in it. As such, in the process of serial dilution of homeopathy they will cease
to exist even before 12c. What will not cease to exist is generation of coherent domains (CD), that
is, ice-like structures initially induced by solute and then by those ice-like structures through the
stages of serial dilution, aided by ambient electromagnetic field in liquid water even at room
temperature as predicted by Quantum Electro-dynamic (QED) considerations. Consequently, nano-
particles of homeopathy must be nano-associates of water molecules.
Clinical experience with homeopathy for more than two centuries suggest that the nano-
associates so formed are responsible for the biological activity, that is, medicinal effect of high
dilution water solutions. Most possibly their action on living bodies starts with structural matching.
Supports come from template principle in biological metabolic process, deformity of bio-molecules
associated with loss of structure of water of diseased cells, action of antibiotics through structural
locking etc.
Key words: nano-particles, nano-associates, coherent domains, homeopathy
22
OP01
MULTIFUNCTIONAL NANOSTRUCTURED MATERIALS: A NEW DIMENSION

FOR MATERIALS SCIENCE
S. K. Bandyopadhyay (Retd.)
Ex-Head, Material Science Studies Division,
Variable Energy Cyclotron Centre.
Address: 6/2J, Naktala Road, Kolkata-700 047
e-mail: drsujitkumar@gmail.com
Abstract
Multifunctional materials are of todays quest. Miniaturization, i.e. development of these
materials in the form of nanomaterials is of primary need considering their application in devices.
Moreover, if these are obtained in nanostructured form, they can bring wonders.
Recently, we have adopted for developing multiferroic BiFeO3 (BFO) with simultaneous
antiferromagnetic, ferroelectric & ferroelastic behaviour in form of nanostructures like nanorods,
nanowire etc. by employing Anodised Alumina (AAO) template with various pore sizes from 20nm
with solution route followed by controlled vacuum filtration and sintering. Diameters of nanorods
are in the range of 20-100 nm as observed by FESEM. Capacitance assayed by cyclic voltammetry
(CV) and charge discharge processes reveals a very high value of specific capacitance of 450F/gm.
Capacitance has been estimated by extrapolating the charge collected at the electrode to that at
scanning rate of infinity which is relevant for the charge collected at the nanorods protruding out
of the template. Charging and discharging times are quite constant over a large number of cycles.
This large value of specific capacitance can be attributed to the nanostructure form of BFO nanorod.
The high value of specific capacitance of BFO nanorods brings forth its use as electrode in storage
energy devices. Also, a high value of polarization as well as a significant magnetic susceptibility
are observed in multiferroic Bismuth Ferrite (BFO) in the form of nanorods protruding out. The
high values of polarization and magnetic susceptibility are attributed to the structured form of
BFO nanorods giving rise to the directionality. There is no leakage current in P-E loop examined at
various fields and frequencies. Magnetocapacitance measurements reflect a significant
enhancement in magnetoelectric coupling also.
We have also developed a variety of conducting polymer (like PANI, PEDOT etc.) and graphene
based nanocomposites with a large value of specific capacitance for use as energy storage device.
Also, some novel nanostructures have been developed using low energy ion beam irradiation. All
these aspects will be discussed.
23
Book of Abstracts
OP02
PHYTOCHEMICAL STABILIZED METAL NANOPARTICLE : A NEWER SOLUTION
TO NEGLECTED TROPICAL DISEASE, VISCERAL LEISHMANIASIS
Suvadra Dasa, Asim Haldera Partha Royb and Arup Mukherjeea*
aDepartment of Chemical Technology, University of Calcutta, 92, A.P.C Road,kolkata-700009,
West Bengal, India.

bDepartment of Pharmaceutical Technology, Adamas University, Kolkata- 700126,
West Bengal, India

Abstract
Leishmaniasis is a WHO classified neglected tropical disease, characterized by both diversity
and complexicity. The disease is caused by more than 20 leishmanial species and is transmitted to
humans by nearly thirty different species of phlebotomine sandflies. Among four main clinical
types of leishmanisis, visceral leishmaniasis (VL) is a systemic disease that is fatal if left untreated
and is caused by leishmania donovani parasite which is endemic in Indian subcontinent and East
Africa. Most wild strains of VL is already reported resistant to chemotherapeutics like antimonials
and paramomycin. Though Miltefosine and liposomal amphotericin B are gradually replacing
pentavalent antimonials and conventional amphotericin B as the preferred first-line therapeutics
but toxic side effects and high cost of therapy are the significant hurdles in their clinical acceptance.
Development of newer therapeutics is therefore urgently required against VL with high specificity,
low systemic toxicity and minimal cost.
Non viral nanoparticulate systems are increasingly important tools in therapeutics for lower
toxicity and specialized cell targeting. Potential of these systems are enormous and nanoparticles
were applied earlier in drug delivery, cancer chemotherapy, diagnosis, immunomodulation and
gene delivery. Specific advantages of nanocarriers reside in facile synthesis and efficient
biomolecular conjugations. Nanocarrier liposomes and polymer conjugates are constrained due
to instability in blood fluid pressure and rapid non specific recognition in the reticuloendothelial
system (RES) systems. Inorganic nanoparticles are much more stable in systemic circulation and
targeted delivery using gold nanoparticles are known. Gold nanoparticles (Aunp) are useful tools
in therapeutics and different applications like drug delivery, diagnosis and imaging were reported.
Size dependent macrophage uptake of gold nanoparticles is one attraction for its possible
explorations. Besides, phytochemicals can be solubilized as gold nano-bio conjugates for an efficient
delivery which is an added advantage. Plant polyphenolic compounds like quercetin, kaempferol,
gallic acid were reported as a potent free radical scavenger and an inducer of differentiation and
programmed cell death in a number of tumor cell lines. These compounds are non toxic to mammals
at pharmacological doses and exerts significant anti-inflammatory, anti-microbial and
antioxidant effect.
Our work is mainly concerned with synthesis of phytochemical functionalized gold
nanoparticles in one pot and their applications against leishmanial parasites in macrophages.
polyphenols were studied to effect bio-reduction for Au+3 to Au0. Uptake of newer gold nanoparticle
in macrophages could be easily monitored under transmission electron microscope. Nanoparticle
cargo was tested against both wild type and drug resistant leishmanial variants. Newer
nanotherapeutics designed can be a useful alternative in VL therapy.
24
OP03
HEALTH IMPACT OF ENGINEERED NANOPARTICLE AND THEIR RISK

ASSESSMENT STUDY BY DIFFERENT MODELS
Sagar Naskar
Department of Pharmaceutical Technology
Adamas University, Kolkata-700126
E-mail: sagar_n2007@yahoo.co.in; Mobile.: 9088218391
Abstract
A significant advancement has been noted in the field of nanotechnology in recent years as
marked in various domains including healthcare. No medicine is free from toxicity and in case of
nanoparticle it is not an exception. Despite tremendous benefits, the unavoidable hazards of
engineered nanoparticles (ENPs) are a serious concern in todays scientific world. However, a few
studies have already demonstrated the toxic effects of nanoparticles on various organisms, including
human beings. Thus the present study is aimed to address the current understanding of the human
health impact of engineered nanoparticle. To assess the hazards of nanoparticles in long term, a
mechanistic understanding of the numerous characteristics that influence toxic effects on biological
systems was deemed essential. The study includes the probable health hazards and the risk
assessment models available to evaluate the toxic effect of nanoparticle in living system. Models
for assessment of nanoparticles toxicity in human red blood cells using immunofluorescence
microscopy techniques (ELISA,Flow cytometry)orstudy in microbesusing Bacillus subtilis, E. coli,
Staphylococcus aureus, Parachlorellakessleri,Sinapisalbaorzebrafish model or experimentalWistar
ratsmodel are remarkable. Though a detailed mechanism of toxicity caused by nanoparticle is not
yet elucidated, a few mechanisms like damage to membrane integrity, protein destabilization and
oxidation, damage to nucleic acids, production of reactive oxygen species, interruption of energy
transduction, release of harmful and toxic components are likely involved in the damage caused
by engineered nanoparticle.
Key Words: Nanotechnology, Health hazards, Risk assessment model
25
Book of Abstracts
OP04
NANOTHERAPEUTICS OF PLANT-BIOACTIVES : IMPROVED AND SAFER

ARSENALS IN PRESENT DAY THERAPY
Partha Roy*, Suvadra Das# and Arup Mukherjee#
*Department of Pharmaceutical Technology, Adamas University
#
Department of Chemical Technology, University of Calcutta
Email: partharoy2502@gmail.com
Abstract
World Health Organization statistics reveal that plant-derived bioactives cater nearly eighty
percent of the world population to meet their respective therapeutic needs. Therapeutic role of
such compounds is observed against plethora of diseases ranging from degenerative diseases like
cancer, metabolic disorders like diabetes to neglected tropical diseases like leishmaniasis. But
majority of these green bioactives like curcumin, silymarin, andrographolide, quercetin are limited
in their clinical acceptance as they are water insoluble resulting in poor bioavailability. Adding to
the complexity most of these bioactives have short biological half-life which makes them further
unsuitable for conventional delivery approaches. But keeping in mind the multifunctional
pharmacology of these compounds and their need of delivery improvements, the nanotherapeutic
design seems the most appropriate solution.
Curcumin nanotherapeutics is reported to exhibit improved efficacy even in multi-drug
resistant cancers with low residual toxicity due to cellular specificity. Liposomal curcumin
nanotherapeutics is also observed to reduce the tumor burden and increase life span of cancerous
animals. Silybin nanotherapeutics is found to efficiently control blood glucose and glycated
hemoglobin levels in experimental diabetic conditions. Nanotherapeutics of terpenoid
andrographolide demonstrated speedy entry into leishamanial parasite infected macrophage cells
and induce the death of the organism. Both silymarin and andrographolide nanotherapeutics
induced significant recovery of hepatocellular damage induced by drugs or chemicals. Literature
reports also prove that the safety window of these green bioactive loaded nanotherapeutics is
much broader compared to available therapeutics for the disease.
Nanotherapeutic design of such versatile bioactives is a useful strategy to improve upon
their biopharmaceutical problems and revive them clinically. Present day disease management is
crippled by the occurrence of drug resistance, fatal residual toxicity and high cost of treatment.
Tailor made plant-derived nanotherapeutics has the potential to overcome drug resistance, express
minimal side-effects and at the same time be cost-effective compared to existing
chemotherapeutics. Extensive preclinical and clinical investigations are required for this newer
therapeutics to facilitate their journey from lab to clinic.
26
OP05
STRATEGIC MANAGEMENT OF BREAST CANCER BY NOVEL NANO-

THERAPEUTICS THROUGH REGULATION OF THE MIRNA CIRCUITRY
Arghya Adhikary
Centre for Research in Nanoscience and Nanotechnology, University of Calcutta
JD-2, Sector III, Salt Lake, Kolkata 700098.
email: adhikaryarghya@gmail.com
Abstract
Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential
medical applications including spectrum of therapeutic properties against different cancers.
However, little is known about their effect on breast cancer cell migration, which is the cause of
over 90% of deaths worldwide. Herein, we have synthesized TQ-encapsulated nanoparticles using
biodegradable, hydrophilic polymers like polyethyleneglycol (PEG) to overcome TQs poor aqueous
solubility, thermal and light sensitivity as well as consequently, minimal systemic bioavailability
which can greatly improve the cancer treatment efficiency. Sizes of synthesized TQ-Nps were found
to be below 50 nm and they were mostly spherical in shape with smooth surface texture. Estimation
of the zeta potential also revealed that all the three TQ-Nps were negatively charged which also
facilitated their cellular uptake. In the present investigation, we provide direct evidence that TQ-
Nps showed more efficiency in killing cancer cells as well as proved to be less toxic to normal cells
at a significantly lower dose than TQ. Interestingly, evaluation of the anti-migratory effect of the
TQ-Nps, revealed that PEG4000- TQ-Nps showed much potent anti-migratory properties than the
other types. Further studies indicated that PEG4000-TQ-Nps could significantly increase the
expression of miR-34a through p53. Moreover, NPs mediated miR-34a up-regulation directly down-
regulated Rac1 expression followed by actin depolymerisation thereby disrupting the actin
cytoskeleton which leads to significant reduction in the lamellipodia and filopodia formation on
cell surfaces thus retarding cell migration.
Drug resistance is a major impediment to the success of cancer chemotherapy. Management
of drug resistance is important towards successful chemotherapy. Our experimental studies also
highlighted that thymoquinone was very effective in sensitizing the drug (doxorubicin) resistant
triple negative breast cancer cells by affecting the drug efflux pumps. To address the problem of
resistance, we have developed nanoparticles that dually deliver the chemotherapeutic drug
(doxorubicin) and the natural phytochemical (thymoquinone) to cancer cells and inhibit the MDR
protein like Pglycoprotein through microRNA 298 which helps to reduce the pumping out of the
therapeutic drugs from the cell. These emerging strategies promise novel and better tailored
combinatorial regimens which may provide new insights into specific therapeutic approach for
clinical cancer treatment.
27
Book of Abstracts
OP06
ROLE OF NANOPARTICLES IN THERAPEUTIC GENE DELIVERY APPLICATIONS
Joydeep Das
Research Assistant Professor
Department of Stem Cell and Regenerative Biotechnology
Humanized Pig Research Center (SRC)
Konkuk University, Seoul 143-701, South Korea
Abstract
Gene therapy is a promising technique for the treatment of various diseases. The
development of minimally toxic and highly efficient non-viral gene delivery vectors is the most
challenging undertaking in the field of gene therapy. Here, I would like to discuss about
dimethyldioctadecylammonium bromide (DODAB)nanoceria (CeO2) hybrids as a new class of
non-viral gene delivery vectors that we have recently developed in our laboratory. These DODAB-
modified CeO2 nanoparticles (CeO2/DODAB) could effectively compact the pDNA, allowing for
highly efficient gene transfection into the selected cell lines. The overall vector performance of
CeO2/DODAB nanohybrids was comparable with Lipofectamine 2000 and DOTAP, and higher than
calcium phosphate and DEAE-dextran for transfecting small plasmids. Besides, CeO2/DODAB
nanovectors could transfect genes in vivo without any sign of toxicity.
The controlled differentiation of stem cells via the delivery of specific genes encoding
appropriate differentiation factors may provide useful models for regenerative medicine and aid
in developing therapies for human patients. However, the majority of non-viral vectors are not
efficient enough to manipulate difficult-to-transfect adult human stem cells in vitro. We determined
the functional applications of 25 kDa branched polyethylenimine-entrapped gold nanoparticles
(AuPEINPs) and covalently bound polyethylenimine-gold nanoparticles (AuMUAPEINPs) (both were
developed in our laboratory) by transfecting hMSCs with the C/EBP beta gene to induce adipogenic
differentiation. Transfection efficacy of these nanoparticles was found to be higher than
polyethylenimine and Lipofectamine 2000. Overexpression of exogenous C/EBP beta significantly
enhanced adipogenesis in hMSCs. These nanoparticle/DNA complexes exhibited favorable
cytocompatibility in hMSCs, therefore, represent safe and highly efficient vehicles for gene delivery
to control hMSC differentiation and for therapeutic gene delivery applications.
Nanoparticles can also be considered as a potential candidate for gene delivery into germ
cells and early stage embryos to produce transgenic animals. Among the several procedures, sperm
mediated gene transfer (SMGT) into oocytes is one of the useful techniques for transgenic animal
production. Studies from our and several other laboratories showed that nanoparticles loaded
with nucleic acids/proteins could form a strong association with mammalian sperm, and could
efficiently introduce exogenous DNA into embryos after in vitro fertilization. Therefore,
investigations into the possibility of applying nanovectors to gene delivery in germ cells and early
embryos will open new horizons in reproductive biology.
28
OP07
NANOSPONGES: A MODERN TOOL IN DRUG DELIVERY SYSTEM

Pintu Kumar De1*, Anindita Saha2, Subhabrata Ray2, Avik Kumar Saha2
1
Department of Pharmaceutical Technology, Adamas University,
Barasat-Barrackpore Road, Jagannathpur, Kolkata-700 126
2
Dr. B.C.Roy College of Pharmacy and AHS, Bidhannagar, Durgapur-713206
*
Corresponding author: E.Mail: pintude234@gmail.com
The major challenges found in making a novel class of drug delivery system is to make the
drug solubilize and to lead the therapy to the target site to fulfill the individual need in the diseased
condition.Nanosponges are solid porous nanoparticulate drug delivery system having three
dimensional structures. Cyclodextrin based nanosponges can be formulated as hyper-crosslinked
polymer based porous particles having a capacity to load both the lipophilic and hydrophilic
molecules. The release of the entrapped molecules can be varied by modifying the structure to
achieve prolonged release kinetics or a faster release.
The objective of the present study was to develop a Cyclodextrin-based nanosponge of a
poorly soluble model drug, Gatifloxacin for solubility enhancement and controlled release of
theloaded moieties from the nanocavity of the spongy delivery system.
The condensation polymerization technique proved to be a versatile technique for
nanosponge formulation having easy scale up techniques and batch to batch reproducibility. Hence
cyclodextrin based nanosponge of gatifloxacin has been formulated by polymer condensation
method and characterization of prepared nanosponges done for the particle size distribution,
surface morphology, solubility study, drug-polymer compatibility, drug entrapment efficiency and
stability studies.The release of the entrapped molecules was found to be varied by modifying the
structure by varying the ratio of cross-linker to polymer.
SEM study revealed the presence of undulating structures on nanosponge surface along
with minute pores. Drug loaded nanosponge shows a highly networked topology and absence of
any crystalline structures. The percentage drug entrapment efficiencies in nanosponge formulations
varied widely (51-93%) depending on the crosslinker polymer ratio and drug loading. In accelerated
stability study as per ICH guidelines no significant changes occurred in physical appearance, size
and drug content in formulation for 3 months.The particle size distribution of
gatifloxacinnanosponges studied by using Malvern zetasizer, mean size of the particles was found
to be varied within nano-range (296 nm to 342nm). The size range indicates that the formed
complexes were of nano size with improves surface area entrapping the still smaller size drug in
the cavity, which will improve the solubility of the drug.
29
Book of Abstracts
The aqueous solubility of Gatifloxacin (solubility of pure gatifloxacin is 0.023mg /ml) as

observed by equilibrium solubility studies was found to be increased by twenty three fold (0.54
mg/ml) in nanosponge formulation. The In vitro release study of prepared nanosponges revealed
a bidirectional change in the nature of nanosponges. It is evident from the dissolution profiles
that a bidirectional trend in the nature of nanosponge can be seen, by varying certain formulation
parameters the drug release can be changed from slow, sustained release to fast and quick release
of drug from matrix. Hence in conclusion the nanosponge formulation of poorly soluble drug can
make the delivery system more stable and with the enhancement of dissolution profile as well as
controlling the release of the drug.
30
OP08
EXPERIMENTAL AND CLINICAL ASSESSMENT OF HEPATO-PROTECTIVE

ACTIVITY OF BANGLADESH PLANTS
Dr. Kamalesh Chandra Paul
Ayurvedic Physician, Rasik Memorial Ayurved Arogya Niketon, Bagerhat, Bangladesh.
Member, Asian Network of Research on Anti-diabetic Plants.
Advisor, Nabin Laboratory, Dhaka.(Quality Division)
Email - k.c.paul884@gmail.com
Abstract
In the course of biological evolution, plants evolved earlier to the animal kingdom and are
the backbone of all life on earth and an essential resource for human well-being. Plants have been
used for medicinal purposes long before prehistoric period and it is a source of medicine even for
life-threatening diseases. Now it is the responsibility of the dedicated scientists and pharmacologist
to find out the appropriate plants which have curative powers for certain disease.
As an Ayurvedic Physician, I conducted a clinical trial to explore the effect of andrographis
paniculate nees (kalamegh), piper, piper longum linn, saussurca lappa C.B clarke.(Kur), citrus Limon
(linn) Burm and zingiber officinale rose (Shut) on viral Hepatitis (Hepatitis-B) transmitted by
inadequately sterilized syringes and needles and by administration of infected blood, plasma or
blood products at Rasik Memorial Ayurved Arogya Niketon Bagerhat, Bangladesh.
The trial was conducted upon 5 patients from 1 January, 2016 to 1 June, 2016, as referred by
the Ayurveda, Charok Songhita and chironjeeb banawshadhi composed by Revernd Shibkali
Vattacharja. Among the 5 patients, 2 patents were given Andrographis paniculate Nus (kalamegh),
piper longum and saussurea lappa C.B clarke and 2 patients were given Nabays Lawha and syrup
Diner manufactured by Hamdard Laboratory wakfow and the last one was given Hingastok Ras.
The patient was advised to take Hingastok Ras 500mg thrice daily before meal and Rohityaka
Rist 20mg thrice daily after meal for 21 days. The patients felt pretty good but the virus level did
not decrease. But the rest ones virus decreasing was so satisfactory. HBsAg virus level of the
patient deceased from 5.891 mg/L to 3.278 mg/L.
After 28 days from the beginning both of the 5 patients were given retreatment with
Hingastok Ras 500mg tab thrice before meal for 42 days and syrup Diner 20ml thrice daily after
meal. After 42 days 3 of those 5 patients felt pretty well and the treatment given with the said
medicine product unprecedented result. In this study it was found that those plants and medicines
HBsAg (Hepatitis-B) virus decreasing power was 60%. To confirm the definite result pathological
reports of the patients were made by respected Dr. Md Manwar Ahsan, Saint Martin Pathological
& Diagnostic Center, Khulna. All concerned reports are available with me.
Result: The above mentioned plants are effective to reduce HBsAg level.
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Book of Abstracts
OP09
BIOAVAILABILITY, BIODISTRIBUTION AND DRUG DELIVERY EFFICIENCY

OF NIFETEPIMINE-LOADED FOLIC ACID FUNCTIONALIZED PH
RESPONSIVE HIGHLY UNIFORM MESOPOROUS SILICA NANOPARTICLES
FOR IMPROVED BREAST CANCER THERAPY
Suman Bhandary and Parimal C Sen
Division of Molecular Medicine, Bose Institute, Centenary Campus
P 1/12, C. I. T. Road, Scheme VIIM, Kolkata-700054, India
Email: suman_bhandary@yahoo.co.in
Abstract
Controlled delivery of drugs in response to environments has the potential of targeting
therapies and personalized treatments. Here, a highly efficacious polyethylene glycol coated, folate
functionalized and pH-responsive tumor microenvironment triggering uniform mesoporous silica
nanoparticles (MSNs) were fabricated for increased solubility, target specific delivery and release
of a hydrophobic anticancer agent, nifetepimine (NFT). Herein, we report at a relatively lower
concentration, the NFT loaded functionalized MSNs (NFT- fMSNs) permeate into tumor
microenvironment via enhanced permeability and retention effect, followed byfolate ligand
anchored active cancer cell targeting. Afterwards, conjugated pH-sensitive linkers expedite escape
of the nanoparticles from endosomal/lysosomal compartments to cytoplasm. In vitro studies show
gatekeepers dissociation boost NFT release, leading to mitochondria mediated apoptosis of breast
tumor cells and cell cycle arrest in the sub G0/G1 phase. In vivo experimentation demonstrated
that NFT- fMSNsexpectedly exhibited tumor inhibitory potential with minimal toxic effects,
additionally deregulated the prime phenotypes associated with angiogenesis and metastasis, and
simultaneously reduce lung metastasis in 4T1 tumor model in syngeneic female BALB/c mice.
Keywords: Mesoporous silica nanoparticles, nifetepimine, pH stimuli-responsive drug delivery,

apoptosis, metastasis, angiogenesis
32
OP10
ANTITUMORIGENIC ACTIVITIES OF NANOENCAPSULATED NIFETEPIMINE :

A POSSIBLE BREAKTHROUGH IN THE THERAPEUTIC INTERVENTION
OF TRIPLE NEGATIVE BREAST CANCER
Ghosh A*., Bhowmik A**., Bhandary S*., Chakraborty A#., Ghosh M.K.**, Sen P.C.*
*Division of Molecular Medicine, Bose Institute, Centenary Campus, Kolkata, India.
** Cancer Biology and Inflammatory Disorder, Indian Institute of Chemical Biology, Kolkata,
India. #Department of Chemistry, Maulana Azad College, Kolkata, India.
Abstract
Triple negative breast cancer (TNBC) is one of the most common invasive malignancies among
women, associated with poor prognosis. Standard chemotherapy targets all dividing cells, resulting
in dose-limiting toxicities. In this study, we demonstrated a strategy of encapsulating a hydrophobic
synthetic compound, nifetepimine, having anticancer properties, in poly (lactic-co-glycolic acid)
nanoparticles to increase selectivity of drug to cancerous cells with minimum toxicity.
Nanoencapsulated nifetepimine (30-100 nm) having loading and encapsulation efficiency of 7.45%
and 75% respectively, was successfully internalized inside TNBC cells upon sustained release
resulting in apoptosis. An in vivo bio-distribution study indicated that nanonifetepimine selectively
accumulated into breast tumor sites of mice, primarily due to prolonged blood circulation time.
Moreover, binding of nifetepimine to epidermal growth factor receptor that remain overexpressed
in most of the TNBC tumors perhaps resulted in significant reduction in breast tumor volume with
improved survival implying high tumor targetability of nanonifetepimine.
33
Book of Abstracts
PP01
A STUDY ON MICROBIAL PROPERTIES OF SOME

COMMONLY OCCURRING MINERALS
Souravi Bardhan1, 2, Shubham Roy1, 3, Moumit Roy Goswami2,
Abhijit Chakrobarty4, Sukhen Das1
1
Department of Physics, Jadavpur University, Kolkata-700032;
2
Department of Environmental Science, Netaji Nagar College for Women,Kolkata;
3
Department of Physics, Asutosh College, Kolkata;
4
Department of Geology, Jogomayadevi College,Kolkata
Email: bardhan666srv@gmail.com
Abstract
Microbial properties of some minerals (Hematite, Galena and Stibnite) were investigated in
this article. Their physical properties were characterized using FESEM and XRD. The Minimum
Inhibitory Concentration (MIC) along with the size dependent microbial activity of different minerals
was studied against Escherichia coli. Minerals (in suspension) were studied by spread plate method
on Nutrient agar plates.
Keywords: Minerals, Escherichia coli, Minimum Inhibitory Concentration, Microbial Activity
34
PP02
HOMOEOPATHIC DRUGS COMPLEMENTARY, ANTIDOTAL AND

INIMICAL TO NUX VOMICA PRODUCE STRONGER ANTI-ALCOHOLIC
EFFECT ON TOADS THAN NUX.
Atheni Konar1,5, Tandra Sarkar1,5, Indrani Chakraborty 3,, NC Sukul 4,5 , A Sukul5 and R. Chakravarty2
1
Centre for Healthcare Science and Technology, IIEST, Shibpur-711103, West Bengal, India.
2
Molecular Hoemeopathy Research Unit, 30 Chowringhee Rd, Kolkata 16, India.
3
Department of Zoology, Vidyasagar College for women, Kolkata, India.
4
Department of Zoology, Visva-Bharati University, Santiniketan, India.
5
Sukul Institute of Homeopathic Research, Shyambati, Santiniketan, India.
Abstract
In homeopathy some drugs are known to act as complementary, antidotal or inimical to a
particular drug. Practioners can follow this rule when they apply one drug following another.
Potentized Nux vomica can reduce acute hypnotic effect of alcohol on toads. Sulphur and Sepia
are reported to be complementary to Nux-vom, while Coffea cruda and Zincum met are antidotal
and inimical to Nux, respectively .The four drugs have been tested on the toad model to find out
their actual relationship with Nux vom. Aim of this study is to verify the complementary effect of
Sulphur and Sepia, antidotal effect of Coffea and inimical effect of Zincum in relation to Nux vom
in the toad model.Five batches of toads, each comprising 20 individuals, were treated by partial
immersion in a drug diluted with distilled water 1:500 for 20 mins. The control consisted of 90%
ethanol diluted with distilled water 1:500.The drugs were Nux vom 200 cH, Sulphur 200 cH, Sepia
200 cH, Coffea 200 cH and Zincum 200 cH. Toads of each batch were separately exposed to 260mM
ethanol solution and tested every 10 min to see if they had lost their righting reflex(RR). For this,
each toad was laid on its dorsal surface. If it failed to turn on its ventrum in a cut-off time of 60 sec
it was considered to have lost its RR. Four more batches of toads were pretreated with Nux vom
200 cH and subsequently treated separately by Sulphur 200 cH, Sepia 200 cH, Coffea 200 cH and
Zincum 200 cH. All the toads were then exposed to 260 mM ethanol solution to record their
tolerance to ethanol anesthesia in terms of time to lose RR. Toads treated with the five drugs took
significantly longer time (P<0.01, one-way ANOVA) to lose RR than those treated with the control.
The time taken to lose RR was significantly longer (P<0.01, one-way ANOVA) with Sulphur 200 CH,
Sepia 200 CH, Coffea 200 CH and Zincum 200 CH than with Nux vom 200 CH alone. The situation
was same when Nux treatment was followed by each of the four drugs. Of the five drugs Coffea
showed the strongest effect. In an earlier study conducted in our lab it was observed that
homeopathic potency prepared by triturating concerned drug particles with copper nanoparticles
produced better biological effect than same potentised drugs prepared by the standard process
of trituration without any nanoparticles. The nanoparticles themselves did not produce any effect
but water structure induced by the concerned drug produced desired effect. In a further study
we want to see the effect of the same drugs prepared with Cupper nanoparticles on the toads.
35
Book of Abstracts
PP03
HIGH DILUTION OF MERCURIC CHLORIDE INCREASES WATER PERMEATION,

CHLOROPHYLL CONTENT AND GROWTH IN GERMINATING SEEDS OF
COWPEA VIGNA UNGUICULATA (L) WALP
Tandra Sarkar1,2 M.Sc, Atheni Konar1,2 M.Sc, Nirmal Chandra Sukul1,3 Ph.D ,
Anirban Sukul1 Ph.D, Pallab Datta2 Ph.D, Ashoke Sutradhar4 Ph.D
1
Centre for Healthcare Science and Technology, IIEST, Shibpur-711103, West Bengal, India.
2
Sukul Institute of Homeopathic Research, Shyambati, Santiniketan-731235, West Bengal, India.
3
Department of Zoology, Visva-Bharati University, Santiniketan 731235, West Bengal, India.
4
Department of Electrical Engineering, IIEST, Shibpur-711103, West Bengal, India.
Abstract
In an earlier study conducted in our lab it was observed that homeopathic potency prepared
by triturating concerned drug particles with copper nanoparticles produced better biological effect
than same potentised drugs prepared by the standard process of trituration without any
nanoparticles. The nanoparticles themselves did not produce any effect but water structure
induced by the concerned drug produced desired effect. In this study we used a homeopathic
potency Merc corr 200 from Dr Reckweg.
It is possible that Merc corr potency prepared by triturating HgCl2 with Cu nanoparticles
may produce better effect on the plant models. Aquaporins (AQP) facilitate water transport in
cells and conductance of CO2 through mesophyll to chloroplast. Hgcl2 inhibits AQP activity. As per
homeopathic principles Hgcl2 at ultra high dilution (UHD) would produce reverse effects. Aim of
this study is to find out whether Mercuric Chloride at UHD could increase water permeation,
chlorophyll content and growth in cowpea seedlings. Germinating seeds were treated with HgCl2
by both high (0.3%) and ultra low doses (Merc cor 200 cH). Water, chlorophyll, protein and sugar
content, and total biomass of treated and untreated embryos were estimated by standard methods.
Percentage of germination was calculated in both the groups. Mercuric chloride at UHD (200cH)
increased germination of seeds, water permeation, biomass, protein, sugar and chlorophyll content
in embryos significantly (P<0.05) as compared to the untreated control and 0.3% HgCl2-treated
seedlings thus showing Mercuric chloride at UHD enhances the activity of AQPs and promotes
water permeation, photosynthesis and growth in cowpea seedlings.
36
PP04
INFLUENCE OF NANO CLAY ON STRUCTURE AND ELECTRICAL PROPERTIES

OF POLY (ETHYLENE) OXIDE BASED SOLID ELECTROLYTES
Mou Saha1, 2, Ruma Ray2, Sujata Tarafdar1
1
Physics Department, Condensed Matter Physics Research Centre,
Jadavpur University, Kolkata-700032, WB, India.
2
Physics Department, Gurudas College, Kolkata 700054, WB, India
Email: sahamou14@gmail.com
Abstract
Solid Polymer Nanocomposite Electrolytes (SPNEs), comprisingof host polymer [poly
(ethylene) oxide (PEO)], salt [ammonium iodide (NH4I)] and nano-filler (L) [Laponite], denoted as
PEO + NH4I + L-x (x = 0 15 wt%), were prepared by solution cast technique.Morphology and
microstructure of SPNE systemis found to be highly composition dependent and changes with
variation in salt as well as laponite concentrations.Inclusion of laponite in salt complexed polymer
electrolyte films revealsvariation in amorphousness due to enhancement in basal space between
clay platelets. Evidence of intercalation or exfoliation as well as enhancement in amorphousness
facilitating ion conduction pathwaysthrough the polymer matrix is found to be significantly high
for SPE filmscontaining 5wt% Laponite and 7 wt% salt component. Behaviour of characteristic
relaxation time of cation coordinated host polymer is also investigated from loss tangent and
imaginary part of electric modulus function. This paper reports a systematic study of nano filler
induced structural variation ofSPNE system.
37
Book of Abstracts
PP05
IN SEARCH OF EPITOPES ON NANOMEDICINES -

FROM PROTEOMICS TO VACCINOMICS
Antara De1,2
1
Adamas University, Barasat, Kolkata
2
Centre for Interdisciplinary Research and Education, Jodhpur Park, Kolkata.
Abstract
Our immune system responds in response to an attack by a pathogen. However, the epitope
which elicits immune response is often only a sequence of few hydrophilic amino acids present on
the surface of a pathogen. Nonetheless, the stretches of amino acids may be continuous or
discontinuous which interact via multiple chemical bonds creating a 3D biomolecule which acts as
immunogen. Peptide vaccines are synthetic bionanoparticles of approximately 10-45 aminoacids
that have experimentally verified potential can act as nanomedicine. However, shorter is the
length of the vaccine, lesser is the production cost and the chances of having anaphylactic shock
in the host organism. Peptide vaccines have broad range of advantages over other traditional
vaccines. They can be tailor made, have low production cost, low risk of contamination, zero fear
of reversion and free from storage problems. Nevertheless, designing a peptide is not absolved
from technical difficulties. It is a multidisciplinary field of research requiring in-depth knowledge
in immunology, cell biology, genetics, computational biology and bioinformatics. We have used
bimolecular modeling, computational biology to design peptide vaccine against human papilloma
virus (HPV), the virus causing cervical cancer, the second most predominant cancer among women
worldwide and influenza virus H7N9, a virus having future pandemic potential.
38
PP06
PHOTO VOLTAGE GENERATION BY USING MIXED DYE WITH

OXIDIZED MULTIWALL CARBON NANOTUBE AND ALSO
WITH POTENTISED ZNO NANOPARTICLE
Poonam Bandyopadhyay1,3, Ruma Basu2,3, Sukhen Das1,3, Papiya Nandy3
1
Department of Physics, Jadavpur University, Kolkta-700032, India;
2
Department of Physics, Jogamaya Devi College, Kolkata-700026, India;
3
Centre for Interdisciplinary Research and Education, Kolkata 700 068, India;
Abstract
We report here our studies on hybrid photoelectrochemical cell containing a commonly
used dyes, phenosafranine and Azure C mixed with oxidized multiwall carbon nanotubes for
conversion of solar energy to electrical energy. We observed that the cell yielded voltage (~763
mV) good storage duration (~66 hrs) and energy conversion efficiency (4.33%) of high magnitude
compared to other cells. The interaction between the mixed dye solution with oxidized multiwall
carbon nanotubes was studied with FTIR, UV-Vis spectroscopy. Both FTIR and Absorption spectra
of the mixed dye-carbon nanotubes system showed that the absorbance of dye molecules increased
with addition of carbon nanotubes due to adsorption of dye molecules on the surface of carbon
nanotubes, which help in increasing incident photon absorption. The back recombination of
photoexcited charges got delayed due to the presence of planar lipid membrane which causes
significant increase in voltage generation, efficiency and storage duration.
Similar result but with lower magnitude, was obtained when mixed dye was conjugated
with potentised ZnO nanoparticles.
39
Book of Abstracts
PP07
EXTRACTION OF ELECTRICAL ENERGY FROM A SYSTEM WITHOUT
ANY SOURCE OF ION
P Nandy1*, K Das1,, P Bandyopadhyay1,2, B K Paul1,, D S Bhar1, S Das1,2, R K Manchanda3,
A K Khurana3, D Nayak3
1
Centre for Interdisciplinary Research and Education, 404 B Jodhpur park, Kolkata-700 068
2
Jadavpur University, Kolkata-700 032
3
Central Council for Research in Homeopathy, New Delhi- 110058
Abstract
For the first time we report here how electrical energy has been extracted and measured in
the absence of any significant source of ions. In an U-shaped glass experimental cell, one platinum
electrode is immersed in the arm containing bi-distilled water and the other in the arm containing
91% ethyl alcohol. The two arms are separated by a platinum foil. A dc power of the order of
nanoW, lasting for many hours, was measured through a resistor (1.0 M).
40
PP08
SUCCUSSION ENHANCES VOLTAGE AND POWER GENERATION IN POLAR

LIQUIDS DUE TO DOMAIN FORMATION AS PREDICTED BY QED
P Bandyopadhyay1,2, D Bera1, K Das1, B K Paul1, S Das1,2, D S Bhar1,
R K Manchanda3, A K Khurana3, D Nayak3, P Nandy1*
1
Centre for Interdisciplinary Research and Education, 404 B Jodhpur Park, Kolkata-700 068, India
2
Department of Physics, Jadavpur University, 188 Raja S. C. Mallik Road, Kolkata-700 032, India
3
Central Council for Research in Homeopathy, 61-65 Institutional Area,
Janakpuri, New Delhi 110058, India
*Corresponding author: pnandy00@gmail.com
Abstract
Using a U-shaped glass tube where one arm contains bi-distilled water and the other arm
ethyl alcohol (91%), the arms being separated by a platinum foil, voltage was generated across
two platinum electrodes and a dc power of the order of nanoW, lasting for many hours, was
measured. The magnitude of both the voltage and power generated increased with vigorous
shaking of the alcohol (succussion).
Considering the absence of any significant quantity of ionic solutes in this system, voltage
generation from two different polar liquids separated by a metal separator is an interesting
phenomenon in the frame of the classical electrochemistry and seems to imply some kind of
other than ionic conduction.
A qualitative explanation of this phenomenon has been offered based on the principle of
Quantum Electrodynamics.
41
Book of Abstracts
PP09
EFFECT OF VIGOROUS SHAKING ON RAMAN SPECTRA OF 91 % ETHANOL,

A VEHICLE FOR HOMEOPATHIC MEDICINE
D. Bera1 ,P. Maitra2, P. Bandyopadhyay1,3, A. Singha1,4, S. Das1,3, K. Das 1,P. Nandy1, D.S.Bhar1,
R.K. Manchanda5, A.K. Khurana5, D. Nayak5
1
Centre for Interdisciplinary Research and Education, Kolkata 700 068
2
Physics Department, Amity University, Kolkata 700135
3
Physics Department, Jadavpur University, Kolkata 700 032
4
Physics Department , Bose Institute, Kolkata 700 009
5
Central Council for Research in Homeopathy, New Delhi 110 058
Abstract
Using Raman scattering, we have studied changes in H-bonding due to increase in potency, caused
by vigorous shaking of 91% ethyl alcohol. To estimate the effect of potentisation of alcohol on the strength
of the stretching OH-vibrations, we have measured the change in the intensity of OH stretching bands at
the frequencies 3240 cm-1, 3420 cm-1 and at 3620 cm-1 corresponding to these bonds. With increase in
potency, the number of OH groups with strong hydrogen bonds decreases while the number of OH groups
with broken and weak hydrogen bonds increases.
Using a U-shaped glass tube where one arm contains bi-distilled water and the other arm 91% ethyl
alcohol, the arms being separated by a platinum foil, voltage was generated across two platinum electrodes
placed symmetrically in the two arms and lasted for many hours. The magnitude of voltage increased
with vigorous shaking of the alcohol.
A qualitative explanation of the relation between the two results has been suggested.
42
PP10
ANTICANCER EFFECT OF FOLATE-DECORATED-CuO-NANOWIRE IN HUMAN

TRIPLE NEGATIVE BREAST CARCINOMA CELLS VIA MITOCHONDRIAL-ROS
GENERATION AND NF-B-miR 425-PTEN PATHWAY
Manisha Ahir, Saurav Bhattacharya, Sushmita Sarker, Priyanka Upadhyay, Arghya Adhikary*
Centre for Research in Nanoscience and Nanotechnology, University of Calcutta,
JD-2, Sector III, Salt Lake, Kolkata-700098, West Bengal, India.
E-mail:ahirmanisha@gmail.com
*Corresponding Author: Dr. Arghya Adhikary. Centre for Research in Nanoscience and
Nanotechnology, University of Calcutta, JD-2, Sector III, Salt Lake, Kolkata-700098, West Bengal,
India. Tel: +91-9830428550, E-mail: adhikaryarghya@gmail.com.
Abstract
Metal oxide nanoparticles are the forthcoming anti-tumor therapeutics and provide a
versatile platform in the development of therapeutic approaches for drug-resistant cancers such
as triple negative breast cancer (TNBC). Copper oxide nanoparticles have been characterized as
anti-cancer agents but its toxicity has been a matter of concern. Herein, we have developed a
targeted CuO Nanowire fabricated with Folic acid (CuO-Nw-FA) that enables enhanced cellular
uptake in TNBC cells without imparting significant toxicity in normal cellular system. In the present
study, we enumerated that CuO-Nw-FA caused mitochondrial-dependent apoptosis in MDAMB-
231 cells. Furthermore, CuO-Nw-FA mediated cytosolic retardation of NF-B favoured inactivation
of miR-425 and henceforth activated PTEN to induce apoptosis in TNBC cells. Simultaneously,
CuO-Nw-FA also restricted the in-vitro cell migration through the miR-425/PTEN axis via pFAK.
Studies extended to ex-ovo and in-vivo mice models further validated the efficacy of CuO-Nw-FA.
Additionally, the accumulations of nanoparticles in tumor as well as different organs in mice were
examined by in-vivo biodistribution and ex-vivo optical imaging studies. Thus our results
cumulatively propose that CuO-Nw-FA cross-talks two distinct signalling pathways to induce
apoptosis and retard migration in TNBC cells and raises the possibility for the use of CuO-Nw-FA
as a potent anti-tumor agent.
43
Book of Abstracts
PP11
EXTRAORDINARY PHOTOLUMINESCENCE ENHANCEMENT IN AU

DECORATED FEW-LAYER WS2
Tara Shankar Bhattacharya, Shib Shankar Singha and Achintya Singha
Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road,
Kolkata 700 009, India, Email:tarashankar1992@mail.jcbose.ac.in
Abstract
Layered transition metal dichalcogenides (LTMDs) have recently gained considerable attention
of the scientific community as these 2D semiconductors have properties more attractive for specific
applications than those of graphene [1]. The LTMDs exhibit a change of electronic structure with
the thickness of the material [2]. The introduction of hybrid 2D materials by means of localized
interactions with zero dimensional (0D) materials may provide a more immediate benefit for
tunability of 2D TMDs functions. A TMDs metal interface, as in gold (Au) - tungsten disulphide
(WS2) is of great interest from the standpoint of fundamental science as it constitutes an excellent
platform to investigate plasmonic-exciton interactions and charge transfer [3-5].
Here we realized WS2Au hybrids structures by growing Au NPs at the edge of the WS2 film.
The surface morphology and distribution of the NPs in the hybrid have been characterized through
electron microscopy. We study the interactions between WS2 and Au NPs through Raman and
Photoluminescence (PL) spectroscopy. A strong enhancement of the PL intensity in the WS2 -Au
composite with respect to bare monolayer WS2 has been observed, and it intensify more as the
number and size of the Au-NPs on WS2 increased. The result is attributed to localized surface
plasmon effect. We present the tuning of the emission energy as a result of charge transfer
betweenWS2 and Au NPs. Our study possibly throws some light to develop the photonic application
of two-dimensional materials.
References
1. Mak et al, Atomically Thin MoS2: A New Direct-Gap Semiconductor, Phys. Rev.Lett. 2010,
105, 136805.
2. Zhao et al. Evolution of Electronic Structure inAtomically Thin Sheets ofWS2 andWSe2, ACS
Nano, 2013, 7 (1), 791797.
3. Polyakov et al. Decoration of WS 2 Nanotubes and Fullerene-Like MoS 2 with
GoldNanoparticles, J. Phys. Chem. C 2014, 118, 2161"2169.
4. Zeng et al. High-responsivity UV-Vis Photodetector Based on Transferable WS2 Film Deposited
by Magnetron Sputtering, Scientific Reports 2016, 20343.
5. Kern et al. Nanoantenna-Enhanced LightMatter Interaction in Atomically ThinWS2, ACS
Photonics 2015, 2, 1260"1265.
44
PP12
ENHANCED RAMAN SCATTERING FROM INDIVIDUAL GE NANOWIRE

Sreyan Raha, Tara Shankar Bhattacharya, Shib Shankar Singha and Achintya Singha
Kolkata 700 009, India, Email: sreyanraha@gmail.com
Abstract
The strong enhancement of the visible electromagnetic (EM) radiation at the surface of
metal nanostructures due to surface plasmon resonances attracts significant attention for
fundamental and application point of view [1,2,3]. The realization of such enhancement of EM
filed in semiconducting and insulating materials, particularly in Germanium (Ge), a low band gap
energy and high hole mobility, is important for potential applications in optoelectronics,
photovoltaics, and biological sensing[4]. The incident EM radiation in a semiconductor creates a
distribution of the electric field, which manifest the Raman intensity from the materials. For certain
combination of the size, wavelength and the material, the resonance enhancement of the Raman
intensity occurs.
Here, we observe a strong enhancement of spontaneous Raman scattering from a single Ge

nanowire compared to the bulk Ge. We study the dependence of this enhancement with
wavelength and polarization of the incident EM radiation. Approximating the nanowire as an
infinite cylinder, we estimated the theoretical value of intensity for TE wave and TM wave.The
observation is in good agreement with the simulated results for the scattering[5].We also have
observed optical antenna effect inGe nanowire. These results expandthe opportunity for
engineering the photonicand sensing properties of Ge and Ge-basednanostructures.
References
1. K. Kneipp, H. Kneipp, I. Itzkan, R. R. Dasari, M. S. Feld; Chem. Rev. 99, 2957 (1999).
2. M. NGom, S. Li, G. Schatz, R. Erni, A. Agarwal, N. Kotov, T.B. Norris; Phys. Rev. B, 80,
113411 (2009).
3. S. A. Maier et al., Nat. Mater. 2, 229 (2003).
4. Burchhart, T.; Zeiner, C.; Lugstein, A.; Henkel, C.; Bertagnolli, E. Tuning the Electrical
Performance of Ge Nanowire MOSFETs by Focused Ion Beam Implantation.
Nanotechnology 2011, 22, 035201.
45
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PP13
ASSESSING THE EFFICIENCY OF THE MESOPOROUS SILICA NANOPARTICLE

FOR THE DELIVERY OF CURCUMIN AND IMPROVING ITS BIOAVAILABILITY
Shatadal Ghosh
Senior Research Fellow, Division of Molecular Medicine Bose Institute (Centenary Campus)
P1/ 12 , CIT Scheme VII-M, Kolkata-700054
Email: dalshata@gmail.com
Abstract
The advancement in the field of nanotechnology has enabled us to explore new techniques
of drug delivery system (DDS). These nanomaterials not only overcome the problems of drug
delivery but will also enhance the therapeutic efficiency of the drug (for instance enhancing the
bioavailability of some naturally occurring antioxidant molecules like curcumin). Mesoporous silica
nanoparticles (MSNs) have been reported to possess remarkable advantages like high chemical
and mechanical stability, greater surface area, large pore volume, tunable pore sizes, well defined
surface chemistry and superior biocompatibility over the organic drug carriers. Moreover, it has
been found that MSNS show very low toxicity which is a common problem with nanoparticle
based DDS. Earlier reports showed that curcumin could be loaded in different nanomaterials
including cyclodextrins, chitosan nanoparticles, liposomes etc. In addition to the above DDS, MSN
could also be considered as a promising carrier molecule for curcumin due to its versatility. Besides,
targeted delivery can also increase the bioavailability of curcumin into tumor tissues and reduce
the toxicity on normal tissues as well.
According to earlier results, the PEGylation (PEG: poly(ethylene glycol)) of nanoparticles has
been used as an effective way to reduce the nonspecific binding of nanoparticles to blood proteins
and macrophages, thereby the bypassing clearance by first-pass organs, such as lung and kidney.
Thus PEGylation favours their EPR effect to be greatly enhanced and prolong their blood circulation
half-lives. In case of the biodegradable matrixes, the covalently PEGylated nanoparticles can keep
higher accessibility to PEG chains during blood circulation compared to the PEG physical adsorption,
and thus possess longer blood circulation half-lives.
The stealth characteristics of PEGylated nanoparticles originates from the steric hindrance
and repulsion effects of PEG chains against blood proteins and macrophages. This phenomenon is
closely correlated to the PEG molecular weight, surface chain density and conformation which
are interrelated. The mushroom and brush conformations may form at low and high surface
PEG chain densities, respectively. The different conformations and molecular weights of PEG chains
directly affect their flexibility and hydrophilicity, respectively, and consequently their steric repulsion
against blood proteins and macrophages. It is, therefore, important to find out the optimal PEG
molecular weight and chain density on nanoparticles for best results.
46
PP14
NETWORK ANALYSIS OF CRACK PATTERNS IN LAPONITE CLAY IN

PRESENCE OF DC ELECTRIC FIELD
Ankita Paul1*, Sudeshna Sircar1, Sujata Tarafdar1, Tapati Dutta2
1
Condensed Matter Physics Research Centre, Jadavpur University
2
St. Xaviers College, Physics Dept., Kolkata
*Presenting Author: ankitapaul2601@gmail.com
Abstract
We report a study of crack patterns formed in laponite gel drying in DC electric field. The
sample dries in a rectangular Perspex box and the field is applied between the two opposite long
edges of the box. Cracks that initially form at the positive electrode show some interesting patterns.
Some of them eventually extend up to the negative electrode and these are mostly straight in
nature, others interact with their neighboring cracks and merge with them, sequentially forming
a hierarchical tree-like-pattern. The final structure varies with the strength of the electric field.
We report here the patterns of the cracks for voltages ranging from 10 to 60 volts and calculate
analytically some characteristic parameters, namely - the clustering co-efficient and efficiency of
the network for each voltage.
Fig,1 : Tree-like-cracks developed in aqueous gel of Laponite on the

application of 60V DC electric field
47
Book of Abstracts
Fig.2: Graph of Efficiency and Clustering co-efficient with various applied voltages
48
PP15
ENHANCED DIELECTRIC PROPERTIES AND CONDUCTIVITY OF

TRITURATED COPPER AND COBALT NANOPARTICLE DOPED PVDF-HFP
FILM AND THEIR POSSIBLE USE IN ELECTRONIC INDUSTRY
A. L. Gayen2, B. K. Paul1,2, D. Roy1, S. Kar1,2, P. Bandyopadhyay1,2, R. Basu1,3,
S. Das1,2,4, D. S. Bhar1, P. Nandy1*
1
Centre for Interdisciplinary Research and Education, Kolkata-700 068, India.
2
Department of Physics, Jadavpur University, Kolkata-700032, India.
3
Department of Physics, Jogamaya Devi College, Kolkata-700026,
4
Department of Physics, Indian Institute of Engineering Science and Technology, Shibpur, India.
*Address for correspondence: Dr. Papiya Nandy, E-mail: pnandy00@gmail.com
Abstract
We have synthesised a novel nanocomposite film by incorporating triturated copper and
cobalt nanoparticles in the poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) films by
simple solution casting technique.
Fourier Transform Infrared Spectroscopy (FTIR) study of these nanocomposite films detected
presence of - and - phases. Scanning electron micrographs showed spherulitic crystal structure
of PVDF-HFP in the nanocomposite film and study of dielectric properties over broadband
frequency of these doped nanocomposite film showed that these films have higher dielectric
permittivity and significantly lower dissipation factor (tan) at room temperature compared to
the pure PVDF-HFP.
The incorporation of metallic nanoparticles in the polymer matrix activates the transition of
phase between and and provides the nanocomposites higher mobile charge carriers which
participate in the interfacial polarization. The room temperature dielectric constant of the pure
PVDF-HFP at 20 Hz frequency increases with increase in concentration of the metal nano particles
and reaches a maximum almost 4 times the value of the pure one. At higher concentrations, the
effect reduces, perhaps due to agglomeration of the nanoparticles.
49
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PP16
ROLE OF MULTIWALLED CARBON NANO TUBE AS NANOFERTILIZER

Anindita Dey1,4, Sukhen Das2,4, Ruma Basu3,4, Papiya Nandy4
1
Department of Botany, Asutosh College, Kolkata-26
2
Department of Physics, Jadavpur University, Kolkata-32
3
Department of Physics, Jogamaya Devi College, Kolkata-26
4
Centre for Interdisciplinary Research and Education, Kolkata-68
*Corresponding authors e-mail: sunimondal@yahoo.com
Abstract
We report here our study on the effect of multiwalled carbon nano tubes (MWCNTs) and its
oxidized form (OMWCNTs) on membrane permeability, germination rate and growth of mustard
plants. We showed that OMWCNTs not only increase the moisture content of seeds but also
enhance the water absorption machinery of root tissues and thereby increases overall plant growth
specially the shoot growth. Plants that are used only for fodder or biofuel or edible purposes can
be grown in medium containing OMWCNTs and for this purpose very low concentration of
OMWCNTs is highly effective.
However, we should remember that high concentration of nanoparticles is harmful to both
plant growth and biomass production.
50
PP17
EFFECT OF HOMEOPATHY MEDICINE AURUM METALLICUM ON

ANISOTROPY OF LIPOSOMAL MEMBRANE
Debbethi Bera1, Peu Das2, Monalisa Chakrabraty 1,3, Poonam Bandyopadhyay1,3,
Sukhen Das1,3, Papiya Nandy1.
1
Centre for Interdisciplinary Research and Education, Pin 700 068
2
Department of Pharmaceutical Technology, Jadavpur University, Pin 700 032
3
Department of Physics, Jadavpur University, Pin 700 032
Abstract
Research and development of multifunctional nanoparticles as pharmaceutical drug carriers
have spurred exponential growth in applications to medicine in the last decade.
By studying the effect of the homeopathic drug Aurum metallicum on liposomal membrane
anisotropy, we observed that with an increase in potency, the membrane anisotropy increased,
suggesting more penetration of the drug into the membrane, thereby causing better effects.
51
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PP18
PHYTOREDUCTION OF COPPER NANOPARTICLES FROM VIGNA RADIATA

AND ITS ANTIBACTERIAL ACTIVITY
M. Chakraborty 1 ,2, A. Dey1,3, N. Bala2,4 , R. Basu 1,5, S. Das1,2 and P. Nandy1
1
Centre for interdisciplinary Research and Education, Pin 700068
2
Physics Department, Jadavpur University, Pin 700 032
3
Botany Department, Asutosh College, Pin 700 026
4
Physics Department,Shrii Chaitanya Banerjee College, Pin 712 503
5
Physics Department,Jogamaya Devi College, Pin 700 026
Abstract
Copper oxide nanoparticles (CONP) was synthesized in a fast and single step method by
reducing the copper salts viz. copper chloride, copper sulphate, and copper nitrate using mung
bean seed electrolytes. The fastest reduction (15-20 minutes) was obtained when copper nitrate
reacted with plant electrolyte. Characterization of the nanoparticles was done by UV-VIS
Spectrophotometry, DLS (Dynamic light scattering), ZETA POTENTIAL, FTIR (Fourier transform
infrared spectroscopy) and FESEM (Field emission scanning electron microscopy). Nanoparticles
of size 18-40 nm were obtained . Phytochemical analysis of the mung bean seed was done to
determine the reducing component responsible for reduction of copper salts and the antibacterial
study of prepared CONP gave a clear indication of its satisfactory application against
Staphylococcus.aureus MTCC no. 96.
52
PP19
WAVY CRACKS IN LAPONITE GELS: MODE SELECTION IN A

STATIC ELECTRIC FIELD
Somasri Hazra, Tapati Dutta, Sujata Tarafdar
Condensed Matter Physics Research Centre, Jadavpur University, Kol-700032
Physics Department, St. Xaviers College, Kolkata 700016
Email: somasriphsh@gmail.com, Contact number: +918981448164
Abstract
Desiccation cracks are shown to follow undulating, corrugated paths even when the speed
of crack propagation is lower than the sound velocity in the medium by two orders of magnitude.
Fast Fourier Transform of the wavy crack path shows that it is a superposition of several sinusoidal
modes and their harmonics.
When the paste is exposed to an electric field during drying, by imposing a 50 V potential,
some of the modes are suppressed. Increasing the voltage to 100 V results in survival of only one
pure sinusoidal mode, having a definite wavelength and all the other modes are suppressed.
We suggest that an effective mixed mode loading develops as a result of faster evaporation
at the upper surface of the paste, and this is responsible for the instability leading to the wavy
contour of the crack. We also try to understand which wavelength will be selected when the
sample is allowed to dry under an electric field of sufficient strength.
53
Book of Abstracts
PP20
STRUCTURE AND ACTIVITY OF LYSOZYME IMMOBILIZED

ON GRAPHENE OXIDE.
Supriyo Beraa, Jesmita Dharb, Rubin Dasguptac, Gautam Basuc,
Soumyananda Chakrabortia and Pinak Chakrabartia, b,*
a
Department of Biochemistry, bBioinformatics Centre, cDepartment of Biophysics
Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata 700054, India.
* Author for correspondence. E-mail: PC: pinak@jcbose.ac.in, pinak_chak@yahoo.co.in
Telephone: +91-33-2569-3253; Fax: +91-33-2355-3886
Abstract
Nanomaterials, such as graphene oxide (GO) are being studied to decipher their suitability in
biomedical applications. Here we investigate the effect on structure and function of hen egg white lysozyme
(HEWL) on being adsorbed on GO, using various biophysical techniques. In spite of there being not much
change in the structure, the catalytic activity is reduced significantly. Fluorescence quenching indicates
complex formation. Fluorescence lifetime measurement suggests that GO binds at or near the active site
near Trp62 and Trp108. Heat change associated with HEWL-GO interaction suggests hydrogen bond and
electrostatic interactions are involved in the HEWL-GO complex. Molecular docking indicates binding of
GO at the active site corroborating experimental findings. Molecular dynamics simulations indicate that
the blocking of the active site affects the flexibility of the surrounding residues and contribute to the
reduction of the activity. Unfolding experiments indicate that HEWL is more prone to thermal denaturation
in presence of GO and a folding intermediate might occur during the process. Together, our results
established molecular details of HEWL-GO interaction and might be useful in eventual biomedical
applications of GO.
Keywords
Graphene oxide, HEWL (hen egg white lysozyme), enzyme activity, protein structure,
molecular dynamics simulation, fluorescence lifetime
54
PP21
EFFECT OF INSULATING NANO FILLER ON CONDUCTIVITY

AND MORPHOLOGY OF PEO PVDF BASED BLEND SOLID
POLYMER ELECTROLYTES
S. K. Patla1,2,Ruma Ray1*, Sanat Karmakar2, Sujata Tarafdar2
1
Gurudas College, Physics Department, Kolkata-700054, WB, India.
2
Jadavpur University, Physics Department, Kolkata-700032, WB, India.
Solid Polymer Electrolytes (SPE) consisting of Poly (Ethylene Oxide) (PEO) and Poly (Vinylidene
Fluoride) (PVDF) blend host polymers, Ammonium Iodide (NH4I) salt, plasticized with Poly(Ethylene
Glycol) (PEG) and loaded with SiO2 nano particles are prepared as thin film by conventional solution
cast technique. The room temperature conductivity is found to be enhanced by an order due to
blend host polymer. In addition to that presence of insulating nano filler changes the polymer
microstructure enormously. Structural variations of the nano-composite for different
concentrations of nano filler (SiO2) have been investigated by X ray Diffraction (XRD) and Fourier
transform infrared spectroscopy (FTIR). The ionic conductivity of PEO PVDF PEG NH4I SiO2
composite, measured by Impedance Spectroscopy (IS) is found to enhance 3.5 times than
composites without filler. We report the effect of nano-filler in the blend polymer matrix and its
consequences on microstructural modifications. Nano filler influenced electrical behavior, namely
dielectric properties, electric modulus and characteristic relaxation time are modified significantly
as a function of nano filler concentration. Maximum DC conductivity is achieved at 0.7 wt% filler
content at room temperature. The relaxation behavior obtained from loss tangent and imaginary
modulus provides relevant insights regarding ion transportation through the modified polymer
matrix as observed from XRD, SEM micrographs and IS results.
Fig. 1. Variation in ionic conductivity with respect to nano filler concentration
References:
1. D. K. Pradhan, R. N. P. Chowdhry, B. K. Samantaray, eExpress Polymer Letters, vol 2, (2008) 630
2. M. Ravi, Y. Pavani et al , Materials Chemistry and Physics, 130 (2011) 442 448
55
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PP22
ANTI-CHOLERA ACTIVITY OF ZNO NANOPARTICLES

Shamila Sarwar, Pinak Chakrabarti.
Department of Biochemistry, Bose Institute,
P1/12 CIT Scheme VIIM, Kolkata, India
Abstract
Cholera, an acute diarrheal disease caused by Vibrio cholerae kills 21,000 to 143,000 people
worldwide every year. Cholera toxin (CT) is the major pathological factor responsible for the disease.
CT binds to the GM1 ganglioside receptor present at the intestinal epithelial cells and gets
internalized thereby causing electrolyte and water efflux, the primary characteristics of the disease.
The rapid emergence of multidrug resistance strains limits the use of antibiotics and the present
therapy (Oral Rehydration Solution) targets to complement the loss. To this end we investigated
the antibacterial activity of ZnO NP against two biotypes of V. cholerae classical and E1 tor- El tor
was more susceptible both in planktonic and in biofilm forms. ZnO NP exerts its effect by disrupting
cellular membrane structure and function and by generating reactive oxygen species. ZnO NP
also interacts with the secreted CT and prevents it from binding to GM1 receptor reducing CT-
mediated fluid accumulation in mice intestine. The synergistic action of NP and antibiotic suggests
an alternative for the treatment of cholera.
56
PP23
IMPROVEMENT OF ELECTROACTIVE PHASE NUCLEATION, DIELECTRIC

AND OPTICAL PROPERTIES OF CHALCONE MODIFIED POLY
(VINYLIDENE FLUORIDE) THIN FILMS
Farha Khatun1, Nur Amin Hoque1, Pradip Thakur*2, Nayim Sepay3,
Swagata Roy1, Sukhen Das*1
1
Department of Physics, Jadavpur University, Kolkata- 700032, India.
Email address: sdasphysics@gmail.com, Mobile: +919433091337
2
Department of Physics, Netaji Nagar College for Women, Kolkata-700092, India.
Email address: pradipthakurju@gmail.com, Mobile: +919830366215
3
Department of Chemistry, Jadavpur University Kolkata- 700032, India.
Chalcone modified Poly (vinylidene fluoride) (PVDF) thin film by adding various amount of
chalcone (1-20 mass%) has been formed by using a simple solvent casting method. Different
techniques such as X-ray diffraction spectroscopy , differential scanning calorimetry have been
used to confirm the improvement of phase nucleation. A strong electrostatic or ion-dipole
interaction between chalcone and CH2dipole of PVDFdue to uniform incorporation of chalcone
molecules in polymer matrix is verified by field emission scanning electron microscopic images
which results a significant change in dielectric properties measured by a LCR meter. A strong
absorption peak of UV-Visible absorption spectroscopy (270-345nm) and emission peak (530 nm)
of photoluminescence spectrum are obtained which is also the evidence of uniform insertion of
chalcone in PVDF matrix. These multi properties make the materials as a strong and potential
candidate for the fabrication of energy storage devices, thin film transistors, UV sensors and
protectors.
References:
1. A. J. Lovinger, Science, 220(1983), 1115-1121.
2. P. Thakur, A. Kool, B. Bagchi, S. Das and P. Nandy, Phys. Chem. Chem. Phys., 17(2015),
1368-1378.
57
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PP24
SYNTHESIS OF DIFFERENT WO3 NANOSTRUCTURES :

A TEMPERATURE DEPENDENT STUDY
Prosenjit Biswas1, Pradip Thakur2*, Arpan Kool1, Nur Amin Hoque1,
Biswajoy Bagchi1, Sukhen Das1*
1
Department of Physics, Jadavpur University, Kolkata-700032, India
Email address : sdasphysics@gmail.com, Mobile: 9433091337
2
Department of Physics, Netaji Nagar College for Women, Kolkata-700092, India
Email address : pradipthakurju@gmail.com, Mobile: 9830366215
Abstract
Nanostructured materials are played a crucial role in modern technological advance in
electronics, optoelectronics, memory devices and more recently in biomedical fields as drug
delivery systems, detecting unit etc. In present study WO 3 nanostructures were prepared via
simple precipitation using phosphotungstic acid and hydrazine hydrate followed by sintering at
temperature range 80oC to 700oC. The formation of nanostructures have been confirmed by X-ray
diffraction patterns. The morphology and structures have been observed by field effect scanning
electron microscope. The structures are seemed to change with different sintering temperatures
of the precursor precipitation.
58
PP25
ENHANCEMENT OF ELECTROACTIVE -PHASE CRYSTALLIZATION AND

DIELECTRIC CONSTANT OF NIO NANOPARTICLE
AND CNIO NANOCOMPOSITE INCORPORATED POLY
(VINYLIDENEFLUORIDE) THIN FILMS.
Swagata Roy1, Pradip Thakur1, 2*, Sukhen Das1*
1
Department of Physics, Jadavpur University, Kolkata- 700032, India.
Email- sdasphysics@gmail.com, Tel: +91 9433091337
2
Email- pradipthakurju@gmail.com, Phone no: +91 9830366215
This work presents a simplistic chemical precipitation technique followed by sintering at
0
400 C, of NiO nanoparticles (NPs) and CNiO nanocomposites (NCs) and their characterization by
X-ray diffraction, UV-visible spectroscopy, zeta potential, field emission scanning electron
microscopy and energy dispersive X-ray spectroscopy. The synthesized NiO NPs and CNiO NC
were doped in the PVDF thin films via simple solution casting method. Formation of a long TTTT
conformation results in the -phase crystallization in the doped PVDF film composites due to
strong iondipole interaction between the negative surfaces of NiONPs or CNiO NCs andCH2
dipoles of polymer chains. Detailed dielectric study of all NiONPs or CNiO NCs modified PVDF
films illustrated significant enhancement of the dielectric constant and better response was
obtained in the three phase CNiO NCsPVDF system in comparison to the two phase NiO NPs
PVDF system. The dielectric constant is found to have increased from 9 (in PVDF) to 317.4 (in C
NiO NCs doped PVDF) at 20 Hz. These results have been explained in terms of MaxwellWagner
Sillars interfacial polarization.
59
Book of Abstracts
PP26
DEVELOPMENT OF COPPER (Cu0) NANOPARTICLES IMPREGNATED

MULLITE REPLICA OF SACRIFICIAL COTTON WOOL: AN ANTIMICROBIAL
NANOCOMPOSITE FOR BIOMEDICAL APPLICATION
Arpan Koola, Pradip Thakurb, Somtirtha Banerjeea, Biswajoy Bagchia, and Sukhen Das*a
a.
Department of Physics, Jadavpur University, Kolkata 700 032, India
b
*Corresponding Author, e-mail: sdasphysics@gmail.com; Phone: +91-9433019337;
Abstract
Porous mullite discs have been synthesized replicating sacrificial cotton wool templates.
Synthesized copper nanoparticles (NPs) were impregnated into template mediated porous mullite
pellets by simple vacuum assisted absorption method using bukners funnel. NPs were characterized
by UV-visible spectroscopy. XRD and FESEM measurements confirmed the presence mullite of
phase. Strong antimicrobial activity was observed against E.coli and S.aureus. Mechanism behind
antimicrobial activity was found to be predominantly membrane damage that mediated cell death
generated from NPs. The release profile of NP loaded HAp pellets showed initial release followed
by slow release over a period of 24 hours. Release data indicated sustained release of NPs from
the pellets. These research show that this NP loaded mullite pellet can be used as therapeutic
system for biomedical applications.
60
PP27
FORMULATION OF GOLD NANOPARTICLES IMPREGNATED

HYDROXYAPATITE: AN ANTIMICROBIALLY ACTIVE SYSTEM FOR
BIOMEDICAL APPLICATION
Somtirtha Banerjeea, Arpan Koola, Biswajoy Bagchia, and Sukhen Das*a
a.
Department of Physics, Jadavpur University, Kolkata 700 032, India
*Corresponding Author, e-mail: sdasphysics@gmail.com; Phone: +91-9433019337;
Abstract
Porous nanocrystalline hydroxyapatite discs (HAp pellet) were synthesized by co-precipitation
method by using cysteine as a chelating agent. Gold nanoparticles (NPs) were impregnated into
the HAp pellets by simple absorption method using Bruckners funnel. NPs was characterized by
UV-visible spectroscopy and TEM method. These pellets was characterized using XRD, FESEM.
XRD measurements that confirmed the presence of hydroxyapatite but it did not reflects any
peak of NPs due to the presence of three NPs on the surface of the pellet below the detection
level. FESEM micrograph of HAp pellet showed interconnected granular porosity and NPs absorbed
HAp pellets assured the presence of NPs on the surface of the pellets. Strong antimicrobial activity
of this three pellets was observed against one gram-positive bacteria and one gram-negative
bacteria. The mechanisms behinds the antimicrobial activity are membrane damage and NPs
generated reactive oxygen species. The release profile of NPs loaded HAp pellet showed initial
release within 6 hours followed by slow release over a period of 24 hours. Release data assured
the sustained release of Nps from the pellets. Biocompatibility studies assured negligible
cytotoxicity to human lung fibroblast cells (WI-38). These research findings clearly proves that
this NPs loaded HAp pellet can be used as antimicrobially active, release retardant, bone
implantable system.
References:
1. Biswajoy Bagchi, Somtirtha Banerjee, Arpan Kool, Pradip Thakur, Suman Bhandary, Nur Amin
Hoque, Sukhen Das. Synthesis of eucalyptus/tea tree oil absorbed biphasic calcium
phosphatePVDF polymer nanocomposite films: a surface active antimicrobial system for
biomedical application. Phys. Chem. Chem. Phys.(2016)DOI: 10.1039/c6cp03493d.
2. S. Kar, B. Bagchi, B. Kundu, S. Bhandary, R. Basu, P. Nandy, S. Das. Synthesis and characterization
of Cu/Ag nanoparticle loaded mullite nanocomposite system: A potential candidate for
antimicrobial and therapeutic applications. Biochimica et Biophysica Acta, 1840 (2014) 3264
3276.
61
Book of Abstracts
PP28
ROLE OF NANOTECHNOLOGY IN EXCAVATING THE ENIGMA OF

CARDIAC DYSFUNCTION
Dr Priyanka De
Assistant Professor, Postgraduate Dept of Biotechnology, St Xaviers College (Autonomous),
30, Park Street (Mother Teresa Sarani), Kolkata-700016, India.
Ph: 919830491984, E mail: udity2002@yahoo.co.in
Abstract
The field of nanotechnology has invaded myriads of aspects of overt health physiology and
metabolism. Cardiovascular disease plays an important role as death trigger all over the world
and nanotechnology has a great role in percolating through various unexcavated features of cardiac
ailments rendering a social impact globally. The application of nanotechnology aims at investigating
the underlying remodeling of the myocardium that occurs in various cardiac ailments, various
alterations in cytoskeletal framework of the heart including role of misfolded proteins and cardiac
chaperones. Comparative studies have been done on novel nanoparticulate agents with respect
to the traditional drug delivery systems with emerging potential delivery efficacy at the level of
molecular targets, targeting methodologies and associated biocompatibility. Nanotechnology has
the immense prospective in understanding the clinical aspects of atherosclerosis, cardiac
hypertrophy and fibrosis leading to myocardial infarction. Cardiovascular nanoimaging technology
can aid in diagnosis of diverse cardiac dysfunctions and track real time monitoring during surgery
and associated pharmacological therapy including stem cell therapy. As a cutting age technology,
the field of nanobiotechnology must be exploited further for more future applications in the
clinical field of cardiovascular diseases.
62
PP29
ANTI-MIGRATORY EFFECT OF PEGYLATED-THYMOQUINONE

NANOPARTICLES ON BREAST CARCINOMA CELLS
TARGETING p53-miR-34a AXIS
Saurav Bhattacharya, Manisha Ahir, Shaswati Das, Mousumi Bhattachajee, Arghya Adhikary*
Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, JD-2, Sector III,
Salt Lake, Kolkata 700098, West Bengal, India
Presenting authors e-mail:sauravbhattacharya13@gmail.com
*Corresponding Author: E-mail: adhikaryarghya@gmail.com.
Introduction:-
Thymoquinone (TQ), a major active constituent of black seeds of Nigella sativa, has potential
medical applications including spectrum of therapeutic properties against different cancers.
However, little is known about their effect on breast cancer cell migration, which causes over 90%
deaths worldwide due to breast cancer. Herein, we have synthesized TQ-nanoparticles (TQ-NPs)
encapsulated with biodegradable, hydrophilic polymer polyethyleneglycol (PEG) to overcome TQs
poor aqueous solubility, thermal and light sensitivity as well as consequently, minimal systemic
bioavailability which can greatly improve its the cancer treatment efficiency.
Methods:-
The physico-chemical characters of synthesized TQ-NPs were evaluated first. Then its in-
vitro biological effects were evaluated on MCF-7 and HBL-100 cell lines and molecular mechanisms
were subsequently validated in Swiss-Albino mice.
Result & Discussion:-
Sizes of PEG4000-TQ-Nps are found to be below 50nm mostly with negatively charged, smooth,
spherical surface facilitating their cellular uptake. It was found that TQ-Nps show more efficiency
in killing cancer cells but at the same time less toxic to normal cells at a significantly lower dose
than TQ itself. Interestingly, evaluation of the anti-migratory effect of the TQ-Nps, reveal that
PEG4000-TQ-Nps show much potent anti-migratory properties than TQ. Further studies indicate
that PEG4000-TQ-Nps can significantly increase the expression of miR-34a through p53 up-regulation.
Moreover, NP-mediated-miR-34a up-regulation directly down-regulates Rac1 expression followed
by actin depolymerisation thereby disrupting the actin cytoskeleton which leads to significant
reduction in the lamellipodia and filopodia formation on cell surfaces thus retarding cell migration.
In vivo evaluation clearly elucidates that PEG4000-TQ-Nps treatment results in significant decline in
tumor size and are also capable of down-regulating Rac1 through miR-34a/p53 axis.
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Book of Abstracts
Conclusion:-
Both in-vitro and in-vivo findings surely indicates that PEG4000-TQ-NPs may act as a novel
nano-preparation which can be extremely effective in targeting migratory breast cancer cells and
may also be explored for treatment of other metastatic cancers.
Figure 1: Graphical representation of the molecular mechanism of anti-migratory effect of PEG4000-

TQ-Nps on breast cancer cells: (A) In case of untreated cells cellular protrusions are present. Evident
from SEM micrograph in the right panel; (B) treatment with PEG4000-TQ-Npsinduces p53-miR-34a
which inhibits Rac1 and thus lesser cell protrusions are visible in the SEM micrograph.
64
PP30
REDOX MEDIATED SYNTHESIS OF STABLE AND BIOCOMPATIBLE Au@Fe2O3

NANOMATERIAL FOR EFFICIENT ELECTROCATALYTIC
HYDROGEN EVOLUTION
Siddheswar Rudra and Mukul Pradhan*
Department of Chemistry, National Institute of Technology Meghalaya
Shillong-793003
E-mail address: mukulchem@gmail.com
Abstract
Green and renewable energy which will be one of the best remedies for the future crisis of
natural resources of energy in Earth that could provide sufficient energy to power humanitys
needs. Nanocomposites having special morphology like nanorod, nanotube, nanoflower etc show
much improved electrocatalytic activity, stability and other properties compare to the individual
component. A highly efficient and stable hydrogen evolution catalyst, AuFe2O3 nanorod composite
has been synthesized by employing a thermodynamically allowed simple redox transformation.
Synthesized composite nanomaterial shows high efficiency for electrochemical hydrogen evolution
compare to the individual component in acidic medium with a lower over potential (36 mV) and
high exchange current density. In addition, synthesized material shows exceptional durability on
conducting 1000 CV cycles and long term stability for 10 h (98% activity retention).
65
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PP31
ANTIBODY TAGGED NANOPARTICLES CONTAINING PACLITAXEL FOR

PROSTATE CANCER THERAPY
Iman Ehsan, Biswajit Mukherjee*
Jadavpur University, Kolkata-700032.
*Corresponding author e-mail: biswajit55@yahoo.com
Abstract
Prostate cancer is one of the most common cancers diagnosed in men. Out of many recent
therapeutic strategies to treat prostate cancer, Paclitaxel has emerged as a promising anticancer
drug for various types of cancers. The objective of this study was to prepare polymeric nanoparticles
and tag with anti PSMA antibody to target PSMA expressing tumors (prostate cancer). PSMA is
prostate specific membrane antigen which is over expressed in prostate cancer. In order to target
PSMA, an anti PSMA monoclonal antibody was utilized which shows cellular internalization. The
polymeric nanoparticles were made by multiple emulsion double evaporation method and
optimized for size, structure, drug loading, release pattern and stability. LNCaP sublines will be
utilized for the study. TEM and flow cytometry methods will be employed to elucidate the
internalization of antibody tagged polymeric nanoparticles. Thus the primary aim is to efficiently
internalize the antibody tagged nanoparticles in prostate cancer cells and release therapeutically
active Paclitaxel in the cells. The proliferation and colony formation ability of prostate cancer
cells and free Paclitaxel will be observed. This may be further investigated in vivo in xenograft
models.
66
PP32
DEVELOPMENT, CHARACTERIZATION AND INVESTIGATION OF DOCETAXEL

LOADED NANOLIPOSOMES TO CROSS BLOOD BRAIN BARRIER IN RATS
Leena Kumari, Tapan Kumar Shaw, Biswajit Mukherjee*
Jadavpur University, Kolkata-700032.
*Corresponding author e-mail: biswajit55@yahoo.com
Abstract
Docetaxel (DTX) is effectively utilized as an antineoplastic agent in brain gliomas. However,
the bloodbrain barrier (BBB) acts as an obstacle to the use of DTX against brain cancers. The
present study focuses on the delivery of DTX- loaded nanoliposomes across the bloodbrain barrier
(BBB) for the treatment of solid tumor of brain (glioma). The DTX-loaded nanoliposomes (L-DTX)
were prepared by lipid layer hydration technique. The prepared formulation was subjected to
various physicochemical and biopharmaceutical characterization studies such as drug-excipients
interaction (FTIR study), surface morphology, zeta potential, in vitro drug release, cellular uptake
and in vivo pharmacokinetic profiles. FTIR study suggests that the drug and excipients were
chemically compatible. In vitro cellular uptake was investigated in C6 glioma cells. The nanoliposome
vesicles were unilamellar having smooth surface and size was less than 50 nm. A sustained drug
release pattern from L-DTX was observed during the entire period of study. From the
pharmacokinetic study, an extended action of DTX from L-DTX was observed in experimental rats
than the free-drug and Taxotere. L-DTX was found to maintain 100% more drug concentration in
brain at 4 h as compared to the marketed formulation. The experimentally developed
nanoliposomes are thus found to be an emerging way to deliver the drug in the brain and this
could be a successful strategy to treat brain cancer using DTX.
67
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PP33
CHITOSAN COATING ON PLGA NANOPARTICLES: A TECHNOLOGY TO

ENHANCE BIOADHESION IN MURINE LUNGS
Paramita Paul, Biswajit Mukherjee*
Department of Pharmaceutical Technology, Jadavpur University,
Kolkata-700032, West Bengal, India
*Corresponding authors email: biswajit55@yahoo.com
Abstract
Existing therapies are inadequate to reach in adequate drug concentration in the lung. A
careful and systematic understanding of the properties of nanoparticles plays a significant role in
the design, development, optimization, and in vivo performances of the nanoparticles to reach in
desired organ. In the present study, Poly-lactide-co-glycolide nanoparticles (140-300 nm) were
developed using a multiple-emulsification technique and later chitosan coating on the nanoparticles
(200-500 nm) were also done for improved pulmonary delivery. The nanoparticles had a reasonable
drug loading with negative zeta potential (ZP) value for PLGA nanoparticles and positive zeta
potential values for chitosan coated PLGA nanoparticles, respectively. In the initial 2 hours, approx
20% of the drug was released from nanoparticles in both phosphate buffer saline, pH 7.4 and
simulated lung fluid, pH 7.4 followed by sustained release for 14 days. In vivo study using confocal
microscopy of the lung section after pulmonary delivery of the FITC labeled formulations to confirm
the better bioadhesion of the chitosan coated PLGA nanoparticles compared to the non-coated
formulations. Thus, the study reveals that pulmonary administration of chitosan coated PLGA
nanoparticles could be a better therapeutic alternative even as compared to the PLGA
nanoparticles.
68
PP34
RIBAVIRIN NANOLIPOSOME FOR TARGETING PERIPHERAL

NERVOUS SYSTEM (PNS)
Soma Sengupta, Biswajit Mukherjee*
Department of pharmaceutical Technology, Jadavpur University
*Corresponding author Email. biswajit55@yahoo.com
Abstract
Targeted drug delivery systems comprise of the advantages of higher concentrations of the
drugs selectively to the affected sites in order to increase their efficiency and simultaneously
decrease their side effects. Nanoliposomes attract attention in the field of targeted drug delivery
due to high stability, the possibility of transporting both hydrophilic and hydrophobic drug, high
carrying capacity due to increased surface area, better bio-availability etc. The objective of this
work is to develop a nanoliposomal formulation of ribavirin using ligand which will selectively
target and penetrate into peripheral neurone cells. Ribavirin is a board spectrum antiviral drug
effective against both DNA and RNA viruses. Ribavirin by its own characteristics can penetrate the
central nervous system (CNS) but is unable to enter into the peripheral nervous system (PNS).
Viral infections usually begin in the peripheral tissue and can then invade the central nervous
system, thus spreading initially into PNS and more rarely the CNS. If we combine ribavirin as
antiviral agent and a local anaesthetic to target the nerve cell to carry the liposome to it and also
reduce excitation of the nerve. Thus in the present investigation, we intend to develop nanosize
liposome with ribavirin and a local anaesthetic. Capability of the formulation to target peripheral
nerve cells will be determined in vitro as well as in vivo in rats. Therefore, development of such
formulation may provide better therapeutic potential against viral infections.
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PP35
PREPARATION, CHARACTERIZATION AND ELECTRONIC APPLICATION

OF XCUO-(1-X) MNO2 NANOCOMPOSITE BY MODIFIED
CHEMICAL SYNTHESIS TECHNIQUE
Dheeraj Mondal1, Sukhen Das1*
1
* Corresponding author e-mail address: sdasphysics@gmail.com
Abstract
In order to improve capacitance performance many fold, copper oxide-manganese dioxide
nanocomposites xCuO-(1-x)MnO2 were synthesized by a modified chemical synthesis technique
for electrochemical supercapacitor application.
The XRD patterns of these samples confirm that the required phase is present with a little
amount of impurities. FESEM microstructure of pure CuO sample shows huge number spherical
shaped nanoperticle present in the matrix whereas copper oxide-manganese dioxide [xCuO-(1-
x)MnO2] nanocomposite samples composed of rod shaped MnO2 particles, surrounding by very
fine spherical CuO nano grains.
The capacitance and dielectric constant of all nanocomposites is decreases with increasing
frequencies following by electronic polarisation effect, and many fold higher than the pure CuO
throughout the frequency range of 20 Hz to 2 MHz. The tangent loss of these nanocomposites is
also considerable in that frequency range. The AC conductivity increases with frequency for all
nanocomposites films.
These properties make the composite as a potential candidate for highly charge storage
electrochemical supercapacitor.
70
PP36
EFFECT OF TRANSIENT LIQUID PHASE SOLDERING TECHNIQUE ON LEAD

FREE SOLDER JOINT INTERFACE FOR CONSUMABLE ELECTRONIC
APPLICATIONS
Monalisa Char1, 2, Subhrangsu Aditya3, Smarajit Manna1, Amit K Chakraborty2 Abhijit Kar1,*
1
JB Centre of Excellence, Jagadis Bose National Science Talent Search, Kolkata-700107, India
2
Department of Physics, National Institute of Technology, Durgapur-713209, India
3
School of Bio-Science and Engineering, Jadavpur University, Kolkata-700032, India
*Email of corresponding author: chatrak130@yahoo.co.in
Abstract
A lead free soldering technique through Transient Liquid Phase Soldering has been used in
this study for developing solder joints for consumer electronics application. A combination of
lead free solder alloy Sn-3.5Ag-0.5Cu (SAC305) with thin film of Sn has been used as the filler
material for producing the solder joint (viz. Cu-Sn-SAC-Sn-Cu). We have demonstrated that TLPS
could produce solder joints at relatively low temperature with homogeneous interfacial
microstructure compared to conventional lead free solder interfaces. The study focuses on the
micro structural and functional properties of the prepared solder joints and MATLAB modeling
has been done to predict the reliability of the solder joints.
Key words: TLP soldering, Interface, Microstructure, Electrical property, Simulation
71
Book of Abstracts
PP37
TARGETING OF BREAST CANCER CELLS BY LIGAND CONJUGATED POLYMERIC

NANOPARTICLES CONTAINING DOXORUBICIN
Laboni Mondal, Biswajit Mukherjee
Jadavpur University, Kolkata-32
Email: labonimondalju@gmail.com
Abstract
Targeted drug delivery is in streamline of research of current years. Nanoparticle has showed
their potency to deliver the drug to specific targeted site, thus avoiding the normal cells and
providing less toxicity and side effect. More recently, polymeric drug delivery especially PLGA
based nanopariculate systems loaded with anticancer drug are evaluated by number of researchers
for successful delivery of potent therapeutic agents, which further conjugated with some specific
ligands are showing enhanced promise for targeted delivery to specific cancerous cells.The present
research study involved development and in vitro characterization of PLGA nanoparticles loaded
with anticancer drug for the purpose of targeted delivery to the breast cancer cells by conjugating
with cancer cell specific antibody. The pre-formulation study includes FTIR analysis that was
performed to observe any interaction between drug and excipients used. In this study the
doxorubicin loaded polymeric nanoparticles were developed by multiple emulsion solvent
evaporation method using different formulation variations. The prepared formulations were
characterized by particle size analysis, zeta potential, Field Emission Scanning electron microscopy
(FESEM), loading, and release pattern of the drug from the formulations for optimization purpose.
Result showed that the particle size were in the nano size range (approx. 200 nm), drug loading in
the nanoparticles was found to be 6-7 %. Through the release study, a sustained drug release
profile was found. Smooth, spherical and uniform-sized nanoparticles were observed in the FESEM
study which was further confirmed by TEM and AFM analysis. The particles are optimized for
further conjugation with specific antibody that is able to target specific breast cancer cell surface
receptor for targeted delivery of the anticancer agent.
72
PP38
FEW-LAYER MoS2 DECORATION WITH GOLD NANOPARTICLES:
TUNING THE PHOTOLUMINESCENCE AND ULTRASENSITIVE
TRACE DETECTION OF BIO-MOLECULE
Shib Shankar Singha1, 2, Dipanjan Nandi1 and Achintya Singha1
1
Kolkata 700 009, India
2
Brahmananda Keshab Chandra College, Department of Physics, 111/2 B.T.Road,
Bonhooghly, Kolkata-700 108, India
Abstract
In the past few years, intensive research efforts have been devoted to the investigation of
ultrathin layered materials such as graphene and various transition metal dichalcogenide (TMDs)1-
4. Molybdenum disulfide (MoS2), widely known TMDs, undergo a transition from indirect (1.2
eV) to a direct band gap (1.9 eV) semiconductor when thickness is reduced to mono/few layer,
leading to an emerging photoluminescence (PL)1,5,6 and shows specific application over the
graphene. The electronic and optoelectronic applications of this material require modulation of
the optical property.
Here, we demonstrate that the PL properties of few-layer MoS2 can be tuned by attaching
gold nanoparticles (Au-NPs) at the edge of the layer via a solution-based chemical doping technique.
The PL intensity is enhanced with respect to bare few-layer MoS2 when the Au-NPs (p-type dopant)
are attached at the edge of the MoS2 layer. 7 We also systematically observed a blueshift in the
excitonic emission as the concentration of the Au-NPs on MoS2 increased. Both phenomena have
been understood to result from the switching between charged exciton (trion) recombination
and neutral exciton recombination.7 A potential application for the AuMoS2 composite has been
demonstrated, by using it as a substrate for surface-enhanced Raman scattering (SERS). 7 Our
work provides a method to tune the optical and electronic properties of MoS2, and the AuMoS2
composite might be useful as an efficient SERS substrate for the ultrasensitive detection of bio-
molecules.
References
1. A. Splendiani, L. Sun, Y. Zhang, T. Li, J. Kim, Y. C. Chim G. Galli and F. Wang, Nano Lett., 2010,
121275.
2. B. Radisavljevic, A. Radenovic, J. Brivio, V. Giacometti A. Kis Nature Nanotechnology, 6,147
150 , 2011.
3. Jiadan Lin, Hai Li and Wei Chen, Applied Physics Lett. 102, 203109, 2013.
4. Goki Eda, Hisato Yamaguchi, Damien Voiry and Manish Chhowalla, Nano Lett., 11 (12), 5111
5116, 2011.
5. K. F. Mak et al, Phys. Rev.Lett. 105, 136805 (2010),
6. H. R. Gutirrez et al, Nano Lett. 13, 3447 (2013).
7. Shib Shankar Singha, Dipanjan Nandi and Achintya Singha, RSC Adv., 5, 2418824193, 2015.
73
Book of Abstracts
PP39
MnO2-CoO NANOCOMPOSITE: PREPARATION, CHARACTERIZATION AND

APPLICATION IN SUPERCAPACITOR
Biplab Kumar Paul1,2*, Debasish Roy1,2, Papia Nandy2, Sukhen Das1,2
1
2
Centre for interdisciplinary Research and Education. Kolkata- 700068
* Corresponding author: Biplab Kumar Paul, e-mail: destinationbiplab@gmail.com
Abstract:
The various molar concentrations of cobalt doped manganese dioxide
nanostructures were synthesized by a hydrothermal technique for electrochemical supercapacitor
application.
DTA analysis of the Manganese dioxide sample ensured that there are two
endothermic reactions have been taken place at temperature range 230RC to 300RC and 440RC
to 470RC and exothermic reactions have been taken place at temperature range 560RC to 600RC
but for Cobalt (Co)doped Manganese dioxide samples three endothermic peak was found at
temperature range 210RC to 240RC, 400RC to 430RC and 730RC to 800RC. The XRD patterns
of these samples revealed that the required phase is present with a little amount of impurities.
FESEM shows in sample MnO2, the nanorods were connected to each other at the ends or the
middle of their bodies and Cobalt (Co) doped Manganese dioxide sample composed of rod
shaped MnO2 particles, surrounding by very fine spherical CoO nano grains. The EDX analysis of
the sample clearly indicates distribution of different material present in sample the composition.
The capacitance and dielectric constant of all nanocomposites is decreases with increasing
frequencies, and higher than the pure MnO2 or CoO throughout the frequency range of 20 Hz to
2 MHz. The tangent loss of these nanocomposites is also considerable in that frequency range.
The AC conductivity increases with frequency for all nanocomposites films.
These properties make the composite as a potential candidate for highly charge storage
electrochemical supercapacitor.
74
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75
Book of Abstracts
With Best Compliments from :
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WORKS LIMITED
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76
PP40
SAFE MEDICINAL APPLICATION OF ZNO- SYZYGIUM JAMBOLANUM
NANOHYBRID IN DIABETES MELLITUS: INVITRO INVIVO STUDIES
Srimoyee Saha1, Madhureema Dey1, Satarupa Bhattacharya1, Sukhen Das1,3*,
Ruma Basu2,3, Papiya Nandy1
1
Department of Physics, Jadavpur University, Kolkata-700032, 2Departm ent of Physics, Jogomaya Devi College,
3
Centre for Interdisciplinary Research and Education
Abstract
Zinc oxide (ZnO) nanoparticles (NP) have been synthesized and functionalized using Syzygium
jambolanum seed extract. Temperature dependent synthesis and particle growth have been
studied. Formation of NPs was confirmed by UV-visible spectroscopy, SEM etc. The synthesized
ZnO nanoparticles as potential antibacterial agent has been studied on Escherichia coli and
Staphylococcus aureus. Studies were conducted to understand the best efficacy of the nanohybrid
dose. HPLC studies have determined that the active ingredient present is quercetin and myrecetin
which when coupled with ZnO becomes a potent antidiabetic agent. Nanohybrids stabilized by
plant metabolites had better antidiabetic effect on streptozotocin induced diabetic mice than
that of large sized ZnO particles. Histopathological data emphasizes the recuperative activity of
the nanohybrid.
PP41
PREPARATION OF COPPER OXIDE NANO-FLOWERS USING HIGH ENERGY
ELECTRON BEAM
Shubham Roy[1,2], Souravi Bardhan[1,3], Santanu Das[1], Keka Basu Choudhury[4],
Sukhen Das*[1]
[1] Department of Physics, Jadavpur University,Kolkata; [2]Department of Physics, Asutosh College, Kolkata;[3]
Department of Environmental Science, Netaji Nagar Womens College, Kolkata, [4]Centre for Interdisciplinary
Research and Education, Kolkata
*Corresponding Author Email: sdphysics@gmail.com
Abstract
Copper oxide Nanoparticles are highly appreciated due to its semiconducting property and high
antimicrobial activity. A novel synthesis route using High Energy Electron Beam has been discussed
in our article. The product formed was confirmed to be copper oxide using XRay Diffraction (XRD).
Field Effect Scanning Electron Microscopy (FESEM) confirms the Nanoflower morphology of the
synthesized samples and found to be evenly distributed and well defined, ranging from 60 nm to
80 nm. This unique, cost effective, relatively simple and time saving synthesis route might play a
significant role in future in the field of Nano-science and Solid State Physics.
Keywords: Electron Beam, Copper oxide Nanoflower, XRD, FESEM.
77
Book of Abstracts
78
79

Book of Abstracts - National Symposium On Nanotechnology: From Materials To Medicines and Their Social Impact

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One Day National Symposium on

25th March, 2017

Prof Siddharta Roy, Dir, Bose Instt Dr K Muraleedharan, Dir, CGCRI

PP14 Ankita Paul: Network Analysis of Crack Patterns in Laponite Clay 47

PP31 Iman Ehsan: Antibody Tagged Nanoparticles Containing Paclitaxel 66

One-Day National Symposium on

From To Code Program

Session 1 - Nanoparticles Chairman: Prof Parimal Sen

12:30 13:30 Poster Session

Session 2 - Nanomedicines & Homeopathy Chairman: Prof. Parames C Sil

A brief note on the

Nanotechnology aims at manipulations of materials in the nanoscale about 1 to 100

Book Writing: As part of our encouragement to members to write books on

Science Workshops for School Students: A special series of annual Workshops on

WEST BENGAL ACADEMY OF SCIENCE AND TECHNOLOGY

(National Council of Science Museums, Ministry of Culture, Govt. of India)

LUXMI CHARITABLE TRUST

Luxmi Charitable Trust supports directly or as a contributing member to such relevant

Dr. Bholanath Chakravarty Memorial Trust

NEW FUNCTIONALITIES IN MATERIALS BY NANOTECHNOLOGY

1. S. Mitra et al J. Phys. Chem. C 115 (2011)

NANO-SCIENCE & TECHNOLOGY :

SOFT MATTER NANOCHEMISTRY IN GUAR GUM FOR APPLICATIONS

SYNTHESIS OF ANISOTROPIC NANOSTRUCTURES FOR SURFACE ENHANCED

NANOTECHNOLOGY APPLICATION IN GLIOMA THERAPY : TARGETED

ULTRAHIGH DILUTIONS AS NANOMEDICINE

DSC REVEALS VARIATION IN ENTHALPY ASSOCIATED WITH FREE

NANOPARTICLES OF HOMEOPATHY: THEIR POSSIBLE IDENTITIES

MULTIFUNCTIONAL NANOSTRUCTURED MATERIALS: A NEW DIMENSION

West Bengal, India.

West Bengal, India

HEALTH IMPACT OF ENGINEERED NANOPARTICLE AND THEIR RISK

Key Words: Nanotechnology, Health hazards, Risk assessment model

NANOTHERAPEUTICS OF PLANT-BIOACTIVES : IMPROVED AND SAFER

STRATEGIC MANAGEMENT OF BREAST CANCER BY NOVEL NANO-

NANOSPONGES: A MODERN TOOL IN DRUG DELIVERY SYSTEM

The aqueous solubility of Gatifloxacin (solubility of pure gatifloxacin is 0.023mg /ml) as

EXPERIMENTAL AND CLINICAL ASSESSMENT OF HEPATO-PROTECTIVE

BIOAVAILABILITY, BIODISTRIBUTION AND DRUG DELIVERY EFFICIENCY

Keywords: Mesoporous silica nanoparticles, nifetepimine, pH stimuli-responsive drug delivery,

ANTITUMORIGENIC ACTIVITIES OF NANOENCAPSULATED NIFETEPIMINE :

A STUDY ON MICROBIAL PROPERTIES OF SOME

HOMOEOPATHIC DRUGS COMPLEMENTARY, ANTIDOTAL AND

HIGH DILUTION OF MERCURIC CHLORIDE INCREASES WATER PERMEATION,

INFLUENCE OF NANO CLAY ON STRUCTURE AND ELECTRICAL PROPERTIES

IN SEARCH OF EPITOPES ON NANOMEDICINES -

PHOTO VOLTAGE GENERATION BY USING MIXED DYE WITH

SUCCUSSION ENHANCES VOLTAGE AND POWER GENERATION IN POLAR

EFFECT OF VIGOROUS SHAKING ON RAMAN SPECTRA OF 91 % ETHANOL,

ANTICANCER EFFECT OF FOLATE-DECORATED-CuO-NANOWIRE IN HUMAN

EXTRAORDINARY PHOTOLUMINESCENCE ENHANCEMENT IN AU

ENHANCED RAMAN SCATTERING FROM INDIVIDUAL GE NANOWIRE

Here, we observe a strong enhancement of spontaneous Raman scattering from a single Ge

ASSESSING THE EFFICIENCY OF THE MESOPOROUS SILICA NANOPARTICLE

NETWORK ANALYSIS OF CRACK PATTERNS IN LAPONITE CLAY IN

Fig,1 : Tree-like-cracks developed in aqueous gel of Laponite on the

ENHANCED DIELECTRIC PROPERTIES AND CONDUCTIVITY OF

ROLE OF MULTIWALLED CARBON NANO TUBE AS NANOFERTILIZER

EFFECT OF HOMEOPATHY MEDICINE AURUM METALLICUM ON

PHYTOREDUCTION OF COPPER NANOPARTICLES FROM VIGNA RADIATA

WAVY CRACKS IN LAPONITE GELS: MODE SELECTION IN A

STRUCTURE AND ACTIVITY OF LYSOZYME IMMOBILIZED

EFFECT OF INSULATING NANO FILLER ON CONDUCTIVITY