25/06/2017 Lichtenberg Junior Research Group Biouid Simulation and Modeling

DRUG DELIVERY AGENTS IN HUMAN BLOOD FLOW

Intensive worldwide research efforts are currently being dedicated to explore the potential of synthetic
micro- and nanoscopic particles as drug delivery agents (DDAs) in the human vascular system. Our
goal is to understand by means of computer simulations the physical multibody interactions between
DDAs and the red blood cells which they encounter on their way from the injection needle through the
cardiovascular system towards their target organ.

To understand the behavior of DDAs on the mesocsale, it is necessary to investigate simultaneously

the microscopic trajectories of many DDAs, their hydrodynamic interactions and collisions with the
highly deformable red blood cells, and the resulting macroscopic flow. Modern algorithms together with
the power of present-day supercomputers are now able to provide such a complete picture which is
very difficult to obtain from an experiment.

Here we use two very different methods: a boundary-integral method and an immersed boundary code
which we contributed to the free software package ESPResSo.

micro-particles flowing within branching blood vessels

Publications

Clustering of microscopic particles in constricted blood flow

C. Bcher, L. Schrack and S. Gekle
Phys. Rev. Fluids 2, 013102 (2017) [ DOI] [ pdf] [ Info]

Cross-stream migration of asymmetric particles driven by oscillating shear

M. Laumann, P. Bauknecht, S. Gekle, D. Kienle and W. Zimmermann
Europhys. Lett. 117, 44001 (2017) [ DOI]

Dispersion of solute released from a sphere flowing in a microchannel

S. Gekle
J. Fluid Mech. 819, 104-120 (2017) [ DOI] [ pdf] [ Info]

Hydrodynamic mobility of a solid particle near a spherical elastic membrane. II. Asymmetric
motion
A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
Phys. Rev. E 95, 053117 (2017) [ DOI] [ pdf]

Hydrodynamic mobility of a solid particle nearby a spherical elastic membrane: Axisymmetric

motion

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25/06/2017 Lichtenberg Junior Research Group Biouid Simulation and Modeling

A. Daddi-Moussa-Ider and S. Gekle

Phys. Rev. E 95, 013108 (2017) [ DOI] [ pdf] [ Info]

Measurement of the magnetic moment of single Magnetospirillum gryphiswaldense cells by

magnetic tweezers
C. Zahn, S. Keller, M. Toro-Nahuelpan, P. Dorscht, W. Gro, M. Laumann, S. Gekle, W. Zimmermann,
D. Schler, and H. Kress
Sci. Rep. 7, 3558 (2017) [ DOI]

Mobility of an axisymmetric particle near an elastic interface

A. Daddi-Moussa-Ider, M. Lisicki and S. Gekle
J. Fluid Mech. 811, 210-233 (2017) [ DOI] [ pdf] [ Info]

Theory and algorithms to compute Helfrich bending forces: A review

A. Guckenberger and S. Gekle
J. Phys. Cond. Mat. 29, 203001 (2017) [ DOI] [ pdf] [ Info]

Elastic cell membranes induce long-lived anomalous thermal diffusion on nearby particles
A. Daddi-Moussa-Ider, A. Guckenberger and S. Gekle
Phys. Rev. E 93, 012612 (2016) [ DOI] [ pdf] [ Info]

Hydrodynamic interaction between particles near elastic interfaces

A. Daddi-Moussa-Ider and S. Gekle
J. Chem. Phys. 145, 014905 (2016) [ DOI] [ pdf] [ Info]

Mechanical behaviour of micro-capsules and their rupture under compression

A. Ghaemi, A. Philipp, A. Bauer, K. Last, A. Fery and S. Gekle
Chem. Eng. Sci. 142, 236-243 (2016) [ DOI] [

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