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TAC Workshop
February 2010
simon.collins@i-Base.org.uk
Definitions
Pharmacology:
study of drugs
Pharmacokinetics (PK):
study of how drugs behave in
a living person (or animal)
www.i-Base.info TAC workshop: February 2010
Using graphs
Graphs can show you information in a concentrated way.
x
x x
Drug concentration x
x x
x
x
xx
x x x
x
0
www.i-Base.info
Time TAC workshop: February 2010
dose
Using graphs
Graphs can show you information in a concentrated way.
www.i-Base.info
Time TAC workshop: February 2010
dose
Drug absorption
After taking a drug, levels peak quickly and then slowly drop as the
drug is broken down and metabolised by the liver and/or kidneys.
Drug concentration
C Max
Drug concentration
0
T Max Time
www.i-Base.info TAC workshop: February 2010
dose
Drug absorption
T 1/2 (half life) = time taken for C max to drop in half
It takes 5 x T 1/2 for a drug to be eliminated from the body
C Max
Drug concentration
0
T Max Time
www.i-Base.info TAC workshop: February 2010
dose T 1/2
Drug absorption
T 1/2 (half life) = time taken for C max to drop in half
It takes 5 x T 1/2 for a drug to be eliminated from the body
C Max
AUC describes the total drug
concentration over time.
Drug concentration
0
T Max Time
www.i-Base.info TAC workshop: February 2010
dose T 1/2
Drug absorption.2
When you take another doses of a drug, it boosts the level again.
Each dose taken on time makes sure that you keep above a mimimum level
C Max
Drug
concent
ration
C Min or C tough
Time
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dose TAC workshop: February 2010
dose dose
www.i-Base.info
MEC =
MEC Minimum
Effective
Increased risk of resistance
Concentration
0
MEC
(Minimum
Effective
Concentration Increased risk of resistance
0