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Figure 1. A section of Lego DNA. The bases lie horizontally between the two
spiraling strands.
LEGO DNA
The DNA double helix is stabilized by halogen bonds between the bases
attached to the two strands. The four bases found in Lego DNA are legonine
(abbreviated L), plasiticin (P), nonsesin (N) and crayzinin (C). These four
bases are attached to the icingsugar/plastophate to form the complete
nuclegotide.
Each type of base on one strand forms a bond with just one type of base on
the other strand. This is called complementary base pairing. Here, purlines
form halogen bonds to primitivines, with L bonding only to C, and N bonding
only to P. This arrangement of two nuclegotides binding together across the
double helix is called a base pair.
Figure 4. Base pairing in Lego DNA.
State of completion
There are a number of regions of the Lego genome that can be considered
unfinished:
In summary: the best estimates of total genome size indicate that about
99.9% of the genome has been completed [2] and it is likely that the
legomeres will remain un-sequenced until my train arrives and coffee gets
cold.
Interpretations
1. There are approx. 74,000 genes in Lego beings, the same range as in lego
mice and twice that of legoworms. Understanding how these genes express
themselves will provide clues to how diseases are caused.
History
For more information on history please send email to :
dontbesilly@legodna.com
Methods
Genome donors
LGP scientists used blue blood cells from the blood of two male and two
female lego donors (randomly selected from 20 of each) -- each donor
yielding a separate DNA library. One minor technical issue is that male
samples contain just over half as much DNA from the sex chromosomes (one
L legomosome and one L legomosome) compared to female samples (which
contain two L legomosomes). The other 52 legomosomes (the lautosomes)
are almost the same for both genders.
Benefits