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geekymedics.com /physiological-changes-pregnancy/
Anna 7/9/2015
Birtles
Estimated due date (EDD): Naegeles rule add 9 months + 7 days to 1st day of LMP. Pregnancy lasts 38wks
from conception/40wks from 1st day of LMP
Trimesters:
Puerperium:
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Renal changes
Endocrine changes
Increased demand of Ca (especially in 3rd trimester and puerperium) leads to increased gut absorption.
Calcium is actively transported across placenta.
Serum Ca + phosphate levels fall (bound to albumin). Ionised Ca remains stable
Liver
Uterine physiology
Morula becomes blastocyst at the 32 cell stage
Implantation 7-14 days post conception: blastocyst attaches and trophoblast cells invade the
endometrium.
Organogenesis: 2-8 wks post conception.
Inner cell mass becomes embryo. Trophectoderm becomes placental trophoblast.
Foetus develops in amniotic cavity, attached to placenta by umbilical cord.
Amnion: membrane lining of cavity, expands as placenta progresses. 2nd layer (chorion) in apposition to the
amnion.
Placenta is anchored to maternal decidua.
Intervillous space supplied by maternal spiral arteries.
Cord has 2 arteries (deoxygenated blood from fetus to placenta) + 1 vein (oxygenated blood from placenta
to foetus).
Uterus holds 5L at term (500x pre-pregnancy): muscle hypertrophy.
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Blood supply from uterine + ovarian arteries.
Cervical mucous plug protects during pregnancy.
Multiple pregnancy
10X higher risk of stillbirth
50% pre-term
Increased risk of IUGR
Monozygotic = earlier split, more independent. DCDA <3 days, 4-7days MCDA, >8d MCMA. Requires tertiary
centre care if monozygotic!
Risks to mother:
Anaemia
Pre-eclampsia
Hyperemesis
Polyhydramnios
Complicated labour
Congenital abnormalities
Twin-to-twin transfusion
Pre-term delivery
Twin entrapment
Foetal growth
Growth governed by intrinsic (maternal height/weight/ethnicity, fetal sex/genes/conditions) and extrinsic
(environmental social class, nutrition, maternal disease) factors.
Small for Gestational Age a foetus that has failed to achieve a specific biometric or estimated weight threshold
by a specific gestational age may be constitutional or due to intra-uterine growth restriction (IUGR).
Assessments of foetal growth: Biparietal distance, head circumference, abdominal circumference, femur length
serial measurements more useful to gauge velocity. Plotted on centiles can show if any dropping
off/lag/acceleration.
Assessment of babys coping: kick charts, CTG, biophysical profile (fetal breathing movements, fetal movements,
fetal tone, amniotic fluid volume).
Assessment of babys nutrition: placental assessment appearance, blood flow characteristics via Doppler
(umbilical fetus to placenta, uterine mother to placenta). Progressively greater resistance leads to absent or
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reversed End Diastolic Flow. (read up on this if youre interested, I wont go into it further! )
Foetal development
Early pregnancy
Day 14 = ovulation
Fertilisation occurs commonly in the fallopian tube
Cell division occurs: zygote morula blastocyst as moving to uterine cavity
Day 23 = implantation beginning of fetal-maternal dialogue
When the blastocyst implants production of hCG by the decidua stimulates the ovary to produce
progesterone (causes modification of maternal physiology).
hCG levels rapidly rise <10wks. Can be detected in serum/urine 4 weeks after LMP (urine PT +ve when
concentration of hCG is 25IU/ml)
Ultrasound
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