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Contextual Outline
The use of other advances in technology, developed from our understanding of the electromagnetic spectrum, and
based on sound physical principles, has allowed medical technologists more sophisticated tools to analyse and interpret
bodily process for diagnostic purposes. Diagnostic imaging expands the knowledge of practitioners and the practice of
medicine. It usually uses non-invasive methods for identifying and monitoring diseases or injuries via the generation of
images representing internal anatomical structures and organs of the body.
Technologies, such as ultrasound, compute axial tomography, positron emission tomography and magnetic resonance
imaging, can often provide clear diagnostic pictures without surgery. A magnetic resonance image (MRI) scan of the
spine, for example, provides a view of the discs in the back, as well as the nerves and other soft tissues. The practitioner
can look at the MRI films and determine whether there is a pinched nerve, a degenerative disc or a tumour. The greatest
advantage of these techniques are their ability to allow the practitioner to see inside the body without the need for
surgery.
This module increases students understanding of the history of physics and the implications of physics for society and
the environment.
The use of
Thisisthe2002syllabusupdate
References
http://www.khwarzimic.org/biomed/us.html
http://www.med.sc.edu:1000/5ultsd.html
http://uwscat.radiology.wisc.edu/tutorial/bmode_imaging
http://www.obultrasound.net/history.html
http://www.obultrasound.net/history2.html
http://www.obultrasound.net/history3.html
http://www.obultrasound.net/lineararrays.html
http://physicsweb.org/articles/world/15/6/7/1/pw1506071 [PET]
Ultrasound imaging and ultrasound angiography are finding a greater role in the detection, diagnosis and
treatment of heart disease, heart attack, acute stroke and vascular disease which can lead to stroke.
Ultrasound is also being used more and more to image the breasts and to guide biopsy of breast cancer.
1. Patient preparation involves removing any articles of clothing or jewellery surrounding the area to be
imaged. In some cases, the patient may be asked to wear a patient gown.
2. The patient is positioned by the technologist on an examination table. A clear gel (which helps "connect" the
ultrasound transducer to the skin) is applied to the area to be examined, for example the abdomen
3. The technologist then brings the transducer into contact with the skin and sweeps it back and forth to image
the area of interest (e.g the foetal baby). The patient is simply required to relax and stay calm during the
examination.
4. The technologist will ask the patient to get dressed and wait while the ultrasound images are reviewed,
either on film or a TV monitor. In many cases, the technologist or physician reviews the ultrasound images in
real time as they are acquired.
5. After the ultrasound images are reviewed, the patient will be released from the imaging department or
center. In some cases, more images will need to be taken. For more information see "what happens during a
diagnostic imaging examination?"
In the 1960's the principles of sonar (developed extensively by the US Defense Department during the Second
World War) were applied to medical diagnostic imaging. The ultrasound process involves placing a small
device called a transducer, against the skin of the patient near the region of interest, for example, against the
back to image the kidneys. The ultrasound transducer combines functions like a stereo loudspeaker and a
microphone in one device: it can transmit sound and receive sound. This transducer produces a stream of
inaudible, high frequency sound waves, which penetrate into the body, and bounce off the organs inside. The
transducer detects sound waves as they bounce off or echo back from the internal structures and contours of
the organs. Different tissues reflect these sound waves differently, causing a signature, which can be
measured and transformed into an image. These waves are received by the ultrasound machine and turned
into live pictures with the use of computers and reconstruction software.
* heart
* pelvis and reproductive organs
* kidneys, liver, pancreas, gall bladder
* eye
* thyroid
* blood vessels
* fetus
Background
Reviewthenatureandpropertiesofsoundfromthepreliminarycourse,particularlythefollowing
points:
Soundisaformofenergyproducedbyvibrationinamedium
Asoundwaveproducesperiodicpressurevariationsinthemediumthroughwhichittravels
Anelasticmediumisnecessaryforthepropagationofsound
Sound propagates as a longitudinal wave consisting of alternating compressions and
rarefactions
Thespeedofsoundisdifferentindifferentmedia
Onepropertyofasoundwaveisitsfrequency,thenumberofoscillationsorfluctuationspersecond
inthemedium.Audiblesoundshavefrequenciesbetweenabout15cyclespersecond(15hertz,Hz)
and20,000cyclespersecond(20kHz).Theupperlimitofhumanhearingisusuallytakentobe20
kHz,andultrasoundreferstosoundwaveswhosefrequencyisabovethislevel.Othermammalsare
notnearlyaslimitedasmanintermsoftheusefulsonicfrequencyrange.Forexamples,batsand
dolphinsutiliseultrasoundwavesthathavefrequenciesashighas125kHzfornavigatingandsonar
visualisation.
Medicalultrasoundapplicationshavebeendescribedthatusefrequenciesfrom500kHzto30MHz.
Formostimagingapplications,ultrasounddevicesoperatebetween3.5MHzandabout10MHz.
Theexceptionisforintravascularimagers,tinycathetertippedprobesoperatingatfrequenciesas
highas 30MHz. Theoptimal ultrasoundfrequencyforanyapplication represents atradeoff
betweentheneedto
(a) acquireultrasoundimageswithahighdegreeofspatialresolution,dictatinguseofhigher
frequencies,and
(b) obtainadequatepenetrationinthetissue.Imagingdepthintotissueislimitedbyattenuation
of the ultrasound waves, and this becomes more severe as the ultrasound frequency is
increased.
Thespeedofultrasoundisdifferentindifferentmedia
Velocity of sound in some Biological Materials
Velocity of Sound Impedance
Material
(m/s) (Rayl x 106)
Air 330 0.0004
Fat 1450 1.38
Water 1480 1.48
Average Human Soft Tissue 1540 1.63
Brain 1540 NA
Liver 1550 1.65
Kidney 1560 1.62
Blood 1570 1.61
Muscle 1580 1.7
Lens of eye 1620 NA
Skull Bone 4080 7.8
Ultrasoundcanbeclassifiedintotwocategories:lowintensityandhighintensity.Thepassageof
lowintensitysoundthroughamediumdoesnotaffectthemediumitself,asisgenerallythecase
with diagnostic devices (e.g. foetus monitors, echocardiograph sensors, and other imaging
apparatus). High intensity signals, on the other hand, affect the medium, as is the case with
therapeuticdevices.Anexampleistheuseofultrasoundtoheatsoremusclesortodisintegrate
kidneystones.
Inordertoobtainultrasoundimages,itwasnecessarytomanuallymovethetransduceracrossthe
specimenarea.Evenfasterscannersrequiredconsiderabletimetogenerateanultrasoundimage;
andconsequentlyonlystatictargetscouldbeeffectivelyscanned.Inordertobeabletomapmoving
targets,suchasabeatingheart,itwasnecessarytodeveloprapidmeansofscanningandtodevelop
realtimetechniqueswhichwouldprovideinstantaneousfeedbacktotheclinicaltechnicianofthe
transducerpositionandthesystemsettings.
Newtypesoftransducershavebeendevelopedtorapidlyscanningbeamsincluding
(1) Pistonshapedtransducersthatrotateormoveaboutfixedaxestomechanicallysteerthebeam
throughashapedsector.
(2) Linearsequentialarraysthataredesignedtoelectronicallyfocusthebeamoverarectangular
imagesection.
(3) Linearphasedarraytransducersthataredesignedtoelectronicallysteerandfocusthebeamat
highspeedinasectorimageformat.
Describe the piezoelectric effect and the effect of using an alternating potential
difference with a piezoelectric crystal
An ultrasonic transducer is a generator of acoustic waves by converting magnetic, thermal or
electricalenergyintomechanicalenergy.Conversely,itcanalsofunctionasasensorbyconverting
An inverse effect also occurs when an electric field is applied across the crystal to induce a
mechanicaldeformation.Itisbythisprinciplethatapiezoelectrictransducerconvertsanoscillating
electricsignalintoanacousticwaveandviceversa.
The most principal materials used for transducers in medical ultrasound are the ferroelectric
materials. A standard material is the ferroelectric ceramic leadzirconatetitanate (PZT), which
carriestheadvantageifhighelectromechanicalconversionefficiencyandlowintrinsiclosses.The
propertiesofPZTcanbealteredbymodifyingtheratioofzirconiumtotitaniumanddopingwith
smallamountsofothermaterialssuchaslanthanum.
Transducer Types
Linear array & curvilinear transducers
Linear Array Transducers
Thesehaveanumberofrectangulartransducerelementsarrangedinaline.Theimagedisplayis
rectangularinshape(Achillestendoninthelowerlegshowninthisultrasoundimage,produced
usingalineararraytransducer).
Disadvantage Wide, flat contact surface requiring the acoustic window (contact point with
patient)tobeequalinsizetothetransducerface.
AdvantageWidefieldofviewformoresuperficialstructures.Electronicfocusingisused.
Curvilinear (Convex Array) Transducers
Thesearecurvedontheirscanningsurface,resultinginaslightlydivergentbeam.Thesedisplaya
wedgeorpieshapedimage.Therequiredacousticwindowdependsonthedegreeofconvexityof
thetransducersurfacebutgenerallyhasanarrowwindowattheskinsurface,whilestillprovidinga
wideangledeeptotheskin.Thistypeoftransducerisgoodforscanningtheabdomen,prostateand
thoraxofsmallanimals(veterinaryultrasound),andtheheartsofallanimals.
Theyhaveagoodabilitytoscanliverandprostate.Electronicfocusingisused.
Becauseofitsconvexshape,thecurvilinearorconvexsectorarrayfitsbetterontheabdomenand
scansawiderfieldofviewthandoesalineararrayconfiguration.Thecurvilineararrayoperatesin
the same manner as the linear array in that the scan lines are directed perpendicular to the
transducerface.Asmanyas512elementsconstituteaconvexsectorarrayincurrentlyavailable
scanners.Anaperturecontainingasmanyas128elementsisselectedtofunctionatagiventime.
Similartothelineararraystheacousticbeamsarefocusedbutnotsteered.
The curvilinear or convex sector array became popular and completely replaced the linear
configurationinthelate1980s.
Note the small acoustic window the area through which the ultrasound enters the
body at the top
Complexultrasoundtransducersarebeingdevelopedforproducingrealtime3Dimages.These
simultaneouslyproducesectorscansinmanyplanes.Highspeeddigitalsignalprocessingpermits
the large amount of gathered data to be assembled into a 3D image. Shown below are three
examplesofthescanningpatternproducedbysuchtransducers.Examplesof3Dultrasoundimages
areshownbelow.
Examplesof3Dultrasoundimagesareshownabove
Mechanical sector transducers
Thesearethesimplestmechanismwhereasingletransducercrystalelementoscillatesinfrontofa
windoworagroupofcrystalsarerotatedinacylinderpastawindow.Aliquidcouplingmediumis
incontactwithboththecrystalandthewindow.Thesetransducersarefocusedmechanicallyand
eachtransducerusuallyhasasinglefocalrange.
Phased array sector transducers
Phasedarraysarearrangedinasimilarmannertothelineararray,exceptthattheelementsaremuch
smaller.Thisproducesasmallerscanhead,suitableforsmallacousticwindows.Eachindividual
crystalisconnectedtoitsowntransmitterandreceiverchannel.Thecrystalsarestimulatedoutof
phaseandconsecutively formawavefrontthat propagates atanangletothetransducerarray
[figuresACbelow].Thetimingofthesignalfromeachtransducercanbealteredtosteerthebeam.
Thetimedifferencebetweeneachsignalelementiscalledaphasedifference.Thephasedifference
canalsobeadjustedtoproduceabeamthatiscurvedatthetransducerfaceandsoasectorshaped
scanimagemaybeproduced,orthebeamcanbefocussedtoaspecificdepth.Thistechnique
producesastrongreflectionfromthefocusdepth,andweakerreflectionsfromotherdepths.This
permitsaclearerimageofthetargetorgantobeproduced.Thebeamangleandsizeiscontrolled
electronically.Phasedarraysresultinbetterresolutionandtheyhavenomovingpartscompared
with the mechanical transducer, however they are more expensive. [See movie
Steering[ultrasound].mov]
Reference: http://www.ecse.monash.edu.au/1302www/Lectures/Imaging/Beamsteering.html
Thesteeredbeam,phasedarraysystemproducesasequenceofpulsesalongthetransducer
arrayproducingabeamfromeachelementofthearraywhichhasitsownuniqueanglewithrespect
tothetransducerfaceresultinginasectorformat.Thecomplexityofthenewerdesignsrequires
sophisticated, highspeed, computercontrolled pulsing of the individual elements circuitry.
Electronicfocussingonbothtransmitandreceiveprovidesalongerfocalzonewithanarrower
beamwidththanconventionalsingleelementdesigns.Similartolineararraydesigns,focussingin
thedirectionatrightanglestothescanplanedeterminestheslicethicknessandisaccomplishedby
theuseofanacousticlens.Sincethebeampathiselectronicallycontrolled,thedirection(vector)of
eachbeamcanbeselectedindividually.Thisuniqueadvantageovermechanicaldesignsallowsthe
systemtoperformsimultaneousBmodeimagingandMmodeorDopplerfunctions.
Theabovediagramshowsanendviewofa2dimensional96elementultrasoundphasedarray
transducer suitable for 3D ultrasound scanning [NC indicates that no electrical connection is
present].Thepanelstructureisflat.Eachelementisapiezoelectrictransducerwithitsownchannel.
i.e.thearrayislike96individualultrasoundscanners.Toproduceanimageusingthedatafrom
suchanarrayrequiresconsiderabledigitalsignalprocessing.
Example(fromultrasoundppt)
Ir Z2 Z1
2
Theratioofthereflectedintensityofultrasoundatatissueboundarytotheoriginalintensityofthe
ultrasoundattheboundaryisequaltotheratioofthesquareoftheacousticimpedancedifferences
tothesquareofthesumoftheacousticimpedances.Thisisrepresentedbytheequation
Ir Z2 Z1
2
Io Z2 Z1
2
Describe how the principles of acoustic impedance and reflection and refraction are
applied to ultrasound
Ultrasound is only reflected when it encounters a boundary between tissues having different
acousticimpedances.
Thegreaterthedifferenceinacousticimpedance,thegreatertheproportionoftheultrasoundthatis
reflected(andthelessertheamountthatistransmittedthroughtheboundary).
Becausebonehassuchahighacousticimpedancecomparedtoothertissues,mostoftheultrasound
energythatencountersboneisreflectedback.Forthisreason,ultrasoundcannotbeusedtoexamine
internalstructureofbone,norcanitbeusedeffectivelytoexaminethebraininsideanadultskull.
Someultrasoundpenetratestheskullofafoetus,becausetheboneoftheskullhasnotcalcifiedit
isatissuecalledcartilage(similartothetissuethatgivesearstheirsemirigidnature).
Because ultrasound is also refracted at a boundary between two different tissues, this can
complicatetheanalysisofthedata.
Explain that the greater the difference in acoustic impedance between two materials
the greater the reflected proportion of the incident pulse
Application oftheequation abovetodifferent pairsofmediademonstrates thatthegreaterthe
differenceinacousticimpedancebetweentwomaterialsthegreaterthereflectedproportionofthe
incidentpulse.Thisisshowninthefollowtwoexamplesoftheapplicationofthisequation.
Itshouldbenoticedherethatifultrasoundstrikesasofttissueboundaryofanytypetravellingfrom
air,orothergas,thenmostoftheultrasoundenergyisreflected.Forthisreason,whenanultrasound
isbeingcarriedout,agelisplacedontheskinandtheultrasoundprobeismovedoverthisgel.The
mostimportantfunctionofthegelistoexcludeanyairfromtheregionbetweenthetransducerand
theskin.Thegelhasanacousticimpedancesimilartohumantissue.Thetermusedtodescribethis
processis impedancematching.Impedancematchingbetweentwomediaresultsinmostofthe
energybeingtransmittedthroughtheinterface,withalmostnoreflection.
Describe the situations in which A scans, B scans and phase and sector scans
would be used and the reasons for the use of each
The size of an object that can be imaged using ultrasound depends on the frequency of the
ultrasound.Allwaveshavethepropertyofbeingdiffractedbyobjectsthatareopaquetothewave.
Ifthesizeoftheobjectislessthanaboutawavelength,thediffractionbecomessosignificantthat
verylittleofthewavereflectsbackfromthesurface.Theoutcomeofthisisalimittotheresolving
ability when using any wave to look at an object. This limit experienced with ultrasound is
summarisedinthefollowingtable.
Lowfrequencywavesaremoreeffectiveinpenetratinghumantissue.Thisfact,whenconsidered
withthediffractionlimitedresolutionresultsinadilemmaforultrasonography.Inordertoproduce
aclearimageofanobjectdeepinthebody,lowfrequencywavesshouldbechosenoverhigh
frequencywaves.Howevertoobtainaclearerimageofsmallerstructures,ahighfrequencyneeds
tobeused.Clearlythefinalchoiceisacompromisebetweentheseconflictingcriteria.
Ultrasound Scanning Modes
Ultrasoundcanbeusedindifferentways,calledmodes,whichproducedifferentdataandimages.
A mode Scans
Whenasingleelementtransducerisusedandthetransducerisstationary,onlyasingledimension
canberecorded.Thatdimensionisthedistanceoftheechoinginterfacefromthetransducer.This
distance is calculated bydetermining the length oftime required forthe echotoreturn tothe
transducerafterthetransducersendstheoriginalpulseofsoundenergy.Thecalculationisbasedon
theaveragespeedofsoundintissue,whichis1540metrespersecond.AtypicalAmode(orA
scan)isshownintheimagebelow(left)andthecentralportionoftheimageontheright.
Principle of A mode
Returningechoesproduceaverticaldisplacementofahorizontaltimebaselinedisplayedonan
oscilloscope.Theamountofdisplacementisproportionaltotheamplitude.Thiswasthefirstuseof
ultrasoundasitisrelativelysimple,requiringlittlesignalprocessingtodisplaythedata.
B Mode Scans
ThemostcommonlyusedmodalityinmedicalultrasoundiscalledBmodeimaging.Anultrasound
transducerisplacedagainstthepatientsskinsurface,directlyovertheregiontobeimaged.The
transducersendsaverybriefpulseofultrasoundintothetissue.Thepulsetravelsintothebodyasa
beam,verymuchlikethebeamofasearchlight. Interfacesalongthewayreflectsomeofthe
ultrasound energy back to the transducer. The transducer, in turn, converts the energy of the
reflected echo into electrical signals, which are sent into amplifiers and signal processing
components of the ultrasound machine. The exact, delay between when the transducer first
launchedtheultrasoundpulseandwhenitpickedupanechoallowsthemachinetocalculatehow
farthereflectinginterfaceisfromthetransducer,giventheknownspeedofultrasoundinthetissue.
Afteralltheechoesarepickedupfromalongthefirstbeam,thetransducersendsasecondpulse
alongaslightlydifferentbeamdirectionintothetissue.Echoesarepickedupthesamewayandsent
forprocessingtoproduceanimage.Thenanotherpulseislaunchedinstilladifferentdirection,
andsoforth.Likethebeamofasearchlightissweptacrossthenightsky,thepulsedbeamfroman
ultrasoundtransducerissweptthroughoutthebody,mappingoutreflectingsurfacesandforming2
dimensionalimages.
Beamsaresweptandultrasoundimagesareformedveryrapidly,essentiallyinrealtime.Asthe
operatorholdsthetransducerincontactwiththeskin,theimageappearsliveonavideomonitor.
By moving and manipulating the transducer different internal views are provided. The images
representcrosssectional,ortomographicviewsoftheplanethatthebeamwassweptacrossin.
Bscanimagesaresometimesreferredtoascontactcompoundscanningbecausethetransducerisin
contactwiththepatientsbodyandthetechnologistmustuseacompoundorrockingmotionto
createanadequateanatomicaldisplay.
AnothermethodofcreatingatwodimensionalimageinBmodeisthe realtime method.Inthis
method,anarrayofmultipletransducerelementsisheldincontactwiththepatientsbody,allowing
atwodimensionalimagetobecreated.
Aboveisanimageofthegallbladder(realtimeBmode)
Thishasbeenmadewithasectorscanneronrealtimeequipment.Thisimageismadewiththe
echoesbeingdisplayedaswhitespotsonadarkbackground.Thegallbladderinthisstudyhasan
abnormallythickwall,whichproducesastrongechosinceitsacousticimpedanceissignificantly
differentfromthatofthesurroundingtissue.
Theimagebelowshowsalongitudinalrepresentationofthekidneywithalargecyst.Thecystisthe
areashowingnointernalechoesthisisduetoitshomogeneousstructure.
Obstetrics
Probably the best known use of medical ultrasound imaging is related to obstetrics. Most
pregnancieshaveultrasoundimagingatsometimeduringthegestation,whethertheyneeditornot.
Theimagebelow(left)isatransaxialimagethroughthefoetalhead.
Noticethesidewallsofthefoetalheadmarkedwithcrosses.Thedistancebetweenthemarkscanbe
measuredandcomparedtoacharttodeterminestageofgestation.
Theimage(aboveright)showstheentirefoetusandisagooddemonstrationoftheclaritywith
whichfoetalpartscanbeshown.Thisisanidealimagingsituationsincetheobjectofinterestis
surroundedbyfluid.Inthisimageyoucanseetheplacentaalongupperwalloftheuterus.Then
thereisaclearspacewithnoechoeswhichisthefluidsurroundingthefoetus.Thewelldefined
foetusislyingontheposteriorwalloftheuteruswithhisfeetproppedupontheplacenta.
Echocardiography
Principle
Pulsed ultrasound from a transducer is used and continuous recording is made of the echoes
receivedfromthevariouspartsoftheheart.
When is echocardiography used?
Echocardiography is used to investigate the heart valve function, left ventricular function,
congenitalheartdiseasesincludingholesintheseptum,cardiactumoursandobstructionsincardiac
bloodvessels.
Duringanultrasoundexam,twosoftrubberpadscomein
contact witheither sideofthe heel. Thesepads sendand
receivehighfrequencysoundwavesthroughtheheelbone.
Thetesttakesaboutoneminuteandisperformedinaseated
position,withthefootplacedandcomfortablysecuredinthe
ultrasound unit. No injections or invasive procedures are
necessary.Highfrequencysoundwavesarepassedthrough
theheel,andthebonedensityisestimatedfromthesound
waves transmitted. The test results are processed
immediately.
The ultrasound systems fortesting osteoporosis are smaller and less expensive than traditional
DEXAsystems.
References
http://www.bonsecours.com/imaging/bone.htm
http://www.spinalman.freeserve.co.uk/heelscanning.htm
http://imaginis.com/osteoporosis/osteo_diagnose.asp
http://courses.washington.edu/bonephys/opultra.html
Describe the Doppler effect with respect to sound and how it is used in ultrasonics
to obtain flow characteristics of blood flow through the heart
Dopplerultrasoundscanningisusedtoimageanystructureortissuethatpulsatesormoves
Itisbasedontheprinciplethatwheneverthereflectorsurfacemoveswithrespecttothetransducer,
thereisashiftinthefrequency.
The Doppler shift effect has been used for a long time in foetal heart rate detectors. Further
developmentsinDopplerultrasoundtechnologyinrecentyearshaveresultedinitsincreasedusein
obstetricsinassessingandmonitoringthewellbeingofthefoetus.
Foetal blood flow is shownin the following colour Doppler image, with a schematic diagram
showingtheareabeingscanned.
ColourDopplerusesredtoshowflowormovementtowardsthetransducerandbluetoshowflow
away from it. Different colours and shades of colour are further used to show graphically the
velocityofmovement.
Outline some cardiac problems that can be detected through the use of the Doppler
effect
BloodflowcharacteristicsinthefoetalbloodvesselscanbeexaminedusingDopplerultrasound.
Diminishedflow,particularlyinthediastolicphaseofapulsecycle(astheheartmusclerelaxes)is
associatedwithbloodcirculationproblemsinthefoetus.Variousratiosofthesystolictodiastolic
flowareusedasameasureofthisfoetalheartfunction.Thebloodvesselscommonlyexamined
Option9.6 page26 GPittgregphy@tpg.com.au
Medical Physics
includetheumbilicalartery,theaortaandthemiddlecerebralarteries. Theuseofcolourflow
mapping can clearly depict the flow of blood in foetal blood vessels in a real time scan, the
direction and velocity of the flow being represented by different colours. Colour Doppler is
particularlyindispensableinthediagnosisandassessmentofcongenitalheartabnormalities.
Thisisthe2002syllabusupdate
Introduction
In1895WilhelmRoentgendiscoveredtheXrays.Thislaidthefoundationforoneofthemost
important diagnostic tools in modern medicine. Using Xrays, it is possible to look inside the
humanbodywithoutcuttingitopen.Howeverthesepicturesarefarawayfrombeingaperfect
imageoftherealbody.
AnormalXrayimageisa2dimensional projection oftherealthreedimensionalobject.This
meansinformationislostduringtheprocess,makingitdifficulttodistinguishbetweendifferent
partsoftheanatomyonthephotograph.
Hipbrokenasaresultofamotorcycleaccident[above]
TouseXraysfortheinvestigationofother,lessdensetissuesofthebody,suchasthe
gastrointestinaltract,thetissuesmustfirstbemadeopaquetoXrays.Generally,patients
areaskedtodrinkamixturecontaininganopaquesubstance,suchasbariumsulfate(the
TwoschematicviewsofanXraytubeareshownintheimagesabove.Aschematicdiagrambelow
showstherelationshipbetweentheelectricfielddirectionandthedirectionoftheaccelerationand
velocityoftheelectronsinthevacuumtube.
Characteristic X-Rays
CharacteristicXraysareemittedfromtheatomsof
heavy elements when their electrons make
transitions between inner electron shells. The
characteristicXraysemissionwhichshownastwo
Compare the differences between soft and hard X-rays
Xrayscoverarangeoftheelectromagneticspectrumfromultraviolettogammarays.Theterm
softXraysisappliedtoXraysclosertotheUVspectrumandhardXraysarethosecloserto
thegammarayspectrum.ThereisnosharpdividinglinewithintheXrayspectrumorbetweensoft
andhardcomponentsandtheUVandgammaradiationoneitherside.SometimeshardXraysare
referredtoasgammaraysandviceversa,dependingonthecontextandtheuseroftheterms.
SoftXrayshavelongerwavelengthsandlowerfrequenciesthanhardXrays.
SoftXraysareusuallydefinedasXrayshavingawavelengthgreaterthan0.1nm(frequencyless
than3x1018Hz).ThesecorrespondtoXraysproducedusinganacceleratingpotentialof12kV.
(ManysourcesstatethatsoftXraysareproducedusingpotentialsupto20kV.Thereisnosharp
dividinglineoragreedstandard.
ThenatureofXraysproducedbyanXraytubedependsonthevoltageappliedtothetube,which
inturndeterminesthekineticenergywithwhichtheelectronsstrikethetungstenanodeinthetube.
HighervoltagesthusgiverisetohardXraysandlowervoltagesproducesoftXrays.
RadiologistsoftenspeakaboutthevoltageusedintheXraytubewhencategorisingXrays,rather
thananintrinsicpropertyoftheXrayssuchasfrequencyorwavelength.
Agoodbrokenwristofanextremebikerider!NotonlyhumansgetXrayedthough.
Thisisaninterestingimagebecausethesurgicaltoolisinsidethepatientwhohadbeenstitched
backupandwasrecoveringafterthesurgery.Thingswerentgoingexactlyasexpected,andthisx
rayshowedwhy.Thepatientwasreturnedtotheoperatingtheatretohavethetoolremoved.Note
thatitisnotpossibletotellthatthetoolisinsidethepatientfromthisXray.Thesameimagecould
beproducedifitwaslyingaboveorbelowthepatient,ontheoutside.InthiscaseasecondXray
wasusedtoconfirmthatitwasindeedinsidethepatient.Thebigquestionremainshowcould
thishappen?
ThedepthperceptionproblemisalsoevidentinthisXray,inwhichthreedimensionshavebeen
projectedintotwo.AgoodknowledgeofanatomyisneededtointerpretXrays.
An Unusual Case
X-ray of Ron Hunt's head. Photo: AP
Ron Hunts friends and family have been calling
himtheMiracleManeversincean45centimetre
longdrillbitpokedthroughhiseyeandouttheback
ofhisskull.
Itdidntseempossibleforhimtobealive,seeing
himwithadrillbitthroughhishead,hisnephew
BenHuntsaid.
TheconstructionworkerfromTruckee,California,
lost an eye but survived the freak accident on
August15withnobraindamageafterfallingfroma
ladderandontothedrill.
The3.8cmdiameterchipaugerdrillbitwasstillinhisheadwhenhisbrother,ChrisHunt,and
nephew,Ben,methiminahospitalemergencyroominReno,Nevada.
Thenursesbracedusforitbeforewesawhim,BenHunttoldtheSierraSunnewspaperof
Truckee.
Itdidntseemrealitseemedlikeamovie.Iwasntsurewhattofeel.
Doctorsexplainedthatthedrillbitpushedhisbrainasideratherthanpushingintoit,whichlikely
wouldhavecausedseriousbraindamageordeath,BenHuntsaid.
WhiledrillingabovehisheadonAugust15,thetwometreladderRonHuntwasstandingonstarted
towobblesohetossedthedrillasideasconstructionworkersaretrainedtodo.
Hethenfellofftheladderfacefirstandontothedrill.
BythetimeIwasfalling,andIletthedrillgodown,Iwasalreadyontopofit,RonHunttold
ABCsGoodMorningAmericaTVshowtoday.
Iranmyhandsupthedrillbit,uptomyeye,andputmyotherhandinthebackofmyheadand
feltitcomingthroughthebackofmyhead,hesaid.
Andthatswhereprettymuchtheshocksetin.
HewastakenbyhelicoptertoWashoeMedicalCentreinReno.
Afterweighingtheiroptions,doctorsessentiallyunscrewedthebittoremoveit.
Wewouldhavecutitoff,butafterafewminutesofdrilling,wenoticedthatitwasloose.Andso
wejustputdownourbladeandtwistedthebit,saidDrPaulLudlow,thesurgeonwhoperformed
theoperation.
Hisnephewthinkshellbeabletolaughaboutitsomeday.
Itsjustgoingtobeoneofthosestories,BenHunttoldtheSierraSun.
Helljokearoundwithhisglasseyeandpopitout.
AP
Copyright2003.TheSydneyMorningHerald.
AbsorptionoftheXraysvariesastheangleischanged.CTusestheeffectofdifferentialabsorption
ofXraysintissuesofdifferentdensity.AnXraysourceemitsphotons,whicharescatteredand
attenuatedastheypassthroughthebody.OntheoppositesideanarrayofdetectorsmeasurestheX
rayintensity.DigitisedinformationontheattenuationoftheXrayspassingthroughtheilluminated
planeatvariousangles,andatvarioustimesduringrotation iscollectedandstored.Theoriginal
intensityoftheXraybeamiscomparedwiththecollecteddata.Bymeasuringtheattenuationat
differentanglesandusingamathematicalalgorithm,itispossibletocalculatethedistributionof
tissuedensity,andhenceconstructatwodimensionalimageofthecorrespondingslicethroughthe
patientsbody.
ComparetheresultingCTXrayimagewithaphotographofachestcrosssection(fromthevisible
humanprojectwebsite).
Aseriesofcrosssectionalimagesisusually
produced by moving the patient in small
incrementsthroughthescanner.Theimages
are often displayed simply as consecutive
slicesasshowninthefollowingimage.
TheCTScannerisabout100timesmore
sensitivethanaconventionalXraymachine.
CTisanaccurateandvaluableimaging
technique.Sequentialsectionscanbelinked
bymeansofanimationsoftwaretosimulate
thepassageofthespecimenthroughafixed
plane.[seemoviefile]
Manysuchimagescanbecombinedusingcomputerimagemanipulationtechniquestoproducea3
dimensionalimage.
Checkoutthewebsiteindicatedforamovieshowingtherotationofthis3Dimagecreatedusing
computeriseddigitalimagemanipulation.
Furtherexamplesof3DCTcanbeseenathttp://www.medphys.ucl.ac.uk/mgi/visct.htm
The image above (left) shows a number of different tissue types (soft tissue, muscle and bone) in a
single image produced by selective analysis of the gathered data to produce different sections
through the patient. A CT X-ray machine is shown on the right.
CTandUltrasoundcanbothproducetrue2Dimagesrepresentingslicesthroughthebody.The
benefitsofCToverultrasoundarethat
CTcanbeusedtoimagebone,whichultrasoundcannotdobecausetherelativelyhighacoustic
impedanceofboneresultsintheultrasoundbeingalmosttotallyreflectedfromthebone,sothat
nointernalfeaturesofthebonearediscernible
CTcanbeusedtoimagetissueunderlyingbone,whereasultrasoundisreflectedfromthebone
surfaceandnothingbeyonditisvisible
CThasbetterresolutionthatultrasound,sofinerdetailisvisibleusingCTthanUS
Inthefollowingdiagram,thelightintheprismmeetstheinterfaceatthecriticalangleic,theangle
atwhichtherefractedraytravelsparalleltotheinterfaceafterrefraction.
Iftheangleofincidence,i,exceedsthecriticalangle,allofthelightwillbereflectedbackintothe
medium,withnonepassingthroughtheinterface.
Forlighttravellingfromamediumintoavacuum(orairasacloseapproximation),thecritical
angleiscalculatedfromtherelationship:
1
Sin(ic)=
n
Note that a critical angle only exists when a ray of light is travelling in a medium of higher
refractiveindexwhenitmeetsaboundarywithamediumoflowerrefractiveindex.
Thissituationcommonlyappliestolighttravellinginatransparentliquidorsolidmediumwhenit
meetsaninterfaceofthatmediumwithair.
Thecriticalangleisalsodefinedforlightpassingfromonetransparentmediumtoanotheroflower
refractiveindex(n1),inwhichcase,thecriticalangleisdefinedas:
n1
sin(ic)=
n2
[notethatthesineratiomustbdelessthan1andhencecriticalangleonlyhasmeaningiflightis
travellingfromamediumofhighertoamediumoflowerrefractiveindex.
Thisisillustratedinthefollowingdiagram.
Fibre Optics
Thephenomenonoftotalinternalreflectionisthebasisofendoscopy.Thisistheprocessbywhich
medicalpractitionersareabletousevisiblelighttoconductaninternalexaminationofapatients
body.Abundleofopticalfibresisusedtobothtransmitlighttothesiteoftheexamination,aswell
astransferringtheimagebackfrominsidethepatient.
Thefollowingimage(belowleft)isatypicalexampleofanimageproducedusingthistechnique.It
isapictureofagastriculcer.[WatchQuantumvideoUlcer]
The light will thus propagate along the fibre, bouncing from side to side as it does so, being
internallyreflectedeachtime.
Itisthisphenomenonoftotalinternalreflectionthatkeepslightconfinedinopticalfibresandisthe
basicprincipleunderlyingtheoperationofanopticalfibre.
Optical fibre technology is used extensively as a means of communication for cable TV,
telecommunications,andcomputerdata.
Opticalfibresarealsousedinavarietyofmedicalinstrumentsusedforvisualexaminationinside
thebodythroughabundleofopticalfibresinsertedthroughasmallopening.Medicalinstruments
usingopticalfibresincludeendoscopes,arthroscopesandlaproscopes.
Minimallyinvasivesurgeryisconductedusingopticalfibreinstrumentstoseeinsidethebody.A
commonexampleisthereplacementoftheanteriorcruciateligamentintheknee.
Images showing a normal anterior cruciate ligament (ACL) and a repaired ACL
Thispartoftheanatomyisfrequentlytorninsportssuchasnetballandfootball,whichinvolve
vigoroustwistingforcesontheknees.
Discuss differences between the role of coherent and incoherent bundles of fibres
in an endoscope
If,inanopticalfibrebundle,allofthefibresareparallelalongthefulllengthofthebundle,sothat
thereisaonetoonecorrespondencebetweenthepositionsofthefibresatoneendofthebundle
andthepositionsoftheoppositeendsofeachfibreattheotherendofthebundle,thenthefibre
bundleissaidtobecoherent.
Thelightfromanobjectprojectedontotheendsofthefibrebundlebyasimplelenswilltravel
alongthefibres,emergingasacorrespondingimageoftheobject,visibleattheotherendofthe
bundle.Thisistheprincipleofthemedicalendoscope.
Inanoncoherentfibrebundle,oneormoreofthefibresswappositionsrelativetoeachotherat
oppositeendsofthefibre.Typically,thearrangementoffibresalongthebundleisrandom,so
althoughthelighttravelsalongeachfibre,aswithacoherentbundle,noimageisproducedatthe
exitend.
Anoncoherentfibrebundleisusedtotransmitlighttothepointwhereobservationsarebeingmade
withtheendoscope.
Whitelightisusedsothatthedoctorcanobservethetissuesinrealcolour.
Explain why different types of optical fibres will affect the image produced by an
endoscope
Acoherentbundleoffibresisessentialinthetransmissionoftheimage.Alensatthedistalend(the
endoppositetotheeyepiece,orcamera)focusesanimageoftheareabeingobservedontotheend
ofthefibre.Thecoherentbundlesendsthisimagetotheotherendofthefibrethroughtheprocess
oftotalinternalreflection.Thecoherentbundleisnecessarytoensurethattheintegrityoftheimage
ismaintainedfromoneendtotheother.Eachfibreinthebundleeffectivelytransmitsapixelfrom
oneendtotheother.
AdvantagesofEndoscopy
Thetissuesareseeninrealcolours
Theprocesstakesplaceinrealtime,enablingthedoctortointerveneintheprocessatany
time
Theprocessisminimallyinvasivecomparedwithopensurgery
Theprocessusesnonionisingradiation,namelylight,anadvantageoverXrays
Used in conjunction with remotely operated miniature surgical instruments, minimally
invasivesurgicalprocedurescanbeperformedandthisissaferforthepatientandallows
themtoleavehospitalinashortertimethanwithconventionalsurgery
DisdvantagesofEndoscopy
Theprocessmustbedoneinrealtimeandistimeconsumingcomparedwithultrasound,X
rays
Theprocesspresentsminorriskstothepatient,especiallyifsurgicalendoscopyisusedand
ananaestheticisrequired
Onlythesurfaceoftissuesisvisible
Explain how an endoscope is used in obtaining tissue samples of internal organs
for further testing
A common use for endoscopes is the removal of tissue samples for testing, for example to
determinewhetheragrowthismalignantornot.Thisiscalledabiopsy.Typicalexamplesinclude
theremovalofpolypsorothergrowthsfromtheintestine.Theendoscopeisusedparticularlyfor
theremovaloftissuesamplesfromtheabdomen.Surgeryinthispartofthebodyhasasignificant
riskassociatedwithitbecauseofthechanceofintestinalbacteriainfectingtheabdomenifthe
Onecommonlyusedtoolconsistsofahollowtubewithadiagonalcuttingbladeattheend.The
tissuesampleispushedorsuckedintothehollowtubeandthebladecutsitandslidesacrossthe
tubeentranceensuringthatthespecimenisnotlostastheendoscopetubeiswithdrawn.
ThefollowinginformationaboutendoscopyisquotedfromtheGrolierEncyclopediaCDROM
Fibre optics is the channelled transmission of light through hair-thin glass fibres. The light is
prevented from escaping the fibre by total internal reflection a process that takes place
when a light ray travels through a medium with an index of refraction higher than that of the
medium surrounding it. In this case the fibre core has a higher refractive index than the
material around the core, and light hitting that material is reflected back into the core, where it
continues to travel down the fibre.
Fibre-optic technology has been applied in many areas, although its greatest impact has come
in the field of telecommunications, where optical fibre offers the ability to transmit audio, video,
and data information as coded light pulses. Other applications include the simple transmission
of light for illumination in awkward places, image guiding for remote viewing, and sensing the
measurement of various properties of materials, structures or living things.
Other Applications of Fibre Optics
Non-communication advances in fibre optics have fallen into two main areas, flexible and rigid
fibres. Sensors are a major flexible fibre application, and uses include the measurement of
pressure, temperature, rotation, fluid flow, and electric current. Other flexible fibre applications
concern high-intensity illumination in general, instrument illumination for automotive and
avionic systems, power transmission for use with robotics, surgical and dental procedures, and
image guiding which involves fibre bundles that are aligned from end to end. The technique is
used for direct viewing of otherwise inaccessible areas, as in medical endoscopes. In rigid
fibre optics, thousands of fibres are fused into a solid block. These optic plates are used for
image transfer from a cathode-ray tube to a permanent photographic recording.
Endoscope
An endoscope is a tubular instrument equipped with optical viewing and lighting systems. It is
used for examining the inside of certain cavities or hollow organs of the body, or to
perform surgery. An endoscope often uses a fibre optic telescope that provides excellent
visibility of minute internal structures. Either suction or pumping methods are used to clear the
Thisisthe2002syllabusupdate
References
http://perso.clubinternet.fr/molaire1/e_plan.html
Protonsandneutronsarecollectivelycallednucleons.
Whatareradioisotopes?
Reference:Materialunderthisheadingisquotedsubstantiallyfromthefollowingwebsite.
http://www.uic.com.au/nip26.htm
Thereare82stableelementsandabout275isotopesoftheseelements.Whenacombination
ofneutronsandprotons,whichdoesnotalreadyexistinnature,isproducedartificially,the
atomwillbeunstableandiscalledaradioactiveisotopeorradioisotope.
Radioisotopes can be manufactured in several ways. The most common is by neutron
activationinanuclearreactor.Thisinvolvesthecaptureofaneutronbythenucleusofan
atomresultinginanexcessofneutrons(neutronrich).
Someradioisotopesaremanufacturedinacyclotroninwhichprotonsareintroducedtothe
nucleusresultinginadeficiencyofneutrons(protonrich).
Thenucleusofaradioisotopeusuallybecomesstablebyemittinganalphaand/orbetaparticle
(orpositron).Theseparticlesmaybeaccompaniedbytheemissionofenergyintheformof
electromagneticradiationknownasgammarays.Thisprocessisknownasradioactivedecay.
Radioactiveproductsusedinmedicinearereferredtoasradiopharmaceuticals.
AdistinctadvantageofnuclearimagingoverXraytechniquesisthatbothboneandsoft
tissuecanbeimagedverysuccessfully.
ThisreactionisthesourceofmostoftheheliumonEarth.LiquidheliumisusedinMRI
imaging machines for the operation of the superconducting electromagnets essential in
creatingtheverystrongmagneticfieldneededforthisimagingprocess.
Theaveragerangeofa1MeVbetaparticleisabout3minairbutonlyabout3mmintissue.
Carbon14decaysbybetadecay.Thereactionisasfollows
14 0
6 C174N 10 e where 1 e representsabetaparticle
Beta Radiation Positron Production
Apositronistheantiparticleoftheelectron.Ithasthesamemagnitudechargeastheelectron,but
itispositive.Ithasthesamemassasanelectron.
When a radioactive nucleus decays to produce a positron, the atomic number of the decaying
nucleusincreasesbyoneandthemassnumberremainsthesame.Aprotonchangesintoaneutron
andapositroninthisprocess.
PositronsareusedinPETscanning(PositronEmissionTomography)
Forenvironmentaldosimetry,importantbothforinternalandexternalexposure.Gammaemitters
depositedinoneorganofthebodycansignificantlyirradiateotherorgans.
Source:NationalGeographic(January1987)
Half-Life
Thetimeittakesforhalfthemass(oratoms)oftheparentisotopetoturnintoitsdaughter
isotopeiscalledthehalflife.
Thefollowinggraphshowshowtheactivityofradioactiveamericiumdecreasesovertime,adirect
resultofthedecreasingnumberofamericiumatomsremaininginthesample.Americium242hasa
halflifeof16.02hours.
Factorsgoverningthechoiceofradioisotopesusedinmedicineinclude
Havingahalflifelongenoughtoexaminemetabolicprocesses,yetshortenoughtominimise
theradiationdosetothepatient.
Rapiduptakeintothedesiredtissuethisisachievedbyincorporatingtheradioisotopeintoan
appropriatecompoundwhichismetabolisedbythetargettissueinthebody.
Rapid excretion from the body this is again a chemical choice, appropriately chosen
compoundsarebrokendownandexcretedasapartofthenormalbodychemistry.
Everyorganinourbodiesactsdifferentlyfromachemicalpointofview.Doctorsandchemists
haveidentifiedanumberofchemicalsabsorbedbyspecificorgans.Thethyroid,forexample,takes
upiodine,thebrainconsumesquantitiesofglucose,andsoon.
With this knowledge, radiopharmacists are able to attach various radioisotopes to biologically
active substances. Once a radioactive form of one of these substances enters the body, it is
incorporatedintothenormalbiologicalprocessesandexcretedintheusualways.
Theamountoftheradiopharmaceuticalgiventoapatientisjustsufficienttoobtaintherequired
informationbeforeitsdecay.Theradiationdosereceivedismedicallyinsignificant.Thepatient
experiencesnodiscomfortduringthetestandafterashorttimethereisnotracethatthetestwas
everdone.Thenoninvasivenatureofthistechnology,togetherwiththeabilitytoobserveanorgan
functioningfromoutsidethebody,makesthistechniqueapowerfuldiagnostictool.
Aradioisotopeusedfordiagnosismustemitgammaraysofsufficientenergytoescapefromthe
body anditmust haveahalflifeshortenoughforittodecayawaysoonafterimagingis
completed.
Technetium-99m
Theradioisotopemostwidelyusedinmedicineistechnetium99m,usedinoverhalfofallnuclear
medicineprocedures.Itisanisotopeoftheartificiallyproducedelementtechnetiumandithas
almostidealcharacteristicsforanuclearmedicinescan.Theseare:
Theradioisotopeslistedintheabovetableareproducedinanuclearreactor.
Theradioisotopeslistedintheabovetableareproducedinamedicalcyclotron.
Radiopharmaceuticals are used in very small
Diagnosticradiopharmaceuticalscanbeusedtoexaminebloodflowtothebrain,to
assessfunctioningoftheliver,lungs,heartorkidneys,toassessbonedamage,andto
confirm other diagnostic procedures. They are increasingly being used in sports
medicine to diagnose stress fractures, which are not generally visible in Xrays.
Anotherimportantuseistopredicttheeffectsofsurgeryandtoassesschangesafter
treatment.
Radiopharmaceuticals are used in very small quantities for diagnostic work just
enough is administered to obtain the required information before the
Identify that during decay of specific radioactive nuclei positrons are given off
11
6C115 B 10 e 15
8 O15 0
7 N 1 e
18
9 F18 0
8 O 1 e
InaPETscannertheseannihilationphotonsaredetectedbyarraysofdetectorssurroundingthe
patient.Avalideventoccurswhentwodetectorsrecordphotonswithinafewnanosecondsof
each other. To compute the 3D distribution of the radionuclide requires a large number of
measurementsfrommanydifferentangles(hencetheringdesignofmanyPETscanners).
Positronemittingisotopesexistforcarbon,oxygen,nitrogenandfluorine,andothers,whichallows
manynaturallyoccurringsubstancesusedbythebody(suchasglucose,ammoniaandwater)tobe
labelledwithradioactivetracersandbyimagingthedistributionofthesetracers,regionalblood
flowandglucosemetabolismcanbeimaged.PETisthusafunctionalimagingtechnology.
Describe how positron emission tomography (PET) technique is used for diagnosis
[reference]
http://neurocog.psy.tufts.edu/images/positron_emission_tomography.htm
PET stands for positron emission tomography. It is a functional imaging technique, allowing
physiciansorresearcherstoassesschemicalorphysiologicalchangesrelatedtometabolism.PET
imagingutilisesavarietyofradiopharmaceuticals,calledtracers,toobtainimages.PETtracers
aresimilartothenaturalsugars,water,proteins,andoxygenfoundinourbodies,butcarryaweak,
radioactivetag.Thesetracersareinjectedintoapatientandcollectinvarioustissuesandorgans.
Gammaraysassociatedwithpositronemissionfromtheseareascanbedetectedandanalysedto
provideafunctionalmapofbrainactivation.ThePETsystemdetectsthegammaradiationemitted
fromtheradioactivetracerinsidethebody,andusesthedatatocalculateanimageofcellular
biologicalactivities.
Whenthebodyschemistryconcentratesapositronemitterinaparticularlocation,Vbelow,more
gammaradiationisemittedfromthatregionthanregionswheretheemitterisnotasconcentrated.
Gammaraydetectorsarearrangedinpairsoppositeeachotheraroundthepatient.Signalsreaching
oppositedetectorsareanalysedbyacomputercalculatesthepositionoftheannihilationeventfrom
thedifferencesintheattenuationofthegammaraystravellingthroughdifferentdistances,d1andd2
inthepatientsbody.Inthediagramabove,detector1willreceivemoregammaradiationfromthe
voxel,V,thandetector2.
PETimagingcananalysesugarmetabolism,bloodflow,oxygenutilisationandalonglistofother
vitalphysiologicalactivities.Ifglucoselabelledwithfluorine18,apositronemitter,isgiventothe
[http://www.triumf.ca/welcome/petscan.html]
Asaresult,PETscanningcanrevealinformationaboutthefunctioninparticularregionsofthe
brain. PET is commonly used to determine what parts of the brain are involved in different
neurologicalillnessesincludingseizures,schizophrenia,andParkinsonsdisease,aswellaswhich
partsareactiveduringspecificactivities,suchassolvingmathsorworkpuzzles.Brainactivity
showninthecolouredPETimagesbelowcomparedwiththecorrespondinganatomicalMRimages.
InPETtheprocessesareverydifferentfromotherimagingmethodssofardiscussed.Incontrastto
CTforexample,radiationthatisusedtoexaminetheobjectdoesntcomefromanexteriorsource,
butisratheremittedbyaradionuclide,injectedintothepatientsbody.
Twoexamplesofsucharadionuclidesisfluorine18andoxygen11.
TheuseoffalsecolourenhancementincreasesthediagnosticcapabilitiesofPET.
AwholebodycolourPETscanofawoman40yearsoldtwoyearsaftermastectomy.PETfound
multiplemetastasesextendingthroughoutthebody,includingmultiplelivermetastases.
Ifyouhaveareaswithhighboneactivity(fromcancerspreadingtobone,fracture,arthritis,etc),
therewillbemoreofthisradioactivephosphatetakenupintothebone,appearingdarkeronthe
bonescan.
Typicalimagesofhealthyboneandcancerousboneareshowninthefollowingimage.
Question: Inthenormalscan,whydoyouthinkthepatientsleftelbowhasanintensefocusof
radioactivity?(Hint:HowdidtheygivethepatienttheMDP?)
Question:Inthenormalscan,thelowerpelvishasaregionofhighintensity.Whyisthis?(Hint:It
maybesofttissue,notbone...lookingatthePETmighthelpyouwiththisquestion.)
Discussion of Bone Scan
Althoughourpatientsimageisalittleoverexposed,notethattherearenumerousintensespots
(althoughsmall)alongthespinethatindicatethatthebreastcancerhasmetastasised,orspreadto
thebone.Onecanalsopickoutmultiplespotsontheleftpelvis,leftandrightshoulders,aswellas
thefirstfourribs.Thisisanextremelybadfindingandtheonlytreatmentispainrelief.Notethat
breast cancer does metastasise to bone. The bone metastases in breast cancer can either be
osteoblastic(increasedbonedeposition)orosteolytic(increasedboneresorption).Itistoughtosay
determinethenatureofthemetsinthiscase.XRayswouldbegoodforfiguringthisout.
Thisisthe2002syllabusupdate
AllmajorhospitalsandmanyprivateimagingbusinessesinAustralianowhavemagneticresonance
imagingmachine.Theycostmorethan2milliondollarstopurchaseandaboutonemilliondollars
peryeartooperateandstaffthem.
AsofOctober2003,therewereabout150MRImachinesinAustralia.Thecombinedeffectof
doctors fears of legal claims against them, and the patients desire to always use the best
technologyavailabletodiagnosediseasehascausedawellpublicisedblowoutinmedicalinsurance
costs.
OneoftheinitialsuccessesofMRIisthatimageswereobtainedoftheplaquethatischaracteristic
ofmultiplesclerosis(MS),givingamuchearlierdiagnosisofMS.PriortoMRI,patientswerekept
insuspensesometimesformanyyearsawaitingapositivediagnosis.AnothercharacteristicofMRI
isthatimagescanbeobtainedofsofttissueveryclosetobone.CThasmanyartefactsinsofttissue
close to bone. Hence MRI gives excellent images of deformed disks in the spine and of
abnormalitiesatthebaseofthebasebothofwhichcannotbeimagedsatisfactorilywithCT.
Identify that protons and neutrons in the nucleus have properties of spin and
describe how net spin is obtained
Bothprotonsandneutronsinthenucleiofatomshaveapropertycalledspin.Thisspinpropertycan
haveoneoftwopossibledirectionsforanygivennucleon.Ifthereareevennumbersofprotonsor
neutrons,thentheirspinsaligninoppositedirectionssothatthenetspinofthepairiszero.
[Image source: National Geographic January 1987]
Ifthereisanoddnumberofprotonsorneutrons,thenthenucleusmustpossessanetspinsince
pairing cannot occur with one of the nucleons. Nuclei having a net spin include hydrogen,
phosphorus31,fluorine19,nitrogen15andcarbon13.
Explanation:Phosphorus31hasamassnumberof31andanatomicnumberof15,itthereforehas
16neutrons.Theneutronnumberbeingevenresultsinpairingoftheirspinsproducinganetspinof
zero.Becausethereisanoddnumberofprotons,onemustbeunpairedandthisunpairedproton
producesthenetspinforthisnuclide.Phosphorus31isarelativelycommonnuclideinthehuman
body.
ThenetspinofhydrogenisusedinMRimagingbecauseitisfoundinthebodyinrelativelylarge
amounts,giventhehighproportionofwatermakingupthebody.
Identify that the nuclei of certain atoms behave as small magnets
Nucleiwithanetspinduetounpairedprotonshaveapropertycalledmagneticmoment.Thiscan
bethoughtofasamagneticeffectcausedbytherotationoftheproton,whichactslikeacirculating
electriccurrentloop,resultingintheformationofamagneticdipoleshown(belowleft).
Thehydrogennucleusisonesuchnucleuswithanetspin.Themagneticpropertiesofhydrogenare
not normally evident because in the gaseous state, the magnetic properties of the nuclei are
randomlyaligned(aboveright),resultinginazeronetmagneticeffect.
Whentheappliedexternalfieldisremoved,theatomsresumearandomorientation.Thisoccurs
duetotherandommotionofatomsassociatedwiththermalvibrationsatanytemperatureabove
0K.
Thedirectionoftheaxisofthemagneticmomentrotatesaboutanaxisparalleltotheexternal
magneticfieldasshowninthediagram(abovecentreandright).Thismotioniscalledprecession.
Thismotionissimilartoaspinningtopwithitsaxisofrotationtiltedatanangletothevertical.
Precessionisthemotionthatresultsintheaxisofrotationofabodysweepingoutaconicalmotion
whenatorqueactstoaffectachangeintheaxisofrotationofthatbody.
Precessionisaconsequenceofthelawofconservationofangularmomentum.
ThefrequencyofprecessioniscalledtheLarmorfrequency.TheLarmorfrequencyisdependent
onthecompositionofthenucleusandthemagnitudeoftheexternalfield.
Foraprotonina2Tmagneticfield,theLarmorfrequencyis85.2MHz.Thiscorrespondstoaradio
frequencyelectromagneticwave.
Discuss the effect of subjecting precessing nuclei to pulses of radio waves
Whenprotonsinastrongmagneticfieldradioareexposedtoradiowaveswithafrequencyequal
totheLarmorfrequency,theirenergyisabsorbedbytheprotonsinaprocesscalledresonance.
Thiscausestheprotonsmagneticalignmenttoflipfromtheparalleltotheantiparallelstate,a
phenomenonsometimesreferredtoasspinflip.
Resonanceoccursbetweentwooscillatingsystemsiftheyhavethesamenaturalvibrational
frequencyandifthereissomemeansbywhichenergycanbetransferredfromonesystemto
theother.Thiscanbeobservedusingaguitarpressingdownonthefifthfretofthefirststring
andpluckingtheadjacentstring.Iftheguitaristunedcorrectly,thefirststringwillalsovibrate.
Thisoccursbecausethetwostringsundertheseconditionshavethesamenaturalfrequencyand
theenergycanbetransferredfromonestringtotheotherviathebodyoftheguitar.
Thehydrogennucleiprefertoreturntotheiroriginalstateinthemagneticfieldandastheydoso,
theyreemittheenergyabsorbedfromtheradiowaveoveraperiodvaryingfrom0.01to0.1ofa
Option9.6 page81 GPittgregphy@tpg.com.au
Medical Physics
second.TheemittedenergyisaradiowavethatisdetectedwiththesamecoilthatemittedtheRF
wavestofliptheprotons.ThesesignalsemittedbytheprotonareusedtocreatetheMRimage.
RF signal flips the hydrogen nucleus The nucleus emits a radio signal as it flips
back
ThereturnoftheprotontothelessexcitedstateafterabsorbingtheRFenergyiscalledrelaxation.
The emission of the energy from the hydrogen nuclei returning to the lower energy state is
describedbytwotimeconstants,T1andT2associatedwithtwodifferentelectromagneticprocesses
(notnecessarytodiscussthesehere!).T1relatestoaninteractionbetweenprecessingprotonsand
the other atoms in the material. T2 relates to an interaction between the precessing nuclei
themselves.
Unlikemanyothermedicalimagingtechniques,thecontrastinanMRimageisstronglydependent
uponthewaytheimageisacquired.ByaddingRForgradientpulses,andbycarefulchoiceof
timings,itispossibletohighlightdifferentcomponentsintheobjectbeingimaged.Inthesequence
descriptionsthatfollowitisassumedthattheimagingmethodusedisEPI,howeveridenticalor
similarmethodscanbeusedwiththeotherMRimagingtechniquesoutlinedabove.
Thebasisofcontrastisthespindensitythroughouttheobject.Iftherearenospinspresentina
regionitisnotpossibletogetanNMRsignalatall.Protonspindensitiesdependonwatercontent.
ThelowprotonspindensityofbonemakesMRIalesssuitablechoiceforskeletalimagingthanX
ray shadowgraphs or Xray CT. Since there is such a small difference in proton spin density
betweenmostothertissuesinthebody,othersuitablecontrastmechanisms mustbeemployed.
ThesearegenerallybasedonthevariationinthevaluesofT1andT2fordifferenttissues.
[referenceforabove2paragraphs:MRIPrinciples.pdf.
SeeNuclearMagneticResonance
http://www.rzuser.uniheidelberg.de/~slange_expired/imaging/chap3.htm
ifyoureallywanttoknow.
Explain that the amplitude of the signal given out when precessing nuclei relax is
related to the number of nuclei present
With magnetic resonance imaging it is possible to produce a map of the hydrogen density
throughoutavolumeofthepatientbecauseincreasesinthedensityofhydrogennucleiproducesa
signalassociatedwiththeirrelaxationhavingagreateramplitude.
Alternatively,imagescanalsobeobtainedusingthevaluesofT 1andT2.Images,whosecontrastis
dominatedbydifferencesintheT1valuesarecalledT1weighted,thosedominatedbyT2differences
Becausetumoursarecharacterisedbyrapidcelldivisionandhigh
growthrates,theytypicallyhaveahigherpercentageofwaterand
similarnoncanceroustissue,andcanthusbeclearlyimagedusing
MR.
Haemoglobinmoleculesinredbloodcellsalsoprovideaclearlyidentifiableresonancesignaland
soMRIcanbeusedtocomparethebloodcontentofdifferenttissues.Thisisoftengreaterin
canceroustissue,becauseofthehighgrowthrates,andsoMRIisaneffectivediagnostictoolfor
canceroustissue.
MRIscansofthebrainshowmorecontrastanddetailthanconventionalXrayorCTscansbecause
ofthedifferencesinwatercontentofthegreymatterandwhitematterofthebrain.Atypicalbrain
MRIisshownbelow(left).ExcellentsofttissueresolutioncanalsobeseenintheMRIofthechest
(right).
Contrast media in MRI
Magneticresonance(MR)contrastagentsareuniqueinradiologybecauseitisnotthechemicalthat
isdetected,butrathertheeffectthatthechemicalhasonsurroundingmoleculesthatisdetected.
MRimagingreliesonsignaloriginatingfromhydrogennucleiinwaterandfat.Theseprotonshave
properties known as T1 and T2 relaxation times, which vary depending on the immediate
surroundings,andaffectsignalmagnitudefromthegivenregion.MRimagingusesmagneticfield
changestoaccentuatethedifferenceinsignalmagnitudesfromdifferentregions.Thereasonthat
differentanatomicstructurescanbeseenonanMRIislargelyduetodifferencesinT1andT2
relaxationtimesbetweendifferenttissues.
Thegradientcoilsproducesmallvariationsinthemagneticfieldacrossthepatientsbodysothat
themagneticfieldintensityhasauniquevalueateverypointinthepatientsbody.Thismeansthat
thehydrogenatomsateachpointhaveaknown,anduniqueLarmorfrequency.Boththeexact
positionandthecorrespondingLarmorfrequencyareaccuratelyknown.
ThepulseofradiowavesistransmittedthroughthepatientsbodyfromtheRFcoils.Thisflipsthe
magneticaxesofthehydrogennuclei.Astheyflipback(relaxation)theatomswithineachvolume
element(voxel)emitradiowaveswithaintensityproportionaltothenumberofhydrogenatomsin
thevoxel.
ThefrequencyoftheRFisvariedandthehydrogennucleiwithineachvoxelresonateattheir
characteristicLarmorfrequency.Dataisthusgatheredconnectingthelocationofthevoxeltothe
hydrogenatomconcentration.FromthisdataonetypeofMRimageiscomputed.
The relaxation data from each voxel are what really provides the key information for the
computationoftheimage.
Insomecases,chemicalagentsthatconcentrateinspecificorgansandwhichresponduniquelyto
MRareintroducedintothebodytoprovideanenhancedimage,similartotheuseofcontrastagents
inxradiography.
MRIisoneofthemoreexpensiveimagingtechnologies.Becauseithasbetterresolvingcapabilities
thanultrasoundandCT,itisoftenusedasalastresortwhenthoseothertechnologiesfail.
Increasingly however, patients are demanding from the outset, access to the best available
technology. Doctors are also coming under increasing pressure from litigants who pursue
compensationwhenadoctorfailstopursueeverypossibleavenuethattechnologyhastooffer.
TheresultisthatsomedoctorsnowroutinelyorderanMRIifthereistheslightestreasonfor
suspectingthatitmayrevealwhatothertechnologieswillnot.Theeconomiccostisveryhigh
because our system of medical insurance means that few patients pay the full cost of such
procedures.
Thecosthowevermustbemet,sincethehospitalsandprivatepracticesusingimagingtechnologies
must factor in capital and ongoing costs. As a result of the growing use of MRI especially,
insurancecostshaveincreasedsubstantially.
Qualityoflifehasimproved.Costshaveincreased.Asasociety,wehavemadeachoice.
Questions
1. Examinetheimagesbelow.
Image1 Image2
Image3 Image4
Identifytheimagingtechnologyusedtoproduceeachoftheimages.
2. Nucleihavinganetspinincludehydrogen,phosphorus31andcarbon13.Explaincarefully
whythesenuclidesmusthaveanetspin.
3. Explainwhyfluorine19hasanuclearmagneticmoment,butnitrogen14doesnot.
4.
5.
6.
7.