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International Journal of Nursing Studies 51 (2014) 5162

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International Journal of Nursing Studies


journal homepage: www.elsevier.com/ijns

Review

Music therapy improves sleep quality in acute and chronic


sleep disorders: A meta-analysis of 10 randomized studies
Chun-Fang Wang *, Ying-Li Sun, Hong-Xin Zang
Department of Cardiovascular Surgery, Center for Cardiovascular Disease, Pingjin Hospital, Logistics University of Chinese Peoples Armed
Police Forces, Tianjin, PR China

A R T I C L E I N F O A B S T R A C T

Article history: Objective: To evaluate the efcacy of music therapy for acute and chronic sleep disorders in
Received 14 November 2012 adults.
Received in revised form 5 March 2013 Design: Systematic review and meta-analysis.
Accepted 16 March 2013
Data sources: A systematic search of publications in PubMed, Embase, and the Cochrane
Library without language restriction was performed.
Keywords:
Review methods: Studies with randomized controlled design and adult participants were
Music
included if music was applied in a passive way to improve sleep quality. Subgroup analysis
Sleep disorders
Sleep quality was conducted to explore the sources of heterogeneity.
Meta-analysis Results: Ten studies involving 557 participants were identied. The sleep quality was
improved signicantly by music (standard mean difference: 0.63; 95% CI: 0.92 to
0.34; p < 0.001), with signicant heterogeneity across studies. Subgroup analysis found
heterogeneity between subgroups with objective or subjective assessing methods of sleep
quality, and between subgroups with difference follow-up durations. No evidence of
publication bias was observed.
Conclusion: Music can assist in improving sleep quality of patients with acute and chronic
sleep disorders. For chronic sleep disorders, music showed a cumulative dose effect and a
follow-up duration more than three weeks is necessary for assessing its efcacy.
2013 Elsevier Ltd. All rights reserved.

What is already known about the topic? What this paper adds

 Chronic sleep disorders are associated with adverse  Music can assist in treating both acute and chronic sleep
health outcomes. disorders.
 Acute sleep disorders of patients after operation or  For chronic sleep disorders, music therapy shows a
patients in intensive care unit are associated with worse cumulative dose effect.
prognosis.  A follow-up duration more than three weeks is necessary
 Music has been used to improve the sleep quality from an for assessing the efcacy of music for chronic sleep
ancient time, but prospective clinical trials presented disorders.
conicting results.
1. Introduction

Sleep is a primitive behavior of humans. Unfortunately,


* Corresponding author at: Department of Cardiovascular Surgery, according to epidemiological studies, about one third of
Pingjin Hospital, No. 220 Chenglin Street, 300126 Tianjin, China.
Tel.: +86 022 60577599; fax: +86 022 60577600.
adults reported sleep disorders (Krueger and Friedman,
E-mail address: wangchunfangemail@gmail.com (C.-F. Wang). 2009), especially in older and shift-workers (Kronholm

0020-7489/$ see front matter 2013 Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.ijnurstu.2013.03.008
52 C.-F. Wang et al. / International Journal of Nursing Studies 51 (2014) 5162

et al., 2008; Rowshan Ravan et al., 2010). As to in-hospital multiple published articles from the same study were
patients, duo to the change of environments and the noise available, only the article with the most detailed informa-
of medical equipments, acute sleep deprivation is com- tion was included.
mon, especially in peri-operative patients or patients in
intensive care unit (Hardin, 2009; Kamdar et al., 2012). 2.2. Data extraction and study quality
Chronic sleep disorders have proved to be associated
with adverse health outcomes, including cardiovascular Our primary outcome was the sleep quality which was
disorders (Cappuccio et al., 2011; Chien et al., 2010), total assessed using subjective methods such as questionnaire, or
mortality (Cappuccio et al., 2010a, 2010b; Castro-Costa objective methods such as polysomnography. All literature
et al., 2011; Kronholm et al., 2011), type 2 diabetes search results were screened independently by two authors
(Cappuccio et al., 2010a, 2010b), respiratory disorders (W-CF and S-YL) for potentially relevant articles, and
(Penzel et al., 2007), and obesity (Cappuccio et al., 2008). In uncertainty or disagreement were resolved by discussion
addition, acute sleep deprivation can also worsen the and consensus. Data extraction was performed using a
prognosis. standardized protocol and data-collection form. Extracted
Pharmacological therapy has been wildly used to treat data included the rst authors name, year of publication,
sleep disorders, but the potential side effects limit a long- study population, the sample size, participants age and
term intervention. Realizing that sleep is affected by both gender, duration of follow-up, the intervention for each
physiological and psychological factors, people resorted to group, method to assess the sleep quality, and result in each
kinds of mind-body interventions such as music therapy, group. Studies were assessed for quality by randomization,
which indeed have been used from a very ancient time blinding, reporting of withdrawals, generation of random
(Cervellin and Lippi, 2011). In fact, music is the most numbers, and concealment of allocation. Trials scored one
welcomed method used by nurses to improve the patients point for each area addressed, with a possible score between
sleep quality (Bouhairie et al., 2006). 0 and 5 (Moher et al., 1998).
Some earlier studies succeeded to prove the efcacy of
music in improving sleep quality (Kullich et al., 2003; Lai 2.3. Statistical analysis
and Good, 2005; Renzi et al., 2000; Zimmerman et al.,
1996). Although a previous meta-analysis (de Niet et al., Since continuous data from different scales were
2009) recommended the music-assisted relaxation to extracted, the standardized mean difference (SMD) was
patients with sleep disorders, the evidence was limited used as the measure of effect and the results were expressed
because only 5 studies were available at that time. The as a SMD with 95% condence intervals (CIs). SMD is
result was challenged by several recent studies with calculated by dividing the mean difference in each study by
negative results (Chan et al., 2010; Chang et al., 2012), and the studys deviation, which makes the results comparable
we noticed that only one study included in that mate- across studies. It should be noted that SMD is an index
analysis showed negative result (Hernandez-Ruiz, 2005). without unit, and the results of 0.2 are usually interpreted as
With accumulating evidence, our goal was to evaluate the small, those of 0.5 as moderate and from 0.8 as large.
efcacy of music for sleep disorders by conducting a meta- The heterogeneity among studies was tested by Q-
analysis of prospective cohort studies. statistic (signicance level at p < 0.10) and I-statistic
(Higgins et al., 2003). The result of I-statistic is I2, which
2. Methods describes the percentage of total variation across studies
that is due to heterogeneity rather than due to chance,
2.1. Search strategy and study selection where high values of the index (I2 > 50%) indicate the
existence of heterogeneity.
We attempted to follow the PRISMA (Preferred The combined SMD were computed using xed-effects
Reporting Items for Systematic reviews and Meta-Analy- models with no evidence of signicant heterogeneity. In the
ses) guideline to report the present meta-analysis (Moher presence of heterogeneity, random-effects models are more
et al., 2009). We systematically searched the electronic appropriate because they assume that the effect being
databases PubMed, Embase, and the Cochrane Library estimated in the different studies are not identical. Publica-
without language restriction. The following search terms tion bias was assessed with funnel plots and Egger regression
were used: sleep, sleep quality, insomnia, music, music test (Egger et al., 1997). Sensitivity analysis was performed
intervention, music relaxation, music therapy. The refer- to explore the inuence of individual studies by deleting 1
ence lists of original and review articles were reviewed to study in each turn. Subgroup analysis was conducted to
identify any additional relevant studies. assess possible sources of heterogeneity by checking the
Studies were included in the meta analysis if they met heterogeneity between subgroups with different average
the following criteria: (1) a randomized controlled design, ages, geographical locations, or follow-up durations, with
(2) adult population over 18 years of age were involved, (3) acute or chronic sleep disorders, and with subjective or
music was applied in a passive way to improve sleep objective sleep quality assessing methods. Signicant
quality, (4) the sleep quality was assessed using a heterogeneity between subgroups indicates that the sub-
subjective or objective method. Studies were excluded group factor may explain part of the total heterogeneity.
if: (1) participants suffering neurological or severe cogni- A p-value < 0.05 was considered to be statistically
tive disorders were enrolled, (2) active use of music was signicant. All statistical analyses were performed using
used as intervention, such as playing instruments. If Stata software (version 11.0; Stata Corporation, College
C.-F. Wang et al. / International Journal of Nursing Studies 51 (2014) 5162 53

Fig. 1. Flow chart of study selection.

Station, TX) and REVMAN software (version 5.0; Cochrane Richards-Campbell Sleep Questionnaire (RCSQ), ve stud-
Collaboration, Oxford, United Kingdom). ies used the Pittsburgh Sleep Quality Index (PSQI), another
one study used the Verran and Synder-Halpern (VSH)
3. Results sleeping scale, and the remaining study used a visual
analog scale (VAS). Two studies used polysomnography to
3.1. Main features of included studies measure the quality of sleep. Among the objective sleep
measures that polysomnography supplied, we selected the
Two hundred and twenty-seven articles were obtained sleep efciency (total sleep time/total recording time) as
from the initial search. Ten studies involving 557 our primary outcome.
participants were identied based on our criteria (Chan
et al., 2010; Chang et al., 2012; Harmat et al., 2008; 3.2. Music and sleep quality
Hernandez-Ruiz, 2005; Kullich et al., 2003; Lai and Good,
2005; Renzi et al., 2000; Richards, 1998; Ryu et al., 2012; The outcomes with different methods were not
Zimmerman et al., 1996) (Fig. 1). The excluded studies are directly comparable. A high PSQI value means a lower
listed in the Appendix. All articles were in English except sleep quality, while a high RCSQ, VSH or SE value means
one in German. Two studies were found to be published the opposite. The scores of RCSQ, VSH or SE were
twice in separate articles (Chan, 2011; Chan et al., 2010; converted by subtracting the real score from the maxi-
Lai and Good, 2005, 2006), and the most detailed one was mum score.
selected. The characteristics of these studies are presented The quality of sleep was improved signicantly by
in Table 1. Four studies focused on post-operative acute music (SMD: 0.63; 95% CI: 0.92 to 0.34; Z = 4.24,
sleep disorders in hospital with the follow-up durations p < 0.001; Fig. 2) using random-effect model, with
less than 4 days. The other 6 studies focused on chronic signicant heterogeneity (I2 = 64%; X2 = 24.88, p = 0.003).
sleep disorders, 2 of them with the follow-up durations Similar effects were shown between subgroups with acute
between 4 and 5 days and the remaining 4 studies with the or chronic sleep disorders ((I2 = 0%; X2 = 0.40, p = 0.53). The
durations between 3 and 4 weeks. funnel plot was inspected and found to be roughly
Eight studies used subjective, self-rating scale to symmetrical, and the Egger regression test also showed
measure the quality of sleep. One study used the no evidence of signicant publication bias (p = 0.42).

Table 1
Characteristics of included studies.

Author Year Age Male (%) Simple Country Followup Participants characteristics Measure Quality
(mean) size duration score

Zimmerman 1996 67 68 96 USA 2 days In hospital, post-CABG RCSQ 2


Richards 1998 66 100 69 USA 1 day In hospital, CCU PSG 2
Renzi 2000 46 60 86 Italy 1 day In hospital, post-anorectal VAS 3
operation
Kullich 2003 48 63 65 Austria 3 weeks In stationary rehabilitation PSQI 2
Hernandez-Ruiz 2005 35 0 28 USA 5 days Abused women in shelter PSQI 2
Lai 2005 67 /* 60 Taiwan 3 weeks In community PSQI 4
Harmat 2008 23 22 94 Hungary 3 weeks Students in university PSQI 4
Chan 2010 76 45 42 Hong Kong 4 weeks In community PSQI 4
Chang 2012 32 6 50 Taiwan 4 days Volunteer PSG 4
Ryu 2012 61 66 58 South Korea 1 day In hospital, post-coronary angiography VSH 4

CABG = Coronary artery bypass grafting; CCU = Coronary care unit; RCSQ = Richards-Campbell Sleep Questionnaire; PSG = Polysomnography; VAS = Visual
analog scale; PAQI = Pittsburgh Sleep Quality Index; VSH = Verran and Synder-Halpern sleeping scale.
* Data were not reported.
54 C.-F. Wang et al. / International Journal of Nursing Studies 51 (2014) 5162

Fig. 2. Forest plot shows difference of sleep quality between participants with music therapy and control group, expressed as standardized mean difference
(SMD).

3.3. Sensitivity and subgroup analysis 4. Discussion

Exclusion of any single study did not materially alter the This study shows music can help to improve the
overall SMD, with a range from 0.55 (95% CI: 0.83 to quality of sleep in a wild range of populations, including
0.28) to 0.72(95% CI: 0.98 to 0.47). No heterogeneity patients after operation with acute sleep disorders, as
was found between subgroups with different average ages, well as students in university and elders in community
participants from hospital or not, or different geographical with chronic sleep disorders. Similar results were shown
locations. Signicant heterogeneity was presented between in subgroups with different ages or geographical
studies with different follow-up durations, and with locations.
subjective or objective sleep quality assessing methods. Substantial heterogeneity was observed among all
Signicant pooled effect was only shown in studies with studies. Subgroup analysis found heterogeneity between
follow-up duration shorter than 4 days or longer than 2 subgroups with objective or subjective methods, and with
weeks, and with subjective methods (Table 2). different follow-up durations, but not between inpatients
and participants out of hospital. The heterogeneity could
Table 2 mostly be explained by the negative results in studies
Subgroup analyses to explore sources of heterogeneity. which focused on chronic sleep disorders but with the
Subgroups Sleep quality follow-up durations less than 3 weeks. Actually, a
cumulative dose effect was showed in four of the included
Studies SMD (95% CI), p for
heterogeneity studies (Chan et al., 2010; Harmat et al., 2008; Kullich et
al., 2003; Lai and Good, 2005), and the effect reached no
Geographic location
USA and Europe 6 0.65( 0.91 to 0.38) plateau after 3 weeks. Previous studies also pointed out
Asia 4 0.61( 1.03 to 0.08) that 3 weeks is a recommended period of time for
p = 0.91 observing chronic changes of sleep patterns and the
Average age (years) effects of a new intervention on sleep quality (Chan et
35 3 0.47( 1.41 to 0.48)
al., 2010). It is a follow-up duration less than 3 weeks that
3565 3 0.81( 1.29 to 0.33)
>65 4 0.60( 0.91 to 0.29) resulted in the absence of positive efcacy of music
p = 0.72 therapy for chronic sleep disorders.
Follow-up duration Although the results of objective methods have proved
<4 days 4 0.74( 1.13 to 0.34)
to be closely related to subjective sleep quality, especially
4 days to 2 weeks 2 0.02( 0.44 to 0.48)
3 weeks to 4 weeks 4 0.79( 1.21 to 0.37) the index of sleep efciency (Akerstedt et al., 1994;
p = 0.02 Kushida et al., 2001), no tool is available for a
Sleep quality assessing methods comprehensive assessment of sleep quality with varied
Objective 2 0.06( 0.60 to 0.48) objective indices like the subjective questionnaires, which
Subjective 8 0.77( 1.04 to 0.50)
may explains the slight heterogeneity between them.
p = 0.02
The consistence of results between participants from
SMD = standardized mean difference.
different geographical locations implies that music is a
C.-F. Wang et al. / International Journal of Nursing Studies 51 (2014) 5162 55

fundamental aspect of human experience and deeply 4.1. Limitations


ingrained in all cultures. Although some studies in Asia
used traditional music other than western classic music There are several limitations to our analysis. First, the
which was mostly used in other studies, these music nature of this intervention makes a double-blinding design
pieces are all characterized by a tempo of 6080 beats per impossible. Secondly, the sample size in each study is
minute, slow stable rhythm, low-frequency tones, and relatively small. Thirdly, the quality of some studies is
soothing and relaxing melodies. Familiarity to the relatively low. Some earlier studies did not detail the
selected music may improve the compliance which methods to generate the random numbers and/or declare
should be considered when implying the music therapy the concealment of allocation, which got quality scores 2 or
(Chi and Young, 2011). 3. Fourthly, substantial heterogeneity was presented.
The possible underlying mechanisms are not fully Although the major source of heterogeneity was detected
understood. As to acute sleep disorders, previous evidence through subgroup analysis, uncontrolled or unmeasured
showed that music was effective for pre-operative anxiety factors potentially produce bias. Fifthly, the longest follow-
(Beccaloni, 2011; Pittman and Kridli, 2011), as well as post- up duration was no more than 4 weeks which left it unclear
operative pain (Engwall and Duppils, 2009). The improve- that whether the efcacy of music can maintain or even be
ment of sleep quality presented in the studies with better after a longer follow-up. Sixthly, although SMD was
postoperative patients can be obviously attributed to the used to pool the results, the difference between various
music-induced relief of anxiety and pain, which may cause subjective methods used in studies could still induce a
acute sleep disorders. Music acts upon the central nervous signicant heterogeneity and bias. Finally, various objec-
system, especially the deeper, more ancient parts of the tive indices were presented by polysomnography, but we
brain such as limbic system. In addition, music also has an only assessed the sleep efciency which may miss some
effect on the modulation of endogenous opioids and other useful information.
oxytocin (Bernatzky et al., 2011), which may contribute to
the efcacy of music therapy for chronic sleep disorders.
However, more researches are needed to explore the 5. Conclusion
mechanisms of kinds of sleep disorders and how music
affects them in different ways. Music appears to be effective in treating acute and
Music therapy is low cost and safe, is easy to learn, and chronic sleep disorders. It is low cost and safe, and could be
could be used readily by nurses in hospital as well as used to improve sleep quality in various populations with
health-care professionals in community. For peri-opera- different ages and culture backgrounds, in hospital or in
tive patients, nurses can offer sleep-inducing music to help community. Our study also gives an indication that music
them sleep and relax. The accidence of chronic sleep shows a cumulative dose effect for chronic sleep disorders.
disorders is high in elderly people. Health-care profes- A follow-up duration more than three weeks is necessary
sionals can encourage them to listen to appropriate music for assessing the efcacy of music, which have an
as an alternative self-care skill and provide them with implication for the design of trial evaluating the efcacy
adequate advice, which may help to improve their quality of music therapy for chronic sleep disorders.
of sleep and life. It should be noted that our results were
Conict of interest: None declared.
limited because of the relatively small size of each included
Funding: None.
study, and the efcacy of music for sleep disorders should
Ethical approval: None.
be tested in larger studies involving populations with acute
or chronic sleep disorders separately.
When music is used to improve sleep quality, the key
issues are the selection of music and the protocol to Appendix 1. List of the excluded articles and the
conduct the intervention. Although the pieces of music reasons for exclusion
selected in previous studies shared in some common
characteristics, some studies identied that the efcacy of Wrong exposure
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