Академический Документы
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Культура Документы
Class:
Imidopyrin analgesic
Mode of Action:
It has a potent analgesic, anti-inflammatory and antipyretic action on animal body.
Indication:
It is used in pain, fever, spastic condition, colic, post surgical analgesic and other
inflammatory condition.
Dosage:
Cattle: 10-20 gm
Horse: 10-30 gm
Sheep/ goat: 1-4 gm
Dog/ Cat: 0.5- 2.5 gm
Contraindication:
Hyper sensitive animals
Preparation:
Name of the Manufacturing Form of the Concentration Presentation
product company preparation
ANALGIN Intervet SPAH Injection 500mg/ml 30 ml
ANALGIN KAPL Injection 500mg/ml 30 ml
ANALGIN Vetindia Injection 500mg/ml 30 ml
GANGIN Ethicare Injection 500mg/ml 30 ml
MORPIN Morvel Injection 500mg/ml 30 ml
VETALGIN Intervet SPAH Injection 500mg/ml 30 ml
CHLORPHENIRAMINE MALEATE
Mode of Action:
Chlorpheniramine maleate exerts H1 receptor antagonist action along with anticholinergic and
sedative effect
Indication :
Allergic dissorder like eczema, urticaria , skin oedema , photo dermatitis , dermetitis , rhinitis ,
pregnancy toxemia, RFM , mastitis , burns , anaphylatic shock and reactions , insect bites ,
stomatitis , serume sickness laminitis , rumen atony in cattle
Dosage :
Precaution :
Sedetion, CNS exitement, GI disturbances, terratogenic effects are the side effects that may occur
Preparations:
Alergo(jeps)
inj. 10mg/ml 100 ml vial 48.00
Anistamin(intas)
inj. 10mg/ml 30 ml vial 19.00
Inj. 10mg/ml 50 ml vial 25.00
Inj. 10 mg/ml 100 ml vial 38.00
Biostamin(ibc)
Inj. 10mg/ml 30 ml vial 00.00
Cadistin(zydus AHL)
Inj.. 10 mg/ml 30 ml vial 16.00
Inj. 10 mg/ml 100 ml vial 33.00
Chloril(TTK)
Inj. 10mg/ml 30 ml vial 17.00
Inj. 10 mg/ml 100 ml vial 35.00
Clomet(geevet)
Inj. 10 mg/ml 30 ml vial 19.00
Inj. 10 mg/ml 100 ml vial 49.00
CPMvet(cipla)
Inj. 10 mg/ml 30 ml vial 15.90
Inj. 10 mg/ml 100 ml vial 36.40
Histanil(vetindia)
Inj. 10 mg/ml 10 ml vial 4.50
Inj. 10mg/ml 30 ml vial 16.60
Inj. 10 mg/ml 100 ml vial 33.30
N-Vil(novitech)
Inj. 10 mg/ml 30 ml vial 16.00
Inj. 10 mg/ml 100 ml vial 27.00
Zeet(Alembic)
Inj. 10 mg/ml 30ml vial 16.00
Inj. 10 mg/ml 100 ml vial 33.50
DEXAMETHASONE
Class:
Mode of action:
It is a catabolic steroid. They are designed to break down the stored resources (fats, sugar
and proteins) of animal body, so that they may be used as fuels in the times of stress and
emergency. So it is known as Life saving drug.
Dexamethasone is a glucocorticoid agonist. It crosses the cell membrane and bind with
high affinity to specific cytoplasmic recptors. These result in modification of
transcription process and ultimately alteration in protein synthesis. This leads to
inhibition of leucocytes infiltration at the site of inflammation. So, it acts as an anti
inflammatory and immuno-suppressive drug. It is 20 30 times more potent than the
naturally occurring hormone hydrocortisone and 10 times more potent than prednisolone.
Indication:
Acute inflammation, bursitis, tendonitis, arthritis, allergic skin disease, asthma,
hypersensitivity reaction, shock, tissue damage, toxemia, stress from trauma, disease,
environment, emotions and fatigue, ophthalmic inflammatory conditions, induction of
parturition, ketosis.
Dosage:
(Total dose)
Contra indications:
Late pregnancy, recent major surgery, deep corneal ulceration, diabetes mellitus, cardiac
insufficiency and renal disease.
Preparations:
Name of the product Manufacturing Form of the Concentration Presentation Price
company preparation (Rs.)
DEXONA Zydus AHL Inj. 4.4 mg/ml 5 ml 9.90
+DEXONA Zydus Alidac Tab. 0.5 mg 10s 2.24
DEXAMETHASONE Vetindia Inj. 4 mg/ml 5ml/10ml 18.0/36.0
DEXAL Geevet Inj. 10ml/30ml 24.0/49.0
NOVIDEX Novitech Inj. 4 mg/ml 5ml 18.00
DEXAMETHASONE KAPL Inj. 4 mg/ml 5ml/10ml
SODIUM
PHOSPHATE
KETOCORT Intas Inj. 4 mg/ml 5ml/10ml
DEXASONE Vetnova-cadila Inj. 4 mg/ml 5ml 16.42
pharma.
ETHAMSYLATE
Class: Haemostatic
Mode of action:
It exerts haemostatic action by stabilizing the capillary wall.
Indicatoins:
Pre and Post-operative haemorrhages, Haemagalactia, Haemorrhages of various origin
Dosage: IM, IV
Cattle, Dog, Cat- 250-500mg QID
Preparations:
1) +ETHACLOT Cosme HC
INJ 125mg/ml 2ml 19.00
2) +ETHAMCIP Cipla
Mode of action:
Indication:
Dosage:
Precautions:
These are also termed as non-narcotic analgesics. Ketoprofen has mainly theree major
types of effect (a) anti-inflammatory effect, (b) analgesic and (c) antipyretic effect. All of
these effects are relate to the primary action of drug inhibition of arachidonate cyclo-
oxygenase and thus inhibition of the production of prostaglandinnds and thromboxanes.
There are two type of cyclo-oxygenase(COX1 AND COX2) . COX1 is a constitutive
enzyme expressed in most tissues, including blood platelet, and is involved in cell-cell
signaling and tissue homeostasis. COX2 is induced in inflammatory cells when they are
activated and is believed to be the inhibitors of both isoenzymes. Clearly the anti-
inflammatory action of Ketoprofen is related to their inhibition of COX2 and their
unwanted effects are due to their inhibition of COX1.
Side effect:
Products:
Class:
Oxicam NSAID(Non-Steroidal Anti- Inflammatory Drug)
Mode of action:
Inhibits the synthesis of PGE2 by more selectively inhibiting the cyclo oxygenase (cox-2)
enzyme, thereby exerting potent anti-inflammatory, anti-exudative, analgesic and anti-
pyretic effects.
Indications:
* Mastitis * Sprain/Fractures
* Pneumonia * Laminitis
* Bronchopneumonia/Pleurisy * Dermatitis
* Metritis * Calf Diarrhoea
* Arthritis/Osteoarthritis * Equine Colic
* Perioperative care * Otitis
* Prolapse * Mastitis-Metritis-Agalactia
syndrome
* Myositis * Degenerative Joint Disorders
Dosage:
PNEUMONIA, PROLAPSE
Cattle, Sheep, Goat, Pig, Horse, Dog 0.5 mg/kg BW
OTHER CONDITIONS
Cattle, Sheep, Goat, Pig, Horse ,Dogs 0.2-0.3 mg/kg BW
Oral dosage for dogs (initial) 0.2mg/kgBW
(maintenance)
0.1mg/kgBW
Precautions:
Do not use in animals suffering from gasto-intestinal disorder, impaired hepatic, cardiac
and renal function or where there is an evidence of individual hyper sensitivity to the
drug.
Preparations:
Mode of action:
Methylprednisolone is a glucocorticoid anti-inflammatory drug. Anti-inflammatory
effects are complex, but they operate primarily via inhibition of inflammatory cells and
suppression of expression of inflammatory mediators. Compared to prednisolone,
Methylprednisolone is 1.25 times more potent.
Dosage:
Dogs:
Class:
Anti-emetic/Anti-vomiting drugs
Action:
Metoclopromide have specific action Dopamine antagonistic action blocking the
Dopamine receptors which induce emesis and also increases gastric motility and emptying
the gastric contents to posterior segment. Another significant of this medication is that it
increases the pressure at the lower esophagus, thereby preventing stomach acid from
entering the esophagus. The medication can be administered in pets with gastroenteritis or
kidney failure.
Indications:
For dogs and cats:
Vomiting due to gastritis, esophageal reflux, impaction, kidney failure.
Dosage:
0.2 - 0.5 mg/kg BW orally
0.01-0.2 mg/kg BW (s/c or i/v)
Precautions:
Restlessness, excitement, extra pyramidal symptoms in young ones. Metoclopromide has
tendency to interact with drugs like cimetidine, tetracycline, insulin, diazepam, atropine
and digoxin. Therefore do not administer the medication if the pet is under treatment that
involves any of this medication.
Side effects:
Includes change in the behavior and mental states in the cat. Anxiety and frenzied behavior
is usually noted in cats. In some cases the medication can also cause symptoms of nausea,
sedation and mild constipation.
Presentation:
TABMETIN Vetsfarma
+PERINORM IPCA
+REGLAN CFL
Mode of action:
Selectively inhibits the cyclo oxygenase (cox-2) enzyme, thereby exerting potent anti-
inflammatory, anti-exudative, analgesic and anti-pyretic effects with decreased gastric
irritation.
Indication:
It is used in cattle, buffalo, sheep, goat and dog for symptomatic relief of pain, pyrexia
and inflammation of musculo skeletal origin and post surgical inflammatory condition.
Dosage:
Dog: 3-5mg/kg BW oral, i/m
Cattle, buffalo,sheep,goat: 2-4mg/kgBW oral, i/m
Precaution:
Use with caution in pregnancy. No sufficient data available for use in horse.
Presantations:
ONDANSETRON
Mode of action:
Clinical use :
Ondanstron is proto type drug of it's class & has been used full in dog & cat to control
emasis which is induce by cisplatin (a potent ematogen) & other chemotherapeutic agent
and rediation treatment.
Ondanstron has been used in small animal suffering from refractory vomiting that has not
responded to other antiemetic. Ex. Vomiting induced by chemotherapy , parvovirus &
hepatic lipidosis.
Ondansetron has been succesfully in puppies with parvovirus entritits that vomit
profusely despite therapy with chlorpromazine or metoclopromide.
Ondansetron dose not block dopomine receptor & apomorphin or motion sickness
induced vomitig.
Adverse effect :
Ondansetron is well tolerated drugs with few side effect. Constipation dizziness &
headache are most reported side effect associated with it's use. They have been no
significant drug
interaction reported with this drugs use. It is broken down by the hepatic cytochrome
P450 system & it has little effect on the metabolism of other drug broken down by this
system.
Dose:
0.1-0.2 mg/kg SC 3 times daily
0.1-0.5 mg/kg IV upto 4 times daily
0.5 mg/kg/hour IV infusion
Preparations :
Sifan Pharmaceuticals
Inj. 2 mg / ml ( Conc. )
Genex Pharma
Tablet 4 mg and 8 mg tab.
PHENIRAMINE MALEATE
Class:
Mode of action:
Pheniramine maleate exterts H1-receptor antagonist action, along with anti-cholinergic
and sedative effect.
Indication:
animals-allergic disorders like eczema, urticaria, skin oedema, photodermatitis,
dermatitis, rhinitis, pregnancy toxemia, RFM, mastitis, burns, anaphylactic shock and
reactions, stomatitis, serum sickness, laminitis, rumen atony in cattle.
Dosage :
Large animal: 5-10 ml
Small animal: o.5-1 ml
Precautions :
Sedation, CNS excitement, GI disturbances, terretogenic effects are the side effects that
may occur.
Presentation:
PHENYL BUTAZONE
It is a weakly acidic lipophillic NSAID, it is metabolised by liver with concentration of drug 2% being
excreted as a parent compound in the urine in some spp. In ruminants bioavailability of phenyl butazone
following I/M administration in cow is 89%, half life is 30-82 hrs.
In horses approved for use in horses as an oral tablet, paste or gel or as and I/V preparation, half life is
3-10 hrs.
Class:
Pyrazolone derivative NSAID
Mode of actions:
Phenylbutazones have anti-inflammatory, anti pyretic & analgesic activity. It produces oxygen
tension reduction & inhibits prostaglandin synthesis by suppressing cyclo oxygenase ( lysosomal
enzyme) activity.
Indications:
Pyrexia, symptomatic treatment of inflammatory & painful condition of muscle, bone, and joints.
Dosage:
Dog- 22mg/kg bwt total daily dose ( maximum dose 800mg/day)
Horse- 1-2 g/450kg bwt total daily dose
Precautions:
Contraindicated in cats due to high toxicity. Accidental injection into carotid artery result in
excitement, prostration and sometimes death.
Preparations:
Sr. no. Name of drug Mfr names. Concentration Major indication Dose Price
1) Artizone-S inj. Vetnex 100 ml IM/IV Ideal drug in the 10-20 126/-
( phenyl butazone Treatment of pyrexia ml/day
IP 200mg, sodium and inflammatory in large
Salicylate IP 20mg) conditions. animals.
Daily doses divided
into 2-3 injections. 5-10ml/
Contraindicated in Day in
Nephritis, cardiac Small
Insufficiency,gastritis Animals.
& haemoglobinuria.
PHENYLBUTAZONE
Class: Pyrazolon derivatives ( salicylate like ) analgesic.
It is a 3,5-dioxo-1,2-diphenyl-4-n-butyl pyrazolidine. It is insoluble in water. It was
synthesized as the result of a search for a compound having therapeutic attributes of
aminopyrine but without its toxicity.
Mechanism of action:
It have anti-inflammatory , antipyretic and analgesic activity. It produce oxygen tension
reduction and inhibits prostaglandin synthesis by suppressing cyclooxygenase
( lysosomal enzyme ) activity.
Indications:
Pyrexia , symptomatic treatment of inflammatory and painful condition of muscle , bone
and joints. Treatment of acute laminitis and osteoarthritis in horse. It is most widely used
equine medicine.
Dosage:
4.4 mg/kg body weight i/v.
Precautions:
Contra indicated in cats due to high toxicity. Accidental injection into carotid artery result
in excitement , prostration and sometime death.
Toxicity:
Idiosyncrasy has been reported in a dachshound following treatment with
phenylbutazone. A fatal condition characterized by severe haemorrhages , billiary stasis ,
and renal tubular degeneration was observed in this case.
SALICYLIC ACID
Class: Salicylate analgesic
Use:
Its principle use internally is in cattle as an antifermantative agent. It is restricted almost
entirely to external application because it is extremely irritating to the gastric mucosa.
Combination with benzoic acid it is used in Whitfields ointment for antifungal activity.
Dosage:
16-24 gm salicylic acid has been used to decrease the amount of gas produced by
bacterial fermentation.
Preparations:
1. ARTIZONE-S Vetnex
INJ ( Phenylbutazone 200 mg, Sodium salicylate 20 mg )/ ml
Dosage : IM , IV
Large animals 10-20 ml
INJ 30 ml 44.00 Rs
INJ 100 ml 126.00 Rs
2. BUTASYL Neospark
INJ (Phenylbutazone 200 mg, Sodium salicylate 20 mg )/ ml
Dosage : IM , IV
Large animals 10-20 ml
INJ 30 ml 39.25 Rs
INJ 100 ml 109.00 Rs
3. CIPIZONE Cipla
INJ (Phenylbutazone 200 mg, Sodium salicylate 20 mg )/ ml
Dosage : IM , IV
Large animals 10-20 ml
INJ 30 ml 00.00 Rs
4. HIGESIC Jeps
INJ (Phenylbutazone , Sodium salicylate )/ ml
Dosage : IM
Large animals 5-15 ml
Small animals 1-5 ml
INJ 30 ml 30.00 Rs
5. SALPHEN Vetindia
INJ (Phenylbutazone 200 mg, Sodium salicylate 20 mg )/ ml
Dosage : IM , IV
Large animals 10-20 ml
INJ 30 ml 41.00 Rs
INJ 100 ml 115.00 Rs
6. UDIL-S VET Morvel
INJ (Phenylbutazone 200 mg, Sodium salicylate 20 mg )/ ml
Dosage : IM , IV
Large animals 10-15 ml
Small animals 5-10 ml
INJ 30 ml 36.55 Rs
TRIAMCINOLONE
Mode of action :
Indication :
Triamcinolone is highly potent gluco-corticoid effective in the treatment of inflammation
and related disorders. It may indicated in the management and treatment of acute arthritis,
tendo synovitis, myocytis, bovine ketosis and allergic and dermatological disorders.
Dosage :
Oral
Dog: 0.050 mg/kg body weight b.i.d /t.i.d
Contraindication:
Do not use in viral infections. Except for emergency therapy. Do not use in animal with
tuberculosis, chronic nephritis, cushingoid syndrome and peptic ulcers. Existence of
congestive heart failure, diabetes, pregnancy glucoma and osteoporosis are relative
Contraindications.
Presentation:
CIPCORT (Cipla)
(Inj.) 6mg / ml 5 ml vial 38.00 Rs.
KENACORT (Piramal
HC) 4 mg 10's 19.10 Rs.
Tab. 10 mg / ml 1 ml 24.44 Rs.
Inj. 40 mg / ml 1 ml 50.62 Rs.
Inj.
TRICORT (Cadila)
Tab. 4 mg 10's 19.90 Rs.
Inj. 10 mg / ml 1 ml 19.90 Rs.
Inj. 40 mg / ml 1 ml 49.95 Rs.
VETALOG (Zydus
AHL )
Inj. 6 mg / ml 5 ml vial 38.00 Rs.
Ranitidine
DRUG CLASS AND MECHANISM: Histamine is a natural chemical that stimulates the stomach
cells to produce acid, Ranitidine belongs to class of medications called H2- blockers, that block the
action of histamine on stomach cells thus reducing stomach acid priduction.
PREPARATION:
Capsules( 150mg,300mg)
Syrup (15ml)
PRESCRIBED FOR:
Ranitidine blocks the action of histamines on stomach cells and reduced stomach acid production.
Ranitidine is useful in healing of stomach and duodenal ulcers and in reducing ulcer pain.
Ranitidine has been effective preventing ulcer recurrence when give in low doses for prolonged
period of time. The doses is higher than that used in treatment of ulcer. It also helps in treating
heatburn ulcers and inflammation of esophagus resulting from acid reflux.
DOSING:
May be taken with or without food since ranitidine is excretes by kidney and metabolized by liver
, dosages of Ranitidine need to be lowered in patient with significantly abnormal liver or kidney
function.
DOSES:
DRUG INTERACTION: Antacids may decrease the absorption of Ranitidine. Ranitidine is not
habit forming. Ranitidine can interfere with the metabolism of alcohol patient taking Ranitidine
.who drink alcohol may have elevated blood alcohol levels.
THERAPEUTIC USE:
Product:
+HISTAC Ranbaxy
+RANITIDINE GSK
+RANTAL JB chemicals
+ZINETAC GSK
Dosage:-
Precaution:-
Side effects:-
Fluid retention, moon face (cushing syndrome), acne, constipation. Prolonged use of it
may cause black or black tarry stool, filling or rounding of face, muscles cramp, muscle
weakness, rapid weight gain, increased intraocular pressure.