Pathophysiology of Sepsis

Predisposing: Precipitating:
Age 1. Sterility of the environment
2. Exposure to bacteria
3. Sterility of Delivery

Organism invades the

bloodstream and multiply

Triggers pro- inflammatory mediators

Leukotrines Interleukin 4-10

Lipoxgenase Cytokines
Histamine
Bradykinin

Results in negative feedback Mechanism

Artries & Arterioles dilate Production of micro Impaired removal of CO2 &
thrombi waste products
Inability to retain IVF
Impairs 02 absorption Epithelial cells tubules slough
of epithelial cells
Filing of fluids in the lungs
Loss of functions of nephrons

Collapse alveoli
Acute Renal Failure

Inability for o2 and CO2 exchange

Decrease Blood Supply to brain

Lung Failure
Gross Hypoxia
Hypoxia of the Heart

Brain Dysfunction
Irritability and exhaustion of
heart muscle
Coma
Heart Failure

Death
 A. Actual diagram

Predisposing: Precipitating:
Unknown 1. Sterility of the environment
2. Exposure to bacteria
3. Sterility of Delivery

Organism invades the

bloodstream and multiply

Triggers pro- inflammatory mediators

Leukotrines Cytokines
Lipoxgenase Interleukin 4-10
Histamine
Bradykinin

Results in negative feedback Mechanism

Production of micro
thrombi

Increase gastric acid Impairs 02 absorption

production of epithelial cells
Loss of functions of nephrons
Disruption of gastric
lining Acute Renal Failure

1.Amorphous
Gastric infection Urate formation

2. Pus cells
Bloated Abdomen formation

3. High Level of
Creatinine