Mr.

Sagar Kishor Savale

Curcumin Anti-cancer agent

Mr. Sagar Kishor Savale

M. Pharm (Pharmaceutics)
Curcumin
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Biological Source: The isolation of a yellow coloring-matter
from the rhizomes of Curcuma longa (turmeric) and named as
Curcumin, which is a member of the ginger family
(Zingiberaceae).

Mr. Sagar Kishor Savale

Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale

Curcumin
 Biosynthesis of Curcumin

Mr. Sagar Kishor Savale

Mr. Sagar Kishor Savale Chemical Constituents
Chemical Name (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6 heptadiene-3,5-dione
Synonyms Polyphenols
Molecular Formula C21 H20 O6 Mr. Sagar Kishor Savale

Molecular Weight 368.39 g/mol

Density 1.28 g/cm3
Log P/ hydrophobicity 1.82
pKa 8.30.04
Refractive Index n20D 1.42
Solubility Slightly Soluble in Water, Soluble in Ethanol and Methanol (10 mg/ml), DMSO (25 mg/ml), acetic acid,
0.1M NaOH, acetone, water (< 0.1 mg/ml).
BCS Class Class II
max Methanol: 430 nm
Appearance Bright yellow-orange powder
Physical State Solid Powder
Melting point 175C
Identification Melting point, infrared absorption spectrophotometry (IR), Differential scanning Calorimetry (DSC)
Dose and dosing frequency: Up to 12 gm per day.

Bioavailability: The mean oral bioavailability of curcumin is 2% due mainly to hepatic first
pass metabolism.

Plasma Protein binding: 90 %

Plasma half-life: 11 hrs.

Mr. Sagar Kishor Savale

Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale

Mechanisam action of Curcumin

(Anti-cancer activity)
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale
Contact:
savalesgar484@gmail.com
+91 9960885333