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International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262


www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789

DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20164323
Original Research Article

Analysis of risk factors in surgical site infection following


caesarean section
Anam ul Haq1*, Aasif Abdullah1, Shazieya Akhtar2

1
Department of Obstetrics and Gynaecology, SKIMS Soura, Srinagar, Jammu and Kashmir, India
2
Department of Pathology, SKIMS Soura, Srinagar, Jammu and Kashmir, India

Received: 10 September 2016


Revised: 13 October 2016
Accepted: 15 October 2016

*Correspondence:
Dr. Anam ul Haq,
E-mail: anamulhaq801@gmail.com

Copyright: the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under
the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial
use, distribution, and reproduction in any medium, provided the original work is properly cited.

ABSTRACT

Background: Objective of the study was to find SSI rate following Caesarean section and Analysis of risk factors.
Methods: This prospective randomized study carried out on 1504 patients, their demographic information, risk
factors and surgical indications were recorded. Postoperatively patients were monitored for signs of SSI.
Results: Out of 1504 patients, 13% developed SSI, Hospital stay, wound class, ASA class, antibiotic prophylaxis and
Type of caesarean showed significant association with SSI.
Conclusions: Reason for incidence of SSI higher than developed countries being only tertiary care hospital dealing
with high risk pregnancies, late referrals from peripheries, Prolonged hospital stay, heavy rush of attendants, faulty
supervision where dose of antibiotics is actually missed, no proper segregation of cases.

Keywords: ASA class, Hospital stay, SSI, Wound class

INTRODUCTION become increasingly important to obtain accurate rates of


SSI.
Infection is the clinical manifestation of the inflammatory
reaction incited by invasion and proliferation of Criteria for defining surgical site infections
microorganisms.1 SSI is the second most common
infectious complication after urinary tract infection Superficial incisional SSI
following caesarean delivery.2 The rates of SSI after
caesarean section reported in the literature range from 3% Infection occurs within 30 days after operation and
to 15% depending on the surveillance method used to infection involves only skin or subcutaneous tissue of the
identify infections, the patient population and the use of incision and at least one of the following.
antibiotic prophylaxis.3-9 Maternal morbidity related to
infections has been shown to be eight fold higher after 1. Purulent discharge from the superficial incision.
caesarean section than after vaginal delivery.10 Among 2. Organisms isolated from the superficial incision.
hospitals reporting to the National Nosocomial Infections 3. At least one of these signs or symptoms of infection:
(NNIS) system, the rate of SSI after caesarean section Pain or tenderness, swelling, redness or heat and
was 2.8% to 6.7% depending on the risk index category.11 superficial incision are deliberately opened by
The incidence rate depends on the following: the surgeon, unless incision is culture negative.
definition of SSI adopted, the intensity of surveillance, 4. Diagnosis of superficial incisional SSI by the
the prevalence of risk factors for SSI in the patient group surgeon or physician.
being audited and whether the survey contains post
discharge data[12].Post discharge surveillance has

December 2016 Volume 5 Issue 12 Page 4256


Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262

Deep incisional SSI Vaginal examinations: Prolonged labour increases the


number of vaginal examinations which predisposes the
Infection occurs within 30 days after operation if no patient to post-partum infection.18
implant is left in place or within one year if implant is in
place and the infection appears to be related to the Surgery related factors
operation and infection involves deep soft tissues of the
incision and at least one of the following: Emergency

1. Purulent drainage from the deep incision but not Women who underwent an emergency caesarean delivery
from the organ/space component of the surgical site. for indications such as placental abruption, non-
2. A deep incision spontaneously dehices or is reassuring fetal heart rate and non progressing second
deliberately opened by a physician when the patient stage of labour were more likely to develop a wound
has atleast one of these signs or symptoms of infection.19
infection: fever, localized pain or tenderness, unless
the site is culture negative. American society of anaesthesiologists score
3. An abscess or other evidence of infection involving
the deep incision is found. The American Society of Anaesthesiologists physical
4. Diagnosis of a deep incisional SSI by a surgeon or status classification is a standardized, reproducible
physician. numeric determination that is used routinely to stratify
severity of illness for surgical patients and is known to be
Organ/space SSI a good indicator of host susceptibility to infection.20,21

Infection occurs within 30 days after operation if no Duration of operation


implant is left in place or within one year if implant is in
place and the infection appears to be related to the Patients who underwent surgery for more than one hour
operation and infection involves any part of the anatomy, constituted another group at risk of infection.22,3
other than the incision, which was opened or manipulated
during an operation and at least one of the following: Antibiotic prophylaxis
1. Purulent drainage from a drain that is placed
Prophylactic antibiotics will reduce the incidence of
through a stab wound into the organ/space
endometritis following both elective and non-elective
2. Organisms isolated from fluid or tissue in the
caesarean delivery by two thirds to three quarters and the
organ/space.
incidence of wound infection by up to three quarters.7
3. An abscess or other evidence of infection is found.
4. Diagnosis or an organ/space SSI by a surgeon or
physician. METHODS

This study was a prospective design study conducted on


Determinants of infection
1504 patients selected randomly from August 2014 to
October 2015 in Lalla Ded Hospital Srinagar J and K.
1. Inoculum of bacteria
2. Virulence of bacteria
3. Adjuvant effects of microenvironment Inclusion criteria
4. Innate and acquired host defences
1. Patients who had undergone caesarean in this hospital
Risk factors for wound infection
Exclusion criteria
Host related factors
1. Any patient operated elsewhere
Socioeconomic status: Low socioeconomic status has
consistently been associated with higher rates of post Purpose of study was explained to patients, and their
caesarean infection.14-16 verbal consent taken.

Preterm delivery: Preterm delivery is a known risk factor Data collection


for sepsis; also many preterm deliveries are
emergencies.17 Demographic information, potential risk factors and
surgical indications were recorded.
Rupture of membranes: One factor repeatedly linked to
post caesarean infectious morbidity is prolonged rupture Postoperatively women were monitored for signs of
of the membranes because of more chances of infection. Temperature was measured every day and
contamination. leukocyte count was done if the patient developed fever

International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4257
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262

(temp over 38.0C). Wound culture was not done Majority of cases (45.9%) had class I wound, whereas
routinely unless infection was suspected. 21.6% had class II wound; 27.1% had class III wound
and 5.4% had class IV wound.
The surgical site was considered infected if pus was
found anywhere along the suture line with or without Majority of cases (48.2%) were with mild systemic
dehiscence. disease, whereas 33.8% were normally healthy, 12.8%
with severe systemic disease and 5.3% with
Data analysis incapacitating systemic disease.

Data was expressed as MeanSD and percentages. Majority of caesareans (66.3%) were emergency and
Critical difference of variance for metric data was (33.7%) were elective.
measured at 95% confidence interval by students t test.
Non metric data was similarly analysed by Fishers exact Maximum number of cases (88.9%) had received
test, Mann-Whitney U test, besides logistic regression prophylactic antibiotics whereas (11.1%) had not
analysis was done for determining best predictors along received any prophylactic antibiotics.
with Odds ratio analysis. P 0.05 considered statistically
significant. Statistical SPSS, Mini Tab and MS Excel Majority of cases had superficial (64.1%) whereas
were used for data analysis. (24.6%) had deep and (11.3%) had organ/space SSI.

Definitions Table 1: Various risk factors of SSI.

American Society of Anaesthesiologists Score (ASA) n %


24 406 27.0
Class I - Normally healthy patient. 25 to 29 777 51.7
Class II - Mild systemic disease. Age (yr) 30 to 34 284 18.9
Class III - Severe systemic disease. 35 37 2.5
Class IV - Incapacitating systemic disease that is mean SD 26.93.4 (18, 40)
threat to life. Class I 690 45.9
Class V - Morbid patient who is not expected to Class II 325 21.6
survive 24 hours. Wound Class
Class III 408 27.1
Class IV 81 5.4
Wound class
Normally healthy 508 33.8
Class I - No rupture of membranes or labour. Mild Systemic
725 48.2
Class II - If there was less than 2 hours of Disease
ASA
membrane rupture without labour or labour of any Severe systemic
classification 192 12.8
length with intact membranes. disease
Class III - For rupture of membranes greater than 2 Incapacitating
79 5.3
hours. systemic disease
Class IV - For purulent amniotic fluid. Prophylactic No 167 11.1
antibiotics
Prior to Incision 1337 88.9
RESULTS given?
Elective 507 33.7
Operation type
Demographic information, potential risk factors and Emergency 997 66.3
surgical indications were recorded. Superficial 125 64.1
Type of SSI
Deep 48 24.6
Host related variables included age, preoperative Organ/Space 22 11.3
diagnosis, a preoperative condition assessed by American 16 to 30 days 12 0.8
Society of Anaesthesiologists (ASA) score and total 4 to 7 days 594 39.5
hospital stay. Total hospital
8 to 15 days 630 41.9
stay (day)
16 to 30 days 268 17.8
Surgery related variables included nature of the
>30 days 12 0.8
operation, wound class and antibiotic prophylaxis.
Surgical Site Yes 195 13.0
Majority of the cases (51.7%) were in age group of 25 to Infection (SSI) No 1309 87.0
29 years, whereas 27% were <24 years; 18.9% between
30-34 years and 2.5% cases were >35 years. Majority of cases (41.9%) had total hospital stay of 8 to
15 days, whereas (39.5%) had total hospital stay of 4 to 7
days, 17.8% stay of 16 to 30 days and 0.8% stay of more
than 30 days.

International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4258
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262

Out of total 1504 cases 195 developed SSI and rate was (21.5%) developed SSI out of 79 cases that had
13 % (Table 1). incapacitating systemic disease. The above results depict
that SSI is more prevalent in cases associated with
In our study (8.3%) cases developed SSI out of 690 cases morbidity with higher class ASA, with P value being
of class I wound, (14.2%) developed SSI out of 325 cases 0.000, which is statistically significant (P <0.05); [OR
of class II wound; (18.1%) developed SSI out of 408 1.92] (Table 3).
cases of class III wound and (22.2%) developed SSI out
of 81 cases of class IV wound. The above results depict Table 2: Association of wound class with SSI.
SSI is more prevalent in contaminated wound class with
P value of 0.000 which is statistically significant (p<0.05) Yes No p
OR
[OR 2.01] (Table 2). n % n % value
Class I 57 8.3 633 91.7 0.4
In ASA classification of patients (9.4%) developed SSI Wound Class II 46 14.2 279 85.8 0.000 1.1
among 508 cases that were normally healthy; (13.5%) class Class III 74 18.1 334 81.9 (Sig)* 1.8
among 725 cases who had mild systemic disease; (6.7%) Class IV 18 22.2 63 77.8 2
among 192 cases that had severe systemic disease and * Significant

Table 3: Association of ASA with SSI.

Yes No
p value OR
n % n %
Normally healthy 48 9.4 460 90.6 0.6
Mild systemic disease 98 13.5 627 86.5 0.000 1.1
ASA classification
Severe systemic disease 32 16.7 160 83.3 (Sig)* 1.4
Incapacitating systemic disease 17 21.5 62 78.5 1.9
* Significant
Table 4: Association of prophylactic antibiotics. cases who had received prophylactic antibiotics, (11.1%)
developed SSI. The above results depict that SSI is more
Prophylactic Yes No prevalent in cases who had not received prophylactic
p antibiotics, with a P value of 0.000, which is statistically
antibiotics OR
n % n % value significant (p<0.05); [OR 3.03] (Table 4).
given
No 46 27.5 121 72.5 5.1
0.000 Operation type showed that among 507 elective cases,
Prior to
149 11.1 1188 88.9 (Sig)* 0.2 8.7% developed SSI while from 997 emergency cases,
incision
* Significant 15.1% developed SSI. The results depict that SSI is more
prevalent in emergency caesareans with a P value being
Among 167 cases who had not received prophylactic 0.000, which is statistically significant (P <0.05) [OR
antibiotics, (27.5%) developed SSI while out of 1337 1.88] (Table 5).

Table 5: Association of operation type with SSI.

Yes No
p value OR
n % n %
Elective 44 8.7 463 91.3 0.5
Operation type 0.000 (Sig)*
Emergency 151 15.1 846 84.9 1.9
* Significant

Table 6: Association of hospital stay with SSI.

Yes No
p value OR
n % n %
4 to 7 days 28 4.7 566 95.3 0.2
Total hospital stay 8 to 15 days 52 8.3 578 91.7 0.5
0.000 (Sig)*
(day) 16 to 30 days 103 38.4 165 61.6 7.8
>30 days 12 100.0 0 0.0 171.7
* Significant

International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4259
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262

Out of 594 cases who had total hospital stay of 4 to 7 prophylaxis before procedure, but it was found that not
days, 4.7% developed SSI; 630 cases who had total all emergency caesareans had received prophylaxis
hospital stay of 8 to 15 days, 8.3% developed SSI; 268 before procedure; reason was either nursing staff had not
cases who had total hospital stay of 16 to 30 days, 38.4% given or it was not prescribed on case sheet. Results from
developed SSI and among 12 cases who had total hospital our study showed among 167 cases who had not received
stay more than 30 days, 100% developed SSI. The above prophylactic antibiotics, (27.5%) developed SSI and out
results depict that SSI is more prevalent in cases with of 1337 cases who had received prophylactic antibiotics
prolonged hospital stay with P value of P = 0.000; [OR (11.1%) developed SSI. The above results depict that SSI
171.60] which is statistically significant (Table 6). is more prevalent in cases who had not received
prophylactic antibiotics. Similar findings were observed
DISCUSSION by Beattie, Rings TR et al, Owens SM et al and Killian
CA et al.3,28,29
The overall abdominal wound infection rate of 13% is
comparable with other studies that have used post Emergency caesarean sections are done usually when
discharge surveillance. Similar findings were observed by patient is in labour; mostly membranes are absent,
Barbut F, Carbonne B, Truchot F et al and Mitt P, Lang increased number of vaginal examinations and sometimes
K, Peri A et al, which found significant percentage of SSI miss the dose of prophylactic antibiotics. All these are
is detected by post discharge surveillance.23,24 potent risk factors for infection. In our study 8.7%
developed SSI, out of 507 elective caesareans and 15.1%
Due to referrals from other hospitals, patients fall in developed SSI out of 997 emergency caesareans. SSI was
higher wound class either because of prolonged labour, more prevalent in emergency caesareans with P value
prolonged rupture of membranes or obstructed labour being 0.000; [OR 1.9] which is statistically significant
which is a potent risk factor for SSI when caesarean (p<0.05). The above results are consistent with studies of
section is done. Schneid-Kofman N et al and Amenu Demisew, Tefera
Belachew et al.19,26
In our study Among 690 cases of class I wound, 8.3%
developed SSI. Out of 325 cases of class II wound, Prolonged stay in hospital means more chances of
14.2% developed SSI. Among 408 cases of class III infection because of cross infection by health care
wound, 18.1% developed SSI and from 81 cases of class workers, poor sanitation and poor asepsis. In our study
IV wound, 22.2% developed SSI. The above results out of 594 cases who had total hospital stay of 4 to 7
depict that SSI is more prevalent in cases with more days, 4.7% developed SSI; 630 cases who had total
contaminated wound class. Similar findings were hospital stay of 8 to 15 days, 8.3% developed SSI; 268
observed by Eriksen H, Saether AR et al, Amenu cases who had total hospital stay of 16 to 30 days, 38.4%
Demisew, Tefera Belachew et al, Mitt P et al, Jido TA, developed SSI and among 12 cases who had hospital stay
Garba ID et al, Killian CA et al, and Schneid Kofman N more than 30 days, 100% developed SSI. The above
et al which showed significant association between results depict that SSI is more prevalent in cases with
surgical wound class and SSI.3,19,24-27 prolonged hospital stay with P =0.000 [OR 171.60] which
is statistically significant. The above results are consistent
Our hospital being a sole tertiary care hospital in valley with the study of Nisa M, Naz T, Afzal I et al.30
and most of the patients who are referred from
pheripheries are usually high risk pregnancies with higher CONCLUSION
ASA class, which is a significant risk factor for SSI. In
our study, Out of 508 normally healthy cases (9.4%) The caesarean delivery rate has been steadily increasing
developed SSI. Among 725 cases with mild systemic over the last 30 years and it is common for major centres
disease (13.5%) developed SSI, Within 192 cases of to have a rate in double figures. The development of a
severe systemic disease, (16.7%) developed SSI and from wound infection after caesarean delivery is a morbid
79 cases who had incapacitating systemic disease, event and may result in significant patient discomfort,
(21.5%) developed SSI. The above results depict that SSI inconvenience, embarrassment, prolonged hospital stay,
is more prevalent in cases associated with morbidity. additional surgery and increased cost of community care
Similar findings were observed by Tran ST et al and following discharge.
Barbut F, Carbonne B, Truchot et al, which showed
significant association between ASA class and SSI.4,23 Incidence of SSI was (13%) following caesarean section
which is higher than developed countries.
Numerous studies have recommended that antibiotic
prophylaxis be given to all caesarean delivery cases for Statistically significant risk factors for SSI include wound
prevention of serious infections. class, ASA class, Antibiotic prophylaxis and operation
type and total hospital stay.
In our hospital we have a protocol of giving antibiotic
prophylaxis to all women undergoing caesarean section. The various reasons for such increased rate of SSI are:
We found all elective caesareans had received

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Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262

1. Only tertiary care institute dealing with high risk 8. Yokoe DS, Christiansen CL, Johnson R.
pregnancies. Epidemiology of and surveillance for postpartum
2. Late referrals. infections. Emerg Infect Dis. 2001;7:837-41.
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4. Heavy rush of attendants and inadequacy of bed Infect Dis. 2004;10:1924-30.
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Funding: No funding sources 1982;143:897-901.
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Southwest Ethiopia. Ethiop J Health Sci. 2011 Cite this article as: Haq AU, Abdullah A, Akhtar S.
July;21(2):91-100. Analysis of risk factors in surgical site infection
following caesarean section. Int J Reprod Contracept
Obstet Gynecol 2016;5:4256-62.

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