Академический Документы
Профессиональный Документы
Культура Документы
DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20164323
Original Research Article
1
Department of Obstetrics and Gynaecology, SKIMS Soura, Srinagar, Jammu and Kashmir, India
2
Department of Pathology, SKIMS Soura, Srinagar, Jammu and Kashmir, India
*Correspondence:
Dr. Anam ul Haq,
E-mail: anamulhaq801@gmail.com
Copyright: the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under
the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial
use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Background: Objective of the study was to find SSI rate following Caesarean section and Analysis of risk factors.
Methods: This prospective randomized study carried out on 1504 patients, their demographic information, risk
factors and surgical indications were recorded. Postoperatively patients were monitored for signs of SSI.
Results: Out of 1504 patients, 13% developed SSI, Hospital stay, wound class, ASA class, antibiotic prophylaxis and
Type of caesarean showed significant association with SSI.
Conclusions: Reason for incidence of SSI higher than developed countries being only tertiary care hospital dealing
with high risk pregnancies, late referrals from peripheries, Prolonged hospital stay, heavy rush of attendants, faulty
supervision where dose of antibiotics is actually missed, no proper segregation of cases.
1. Purulent drainage from the deep incision but not Women who underwent an emergency caesarean delivery
from the organ/space component of the surgical site. for indications such as placental abruption, non-
2. A deep incision spontaneously dehices or is reassuring fetal heart rate and non progressing second
deliberately opened by a physician when the patient stage of labour were more likely to develop a wound
has atleast one of these signs or symptoms of infection.19
infection: fever, localized pain or tenderness, unless
the site is culture negative. American society of anaesthesiologists score
3. An abscess or other evidence of infection involving
the deep incision is found. The American Society of Anaesthesiologists physical
4. Diagnosis of a deep incisional SSI by a surgeon or status classification is a standardized, reproducible
physician. numeric determination that is used routinely to stratify
severity of illness for surgical patients and is known to be
Organ/space SSI a good indicator of host susceptibility to infection.20,21
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4257
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262
(temp over 38.0C). Wound culture was not done Majority of cases (45.9%) had class I wound, whereas
routinely unless infection was suspected. 21.6% had class II wound; 27.1% had class III wound
and 5.4% had class IV wound.
The surgical site was considered infected if pus was
found anywhere along the suture line with or without Majority of cases (48.2%) were with mild systemic
dehiscence. disease, whereas 33.8% were normally healthy, 12.8%
with severe systemic disease and 5.3% with
Data analysis incapacitating systemic disease.
Data was expressed as MeanSD and percentages. Majority of caesareans (66.3%) were emergency and
Critical difference of variance for metric data was (33.7%) were elective.
measured at 95% confidence interval by students t test.
Non metric data was similarly analysed by Fishers exact Maximum number of cases (88.9%) had received
test, Mann-Whitney U test, besides logistic regression prophylactic antibiotics whereas (11.1%) had not
analysis was done for determining best predictors along received any prophylactic antibiotics.
with Odds ratio analysis. P 0.05 considered statistically
significant. Statistical SPSS, Mini Tab and MS Excel Majority of cases had superficial (64.1%) whereas
were used for data analysis. (24.6%) had deep and (11.3%) had organ/space SSI.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4258
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262
Out of total 1504 cases 195 developed SSI and rate was (21.5%) developed SSI out of 79 cases that had
13 % (Table 1). incapacitating systemic disease. The above results depict
that SSI is more prevalent in cases associated with
In our study (8.3%) cases developed SSI out of 690 cases morbidity with higher class ASA, with P value being
of class I wound, (14.2%) developed SSI out of 325 cases 0.000, which is statistically significant (P <0.05); [OR
of class II wound; (18.1%) developed SSI out of 408 1.92] (Table 3).
cases of class III wound and (22.2%) developed SSI out
of 81 cases of class IV wound. The above results depict Table 2: Association of wound class with SSI.
SSI is more prevalent in contaminated wound class with
P value of 0.000 which is statistically significant (p<0.05) Yes No p
OR
[OR 2.01] (Table 2). n % n % value
Class I 57 8.3 633 91.7 0.4
In ASA classification of patients (9.4%) developed SSI Wound Class II 46 14.2 279 85.8 0.000 1.1
among 508 cases that were normally healthy; (13.5%) class Class III 74 18.1 334 81.9 (Sig)* 1.8
among 725 cases who had mild systemic disease; (6.7%) Class IV 18 22.2 63 77.8 2
among 192 cases that had severe systemic disease and * Significant
Yes No
p value OR
n % n %
Normally healthy 48 9.4 460 90.6 0.6
Mild systemic disease 98 13.5 627 86.5 0.000 1.1
ASA classification
Severe systemic disease 32 16.7 160 83.3 (Sig)* 1.4
Incapacitating systemic disease 17 21.5 62 78.5 1.9
* Significant
Table 4: Association of prophylactic antibiotics. cases who had received prophylactic antibiotics, (11.1%)
developed SSI. The above results depict that SSI is more
Prophylactic Yes No prevalent in cases who had not received prophylactic
p antibiotics, with a P value of 0.000, which is statistically
antibiotics OR
n % n % value significant (p<0.05); [OR 3.03] (Table 4).
given
No 46 27.5 121 72.5 5.1
0.000 Operation type showed that among 507 elective cases,
Prior to
149 11.1 1188 88.9 (Sig)* 0.2 8.7% developed SSI while from 997 emergency cases,
incision
* Significant 15.1% developed SSI. The results depict that SSI is more
prevalent in emergency caesareans with a P value being
Among 167 cases who had not received prophylactic 0.000, which is statistically significant (P <0.05) [OR
antibiotics, (27.5%) developed SSI while out of 1337 1.88] (Table 5).
Yes No
p value OR
n % n %
Elective 44 8.7 463 91.3 0.5
Operation type 0.000 (Sig)*
Emergency 151 15.1 846 84.9 1.9
* Significant
Yes No
p value OR
n % n %
4 to 7 days 28 4.7 566 95.3 0.2
Total hospital stay 8 to 15 days 52 8.3 578 91.7 0.5
0.000 (Sig)*
(day) 16 to 30 days 103 38.4 165 61.6 7.8
>30 days 12 100.0 0 0.0 171.7
* Significant
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4259
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262
Out of 594 cases who had total hospital stay of 4 to 7 prophylaxis before procedure, but it was found that not
days, 4.7% developed SSI; 630 cases who had total all emergency caesareans had received prophylaxis
hospital stay of 8 to 15 days, 8.3% developed SSI; 268 before procedure; reason was either nursing staff had not
cases who had total hospital stay of 16 to 30 days, 38.4% given or it was not prescribed on case sheet. Results from
developed SSI and among 12 cases who had total hospital our study showed among 167 cases who had not received
stay more than 30 days, 100% developed SSI. The above prophylactic antibiotics, (27.5%) developed SSI and out
results depict that SSI is more prevalent in cases with of 1337 cases who had received prophylactic antibiotics
prolonged hospital stay with P value of P = 0.000; [OR (11.1%) developed SSI. The above results depict that SSI
171.60] which is statistically significant (Table 6). is more prevalent in cases who had not received
prophylactic antibiotics. Similar findings were observed
DISCUSSION by Beattie, Rings TR et al, Owens SM et al and Killian
CA et al.3,28,29
The overall abdominal wound infection rate of 13% is
comparable with other studies that have used post Emergency caesarean sections are done usually when
discharge surveillance. Similar findings were observed by patient is in labour; mostly membranes are absent,
Barbut F, Carbonne B, Truchot F et al and Mitt P, Lang increased number of vaginal examinations and sometimes
K, Peri A et al, which found significant percentage of SSI miss the dose of prophylactic antibiotics. All these are
is detected by post discharge surveillance.23,24 potent risk factors for infection. In our study 8.7%
developed SSI, out of 507 elective caesareans and 15.1%
Due to referrals from other hospitals, patients fall in developed SSI out of 997 emergency caesareans. SSI was
higher wound class either because of prolonged labour, more prevalent in emergency caesareans with P value
prolonged rupture of membranes or obstructed labour being 0.000; [OR 1.9] which is statistically significant
which is a potent risk factor for SSI when caesarean (p<0.05). The above results are consistent with studies of
section is done. Schneid-Kofman N et al and Amenu Demisew, Tefera
Belachew et al.19,26
In our study Among 690 cases of class I wound, 8.3%
developed SSI. Out of 325 cases of class II wound, Prolonged stay in hospital means more chances of
14.2% developed SSI. Among 408 cases of class III infection because of cross infection by health care
wound, 18.1% developed SSI and from 81 cases of class workers, poor sanitation and poor asepsis. In our study
IV wound, 22.2% developed SSI. The above results out of 594 cases who had total hospital stay of 4 to 7
depict that SSI is more prevalent in cases with more days, 4.7% developed SSI; 630 cases who had total
contaminated wound class. Similar findings were hospital stay of 8 to 15 days, 8.3% developed SSI; 268
observed by Eriksen H, Saether AR et al, Amenu cases who had total hospital stay of 16 to 30 days, 38.4%
Demisew, Tefera Belachew et al, Mitt P et al, Jido TA, developed SSI and among 12 cases who had hospital stay
Garba ID et al, Killian CA et al, and Schneid Kofman N more than 30 days, 100% developed SSI. The above
et al which showed significant association between results depict that SSI is more prevalent in cases with
surgical wound class and SSI.3,19,24-27 prolonged hospital stay with P =0.000 [OR 171.60] which
is statistically significant. The above results are consistent
Our hospital being a sole tertiary care hospital in valley with the study of Nisa M, Naz T, Afzal I et al.30
and most of the patients who are referred from
pheripheries are usually high risk pregnancies with higher CONCLUSION
ASA class, which is a significant risk factor for SSI. In
our study, Out of 508 normally healthy cases (9.4%) The caesarean delivery rate has been steadily increasing
developed SSI. Among 725 cases with mild systemic over the last 30 years and it is common for major centres
disease (13.5%) developed SSI, Within 192 cases of to have a rate in double figures. The development of a
severe systemic disease, (16.7%) developed SSI and from wound infection after caesarean delivery is a morbid
79 cases who had incapacitating systemic disease, event and may result in significant patient discomfort,
(21.5%) developed SSI. The above results depict that SSI inconvenience, embarrassment, prolonged hospital stay,
is more prevalent in cases associated with morbidity. additional surgery and increased cost of community care
Similar findings were observed by Tran ST et al and following discharge.
Barbut F, Carbonne B, Truchot et al, which showed
significant association between ASA class and SSI.4,23 Incidence of SSI was (13%) following caesarean section
which is higher than developed countries.
Numerous studies have recommended that antibiotic
prophylaxis be given to all caesarean delivery cases for Statistically significant risk factors for SSI include wound
prevention of serious infections. class, ASA class, Antibiotic prophylaxis and operation
type and total hospital stay.
In our hospital we have a protocol of giving antibiotic
prophylaxis to all women undergoing caesarean section. The various reasons for such increased rate of SSI are:
We found all elective caesareans had received
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4260
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262
1. Only tertiary care institute dealing with high risk 8. Yokoe DS, Christiansen CL, Johnson R.
pregnancies. Epidemiology of and surveillance for postpartum
2. Late referrals. infections. Emerg Infect Dis. 2001;7:837-41.
3. Prolonged hospital stay of those cases where in 9. Yokoe DS, Noskin GA, Cunningham SM. Enhanced
hospital stay is must. identification of postoperative infections. Emerg
4. Heavy rush of attendants and inadequacy of bed Infect Dis. 2004;10:1924-30.
strength. 10. Ott WJ. Primary caesarean section: Factors related to
5. Faulty supervision where dose of antibiotics is postpartum infection. Obstetrics and Gynaecology.
actually missed before caesarean. 1981;57:171-6.
6. No proper segregation of infected from healthy 11. National Nosocomial Infections Surveillance
cases. System. National Nosocomial infections Surveillance
7. Attempting home deliveries by dais [NNIS] System Report, data summary from January
8. Culture and taboos of not bathing for six weeks still 1992 through June 2004, issued October 2004. Am J
prevalent in our community. Infect Control. 2004;32:470-85.
12. Smyth ET, Emmerson AM. Surgical site infection
The interventions which are expected to decrease SSI rate surveillance. J Hosp Infect. 2000;45:173-84.
are: 13. Mangram AJ, Horan TC, Pearson ML, Silver LC,
Jarvis WR. Guideline for prevention of surgical site
1. Decrease hospital stay infection. Hospital Infection Control Practices
2. Educating women about cleanliness Advisory Committee. Infect Control Hosp.
3. Antibiotic prophylaxis to all before procedure Epidemiol. 1999;20:250-78.
4. Separate labour room for septic patients 14. Henderson E, Love EJ. Incidence of hospital
5. Limiting attendants rush acquired infections associated with caesarean
6. Early referral of cases where chances of caesarean section. Journal of Hospital Infection. 1995;29:245-
are high. 55.
7. Educating people about 100% institutional 15. Blanco JD, Gibb RS, Castaneda YS, St Clair PJ.
deliveries Correlation of quantitative fluid cultures with
8. Importance of post discharge surveillance. endometritis following caesarean section. American
Journal of Obstetrics and Gynecology.
Funding: No funding sources 1982;143:897-901.
Conflict of interest: None declared 16. Apuzzio JJ, Reyelt C, Pelosi M, Purnendu S, Louria
Ethical approval: The study was approved by the DB. Prophylactic antibiotics for caesarean section:
Institutional Ethics Committee comparison of high and low risk patients for
endomyometritis. Obstetrics and Gynaecology
REFERENCES 1982;59:693-8.
17. King C. Infection following caesarean section: A
1. Mollit D, Ziegler MA. Operative Pediatric Surgery. study of the literature and cases with emphasis on
McGraw-HILL; 2003:161-178. prevention. The Central African Journal of Medicine.
2. Hillian J. Post-operative morbidity following 1989 Dec;35(12):556-70.
caesarean delivery. J Adv Nurs. 1995;22:1035-42. 18. Imseis HM, Trout WC, Gabbe SG. The
3. Killian CA, Graffunder EM, Vinciguerra TJ, Venezia microbiologic effect of digital cervical examination.
RA. Risk factors for surgical site infections American Journal of Obstetrics and Gynaecology.
following caesarean section. Infection Control and 1999;180:578-580.
Hospital Epidemiology. 2001;22(10):613-7. 19. Schneid-Kofman N, Sheiner E, Levy A, Holcberg G.
4. Tran TS, Jamulitrat S, Chongsuvivatwong V, Greater Risk factors for wound infection following caesarean
A. Risk factors for postcaesarean surgical site deliveries. International Journal of Gynaecology and
infection. Obstetrics and Gynaecology. Obstetrics. 2005 Mar;90:10-5.
2000;95(3):367-371. 20. Owens WD, Felts JA, Spitznagel EL. ASA physical
5. Lasley DS, Eblen A, Yancey MK, Duff P. The effect status classification: A study of consistency of
of placental removal method on the incidence of post ratings. Anaesthesiology. 1978;49:239-43.
caesarean infections. Am J Obstet Gynaecol. 21. Garibaldi RA, Cushing D, Lerer T. Predictors of
1997;176:1250-54. intraoperative acquired surgical wound infections.
6. Cooper NJ, Sutton AJ, Abrams KR. Decision Journal of Hospital Infection. 1991;189(A):289-98.
analytical economic modeling within a Bayesian 22. Koigi-Kamau R, Kabare LW, Wanyoike-Gichuhi J.
framework: application to prophylactic antibiotics Incidence of wound infection after caesarean
use for caesarean section. Stat Methods Med Res. delivery in a district hospital in Central Kenya. East
2002;11:491-512. African Medical Journal. 2005;82(7):357-61.
7. Smaill F, Hofmeyr GJ. Antibiotic prophylaxis for 23. Barbut F, Carbonne B, Truchot F, Spielvogel C,
caesarean section (Review).The Cochrane Database Jannet D, Goderel I. Surgical site infections after
of Systematic Reviews. 2006;(3):CD000933. caesarean section: results of a five year prospective
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4261
Haq AU et al. Int J Reprod Contracept Obstet Gynecol. 2016 Dec;5(12):4256-4262
surveillance. J Gynecol Obstet Biol Reprod. 2004 27. Jido TA, Garba ID. Surgical site infection following
Oct;(396):487-96. caesarean section in Kano, Nigeria. Ann Med Health
24. Mitt P, Lang K, Peri A, Maimets M. Surgical site Sci Res. 2012;2:33-6.
infections following caesarean section in an Estonian 28. Beattie PG, Rings TR, Hunter MF, Lake Y. Risk
university hospital: postdischarge surveillance and factors for wound infection following caesarean
analysis of risk factors. Infect Control Hosp section. Aust N Z J Obstet Gynaecol. 1994
Epidemiol. 2005;26:449-54. Aug;34(4):398-402.
25. Eriksen HM, Saether AR, Lower HL, Vangen S, 29. Owens SM, Brozanski BS. Antimicrobial
Hjetland R, Lundmark H, et al. Infections after prophylaxis for caesarean delivery before skin
caesarean sections. Tidsskr Nor Legeforen. incision. Obstet Gynaecol. 2009 Sep;114(3):573-9.
2009;129:618-22. 30. Nisa M, Naz T, Afzal I, Hassan L. Scope of surgical
26. Amenu D, Belachew T, Araya F. Surgical Site Site Infection [SSI] in Obstetrics and Gynaecology.
Infection Rate and Risk Factors Among Obstetric JPMI. 2005;19(4):438-41.
Cases of Jimma University Specialized Hospital,
Southwest Ethiopia. Ethiop J Health Sci. 2011 Cite this article as: Haq AU, Abdullah A, Akhtar S.
July;21(2):91-100. Analysis of risk factors in surgical site infection
following caesarean section. Int J Reprod Contracept
Obstet Gynecol 2016;5:4256-62.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology Volume 5 Issue 12 Page 4262