In-vivo Brain-distribution study in rats

Mr. Sagar Kishor Savale

M. Pharm (Pharmaceutics)
Mr. Sagar Kishor Savale

In vivo pharmacokinetic study was carried out using Wistar albino rats
Mr. Sagar Kishor Savale

This in vivo brain-distribution studies can be divided in two groups each group
consist of six animals.

Groups I Groups II
Mr. Sagar Kishor Savale

Groups I

The rats are held from the back in slanted

position during intranasal (IN) administration
Mr. Sagar Kishor Savale

Groups II

For second group plain drug suspension (PDS) are administered in intravenously (IV) with the help of
tuberculin syringe (1 mL), at the delivery site.
Mr. Sagar Kishor Savale
Mr. Sagar Kishor Savale

The rats are euthanatized by using CO2 chamber

Mr. Sagar Kishor Savale

The animals were decapitated immediately

after blood collection by retro-orbital plexus
puncture (at different time of interval)
Mr. Sagar Kishor Savale

The rats are sacrificed at different time of intervals

Mr. Sagar Kishor Savale

After Blood Collection, Skull was openand the brain was carefully excised
Mr. Sagar Kishor Savale
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