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Emirates Stadium
DOA PENERANG HATI
CHAPTER TOPICS
1 Introduction
2 Hierarchy of Biological Organization
3 Scientific Methods
4 Chemical Bonds and Water
5 Biological Molecules
6 Prokaryotic and Eukaryotic Cells
Plasma Membrane and Transport of
7
Molecules
LEARNING OUTCOMES
By the end of this chapter, you should be able to:
Understand the structure and function of plasma
membrane
Understand the characteristic of protein
Main macromolecules:
Lipids (most abundant phospholipids)
Proteins
Some carbohydrates
Phospholipids and most other
membrane constituents
amphipathic molecules
Have both hydrophobic &
hydrophilic regions
MEMBRANE MODEL EVOLVED TO
FIT NEW DATA
Hydrophobic
tails
Hydrophilic
head
EVOLUTION OF MEMBRANE MODEL
1935 Davson & : Proposed a Sandwich Model
Danielli
: Phospholipid bilayer lies between two
layers of globular proteins
Lateral movement
(~107 times per second) Flip-flop
(~ once per month)
The fluidity of membranes
The lateral movements of phospholipids are rapid, about 2
microns per second.
Many larger membrane proteins move more slowly but do
drift.
Some proteins move in very directed manner, perhaps
guided/driven by the motor proteins attached to the
cytoskeleton.
Other proteins never move, anchored by the cytoskeleton.