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-unknown cause
Risk factor:
Female
Breast
Lung
Cervical
3. Geographic Location
4. Race (african,american)
5. Radiation exposure
6. Viruses (HPV,HSV, HepB,EBN)
7. Chemical agent (killer triad of ca)
Alcohol,smoke,asbestos
8. Diet low fiber high fat
Nitrates
Over cooked food
Over used oil
Prevent cancer
S-DNA synthesis
G2-pre mitosisy
M- mitosis/division
Note: cell cycle specific-focus on 1 phase cell cycle non specific-effect on any phase
Adverse effect
Hemorrhagic cystitis(cytoxan)
Increase fluid intake
Tinnitus,nephrotoxic,ototoxic(platnol
II. Anti Merabolities (cell specific) (s)
Florouracil (5fu)
Methotrexate-(folic acid anntagonist)
Antidole:Follic acid (leucovorin/nelkovin)
Adverse effect
Side effect:
Wt gain
Hyperglycemia
Radiation Therapy
I. To kill tumor
II. Reduce size
III. Relieve obstruction
Luternal radiation / brachytherapy
2 types :
Sealed (implanta)
Unsealed (IV/oral)
Body fluid
Factor :
Distance: 6ft
Not allowed :
Pregnant
Infection
Children
Newly vacinated ind.
Nursing responsibilty
Private room
Decrease: WBC-leukepenia
RBC- anemia
Platelet- thrombopenia
Ovaries/testes (infertility/stevility)
Orchyopexy
Dophorexy: replacing testis/ovaries
Nursing care
Anemia-fatigue-rest
Leukopenia-immuno suppression-isolation
Thrombocytopenia-bleeding safety
Skin-radio therapy-radiodermatitis( burned skin) (4-6 wks)
Chemotheraphy (extravasation)
Sx:
Redness on IV site-monitor
Pair/burning sensation
Slowing of infusion
Stop chemotherapahy
Do cold compress except vinca alkaloid
Hair-alopecia-recommended use og wigs, capsar scarf
-hair loss is temporary
Oral care:
-NSS
-increase Ofi
-Avoid spicy, alcohol drinking
-KY Jelly
-Lip Balm
-popsicles
-ice chips
Vagina-dryness
Ky jelly
Perineal care
Provoked-activity
Quality-own description and avoid close ended
Radiation- locate using finger
Pain mgt:
1) Opiods
Morphine SO4(morepain pancreas in MS 10th use again 12th edition
Meperidine (demerol ) (seizure)
Fentanyl
CNS problems SE
1st sx of Adverse
Eff.resp.depression
Check RR
(narcan)
Drowsiness (1st 24o of taking SAFE) safety offf pt.
Nausea
pruritus
Constipation (common SE)
Urinary retention
2) Non-opiods (NSAIDS)
Acetaminophen + Ibuprofen
Anargesic/antipyreric
-Risk factors:
Late menopause
Obesity
Nulli parity
Generic
Female/forty
Oral contraceptives
Early menarche
Late menopause
Early menarche
Obesity= increase fats (increase estrogen)-fat soluble-hormone- increase libido
Nulli parity = /not or never pregnant
Genetic
Female/forty-94% female
1% transgender
Oral contraceptives (estrogen)
Prevention:
Breast self-exam
20y/o /month (7 days after mens)
Same day each month
Irregular/menopause/post hysterectomy
Breast health worker exam/ breast exam
24-30y/o (q 3yrs)
40 and above yearly
Inspect/palpate
Asymmetric breast
Venous prominence
Orange pill skin ( de orange)
- Advance stage of breast ca.
Lump/mass
Discharges
Arcular
Nipple dimpling
-
- Malignant
Fixed
Non-movable
Irregular
- Check discharges
Mamography:
Mom: (34)
Auntie: (42)
No any chemical
H2O wash
Cancer
Breast: confirmatory
Biopsy
Surgical
Incision(portion)
Excision (mass whole+ surrounded tissue)
Mgt:
Chemotherapy
Radiation therapy
Meds ( Tamoxafen Nolvadex)
-20 mg 1 day
-hormonal med (anti-estrogenic)
-s/e: menopausal syndrome
Hot flashes
Surgery: lumpectomy/excision
- Quadratectomy
- Simple mastectomy/total mastectomy
- Radical mastectomy-breasts/ lympnodes/pectoralis
Complication after mastectomy
Lymph edema (semi fowlers affected arm)
No procedure on the affected arm
Arm exercise
STD (HX)
Testosterone
African/American
Fat/increase fat
Forty increase
SX: Assymptomatic
Enlargement of prostate gland
Dysuria
Hematuria
Urinary retention
Perianal/rectal pain
Low back pain
Sx of metastasis
DX:
Prostate specific antigen
-40 above (yearly)
-cancer marker
DRE- digital Rectal exam
-40 above (yearly)
-clean gloves/ pos. lateral recumbent
Biopsy- confirm
Mgt:
Chemotherapy
Raduation
Meds
o Gonadotrophin releasing hormone increase testosterone(-) feedbach
mechanism)
-LRH
-lupron
-zoldex(subcutaneous every 1-3 mons)
o Diethyl istebesterol
(DES)
-Estrogen med that antagonize testosterone.
Testiscular cancer- unknown
Male- 100%
RF:
Cryptorchidism- <50%
Age- 15-35 y/o
Trauma
DES (maternal use)
-pills
Orchitis
Genetics
SX:
Testicular self exam
-before 15 y/o / month-sameday
Inspect/auscultate/ - bruit (doctor)
-inspect : mirror
Size/shape/symmetry
SX:
Painless enlargement (affected)
Heaviness/dragging
Pea size lump
Low back pain
Palpation- thumb/forefinger/index/middle finger/done after warm bath
ROLL
Unilateral
One remove
No imporence
No sterility
Bilateral
Both remove
With impotence
With sterility
Cervical cancer
RF:
HPV- strongest factor for cervical cancer
Multiple sexual partner
35-45 y/o
Multi parity (above 5 preg.)
Early coins (below a6 y/o)
Long term oral contraceptives
Smoking
SX:
Early signs
Post coital bleed
-painless bleeding
Methorrhagia
Menorrhagia
Discharge
Late signs
Bleeding
-dark.foul smell
Anemia
Wt. loss
Pap smear.
Colorectal cancer
RF:
Polyps
Hx of irritable bowel dse.(ulcerative colitis)
Increase fat- obese
SX:
Change in bowel movement
A sore doesnt heal
Unusual bleeding/discharge
Thickening lump
Indigestion
Ovicus change in nagging of /hoarseness
Sudden lost wt.
Anemia
Abd. Distention
Abd. Cramping
Constipation
Melenal hematochizia
Rectal lesion
Hematochizia
Rectal pain
Constipation
Feeling oof incomplete exsacerbarion after bowel movement
DX/LAB
Preparation
3 days low fiber
1day clear liquid
Night before laxative NPO
AM cleansing enema
Chemo/Radiation/Surgery
CVS function:
- Tissue perfusion
Blood volume 5-6 L
Heart
Blood vessel
- Artery- resistnace vessel
- Vein capacitance vessel
Shock: inadequate tissue perfection due to collapse cardio
Thromboangitis obliterans
-irreversible
Obliteration remove plaque> affecting medium vein/arteries
-permanent
DVI phlebothrombosis
-sudden pain
Thromboplebilis cause
-inflammation
Asymptomatic maneuver to fast
Varicous vein
Superficial vein
Deep vein
Prolong standing
Destroyed blood
-stasis of blood
Injury to B.V
Position the leg elevated
Management:
-surgical
Vein striping- remove thrombus
-scluos therapy
Diagnostic test
Doppler ultrasound
Angiography-deflimitive
-arteography
-venography
Mgt.
Immobilize
Analgesic IV
Heparin IV
Surgical mgt:
Insution of scent
Medical mgt:
Elastic stocking
-as ordered
Sleeping-remove
Molning- balik
Trombolytic
-urokinase
-streptokinase
Shepiase
Buergers Disease
Idiopatnic
R factor
- Smoking
- Men/women(20-40 y/o)
- Stress is risk factor
- HPN
- DM
Nicotine vasoconstriction
addiction
Read
Cyanide NeuroToxic
Methane- gas
TAR- canus
Arsenic rat poison
Formative- preserve
Lower extremities
PAIN
Clandication
Pain on walking
INDEPENDENT
Stop smoking
Avoid trauma/infection
Contol BP
Control sugar
Avoid Stress
DEPENDENT
Analgesic NSAID
Vaso dilator rarely given
-dont dilate dilate ds. Vessel, It dilate normal vessel
Ampulation/Blue white red dse.
Reyneulds dse.
Idiophatic
Exposure to cold temp.
Women than men
Young adult
Smoking,HPN,DM,stress
Reyneulds phenomenon
Connective tissue dse.
-phematoid
Scherodema
Exposure to cold temp.
Vasospasm of arterioles
Hand/finger(ischema)
BLUE
Severe spam
WHITE
Peperfusion
RED
Nsg intervention
ARTERIAL ULCER
VENUS ULCER
-cyanotic
-irregular border
-edema (+) pulses difficult to palpate
ANATOMY/PHYSIOLOGY
Left CA
- Left anterior descending branch
- Circumference branch
Right CA
- Posterior interventicular
- Marginal branch
Conducting System
SA node
AV node
Bundle of chis
Right and left
Fiber
Impulses
Conducting to transmit impulse
Conduction:
- Nerve cell
- Mucle cell
Action potential- a rapid change in membrane potential
Arial systole
Isovolumetric ventricular increase P due to close all value contraction
Maximum injection
Isovolumetric ventricular relaxation
Rapid ventricular filling
Diastasis time
S3
S4 gallop normal inandible
Stroke volume 70 ml
-volume affected/beat
Factor affecting SV
Preload-volume of blood is already in the heart before it contract
(remons return)
Factors affecting preload
Positioning
Breathing pattern
Deep inspiration increase SV
Straining/intathoraxic decrease SV
Factors:
SNS
PNS
Thyroid hormone
Temp
Enelcise
SV x HR
Vol/beat (70) beat/min (70)
-cardiac output
4900vol/min
Increase BP
Primary: idiopatnic
Secondary: causes tumorpheocromocytoma
Increase nerepinephrine increase
BP SNS
Anti hypertensive drug
1. Alpha, antagonist
Block a receptor (vasodilator)
Prazosin.terazosin.doxazosin
2. Alpha2 agonist
-found in CNS decrease flowof nor epi
Symphatetic response
-clonidine(catapres)
-methyldopa)dl domet)
3. Beta antagonist/blocker
B1- decrease HR decrease BP
B2- lungs bronchoconstriction
B1 blocker,metoprolel.atinolse
(RAAS)
Rennin angiotensin 1
Angiotensin2
V.
Constriction
increase BP
aldosteron Na retension
4. ACE inhibitor (vasodilation)
s/e: cough production
Captropil
Enalapril
Quinapril
5. A II receptor blocker
Tumisutan
Valsautan
Losautan
6. Druretii
Thiazide D.
Hydrochloeothyzine- distal tubeles
Best in morning
Urine output
7. Vaso dilator (smooth muscle of blood cell)
-Direct acting
Relax smooth muscle of blood vessel
*hydralazin (apresolin)
*Nitrates (sensitive to ligh/heat)
-Indirect acting
Vaso dilator
*decrease the release of Ca in the smooth muscle
Ex:Crannel blocker
-nifedipine
-amlodipine
Felocipine
Diltiazon
Verapamil
Rfactor: modifiable
Non modifiable:
Rall. Men
Testosterone Cyclooxydenase enzymeV.constrictionestrogen
(+) V.dilation
Decrease Lumen og B.V- ischemia
CAD- ischemic heart dse.
Angina peetoris
-imbalance og O2 in the heart work load
Gral- reverse the ischemia
Prevocation-position/location
Pain scale
(+) facial gramace
(+)lewne sign
Quality
-stabbing
-Crusting
-heaviness
constant and not affects by breathing & movement og chest
Mayocardial infection
Nectrosis irreversible damage
Realiving factor
Rest
NTG
None
Symptoms associated
Diaphoresis
Puler
N/V
Bowel dysfunction
Time
-3-5 mins (<15 min) (>30min)
Angina rectoris
-decrease O2 increase work load
In affective perfusion
Types og angina:
Stable heart work load RESA
Unstable angina
-sevre atherosclerosis decrease O2
> dependent (first)
NTG.O2
Pulmonary metal
Coronary rasopasm decrease O2
NTG On
DX test:
ECG T. Wave inversion difimitive
Blood test increase homocystein level
C reactive protein
Coronary angiography
Mgt.
NTG (sublingnal)
-fast action
-coronary V. dilation increase O2
-peripheral V. dilation --? Decrease heart work load
Mononitrate
-slow onset of action
Coronary V. dilation increase O2peripheral V dilation --? Decrease heart work load
Beta Blocker
-beta blocker
Decrease HR decrease heart contraction- decrease heart work load
Ca channel blocker
> peripheral V. dilation
>diltianeum
>verapamb
Medical mgt:
Pain relief-morphine
Relieve anxiety
Thrombo entie therapy
ACE inhibitor
Surgery
-CABG
-PTCA
Preventing of impulses
6 or more per min
Normal ECG
Heart Failure
Inability to pump effectively
CARDIAC decompesation
Syndrome
Etiology
>cardiac dse.
-IM
-disrhytmia
-congenital heart dse.
2 types:
1 left sided- LV fails
Right sided- RV fails
P, Edema
Cough, orthopere, dysprea decrease GIT, weakness (+) chackle
Decrease Kidney
Ineffective airway clearance
Ineffective breathing pattern
Impared gas exchange
Decrease CO
Ineefective tissue perfusion
Activity intolerance
Fluid volume excess
DX Test
-chest X ray
-cardiomegaly pulmonary congestion
Mgt:
>high fowlers
O2 therapy
Diaretics loop og heale
-edema
-cardiac Work Load
Cardiac Glucoside
Diagoxin (0.5-2mg/ml)
(+) intropic increase heart contractility cell
Increase the release of Ca in the heart rate
(-)chronotropic decrease HK
By prolong cardiac pepolargation by slowing K out In all.
Nsg care:
Insert HR with hold <60
Monitor K level- hypo K
Hypokalemma increase diatalis toxiaty
Monitor ECG
Avoid Ca channel vlocker while taking cardiac glycoside
Dont give while taking mal that decrease HR
Minitor level
Monitor digitudistoxicity
-N.V
-lack of appetite
-Gi toxicity
Visual disturbance
Tiology
Infection
Trauma
Connective dse. (SLE)
Malignance
Complication
Pericardial ceffusion-accumulatae fluid
Cardiac tanponade
>distant/mupple heart sound
>Becks TRIAD
-decrease BP
-Increase venus pressure
-muple sound
PLANNING
1.Strategy plan Long term/broad
2.Operational plan daily/short term
3.Contigency urgency
4.Projectal plan expected
ELEMENTS OF PLANNING
1.Forecasting
2.Establish mission/vision and polices
3.Bun getting
HOSPITAL population serve-carative-rehabilitation
HOSPITAL LICENSURE
1.diagnose
2.treat tend
3.care sundered
HOSPITAL categories (Phil health)
1.Primary 49