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Audiology
Audiol Neurotol 2013;18:201207 Received: September 27, 2012
Neurotology Accepted after revision: February 11, 2013
DOI: 10.1159/000349913
Published online: May 14, 2013
Difference audiogram
4 4
Difference uHear
Fig. 2. Difference in grades of hearing levels
of the diseased minus the nondiseased ear
(y-axis) for each frequency (x-axis) for sub- 2 2
ject 12. This difference is the basis for clin-
ical decision making. Subject 12 represents
a typical result as uHear measured the 0 0
hearing loss accurately at mid and high
tones but underestimated the hearing loss 2 2
in low tones. This deviation was the result
250 500 1000 2000 4000 6000 250 500 1000 2000 4000 6000
of increased thresholds at low frequency Frequency (Hz) Frequency (Hz)
for the nondiseased ear and the reduced in-
teraural difference.
4 2
Hearing grade
3
3
uHear
2
4
1
5
0
6
0 1 2 3 4 5 250 500 1000 2000 4000 6000
Audiogram Frequency (Hz)
Fig. 3. Relationship between the standard and study hearing tests Fig. 4. Average hearing thresholds (in hearing grades) at each fre-
for the cohort. For each subject a graph depicting the difference quency for the study and standard audiogram and for the diseased
between the hearing grades of the nondiseased and diseased ear at and nondiseased ears. uHear measured inaccurately elevated
each frequency was plotted (as seen in fig.2). The average differ- thresholds at low frequencies. The deviation is more pronounced
ence was calculated for each test separately. This average repre- for the nondiseased ear. The solid line depicts the standard audio-
sents the result of the hearing test. The correlation between the gram and the dashed line depicts the uHear results. For each of
average of the standard vs. study audiogram was 0.83 (Spearmans them the bottom line is the diseased ear and the top the nondis-
correlation coefficient). eased ear.
(table1a). Sensitivity was estimated to be 0.76 and speci- hearing happens in 32% [Wilson, 1980] to 64% [Mattox
ficity 0.91. The second criterion was loss of at least 2 hear- and Simmons, 1977] of patients. Treatment with steroids
ing grades across 2 or more consecutive frequencies (ta- can improve a patients chance of regaining hearing [Wil-
ble1b). Sensitivity was estimated to be 0.96 and specific- son et al., 1980; Chen et al., 2003]. There is an inverse cor-
ity 0.86. The least stringent criterion used was defined as relation between the chance to respond to steroid treat-
a loss of at least 1 hearing grade across 2 or more consecu- ment and the time elapsed until its initiation [Rauch,
tive frequencies (table 1c). Sensitivity was 0.94, but not 2008]. Hence, SSNHL is thought of as an emergency.
enough normals were found through the audiogram to The gold standard for the diagnosis of SSNHL is a stan-
calculate specificity. For all 3 definitions, the point esti- dard audiogram performed in a soundproof booth by a
mates of sensitivity and (when estimable) specificity were qualified audiologist. Unfortunately, this test may not be
reasonably high. However, the sample size of 32 was too available 24 h a day, 7 days a week. In addition, some
small to provide tight confidence intervals. populations such as military personnel or those in small-
uHear reflected hearing thresholds more accurately in er or remote communities may not have this service read-
mid and high tones compared to low tones (fig.4). Low- ily available. Since steroids have potential significant side
tone inaccuracy is more prominent in the nondiseased effects, treatment is best reserved to patients with a high
ear. probability of suffering from SSNHL. Medical history and
physical examination are often insufficient to reliably in-
dicate the need for treatment. For example, commonly
Discussion available tuning forks are 512 and 1024 Hz, leaving a wide
spectrum of hearing frequencies untested during physical
SSNHL was first recognized in the medical literature examination. If a standard audiogram cannot be obtained
in 1944 [De Kleyn, 1944]. Although almost 70 years have at initial presentation of a patient complaining of a sud-
elapsed since this publication, the etiology remains un- den drop in hearing, the clinician faces a decision to start
known in most cases [Chau et al., 2010]. SSNHL can be treatment based on history and physical examination or
associated with significant morbidity as a result of hear- to delay treatment until an audiogram is made available.
ing loss, tinnitus and dizziness. Spontaneous recovery of This dilemma was the motivation for the current study.
Difference audiogram
4 4
Difference uHear
Fig. 5. Subject 6 had severe hearing loss at
6000 and 8000 Hz as reflected in a standard 2 2
audiogram. In the study test 8000 Hz is not
measured, resulting in measurement of
0 0
hearing loss limited to 6000 Hz. A loss lim-
ited to 1 frequency could be considered in-
sufficient for treatment with steroids. The 2 2
y-axis represents the difference in grades of 250 500 1000 2000 4000 6000 250 500 1000 2000 4000 6000
hearing levels of the diseased minus the Frequency (Hz) Frequency (Hz)
nondiseased ear; the x-axis represents the
frequencies tested.
fore a standard audiogram is available. For the most This inaccuracy probably results from the acoustic
relaxed criterion of hearing loss studied, i.e. loss of at characteristics of the particular earbuds used in the study
least 1 grade of hearing over 2 or more frequencies, the and from the presence of ambient noise in the test envi-
sensitivity was high (0.94) as expected but the cohort was ronment. Imperfect fitting of earbuds, especially if creat-
too small to calculate specificity. As a result, it is impos- ing a vent effect, can cause this phenomenon as well.
sible to draw a conclusion regarding treatment for this Szudek et al. [2012] found that testing in a soundproof
group based on the studys data. Milder forms of SSNHL room did not eliminate this low-tone deviation.
have a better chance for spontaneous recovery [Rauch, The regulatory and legal status of smartphone and tab-
2008] and may not warrant treatment even when proven let computer-based applications for clinical use has not
by a standard audiogram. been established [Sherwin-Smith and Pritchard-Jones,
The comparison of the average differences between 2012]. An application aiding clinical decision making
hearing in the diseased and nondiseased ears for the study may be viewed as a medical device. Such applications are
versus standard hearing test resulted in a high correlation currently exempt from the usual approval procedures for
coefficient of 0.83 (fig.3). The average difference can be medical devices. Ideally, applications used for clinical de-
used as a single factor representing the overall output of cision making and treatment will be prevalidated inde-
the hearing tests. The good correlation between the aver- pendently for a particular indication such as the one pre-
ages of the study and standard audiogram is another sented in this paper.
method to validate its use for the evaluation of single- A few additional limitations of this study are worth
sided SSNHL. mentioning. Accuracy of the iPod-based hearing test is
uHear reflected hearing thresholds more accurately in sensitive to variables such as the quality and characteris-
mid and high tones compared to low tones (fig.4). These tics of the software application and earbuds and ambient
findings corroborate those of Szudek et al. [2012] and noise during testing. These variables may restrict some
Himmelfarb et al. [2012]. This can result in wrongly ex- aspects of generalization of the data and analysis present-
cluding eligible patients from treatment. The clinical im- ed in this paper to other applications, earbuds and envi-
plication can be seen in the results of the testing of subject ronments. However, most of these limitations can be
12 (fig.2). uHear accurately measured hearing thresholds overcome by evaluating the smartphone-based hearing
at mid and high frequencies; however, due to elevated testing of normal hearing ears prior to evaluating dis-
thresholds at low frequencies in the nondiseased ear the eased ears. As hearing at 8000 Hz is not tested, accuracy
interaural difference is reduced, masking some of the of the study test is reduced for patients suffering from
hearing loss. In addition, since low-tone sensitivity is high tone loss, for example subject 6 (fig.5), who experi-
moderate, prognostication based on the type of the au- enced hearing loss in excess of 60 dB at 6000 and 8000 Hz.
diogram [Kuhn et al., 2011] will have limited accuracy. Based on these findings he was treated (successfully) with
systemic steroids. However, based on the study test he
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