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Polymerase Chain Reaction (PCR) A Global Market Overview

The report reviews, analyzes and projects the global market for Polymerase Chain Reaction (PCR) for the period 2014-2022.
PCR product segments analyzed in this report include Instruments, Reagents & Consumables and Software & Services.
Application Areas of PCR analyzed comprise Clinical Diagnostics, Life Sciences and Others. This study also analyzes PCR end-
use sectors including Academic & Research Institutes, Clinical Diagnostics Labs & Hospitals, Pharmaceutical & Biotechnology
and Others.

Published: October 2017

Report Code: BT026
Pages: 344
Charts: 216
Price: $4860 Single User License, $7560 Enterprise License

Report Synopsis Droplet Digital PCR Surpasses Real-Time PCR in Detecting Environmental DNA
PCR Testing for Veterinary Diseases Gaining Momentum
Polymerase chain reaction (PCR) is a technology that has opened up
Capillary Loop Convective Polymerase Chain Reaction Platform with Real-
new vistas for advances in life sciences research and molecular
Time Fluorescence Detection Improves Amplification Efficiency
diagnostics due to its attributes, such as detection and quantification
Key business trends focusing on product innovations/developments, M&As,
of DNA and RNA genetic materials. North America leads the global JVs and other recent industry developments
market for PCR, estimated at US$3.5 billion (40.3% share) in 2017,
Major companies profiled 33
which is expected to maintain a 20172022 CAGR of 7.5% in reaching
The industry guide includes the contact details for 161 companies
a projected US$5 billion by 2022.

AsiaPacific is expected to witness the fastest similar period robust Product Outline
CAGR of 9.2% and reach US$2.5 billion by 2022. Global demand for The report analyzes the market for the key product segments of PCR including:
PCR in Clinical Diagnostics Labs & Hospitals, among end use sectors, is Instruments

slated to record the fastest CAGR of 8.6% during the aforementioned Reagents & Consumables

analysis period. Software & Services

Application Areas of PCR analyzed comprise the following:
Clinical Diagnostics
Life Sciences
Others
End-Use Sectors of PCR analyzed comprise the following:
Academic & Research Institutes
Clinical Diagnostics Labs & Hospitals
Pharmaceutical & Biotechnology
Others

Analysis Period, Units and Growth Rates

The report reviews, analyzes and projects the global PCR market for the
period 2014-2022 in terms of market value in US$ and the compound annual
growth rates (CAGRs) projected from 2017 through 2022

Geographic Coverage
Research Findings & Coverage North America (The United States, Canada and Mexico)
Europe (France, Germany, Italy, The United Kingdom, and Rest of Europe)
Global PCR market is examined in this report with respect to latest prominent
technologies, major application areas and key end-use sectors Asia-Pacific (China, India, Japan, South Korea and Rest of Asia-Pacific)
The report exclusively analyzes each application area, technology and end- Rest of World
use sector of PCR by a major geographic region

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Page 1
 Polymerase Chain Reaction (PCR) A Global Market Overview
October 2017 |344 Pages | 216 Charts | Price $4860

SAMPLE COMPANY PROFILE SAMPLE TABLE/CHART

Glance at 2017 Global Polymerase Chain Reaction (PCR) Market Share (%) by
AGILENT TECHNOLOGIES, INC. (UNITED STATES) Geographic Region North America, Europe, Asia-Pacific and Rest of World
5301 Stevens Creek Blvd, Santa Clara, California 95051
Phone: 408-345-8886, Fax: 408-345-8474
Website: www.agilent.com

Business Overview
California, United States-based Agilent Technologies, Inc.,
established in 1999, is a global leader in life sciences, diagnostics
and applied markets. The company is engaged in offering products
comprising atomic absorption, automation, bioanalyzer &
tapestation (bioanalyzer DNA & RNA kits), capillary
electrophoresis & CE/MS, cell analysis (seahorse), certified pre-
owned instruments, CGH & CGH+SNP microarrays, Dako products,
dissolution, FISH probes, fluorescence, FTIR, gas chromatography,
gene expression microarrays, ICP-MS, ICP-OES, iLab operations North American Polymerase Chain Reaction (PCR) Market Analysis (2014-2022)
by Product Segment Instruments, Reagents & Consumables and Software &
software, lab supplies, liquid chromatography, mass
Services in USD Million
spectrometry, miRNA microarrays, MP-AES, Amplicon target
amplification (Multiplicom), mutagenesis & cloning, next
generation sequencing, Raman spectroscopy (cobalt light
systems), sample preparation, software & informatics, UV-Vis &
UV-Vis-NIR, and vacuum technologies for the food, environmental
and forensics, pharmaceutical, diagnostics, chemical and energy,
and life sciences and diagnostic research markets. The PCR & RT-
PCR product line offered by the company encompasses PCR
instruments & plastics, high fidelity PCR enzymes, high yield &
sensitivity, high GC, inhibited & difficult target, routine PCR & RT-
PCR, optimization, ladders & markers, PCR & RT-PCR nucleic acid
purification, polymerases & modifying enzymes, PCR-RFLP, and 2014 2017 2022
specialty kits. The qPCR portfolio includes AriaMx-qPCR
instruments & software, AriaDx-qPCR for molecular diagnostics, KEY PLAYERS PROFILED
Mx3005P & Mx3000P - qPCR instruments & software, qPCR Abbott Laboratories
plastics & accessories, Brilliant SYBR master mixes, Brilliant Abbott Molecular Inc.
probe master mixes, HRM master mix, specialty master mixes & Agilent Technologies, Inc.
kits, cDNA synthesis, qPCR reference & controls, cell lysis & Becton, Dickinson and Company
BD Biosciences, Systems and Reagents Inc.
stabilization, purified total RNA, and nucleic acid purification.
Biocartis NV
Bio-Rad Laboratories, Inc.
Product Portfolio Danaher Corporation
PCR & RT-PCR Product Particulars
Beckman Coulter, Inc.
Eppendorf AG
PCR Instruments & Plastics SureCycler 8800 thermal cycler; PCR plastics and F. Hoffmann-La Roche Ltd
accessories (plates and tubes, StrataCooler LP Roche Diagnostics Corporation
benchtop cooler, StrataCooler Cryo preservation
modules)
Fluidigm Corporation
GE Healthcare Life Sciences
High Fidelity PCR Enzymes PfuUltra II Fusion HS DNA polymerase; Herculase II Merck KGaA
Fusion DNA polymerases; PfuTurbo Cx Hotstart DNA Ocimum Biosolutions Ltd.
polymerase; Easy-A Hi-Fi cloning enzyme; AccuScript
Hi-Fi Reverse Transcriptase (RT)
Qiagen N.V.
Thermo Fisher Scientific, Inc.
High Yield & Sensitivity Herculase II Fusion DNA polymerases; Paq5000 DNA
polymerase; PicoMaxx Hi-Fi PCR system & master mix;
AffinityScript Multi-Temp RT & RT-PCR
REGION COVERAGE
North America (United States, Canada and Mexico)
High GC, Inhibited & Difficult Herculase II Fusion DNA polymerases; Pfu Turbo Cx
Target Hotstart DNA polymerase; AffinityScript Multi-Temp Europe (France, Germany, Italy, The United Kingdom and Rest of Europe)
RT & RT-PCR; SureDirect Blood PCR kit; PicoMaxx Hi-Fi Asia-Pacific (China, India, Japan, South Korea and Rest of Asia-Pacific)
PCR systems & master mix
Rest of World
.more .more

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TABLE OF CONTENTS
PART A: GLOBAL MARKET PERSPECTIVE......... 1
1. INTRODUCTION .................................................. 1
1.1 Product Outline.................................................... 3
1.1.1 What is Polymerase Chain Reaction (PCR)? ...... 3
1.1.1.1 Procedure of PCR ........................................... 3
1.1.1.1.1 Initialization ................................................ 4
1.1.1.1.2 Denaturation............................................... 4
1.1.1.1.3 Annealing .................................................... 4
1.1.1.1.4 Extension/Elongation .................................. 4
1.1.1.1.5 Final Elongation .......................................... 4
1.1.1.1.6 Final Hold .................................................... 5
1.1.1.2 The Exponential Cycle of PCR ......................... 5
1.1.1.3 Design of Primers ........................................... 5
1.1.1.4 Components Required for PCR ...................... 6
1.1.1.4.1 Buffer Components ..................................... 6
1.1.1.4.2 Additives and Inhibitors .............................. 7
1.1.1.4.3 Thermal Cycler and Thermal Cycling
Conditions.................................................................. 8
1.1.1.5 Scrutiny of Fragment Identity ........................ 9
1.1.2 PCR Techniques............................................... 10
1.1.2.1 Digital PCR (dPCR) ........................................ 10
1.1.2.1.1 Principles of Digital PCR ............................ 10
1.1.2.2 Real-Time PCR .............................................. 11
1.1.2.2.1 Principle of Real-Time PCR ........................ 11
1.1.2.2.2 Fluorescent Dyes, Primers, and Probes Used
in Real-Time PCR...................................................... 12
1.1.2.2.3 Applications of Real-Time PCR .................. 12
1.1.2.3 Other PCR Techniques ................................. 13
1.1.2.3.1 Allele-Specific PCR..................................... 13
1.1.2.3.2 Assembly PCR or Polymerase Cycling
Assembly (PCA) ........................................................ 13
1.1.2.3.3 Asymmetric PCR........................................ 13
1.1.2.3.4 Helicase-Dependent Amplification ........... 13
1.1.2.3.5 Hot Start PCR ............................................ 13
1.1.2.3.6 Intersequence-Specific PCR (ISSR) ............ 14
1.1.2.3.7 Inverse PCR ............................................... 14
1.1.2.3.8 Ligation-Mediated PCR ............................. 14
1.1.2.3.9 Methylation-Specific PCR (MSP) ............... 14
1.1.2.3.10 Miniprimer PCR ....................................... 14
1.1.2.3.11 Multiplex Ligation-Dependent Probe
Amplification (MLPA) ............................................... 14
1.1.2.3.12 Multiplex PCR.......................................... 14
1.1.2.3.13 Nested PCR ............................................. 15
1.1.2.3.14 Overlap-Extension PCR or Splicing by
Overlap Extension (SOE) .......................................... 15
1.1.2.3.15 Reverse Transcription PCR (RT-PCR) ....... 15
1.1.2.3.16 Solid Phase PCR....................................... 15
1.1.2.3.17 Thermal Asymmetric Interlaced PCR (TAIL-PCR) . 15
1.1.2.3.18 Touchdown PCR (Step-Down PCR) .......... 15
1.1.3 Applications of PCR ......................................... 16
1.1.3.1 Virology........................................................ 16
1.1.3.2 Mycology and Parasitology .......................... 16
1.1.3.3 Microbiology ................................................ 17
1.1.3.3.1 Bacteriology .............................................. 18
1.1.3.4 Dentistry ...................................................... 18
1.1.3.5 Agricultural Biotechnology........................... 19
1.1.3.6 Other Select Applications............................. 19
2. KEY MARKET TRENDS ........................................ 21
2.1 Expediting the PCR Process Now Possible .......... 21
2.2 Emergence of Ultrafast Real Time Q-Plasmonic PCR .. 22
2.3 Contemporary Research Using BNA-Based Digital PCR.. 22
Bridged Nucleic Acids (BNA) Technology ................. 23
2.4 Detection of Early-Stage Liver Cancer Improves by
Using CTC-iChip with Digital PCR Assay.................... 24
2.5 Propidium Monoazide-PCR Assay Developed for
Detecting viable Lactobacillus brevis in Beer ........... 24
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Polymerase Chain Reaction (PCR) A Global Market Overview
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2.6 PCR Testing for Veterinary Diseases Gaining
Momentum.............................................................. 25
2.7 RT-qPCR Improves Detection of Mycobacterium
tuberculosis ............................................................. 26
2.8 Capillary Loop Convective Polymerase Chain
Reaction Platform with Real-Time Fluorescence
Detection Improves Amplification Efficiency ........... 27
2.9 Droplet Digital PCR Surpasses Real-Time PCR in
Detecting Environmental DNA ................................. 28
2.10 Nanoparticle-Assisted PCR Overcomes Technical
Challenges ............................................................... 28
2.11 Litmus Test Used for Detecting DNA Amplicons
of PCR ...................................................................... 28
2.12 dPCR Used for Characterizing DNA Reference
Materials.................................................................. 29
2.13 Innovative PCR Technique Improves Sequencing
of Minute cfDNA ...................................................... 29
3. KEY GLOBAL PLAYERS ........................................ 30
Abbott Laboratories (United States) ............................... 30
Agilent Technologies, Inc. (United States) ....................... 32
Becton, Dickinson and Company (United States) ............ 34
Biocartis Nv (Belgium) ..................................................... 35
Bio-Rad Laboratories, Inc. (United States)....................... 36
Danaher Corporation (United States) .............................. 37
Eppendorf Ag (Germany) ................................................ 39
F. Hoffmann-La Roche Ltd (Switzerland) ......................... 40
Fluidigm Corporation (United States) .............................. 42
Ge Healthcare Life Sciences (United Kingdom) ............... 43
Merck Kgaa (Germany) ................................................... 44
Ocimum Biosolutions Ltd. (India) .................................... 45
Qiagen N.V. (The Netherlands) ....................................... 46
Thermo Fisher Scientific, Inc. (United States).................. 49
4. KEY BUSINESS TRENDS ...................................... 51
Thermo Fishers DNA Detection Kit Receives FBI approvals
to Identify male-specific Y chromosome markers ........... 51
Genomic Health and Biocartis Enter into Agreement to
Develop Oncotype DX Breast Recurrence Score Test ...... 51
Bio-Rad Unveils RT-PCR Assay Kit for Simultaneous
Detection of Zika, Dengue, and Chikungunya Viruses ..... 52
Angle Plc Enters into Marketing Partnership with QIAGEN .... 52
QIAGEN and Clinical Genomics Join Forces to work on
Colorectal Cancer ............................................................ 52
FDA Approval for Thermo Fishers TaqPath Zika Virus Kit 53
Bioline Expands JetSeq portfolio .................................. 53
Thermo Fisher Completes CE-IVD Registration of its
QuantStudio 5 Dx System for In Vitro Diagnostic Use in
Europe ............................................................................ 53
Fluidigm and Ascendas Genomics Partner to Develop
Microfluidic Molecular Diagnostics in China ................... 54
Agilent Technologies Launches AriaDx Real-Time PCR
System in Europe ............................................................ 54
Fluidigm Unveils Advanta Immuno-Oncology Gene
Expression PCR Assay ...................................................... 54
Formulatrix, Inc Introduces CONSTELLATION Digital PCR
System ............................................................................ 55
Roche Introduces Cobas MRSA/SA Nucleic Acid Test ...... 55
Bio-Rad Launches First Droplet Digital PCRBased Assays .. 55
Bio-Rad Unveils CFX Maestro Software for PCR Data
Analysis ........................................................................... 56
FDA Approval for QIAGENs Artus CMV QS-RGQ MDx Kit
for CMV Testing .............................................................. 56
Roche Receives FDA Approval for CMV Viral Load Testing
on Cobas 6800/8800 Systems ....................................... 57
FDA 510(K) Clearance for BDCs Molecular Test for
Harmful Intestinal Bacteria Causing Infectious Diarrhea . 57
Sysmex to Acquire Oxford Gene Technology................... 58
Seegene Enters the U.S. Diagnostic Market in
Collaboration with Thermo Fisher ................................... 58
Seegene Develops Second-Generation real-time PCR
technology Universal SG Fluorescence-labeled oligo ...... 58
Bruker to Release new Clinical Microbiology kits and
Assays at ECCMID ........................................................... 59
Roche Introduces Cobas Liat PCR System with New Assays ... 60
QIAGEN to Release AR-V7 Test in Prostate Cancer for
Research Use Only .......................................................... 60
QIAGEN and CACER-ID Consortium Collaborate on Liquid
Biopsies Workflows ........................................................ 61
QIAGEN Introduces First FDA-Cleared JAK2 Test for
Leukemia Disease ........................................................... 61
Roche Launches Cobas HPV on the Cobas 6800/8800
Systems for Cervical Cancer ............................................ 62
Bioline Unveils New JetSeq DNA Quantification Kits ...... 62
Thermo Fisher Launches QuantStudio 5 Real-Time PCR
System for Forensic Laboratory Use ............................... 62
Digital PCR Upholds High Reproducibility International
Multicenter Study ........................................................... 63
Promega and Hitachi Technologies Team-Up for Capillary
Electrophoresis (CE) Instrument ..................................... 63
U.S. FDA Grants Abbott the First Commercial
Authorization for a Molecular Test to Detect Zika Virus
Using Whole Blood ......................................................... 64
Global Liquid Biopsy Researchers Participate in Precision
Medicine World Conference on NGS & PCR Technologies ..... 64
Bio-Rad to Acquire RainDance Technologies .................. 65
Bioline Unveils EPIK miRNA Assays .............................. 65
Bruker Acquires InVivo Biotech ...................................... 65
QIAGEN Introduces CALR Mutation Assay for MPN
Diagnosis ........................................................................ 66
Roche and Merck KGaA Enter into Distribution Agreement... 66
Biocartis and Thermo Fisher Announce Agreement ....... 67
RainDance Technologies Unveils RainDrop Plus Digital PCR
System ............................................................................ 67
Promega Corporation Launches Promega PCR
Optimization Kit.............................................................. 67
Bruker Acquires Nucleic Acid Testing (NAT) Assays and
Syndromic Panel Technology .......................................... 68
BD MAX Vaginal and CT/GC/TV Panels receives FDA
approval ......................................................................... 68
Biocartis receives 1.4 M grant from VLAIO .................. 68
LabCorp launches cobras 8800 system from Roche ........ 69
RainDance Technologies Showcases its Picodroplet
Platform at ASHG 2016 ................................................... 69
Droplet Digital Technology Presented at ASHG 2016 ... 69
Thermo Fisher scientific Launches NGM Detect Kit ........ 69
Bioline accredited to the ISO 13485 Quality Standard .... 70
Bioline Expands the SensiFAST family of real-time PCR
products ......................................................................... 70
Thermo Fisher Scientific Partners with Hamilton Bonaduz
AG .................................................................................. 70
Maxwell RSC PureFood GMO and Authentication Kit from
Promega ......................................................................... 70
Bio-Rad Introduces an Assay website to identify or design
Droplet Digital PCR Assays ........................................... 71
Roche receives FDA, CLIA waiver for cobas Influenza A/B
& RSV test....................................................................... 71
Renewal of Thermo Fisher Scientific and DuPont Nutrition
& Health's Deal to Supply BAX System Q7 Platform ....... 71
Release of Bio-Rad's New ddPCR CHO and ddPCR E. coli
Residual DNA Quantification Kits .................................... 71
Bio-Rad's Droplet Digital PCR-Based Assay for Rapid and
Cost-Effective Quantification of Genome-Editing Events 72
BD Collaborated with Check-Points to Develop and Supply
BD MAX Assays for CRO Detection............................... 72
Seegene to Launch Universal SG Fluorescence Oligo
System ............................................................................ 72
Release of Bioline's New MyTaq Plant-PCR Kit ............. 72
US FDA Granted Emergency Use Authorization for Idylla
Ebola Virus Triage Test ................................................... 73
First Prospective Clinical Trial of Liquid Biopsy Using ddPCR
Validated the Use of cfDNA as a Predictive Diagnostic Tool ... 73
Thermo Scientific SureTect Real-Time PCR Assays for
Precise Detection of Molecular Pathogens ..................... 74
Five New ddPCR Multiplex Mutation Screening Kits
Launched by Bio-Rad ...................................................... 74
New Thermo Scientific SureTect Cronobacter Species Real-
Time PCR Assay to Aid Infant Formula Producers ........... 74
US FDA Approved cobas Zika test to Screen Blood
Samples on the cobas 6800/8800 Systems ................... 75
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COBAS AmpliPrep/COBAS TaqMan HCV Test, v2.0, the
First Quantitative HCV RNA Test to Receive FDA Approval
for Use as an Aid to Diagnose an Active HCV Infection ... 75
New Three-Color Crystal Digital PCR System Launched by
Stilla Technologies .......................................................... 75
Unveiling of Bioline's EPIK miRNA Select Kits ............... 75
CE IVD Marking for Bio-Rad's QX200 Droplet Digital PCR System.....76
Thermo Scientific SureTect Escherichia coli O157:H7 PCR Assay
Granted NF Validation Certificate by AFNOR Certification ..... 76
GE Healthcare to Set Up Headquarters in Chicago ......... 76
Milestone Reached by Qiagen with its Portfolio of Master
Collaboration Agreements with Major Pharmaceutical
Companies to Develop Companion Diagnostics.............. 76
Biocartis Joined Forces with Merck to Develop and
Commercialize a New Liquid Biopsy RAS Biomarker Test
for mCRC Patients .......................................................... 77
US FDA Approved Roche's cobas HIV-1 Viral Load Test for
Use on the cobas 6800/8800 Systems .......................... 77
JetSeq DNA Library Preparation Kit, the First Product in a
New Line of Kits from Bioline for NGS Sample Preparation ... 77
Roche Finalized the Acquisition of Kapa Biosystems....... 78
RainDance to Develop Ultra-Sensitive, Highly Precise and
Low Cost NGS and Digital PCR Methods in Collaboration
with BSRI ........................................................................ 78
Sigma-Aldrich Acquired by Merck ................................... 78
Addition of HIV-1, HCV and HCV GT Assays Broaden
Roche's Available Menu on the cobas 4800 System ....... 79
Roche's cobas HBV and cobas HCV viral load tests, the
first assays with US FDA Approval for use on the cobas
6800 and cobas 8800 Systems ...................................... 79
RIVM Selected Roche to Implement the cobas HPV Test
as the First-Line, Primary Screening Test in the National
Cervical Cancer Screening Program ................................ 79
Release of Bio-Rad's One-Step RT-ddPCR Advanced Kit for
Probes ............................................................................ 79
Launch of Roche's First Oncology Assay Using Either
Plasma or Tumour Tissue Samples ................................. 80
FDA CLIA Waiver Granted for Roche's cobas Influenza
A/B Test for Use on the cobas Liat System ................... 80
Seegene Joined Forces with BD for the Development of
Multiplex Real-Time PCR Reagents for the BD MAX System80
Release of Bioline's New EPIK miRNA Panel Assays ..... 80
MHTP's Medical Genomics Facility to House Australia's
First Single-Cell Genomics Centre of Excellence ............. 81
FDA Approved Qiagen's therascreen EGFR Test as a
Companion Diagnostic for Guiding the Use of
AstraZeneca's IRESSA in Treating NSCLC Patients ......... 81
MDRO Tests Developed by Fluidigm in Collaboration with OpGen.....81
Seegene to Develop Multiplex assay panels menu for
Qiagen's QIAsymphony RGA MDx Automation Platform 81
Hitachi High-Technologies Collaborated with Qiagen to Develop
New Automation Systems Based on PCR and NGS Technologies .. 82
CE Marking Obtained by Beckman Coulter's DxN VERIS
HCV Assay and DxN VERIS HIV-1 Assay ........................... 82
510(k) Clearance Received by Roche's cobas Cdiff Test .. 82
510(k) Clearance Received by Roche's cobas HSV 1 and 2 Test . 82
Biocartis Collaborated with Fast-track Diagnostics to
Develop a Range of Multiplex Infectious Disease Tests on
its Idylla System ........................................................... 83
Seegene's Allplex Gastrointestinal Full Panel Assay
Received CE-IVD Mark .................................................... 83
US FDA Granted CLIA Waiver for Roche's cobas Strep A
Test for Use on the cobas Liat System .......................... 83
Roche's cobas KRAS Mutation Test Received FDA
Approval for Diagnostic Use ........................................... 83
DxN VERIS Molecular Diagnostics System Presented by
Beckman Coulter at ECCMID in Denmark ....................... 84
RainDance Form Distribution Pacts to Meet the Increasing
Demand for Liquid Biopsy Applications outside the US .. 84
An Integrated Multiplex Real-time PCR Assay for
Bloodstream Infections Developed by Biocartis in
Collaboration with Microbiome ...................................... 84
BD MAX CT/GC/TV and CT/GC Assays Received CE Mark ... 85
Promega releases the PowerQuant System ................. 85
Commercial availability of Roches cobas DPX test for
parvovirus B19 (B19V) and hepatitis A virus (HAV) ......... 85
Roche launches cobas HBV assay and receives CE mark 85
Bio-Rad launches new PrimePCR Droplet Digital PCR
(ddPCR) Assays ............................................................ 85
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Polymerase Chain Reaction (PCR) A Global Market Overview
October 2017 |344 Pages | 216 Charts | Price $4860
Bio-Rad Laboratories launches PrimePCR Assays for Real-
Time PCR ......................................................................... 86
SciLifeLab sets up Swedish national center for single-cell
biology ............................................................................ 86
Roche MRSA/SA Test receives FDA clearance ................. 86
Qiagen secures additional EGFR pathway-related
intellectual property licenses from Roche ....................... 86
Life Science Industry awards for Bio-Rad Protein
Expression Products, Genomic Workflow Solutions ........ 87
Bio-Rad launches ddPCR KRAS Screening Multiplex Kit ... 87
cobas TaqScreen MPX Test, v2.0 Receives FDA Approval .... 87
5. GLOBAL MARKET OVERVIEW ............................. 88
5.1 Global Polymerase Chain Reaction Market
Overview by Product Segment ................................ 89
5.1.1 Polymerase Chain Reaction Product Segment
Market Overview by Global Region ......................... 91
5.1.1.1 Instruments ................................................. 91
5.1.1.2 Reagents & Consumables ............................ 93
5.1.1.3 Software & Services ..................................... 95
5.2 Global Polymerase Chain Reaction Market
Overview by Application Area ................................. 97
5.2.1 Polymerase Chain Reaction Application Area
Market Overview by Global Region ......................... 99
5.2.1.1 Clinical Diagnostics ...................................... 99
5.2.1.2 Life Sciences ............................................... 101
5.2.1.3 Other Applications ..................................... 103
5.3 Global Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 105
5.3.1 Polymerase Chain Reaction End-Use Sector
Market Overview by Global Region ....................... 107
5.3.1.1 Academic & Research Institutes ................ 107
5.3.1.2 Clinical Diagnostics Labs & Hospitals ......... 109
5.3.1.3 Pharmaceutical & Biotechnology Sectors .. 111
5.3.1.4 Other End-Use Sectors ............................... 113
PART B: REGIONAL MARKET PERSPECTIVE ..115
REGIONAL MARKET OVERVIEW ........................... 117
1. NORTH AMERICA ............................................ 117
1.1 North American Polymerase Chain Reaction
Market Overview by Geographic Region ............... 118
1.2 North American Polymerase Chain Reaction
Market Overview by Product Segment .................. 120
1.2.1 Polymerase Chain Reaction Product Segment
Market Overview by NA Region ............................. 122
1.2.1.1 Instruments ............................................... 122
1.2.1.2 Reagents & Consumables .......................... 124
1.2.1.3 Software & Services ................................... 126
1.3 North American Polymerase Chain Reaction
Market Overview by Application Area ................... 128
1.3.1 Polymerase Chain Reaction Application Area
Market Overview by NA Region ............................. 130
1.3.1.1 Clinical Diagnostics .................................... 130
1.3.1.2 Life Sciences ............................................... 132
1.3.1.3 Other Applications ..................................... 134
1.4 North American Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 136
1.4.1 Polymerase Chain Reaction End-Use Sector
Market Overview by NA Region ............................. 138
1.4.1.1 Academic & Research Institutes ................ 138
1.4.1.2 Clinical Diagnostics Labs & Hospitals ......... 140
1.4.1.3 Pharmaceutical & Biotechnology Sectors .. 142
1.4.1.4 Other End-Use Sectors ............................... 144
1.5 Major Market Players ...................................... 146
Abbott Laboratories (United States) ............................. 146
Abbott Molecular Inc. (United States) ........................... 147
Agilent Technologies, Inc. (United States) ..................... 148
Becton, Dickinson And Company (United States) .......... 150
Bd Biosciences, Systems and Reagents Inc. (United States) . 150
Bio-Rad Laboratories, Inc. (United States)..................... 151
Raindance Technologies, Inc. (United States) ............... 152
Bruker Corporation (United States)............................... 153
Complete Genomics, Inc. (United States) ..................... 153
Danaher Corporation (United States) ........................... 154
Beckman Coulter, Inc. (United States) .......................... 155
Fluidigm Corporation (United States) ........................... 156
Formulatrix, Inc. (United States) ................................... 157
Illumina Inc. (United States) ......................................... 158
Epicentre (United States)............................................ 159
Promega Corporation (United States) .......................... 160
Roche Diagnostics Corporation (United States) ............ 161
Sigma-Aldrich (United States) ....................................... 161
Thermo Fisher Scientific, Inc. (United States) ............... 162
1.6 Country-wise Analysis of North American
Polymerase Chain Reaction Market ....................... 164
1.6.1 The United States ....................................... 164
1.6.1.1 United States Polymerase Chain Reaction
Market Overview by Product Segment .................. 165
1.6.1.2 United States Polymerase Chain Reaction
Market Overview by Application Area ................... 167
1.6.1.3 United States Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 169
1.6.2 Canada ....................................................... 171
1.6.2.1 Canadian Polymerase Chain Reaction Market
Overview by Product Segment .............................. 172
1.6.2.2 Canadian Polymerase Chain Reaction Market
Overview by Application Area ............................... 174
1.6.2.3 Canadian Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 176
1.6.3 Mexico ....................................................... 178
1.6.3.1 Mexican Polymerase Chain Reaction Market
Overview by Product Segment .............................. 179
1.6.3.2 Mexican Polymerase Chain Reaction Market
Overview by Application Area ............................... 181
1.6.3.3 Mexican Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 183
2. EUROPE .......................................................... 185
2.1 European Polymerase Chain Reaction Market
Overview by Geographic Region ............................ 186
2.2 European Polymerase Chain Reaction Market
Overview by Product Segment .............................. 188
2.2.1 Polymerase Chain Reaction Product Segment
Market Overview by European Region .................. 190
2.2.1.1 Instruments ............................................... 190
2.2.1.2 Reagents & Consumables .......................... 192
2.2.1.3 Software & Services ................................... 194
2.3 European Polymerase Chain Reaction Market
Overview by Application Area ............................... 196
2.3.1 Polymerase Chain Reaction Application Area
Market Overview by European Region .................. 198
2.3.1.1 Clinical Diagnostics .................................... 198
2.3.1.2 Life Sciences............................................... 200
2.3.1.3 Other Applications ..................................... 202
2.4 European Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 204
2.4.1 Polymerase Chain Reaction End-Use Sector
Market Overview by European Region .................. 206
2.4.1.1 Academic & Research Institutes ................ 206
2.4.1.2 Clinical Diagnostics Labs & Hospitals ......... 208
2.4.1.3 Pharmaceutical & Biotechnology Sectors .. 210
2.4.1.4 Other End-Use Sectors ............................... 212
2.5 Major Market Players ...................................... 214
Biocartis Nv (Belgium) .................................................. 214
Bioline Reagents Limited (United Kingdom) ................. 215
Dnavision Sa (Belgium) ................................................. 216
Eppendorf Ag (Germany) .............................................. 217
Exiqon A/S (Denmark) .................................................. 218
F. Hoffmann-La Roche Ltd (Switzerland) ....................... 219
Ge Healthcare Life Sciences (United Kingdom) ............. 220
Merck KGaA (Germany) ................................................ 221
Qiagen N.V. (The Netherlands) ..................................... 222
Stilla Technologies (France) .......................................... 225
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2.6 Country-wise Analysis of European Polymerase
Chain Reaction Market .......................................... 226
2.6.1 France ........................................................ 226
2.6.1.1 French Polymerase Chain Reaction Market
Overview by Product Segment .............................. 227
2.6.1.2 French Polymerase Chain Reaction Market
Overview by Application Area................................ 229
2.6.1.3 French Polymerase Chain Reaction Market
Overview by End-Use Sector .................................. 231
2.6.2 Germany .................................................... 233
2.6.2.1 German Polymerase Chain Reaction Market
Overview by Product Segment .............................. 234
2.6.2.2 German Polymerase Chain Reaction Market
Overview by Application Area................................ 236
2.6.2.3 German Polymerase Chain Reaction Market
Overview by End-Use Sector .................................. 238
2.6.3 Italy ........................................................... 240
2.6.3.1 Italian Polymerase Chain Reaction Market
Overview by Product Segment .............................. 241
2.6.3.2 Italian Polymerase Chain Reaction Market
Overview by Application Area................................ 243
2.6.3.3 Italian Polymerase Chain Reaction Market
Overview by End-Use Sector .................................. 245
2.6.4 The United Kingdom .................................. 247
2.6.4.1 United Kingdom Polymerase Chain Reaction
Market Overview by Product Segment .................. 248
2.6.4.2 United Kingdom Polymerase Chain Reaction
Market Overview by Application Area ................... 250
2.6.4.3 United Kingdom Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 252
2.6.5 Rest of Europe ........................................... 254
2.6.5.1 Rest of Europe Polymerase Chain Reaction
Market Overview by Product Segment .................. 255
2.6.5.2 Rest of Europe Polymerase Chain Reaction
Market Overview by Application Area ................... 257
2.6.5.3 Rest of Europe Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 259
3. ASIA-PACIFIC................................................... 261
3.1 Asia-Pacific Polymerase Chain Reaction Market
Overview by Geographic Region ............................ 262
3.2 Asia-Pacific Polymerase Chain Reaction Market
Overview by Product Segment .............................. 264
3.2.1 Polymerase Chain Reaction Product Segment
Market Overview by Asia-Pacific Region................ 266
3.2.1.1 Instruments ............................................... 266
3.2.1.2 Reagents & Consumables .......................... 268
3.2.1.3 Software & Services ................................... 270
3.3 Asia-Pacific Polymerase Chain Reaction Market
Overview by Application Area ............................... 272
3.3.1 Polymerase Chain Reaction Application Area
Market Overview by Asia-Pacific Region................ 274
3.3.1.1 Clinical Diagnostics .................................... 274
3.3.1.2 Life Sciences ............................................... 276
3.3.1.3 Other Applications ..................................... 278
3.4 Asia-Pacific Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 280
3.4.1 Polymerase Chain Reaction End-Use Sector
Market Overview by Asia-Pacific Region................ 282
3.4.1.1 Academic & Research Institutes ................ 282
3.4.1.2 Clinical Diagnostics Labs & Hospitals ......... 284
3.4.1.3 Pharmaceutical & Biotechnology Sectors .. 286
3.4.1.4 Other End-Use Sectors ............................... 288
3.5 Major Market Players ...................................... 290
Hokkaido System Science Co., Ltd. (Japan) .................... 290
Ocimum Biosolutions Ltd. (India) .................................. 291
Shimadzu Corporation (Japan) ...................................... 292
3.6 Country-wise Analysis of Asia-Pacific Polymerase
Chain Reaction Market .......................................... 293
3.6.1 China ......................................................... 293
3.6.1.1 Chinese Polymerase Chain Reaction Market
Overview by Product Segment .............................. 294
3.6.1.2 Chinese Polymerase Chain Reaction Market
Overview by Application Area ............................... 296
3.6.1.3 Chinese Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 298
3.6.2 India .......................................................... 300
3.6.2.1 Indian Polymerase Chain Reaction Market
Overview by Product Segment .............................. 301
3.6.2.2 Indian Polymerase Chain Reaction Market
Overview by Application Area ............................... 303
3.6.2.3 Indian Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 305
3.6.3 Japan ......................................................... 307
3.6.3.1 Japanese Polymerase Chain Reaction Market
Overview by Product Segment .............................. 308
3.6.3.2 Japanese Polymerase Chain Reaction Market
Overview by Application Area ............................... 310
3.6.3.3 Japanese Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 312
3.6.4 South Korea ............................................... 314
3.6.4.1 South Korean Polymerase Chain Reaction
Market Overview by Product Segment .................. 315
3.6.4.2 South Korean Polymerase Chain Reaction
Market Overview by Application Area ................... 317
3.6.4.3 South Korean Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 319
3.6.5 Rest of Asia-Pacific ..................................... 321
3.6.5.1 Rest of Asia-Pacific Polymerase Chain Reaction
Market Overview by Product Segment .................. 322
3.6.5.2 Rest of Asia-Pacific Polymerase Chain Reaction
Market Overview by Application Area ................... 324
3.6.5.3 Rest of Asia-Pacific Polymerase Chain Reaction
Market Overview by End-Use Sector ..................... 326
4. REST OF WORLD .............................................. 328
4.1 Rest of World Polymerase Chain Reaction Market
Overview by Product Segment .............................. 329
4.2 Rest of World Polymerase Chain Reaction Market
Overview by Application Area ............................... 331
4.3 Rest of World Polymerase Chain Reaction Market
Overview by End-Use Sector.................................. 333
Hy Laboratories Ltd (Hylabs) (Israel) A Major Market
Player ........................................................................... 335
PART C: GUIDE TO THE INDUSTRY............... 336
1. NORTH AMERICA ............................................... 336
2. EUROPE.............................................................. 340
3. ASIA-PACIFIC ...................................................... 341
4. REST OF WORLD ................................................ 342
PART D: ANNEXURE ....................................343
1. RESEARCH METHODOLOGY ............................... 343
2. FEEDBACK .......................................................... 345

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