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History of the Ketogenic Diet

Before discussing the theory and metabolic effects of the ketogenic diet, it is useful to

briefly review the history of the ketogenic diet and how it has evolved. There are two primary

paths (and numerous sub-paths) that the ketogenic diet has followed since its inception:

treatment of epilepsy and the treatment of obesity.

Fasting

Without discussing the technical details here, it should be understood that fasting (the

complete abstinence of food) and ketogenic diets are metabolically very similar. The
similarities

between the two metabolic states (sometimes referred to as starvation ketosis and dietary

ketosis respectively) have in part led to the development of the ketogenic diet over the years.

The ketogenic diet attempts to mimic the metabolic effects of fasting while food is being

consumed.

Epilepsy (compiled from references 1-5)

The ketogenic diet has been used to treat a variety of clinical conditions, the most well

known of which is childhood epilepsy. Writings as early as the middle ages discuss the use of

fasting as a treatment for seizures. The early 1900s saw the use of total fasting as a treatment

for seizures in children. However, fasting cannot be sustained indefinitely and only controls

seizures as long as the fast is continued.

Due to the problems with extended fasting, early nutrition researchers looked for a way to

mimic starvation ketosis, while allowing food consumption. Research determined that a diet
high

in fat, low in carbohydrate and providing the minimal protein needed to sustain growth could

maintain starvation ketosis for long periods of time. This led to development of the original

ketogenic diet for epilepsy in 1921 by Dr. Wilder. Dr. Wilders ketogenic diet controlled
pediatric

epilepsy in many cases where drugs and other treatments had failed. The ketogenic diet as
developed by Dr. Wilder is essentially identical to the diet being used in 1998 to treat
childhood

epilepsy.

The ketogenic diet fell into obscurity during the 30s, 40s and 50s as new epilepsy drugs

were discovered. The difficulty in administering the diet, especially in the face of easily
prescribed

drugs, caused it to all but disappear during this time. A few modified ketogenic diets, such as
the

Medium Chain Triglyceride (MCT) diet, which provided greater food variability were tried
but they

too fell into obscurity.

In 1994, the ketogenic diet as a treatment for epilepsy was essentially rediscovered in the

story of Charlie, a 2-year-old with seizures that could not be controlled with medications or
other

treatment, including brain surgery. Charlies father found reference to the ketogenic diet in the

literature and decided to seek more information, ending up at Johns Hopkins medical center.

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Charlies seizures were completely controlled as long as he was on the diet. The amazing

success of the ketogenic diet where other treatments had failed led Charlies father to create
the

Charlie Foundation, which has produced several videos, published the book The Epilepsy
Diet

Treatment: An introduction to the ketogenic diet, and has sponsored conferences to train

physicians and dietitians to implement the diet. Although the exact mechanisms of how the

ketogenic diet works to control epilepsy are still unknown , the diet continues to gain
acceptance

as an alternative to drug therapy.

Other clinical conditions

Epilepsy is arguably the medical condition that has been treated the most with ketogenic

diets (1-3). However, preliminary evidence suggests that the ketogenic diet may have other
clinical uses including respiratory failure (6), certain types of pediatric cancer (7-10), and
possibly

head trauma (11) . Interested readers can examine the studies cited, as this book focuses

primarily on the use of the ketogenic diet for fat loss.

Obesity

Ketogenic diets have been used for weight loss for at least a century, making occasional

appearances into the dieting mainstream. Complete starvation was studied frequently
including

the seminal research of Hill, who fasted a subject for 60 days to examine the effects, which
was

summarized by Cahill (12). The effects of starvation made it initially attractive to treat morbid

obesity as rapid weight/fat loss would occur. Other characteristics attributed to ketosis, such
as

appetite suppression and a sense of well being, made fasting even more attractive for weight
loss.

Extremely obese subjects have been fasted for periods up to one year given nothing more than

water, vitamins and minerals.

The major problem with complete starvation is a large loss of body protein, primarily from

muscle tissue. Although protein losses decrease rapidly as starvation continues, up to one half
of

the total weight lost during a complete fast is muscle and water, a ratio which is unacceptable.

In the early 70s, an alternative approach to starvation was developed, termed the Protein

Sparing Modified Fast (PSMF). The PSMF provided high quality protein at levels that would

prevent most of the muscle loss without disrupting the purported beneficial effects of
starvation

ketosis which included appetite suppression and an almost total reliance on bodyfat and
ketones

to fuel the body. It is still used to treat severe obesity but must be medically supervised (13).

At this time, other researchers were suggesting low-carbohydrate diets as a treatment for

obesity based on the simple fact that individuals tended to eat less calories (and hence lose
weight/fat) when carbohydrates were restricted to 50 grams per day or less (14,15). There was

much debate as to whether ketogenic diets caused weight loss through some peculiarity of

metabolism, as suggested by early studies, or simply because people ate less.

The largest increase in public awareness of the ketogenic diet as a fat loss diet was due to

Dr. Atkins Diet Revolution in the early 1970s (16). With millions of copies sold, it
generated

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extreme interest, both good and bad, in the ketogenic diet. Contrary to the semi-starvation and

very low calorie ketogenic diets which had come before it, Dr. Atkins suggested a diet limited
only

in carbohydrates but with unlimited protein and fat. He promoted it as a lifetime diet which

would provide weight loss quickly, easily and without hunger, all while allowing dieters to eat
as

much as they liked of protein and fat. He offered just enough research to make a convincing

argument, but much of the research he cited suffered from methodological flaws.

For a variety of reasons, most likely related to the unsupported (and unsupportable)

claims Atkins made, his diet was openly criticized by the American Medical Association and
the

ketogenic diet fell back into obscurity (17). Additionally, several deaths occurring in dieters

following The Last Chance Diet - a 300 calorie-per-day liquid protein diet, which bears a

superficial resemblance to the PSMF - caused more outcry against ketogenic diets.

From that time, the ketogenic diet (known by this time as the Atkins diet) all but

disappeared from the mainstream of American dieting consciousness as a high carbohydrate,

lowfat diet became the norm for health, exercise performance and fat loss.

Recently there has been a resurgence in low carbohydrate diets including Dr. Atkins New

Diet Revolution (18) and Protein Power by the Eades (19) but these diets are aimed
primarily

at the typical American dieter, not athletes.

Ketogenic diets and bodybuilders/athletes


Low carbohydrate diets were used quite often in the early years of bodybuilding (the fish

and water diet). As with general fat loss, the use of low carbohydrate, ketogenic diets by
athletes

fell into disfavor as the emphasis shifted to carbohydrate based diets.

As ketogenic diets have reentered the diet arena in the 1990s, modified ketogenic diets

have been introduced for athletes, primarily bodybuilders. These include so-called cyclical

ketogenic diets (CKDs) such as The Anabolic Diet (20) and Bodyopus (21).

During the 1980s, Michael Zumpano and Daniel Duchaine introduced two of the earliest

CKDs: The Rebound Diet for muscle gain, and then a modified version called The
Ultimate Diet

for fat loss. Neither gained much acceptance in the bodybuilding subculture. This was most

likely due to difficulty in implementing the diets and the fact that a diet high in fat went
against

everything nutritionists advocated.

In the early 1990s, Dr. Mauro DiPasquale, a renowned expert on drug use in sports,

introduced The Anabolic Diet (AD). This diet alternated periods of 5-6 days of low
carbohydrate,

moderate protein, moderate/high fat eating with periods of 1-2 days of unlimited carbohydrate

consumption (20). The major premise of the Anabolic Diet was that the lowcarb week would

cause a metabolic shift to occur, forcing the body to use fat for fuel. The high carb
consumption

on the weekends would refill muscle carbohydrate stores and cause growth. The carb-loading

phase was necessary as ketogenic diets can not sustain high intensity exercise such as weight

training.

DiPasquale argued that his diet was both anti-catabolic (preventing muscle breakdown) as

well as overtly anabolic (muscle building). His book suffered from a lack of appropriate

references (using animal studies when human studies were available) and drawing incorrect

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conclusions. As well, his book left bodybuilders with more questions than it provided
answers.

A few years later, bodybuilding expert Dan Duchaine released the book Underground

Bodyopus: Militant Weight Loss and Recomposition (21). Bodyopus addressed numerous
topics

related to fat loss, presenting three different diets. This included his approach to the CKD,
which

he called BODYOPUS. BODYOPUS was far more detailed than the Anabolic Diet, giving
specific

food recommendations in terms of both quality and quantity. As well, it gave basic workout

recommendations and went into more detail regarding the physiology of the diet.

However, Bodyopus left many questions unanswered as evidenced by the numerous

questions appearing in magazines and on the internet. While Duchaines ideas were accepted
to

a limited degree by the bodybuilding subculture, the lack of scientific references led health

professionals, who still thought of ketogenic diets as dangerous and unhealthy, to question the

diets credibility.

A question

Somewhat difficult to understand is why ketogenic diets have been readily accepted as

medical treatment for certain conditions but are so equally decried when mentioned for fat
loss.

Most of the criticisms of ketogenic diets for fat loss revolve around the purported negative
health

effects (i.e. kidney damage) or misconceptions about ketogenic metabolism (i.e. ketones are
made

out of protein).

This begs the question of why a diet presumed so dangerous for fat loss is being used

clinically without problem. Pediatric epilepsy patients are routinely kept in deep ketosis for

periods up to 3 years, and occasionally longer, with few ill effects (3,5). Yet the mention of a
brief

stint on a ketogenic diet for fat loss and many people will comment about kidney and liver
damage, ketoacidosis, muscle loss, etc. If these side effects occurred due to a ketogenic diet,
we

would expect to see them in epileptic children.

Its arguable that possible negative effects of a ketogenic diet are more than outweighed by

the beneficial effects of treating a disease or that children adapt to a ketogenic diet differently

than adults. Even then, most of the side effects attributed to ketogenic diets for fat loss are not

seen when the diet is used clinically. The side effects in epileptic children are few in number
and

easily treated, as addressed in chapter 7.

References cited

1. The Epilepsy Diet Treatment: An introduction to the ketogenic diet John M. Freeman,
MD ;

Millicent T. Kelly, RD, LD ; Jennifer B. Freeman. New York: Demos Vermande, 1996.

2. Berryman MS. The ketogenic diet revisited. J Am Diet Assoc (1997) 97: S192-S194.

3. Wheless JW. The ketogenic diet: Fa(c)t or fiction. J Child Neurol (1995) 10: 419-423 .

4. Withrow CD. The ketogenic diet: mechanism of anticonvulsant action. Adv Neurol (1980)

27: 635-642.

5. Swink TD, et. al. The ketogenic diet: 1997. Adv Pediatr (1997) 44: 297-329.

6. Kwan RMF et. al. Effects of a low carbohydrate isoenergetic diet on sleep behavior and

pulmonary functions in healthy female adult humans. J Nutr (1986) 116: 2393-2402.

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7. Nebeling LC. et. al. Effects of a ketogenic diet on tumor metabolism and nutritional status
in

pediatric oncology patients: two case reports. J Am Coll Nutr (1995) 14: 202-208.

8. Nebeling LC and Lerner E. Implementing a ketogenic diet based on medium-chain


triglyceride

oil in pediatric patients with cancer. J Am Diet Assoc (1995) 95: 693-697.

9. Fearon KC, et. al. Cancer cachexia: influence of systemic ketosis on substrate levels and

nitrogen metabolism. Am J Clin Nutr (1988) 47:42-48.


10. Conyers RAJ, et. al. Cancer, ketosis and parenteral nutrition. Med J Aust (1979) 1:398-
399.

11. Ritter AM. Evaluation of a carbohydrate-free diet for patients with severe head injury. J

Neurotrauma (1996) 13:473-485.

12. Cahill GF and Aoki T.T. How metabolism affects clinical problems. Medical Times (1970)

98: 106-122.

13. Walters JK, et. al. The protein-sparing modified fast for obesity-related medical problems.

Cleveland Clinical J Med (1997) 64: 242-243.

14. Yudkin J and Carey M. The treatment of obesity by a high-fat diet - the inevitability of

calories. Lancet (1960) 939-941.

15. Yudkin J. The low-carbohydrate diet in the treatment of obesity. Postgrad Med (1972)

51: 151-154.

16. Dr. Atkins Diet Revolution Robert Atkins, MD. New York: David McKay Inc.

Publishers, 1972.

17. Council on Foods and Nutrition A critique of low-carbohydrate ketogenic weight reducing

regimes. JAMA (1973) 224: 1415-1419.

18. Dr. Atkins New diet Revolution Robert Atkins, MD. New York: Avon Publishers, 1992.

19. Protein Power Michael R. Eades, MD and Mary Dan Eades, MD. New York: Bantam
Books,

1996.

20. The Anabolic Diet Mauro DiPasquale, MD. Optimum Training Systems, 1995.

21. BODYOPUS: Militant fat loss and body recomposition Dan Duchaine. Nevada: Xipe

Press, 1996.

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