EPIFIZA

CH2-CH-COOH HO
CH2-CH-COOH
NH2 triptofan hidroxilaza
N NH2
H N
triptofan H
5-OH-triptofan

HO
CH2-CH2-NH2 HO
5-OH-triptofan- CH2-CH2-NH-CO-CH3
decarboxilaza serotonin-N-acetil
N transferaza
H N
CO2 serotonina H
N-acetil-serotonina

CH3-O
HO-indol-O-metil CH2-CH2-NH-CO-CH3
transferaza
N
H
melatonina

GLANDA TIROID
CH2-CH-COOH CH2-CH-COOH CH2-CH-COOH
NH2 NH2 NH2
I2
+
iodinaza I I I
OH OH OH
tirozina mono-iodotirozina di-iodotirozina

I I

HO O CH2-CH-COOH
NH2
I
triiodotironina (T3)

I I

2 DIT HO O CH2-CH-COOH
NH2
I I

tetraiodotironina (tiroxina, T4)

 GLANDA CORTICOSUPRARENAL

CO-CH3 CO-CH3

3-BHOSDH-aza
HO O
HO
colesterol
pregnenolona progesteron

CO-CH2-OH
OH
CO-CH2-OH
HO

O
11-deoxicortizol
11-BHO-aza O
corticosteron
CO-CH2-OH
HO OH

O
cortizol

CO-CH3 CO-CH3

3-BHOSDH-aza
HO O
HO
colesterol
pregnenolona progesteron

CO-CH2-OH
CHO
HO
CO-CH2-OH
HO
aldosteron
sintaza
O
aldosteron
O
corticosteron
 GLANDA MEDULOSUPRARENAL

CH2-CH-COOH CH2-CH-COOH CH2-CH2-NH2

NH2 NH2
DOPA-decarboxilaza dopamin
tirozin
hidroxilaza
hidroxilaza OH OH
CO2
OH OH OH
tirozina DOPA dopamina

HO-CH-CH2-NH2 HO-CH-CH2-NH-CH3

feniletanolamino-
OH N-metil-transferaza OH

OH OH
noradrenalina adrenalina

HORMONI SEXUALI

CO-CH3
O

HO O
HO
colesterol androstendiona
pregnenolona
aromataza
OH

O
testosteron
HO
aromataza estrona
OH 17-BHOSDH-aza

OH

OH

HO
estradiol HO
estriol
 CO-CH3
O

HO
HO O
colesterol dehidroepiandrosteron
pregnenolona
3-BHOSDH-aza
17-BHOSDH-aza
O
OH

O
17-BHOSDH-aza
androstendiona O
androstendiol

3-BHOSDH-aza
OH OH

5--reductaza

O O
dihidrotestosteron testosteron