Вы находитесь на странице: 1из 10

BRS Pharm

1. abciximab: antibody against glycoprotein 2b/3a receptor 23. alprazolam: intermediate-acting benzodiazepine used for
2. abciximab: prevents platelet activation panic disorder and phobias
3. abciximab: anticoagulant preventing restenosis after 24. alteplase: converts fibrin-bound plasminogen to plasmin
angioplasty 25. aluminum hydroxide: constipating antacid
4. ABVD: adriamycin, bleomycin, vinblastine, dacarbazine 26. amantadine: prophylaxis against influenza A and rubella
5. acarbose: inhibits a-galactosidase 27. amantidine: inhibits fusion of viral particles within
6. acebutolol: selective b1 blocker endosome of the cell
7. acetaminophen: COX inhibitor which inhibits 28. amantidine: not effective against influenza B
prostaglandin synthesis 29. amantidine: binds to M2 protein
8. acetaminophen: analgesic, antipyretic (but not 30. amiloride: block sodium channels in the cortical collecting
anti-inflammatory) tubules
9. acetaminophen: massive hepatic necrosis 31. amiloride: hyperkalemic metabolic acidosis
10. acetazolamide: inhibits carbonic anhydrase in the 32. aminocaproic acid: orally active inhibitor of plasminogen
proximal convoluted tubule activation
11. acetazolamide: metabolic acidosis 33. aminocaproic acid: inhibits fibrinolysis
12. acetazolamide: give to alkalinize the urine in aspirin 34. aminocaproic acid: used for acute bleeding in hemophilic
toxicity patients
13. acyclovir: used to treat herpes 35. aminoglutethimide: blocks conversion of cholesterol to
14. acyclovir: guanosine analog pregnenolone
15. acyclovir: activated by thymidine kinase of the virus it 36. aminoglycosides: bactericidal
treats 37. aminoglycosides: ototoxic and nephrotoxic
16. acyclovir: functions as a chain terminator when 38. amiodarone: blocks sodium channels
incorporated into viral DNA 39. amiodarone: corneal microdeposits
17. adenosine: short acting agent given IV for AV nodal 40. amiodarone: class III antiarrythmic
arrhythmias
41. amiodarone: photosensitivity
18. adenosine: causes cutaneous flushing
42. amiodarone: pulmonary fibrosis
19. albuterol: selective b2 agonist
43. amphetamines: indirect sympathomimetic MOA
20. allopurinol: suicide inhibition of xanthine oxidase
44. amphotericin B: disrupts fungal membranes by binding
21. allopurinol: increases xanthine and hypoxanthine, which ergosterol
are less likely to form crystals than uric acid
45. ampicillin: extended spectrum penicillin used to treat
22. allopurinol: slows production of uric acid, used to treat gram negatives
gout (and cancer)
46. anastrazole: aromatase inhibitor
47. anastrozole: inhibitor of steroid synthesis

1
48. anastrozole: inhibits conversion of androstenedione to 74. bromocriptine: D2 agonist
estrone 75. bromocriptine: inhibits PRL release
49. antimalarials: erythema multiforme 76. bromocriptine: used to treat hyperprolactinemia due to
50. aspirin: PGE inhibitor pituitary adenoma
51. aspirin: predisposes to acute gastritis by inhibiting PGE in 77. bromocriptine: ergot alkaloid
the stomach 78. busulfan: pulmonary fibrosis
52. aspirin: irreversible inhibitor of cyclooxygenase 79. calcium carbonate: hypercalcemic alkalosis
53. aspirin: analgesic, antipyretic, antiplatelet, 80. calcium carbonate: renal calculi
anti-inflammatory
81. calcium channel blockers: causes cutaneous flushing
54. atenolol: selective b1 blocker
82. capsaicin: impairs release of substance P
55. azithromycin: macrolide
83. capsaicin: used topically for RA
56. aztreonam: b-lactamase resistant monobactam
84. captopril: inhibit breakdown of bradykinin
57. aztreonam: used only with aminoglycosides against gram
85. captopril: functions at the collecting tubules
negative rods
86. captopril: CI in pregnancy
58. aztreonam: cannot be used against gram positives or
anaerobic bacteria 87. carbachol: nicotinic and muscarinic agonist
59. bacitraicin: inhibits bacterial cell wall synthesis 88. carbamazepine: inducer of p450
60. barbiturates: erythema multiforme 89. carbapenem: given with cliastatin
61. barbiturates: inducer of p450 90. carbapenem: used against gram positive cocci, gram
negative rods, and anaerobes
62. beclomethasone: synthetic glucocorticoid that readily
penetrates the airway mucosa, used for asthma 91. carbenicillin: used against enterobacter and pseudomonas
63. benztropine: antimuscarinic 92. carmustine: alkylating agent that causes DNA
cross-linking and strand breaks
64. benztropine: CI are prostatic hyperplasia, GI obstruction,
glaucoma 93. carmustine: used to treat brain tumors, highly lipophilic
nitrosourea drug
65. benztropine: antimuscarinic used to treat tremors and
rigidity in parkinsons, but does nothing for 94. carvedilol: used for CHF
bradykinesia 95. carvedilol: nonselective beta blocker and alpha-1 blocker
66. bethanechol: muscarinic agonist 96. cefixime: used to treat gonnorhea
67. bismuth subsalicylate: used with metronidazole and 97. ceftriaxone: used for septic meningitis
tetracycline for PUD caused by h.pylori 98. celecoxib: COX-2 inhibitor
68. bisphosphonates: esophageal ulcerations 99. celecoxib: sulfa drug
69. bleomycin: mixture of glycoproteins that produce free 100. cephalosporins: bactericidal
radicals upon binding DNA
101. cephalosporins: causes disulfiram-like reaction
70. bleomycin: causes strand breaks in DNA
102. chloramphenicol: gray baby syndrome in babies deficient
71. bleomycin: G2 phase inhibitor in hepatic gluconosyltransferase
72. bleomycin: can cause pulmonary fibrosis 103. chloramphenicol: aplastic anemia
73. bleomycin: pulmonary fibrosis

2
104. chloroquine: primary drug for acute malaria 129. cyclosporin: binds to cyclophilins and inhibits the
105. chloroquine: disrupts hemoglobin breakdown, with toxic transcription of cytokine genes
accumulation of heme in RBC 130. cyclosporin: impairs T cell IL-2 production, used in
106. cholestyramine: bind bile acids to prevent enterohepatic transplant patients
recycling 131. daclizumab: binds IL-2 receptor on activated T cells
107. cimetidine: gynecomastia and galactorrhea 132. daclizumab: used for patients with renal allografts
108. cimetidine: p450 inhibitor 133. danazol: inhibitor of p450
109. cimetidine: gynecomastia 134. danazol: used for endometriosis and fibrocystic disease of
110. cinchonism: headache, vertigo, blurry vision, tinnitus the breast
111. cisapride: stimulates peristalsis by release of Ach from 135. dantrolene: decreases the release of calcium from the
myenteric plexus sarcoplasmic reticulum
112. cisapride: long QT 136. dantrolene: used to treat malignant hyperthermia
113. cisplatin: alkylating agent 137. daunorubicin: used to treat AML
114. cisplatin: causes nephrotoxicity and acoustic nerve 138. deferoxamine: rapid infusion causes hypotensive shock
damage 139. deferoxamine: used to treat acute iron toxicity
115. cisplatin: ototoxic and nephrotoxic 140. DES: clear cell carcinoma of the vagina in daughters
116. clarithromycin: macrolide 141. desmopressin: selective V2 agonist
117. clavulanic acid: beta lactamase inhibitor 142. detromethrophan: depresses cough center in the medulla
118. clindamycin: bacteriostatic at the 50s ribosome 143. dicloxacillin: bulky R-group prevents degradation by
119. clindamycin: treatment of bacteroides penicillinase
120. clomiphene: blocks negative feedback at the pituitary 144. didanosine (ddI): dose-limiting pancreatitis
121. cocaine: inhibits catecholamine reuptake, resulting in 145. digibind: fab fragment antibody
cardiotox and hypertension 146. dimercaprol: chelates metals to keep them from damaging
122. colchicine: inhibits microtubule assembly, and therefore proteins
leukocyte migration and phagocytosis 147. dimercaprol: used to treat heavy metal poisoning
123. colchicine: leukocyte inhibitor used to treat attacks of 148. diphenhydramine: inhibit histamine binding to H1
gouty arthritis receptors
124. colchicine: microtubule inhibitor 149. diphenhydramine: causes drowsiness
125. cosyntropin: used for diagnosis of addison's disease 150. diphenhydramine: used for allergies and motion sickness
126. cromolyn sodium: stabilizes mast cell membrane 151. diphenoxylate: suppress GI motility
127. cyclophosphamide: causes hemorrhagic cystitis 152. disulfiram: inhibits aldehyde dehydrogenase, causing an
128. cyclophosphamide: alkylating agent used to treat cancers accumulation of acetaldehyde

3
153. doxorubicin: intercalates in DNA to reduce replication 180. fludrocortisone: used in postadrenalectomy therapy
and transcription 181. flumazenil: antagonizes benzodiazepines and zolpidem
154. doxorubicin: causes dilated cardiomyopathy 182. flumazenil: used for benzodiazepine overdose
155. dynorphins: bind kappa receptors 183. flunitrazepam: benzodiazepine used as a date rape drug
156. enkephalin: binds delta receptors 184. fluoroquinolones: bactericidal
157. entacapone: inhibits conversion of levodopa to 185. fluoroquinolones: bactericidal inhibitor of DNA gyrase
3-0-methyldopa
186. fluoroquinolones: used for gram negative rods, some gram
158. ephedrine: ma-huang positives, and neisseria
159. EPO: recombinant drug used for anemia 187. fluoroquinolones: bad for cartilage
160. erythromycin: bacteriostatic inhibitor of 50s 188. fluorouracil: S phase antimetabolite
161. erythromycin: macrolide 189. fluorouracil: causes myelosuppression
162. erythromycin: GI irritation and acute cholestatic hepatitis 190. fluorouracil: inhibits thymidylate synthase
163. erythromycin: p450 inhibitor 191. fluorouracil: used to treat colon cancer and basal cell
164. etanercept: a fusion product of TNF-alpha receptor and carcinoma
Fc portion of antibody 192. flutamide: used to antagonize residual androgens after
165. etanercept: used in RA and inflammatory bowel disease orchiectomy
166. ethambutol: TB 193. flutamide: side effects include gynecomastia and libido
167. ethinyl estradiol/mestranol: lowers risk of coronary changes
disease, slows osteoporosis, ameliorates hot flashes 194. flutamide: androgen receptor antagonist
168. ethosuxamide: stevens-johnson 195. folic acid: will correct anemia but not neuro sx associated
169. ethosuxamide: inhbits T-type calcium channels with b12 deficiency
170. ethylene glycol: causes metabolic acidosis and 196. foscarnet: treats CMV
precipitation of oxalate crystals in the kidney 197. foscarnet: inhibits viral DNA polymerase
171. etoposide: G2 phase inhibitor 198. gabapentin: partial seizures
172. etoposide: causes double stranded breaks in DNA 199. ganciclovir: guanosine analog converted by CMV to
173. etoposide: inhibits topoisomerase II triphosphorylated form
174. etoposide: used to treat small cell carcinoma of the lung 200. ganciclovir: SE: neutropenia, leukopenia,
and prostate and testicular cancers thrombocytopenia
175. fexofenadine: nonsedating antihistaminic 201. ganciclovir: metabolized by viral transferases
176. filgrastim: G-CSF 202. ganciclovir: requires phosphorylation by viral kinases to
work
177. fluconazole: inhibits formation of ergosterol
203. glitazones: increase insulin sensitivity
178. fluconazole: prophylaxis against cryptococcus neoformans
204. glitazones: stimulate PPAR-gamma receptor
179. fluconazole: used to treat oral candidiasis
205. gold salts: nephrotoxic
206. gold salts: used in RA
207. gold salts: decreases lysosomal and macrophage function

4
208. griseofulvin: keratinized tissue 236. isoniazid: G6PDH
209. griseofulvin: ringworm 237. isoniazid: SLE like syndrome
210. griseofulvin: binds tubulin 238. ivermectin: onchocera volvulus and strongyloides
211. griseofulvin: inducer of p450 stercoralis
212. griseofulvin: microtubule inhibitor 239. ivermectin: increases GABA transmission in the worm
213. halothane: massive hepatic necrosis 240. ketamine: should be given with benzodiazepines
214. HCTZ: hypokalemia, alkalosis, hyperuricemia, 241. ketoconazole: interfere with fungal cell wall synthesis
hyperlipidemia 242. ketoconazole: p450 inhibitor
215. heparin: activates AT3 243. ketoconazole: gynecomastia
216. heparin: inactivates thrombin 244. ketorolac: parenteral NSAID
217. HRT: increased risk of breast and ovarian cancer 245. lamivudine: inhibits reverse transcriptase of hepatitis B
218. hydantoins: erythema multiforme 246. lamotrigine: stevens-johnson
219. hydralazine: SLE like syndrome 247. leucovorin: treats myelosuppression
220. hydroxyurea: used for sickle cell crisis 248. leuprolide: treatment for endometriosis
221. hydroxyurea: increases levels of HbF 249. leuprolide: treatment for BPH and precocious puberty
222. hydroxyurea: inhbits DNA synthesis by blocking 250. leuprolide: stimulates release of FSH and LH
conversion of ribonucleotides to deoxyribonucleotides 251. leuprolide: GnRH agonist used to treat prostate cancer
223. ibuprofen: similar to aspirin, lacks antiplatelet effects 252. lithium: inhibits IP3 and DAG
224. ibuprofen: reversibly inhibits COX 253. lithium: causes tremor, hypothyroidism, polydipsia,
225. indomethacin: potent NSAID used to close a PDA polyuria
226. infliximab: binds and inhibits TNF-alpha 254. loop diuretics: ototoxic and nephrotoxic
227. interferon alpha: produced by virally infected cells to 255. loperamide: suppress GI motility
prevent infection of adjacent cells 256. loratadine: nonsedating antihistaminic
228. interferon alpha: used to treat CML, malignant myeloma, 257. losartan: functions at the collecting tubules
kaposi sarcoma, hairy cell leukemia
258. losartan: CI in pregnancy
229. interferon alpha: recombinantly produced cytokine
259. lysergic acid diethylamide: hallucinogenic, nausea,
230. ipecac syrup: acts to stimulate chemoreceptor trigger zone weakness
of the medulla
260. magnesium hydroxide: laxative antacid
231. ipratropium: dry mouth side effect
261. MAO-B: degrades dopamine
232. ipratropium: antimuscarinic for COPD and asthma
262. MAOI: inhibits breakdown of amine neurotransmitters
233. isocarboxazid: MAOI
263. MAOI + SSRI: serotonin syndrome
234. isoniazid: inhibits synthesis of mycolic acid
264. marijuana: lowers intraocular pressure in glaucoma
235. isoniazid: SE neuritis and hepatitis

5
265. mebendazole: inhibits microtubule synthesis and glucose 291. metoclopramide: prokinetic agent used to block emesis
uptake by helminths 292. metoclopramide: blocks D2 receptors in the area
266. mebendazole: used to treat pinworms postrema
267. mebendazole: microtubule inhibitor 293. metoprolol: selective b1 blocker
268. mefloquine: used for prophylaxis of p. falciparum due to 294. metronidazole: activated by anaerobes and parasites
low SE 295. metronidazole: interferes with nucleic acid synthesis
269. meperidine: causes relaxation of the sphincter of oddi 296. metronidazole: used to treat amebiasis, trichomoniasis,
270. meperidine: causes increased ICP giariasis, and c. diff
271. mercaptopurine (6-MP): activated by 297. metronidazole: bactericidal
hypoxanthine-guanine phosphoribosyltransferase 298. metronidazole: causes disulfiram-like reaction
(HGPRT)
299. mifepristone: blocks binding of progesterone to
272. mercaptopurine (6-MP): inhibits many enzymes involved cytoplasmic receptors
in purine metabolism
300. minoxidil: direct-acting vasodilator
273. mescaline: hallucinogenic, nausea, weakness
301. minoxidil: used topically bc of benefit of hypertrichosis
274. metformin: biguanide compound
302. misoprostol: PGE analog
275. metformin: increases peripheral glycolysis
303. misoprostol: decreases gastric acid production, increases
276. methadone: treatment of opiod withdrawal mucus production
277. methanol: causes damage by being converted to 304. misoprostol: eicosanoid preparation used for pts taking
formaldehyde in the liver lots of NSAIDs
278. methanol: retinal damage, blindness, metabolic acidosis, 305. monteleukast: LTD4 and LTE4 antagonist
coma
306. MOPP: mechlorethamine, oncovin, procarbazine,
279. methi, naf, diclox: beta lactams prednisone
280. methicillin: bulky R-group prevents degradation by 307. morphine: binds mu receptors
penicillinase
308. MPTP: destroys dopaminergic neurons of the nigrostriatal
281. methimazole: same as PTU but crosses placenta and tract
enters breast milk
309. n-acetylcysteine: protects against fulminant hepatic
282. methotrexate: S phase inhibitor failure
283. methotrexate: inhibits DHFR 310. n-acetylcysteine: used for acetaminophen overdose
284. methotrexate: folic acid analog 311. nafcillin: bulky R-group prevents degradation by
285. methylphenidate: stimulates the release of catecholamines penicillinase
286. methylsergide: blocks serotonin receptors 312. naloxone: mu opioid receptor antagonist
287. methylsergide: causes fibroplasia of retroperitoneum and 313. naloxone: used to treat opioid overdose
subendocardium 314. neomycin: used to treat hepatic encephalopathy
288. methylsergide: used to prevent migraines 315. neomycin: prevents accumulation of nitrogenous
289. metoclopramide: facilitates acetylcholine while blocking microbial metabolites
dopamine in the enteric nervous system
290. metoclopramide: SE are sedation, diarrhea,
extrapyramidal symptoms

6
316. nevirapine: NNRTI used to treat HIV 341. paclitaxel: prevents mitotic spindle breakdown
317. niacin: directly reduces secretion of VLDLs 342. paclitaxel: interferes with anaphase
318. niacin: increases HDL 343. paclitaxel: microtubule stabilizing agent
319. niacin: causes cutaneous flushing 344. penicillamine: used to treat wilson disease
320. nifurtimox: used to treat chagas disease 345. penicillamine: used to treat RA
321. nitrofurantoin: can cause hemolysis in G6PDH deficient 346. penicillamine: used to treat copper toxicity bc it is a
patients chelator
322. nitrofurantoin: can accumulate to toxic levels in patients 347. penicillins: inhibits transpeptidation step in bacterial cell
with renal failure wall synthesis
323. nitrofurantoin: urinary antiseptic that requires 348. penicillins: erythema multiforme
acidification 349. penicillins: bactericidal
324. nitroglycerin: postural hypotension, headache, flushing 350. PGE: used to maintain a PDA in congenital heart disease
325. nitroglycerin: causes increase in cGMP in vascular 351. phencyclidine (pcp): nystagmus, hypertension, seizure
smooth muscle
352. phenelzine: MAOI
326. nitroprusside: stimulates guanyl cyclase
353. phenobarbital: binds GABA receptors
327. nitroprusside: increases cGMP in vascular smooth muscle
354. phenobarbital: increases the duration of chloride channel
328. nitrous oxide: has a high MAC opening
329. nystatin: disrupts fungal membrane permeability by 355. phenobarbital: used to treat tonic-clonic seizures and
binding to ergosterol crigler-najjar
330. nystatin: used to treat oral candidiasis and diaper rash 356. phenoxybenzamine: adrenergic antagonist (alpha
331. octreotide: used to treat carcinoid, gastrinoma, receptors)
somatotropic pituitary adenoma 357. phentolamine: used in diagnosing pheochromocytoma
332. omeprazole: H/K ATPase inhibitor 358. phenytoin: inducer of p450
333. ondansetron: serotonin-3 inhibitor that acts at the area 359. phenytoin: SLE like syndrome
postrema
360. phenytoin: interferes with folate absorption
334. opiods: causes biliary spasm
361. phenytoin: SE are gingival hyperplasia, hirsutism,
335. opioid overdose: constricted pupils, clammy skin, nausea, anemia, and birth defects
drowsiness, resp depression
362. phenytoin: class 1b antiarrhythmic
336. opioid withdrawal syndrome: nausea, chills, sweats,
363. pilocarpine: treatment of glaucoma
lacrimation, cramps, rhinorrhea, yawning, piloerection,
diarrhea, tremor 364. pilocarpine: muscarinic agonist
337. organophosphates: anticholinesterases used in chemical 365. piperacillin: used against enterobacter and pseudomonas
warfare 366. polymyxin b: cationic detergent that disrupts bacterial
338. oseltamivir: neuraminidase inhibitor that prevent viral membranes
spreading 367. polymyxin b: causes neurotoxicity and acute tubular
339. oseltamivir: used against influenza a necrosis
340. paclitaxel: microtubule inhibitor 368. polymyxin b: only used topically

7
369. pralidoxime: antidote for anticholinesterases such as 396. reserpine: enters the CNS and may cause suicidal
organophosphates depression and parkinsonian symptoms
370. praziquantel: used for fluke and tapeworm infections 397. reserpine: antihypertensive agent that blocks the storage
371. prazosin: first dose syncope and release of catecholamines and serotonin from
neurons
372. prazosin: miosis
398. RhoGAM: antibody to Rh(D) antigen that opsonizes
373. prednisone: triggers apoptosis
399. ribavirin: guanosine analog
374. prednisone: treatment for leukemia, lymphoma, RA,
asthma 400. ribavirin: inibits steps in RNA synthesis
375. primaquine: G6PDH 401. ribavirin: used to treat viral hemorrhagic fevers and
hepatitis C
376. probenecid: competes with uric acid for reabsorption in
the proximal tubule 402. ribavirin: used to treat RSV
377. probenecid: inhibits secretion of weak acids 403. rifampin: inhibits DNA-dependent RNA polymerase
378. probucol: decreases HDL as well as LDL 404. rifampin: imparts red-orange color to secretions
379. probucol: prevents restenosis after angioplasty 405. rifampin: TB
380. probucol: acts as an antioxidant 406. rifampin: inducer of p450
381. procainamide: SLE like syndrome 407. risperidone: causes high sedation
382. procarbazine: causes disulfiram-like reaction 408. risperidone: atypical antipsychotic with lots of
extrapyramidal SE
383. propylthiouracil: inhibits iodination step of thyroid
hormone synthesis 409. risperidone: blocks D2 and serotonin-2 receptors
384. protamine sulfate: reverses effects of heparin 410. ritonavir: inhibit protease in the HIV pol gene
385. psilocybin: hallucinogenic, nausea, weakness 411. rituximab: binds CD20 antigen on B cells
386. pyrantel pamoate: stimulates nicotinic receptors in 412. rituximab: treatment of non-hodgkin lymphoma
nematodes 413. rofecoxib: COX-2 inhibitor
387. pyrazinamide: TB 414. rofecoxib: sulfa drug
388. pyridostigmine: used for tubocurarine toxicity 415. ropinirole: forestalls the use of levodopa in parkinson's
389. quinine: blocks DNA replication and RNA transcription in disease
p. falciparum within RBCs 416. salicylates: erythema multiforme
390. quinine: causes cinchonism 417. salmeterol: may cause tremors and arrhythmias
391. quinine: used for malaria 418. sargramostim: recombinant GM-CSF
392. raloxifene: estrogen partial agonist 419. scopolamine: competitive cholinergic antagonist used for
393. raloxifene: does not increase the risk of endometrial motion sickness
cancer 420. selegiline: inhibits MAO-B
394. repaglinide: rapid onset sulfonylurea
395. repaglinide: binds potassium channels to facilitate insulin
release

8
421. selegiline: inhibits degradation of dopamine in CNS, used 450. sumatriptan: used for acute migraine and cluster
with levodopa for parkinson's headaches
422. spironolactone: potassium sparing diuretic 451. tacrolimus: binds to the immunophilin FK-binding protein
423. spironolactone: aldosterone antagonist 452. tacrolimus: used in transplant patients
424. spironolactone: functions at the collecting tubule 453. tamoxifen: increases risk of endometrial cancer
425. spironolactone: gynecomastia 454. tamoxifen: estrogen receptor partial antagonist
426. statins: may cause elevated liver enzymes 455. tamoxifen: increases risk of endometrial carcinoma
427. statins: may cause myositis 456. tazobactam: beta lactamase inhibitor
428. statins: may cause increased CK from skeletal muscle 457. tetracycline: inhibits 30s ribosome
429. streptogramins: p450 inhibitor 458. tetracycline: bacteriostatic drug
430. streptogramins: arthralgias and myalgias 459. tetracycline: CI in pregnant women due to bone dysplasia
431. streptogramins: used to treat MRSA and VRE and dental enamel defects
432. streptokinase: catalyzes conversion of plasminogen to 460. tetracycline: photosensitivity
plasmin 461. thalidomide: used to treat SLE, multiple myeloma, and
433. streptomycin: TB leprosy
434. succimer: orally active metal chelator 462. thalidomide: suppresses production of TNF-alpha
435. succinylcholine: muscle relaxant 463. thalidomide: potent immunosuppressant
436. succinylcholine: nicotinic agonist that opens sodium 464. theophylline: methylxanthine used for asthma
channels 465. theophylline: inhibits phosphodiesterase
437. sucralfate: requires acidic environment to polymerize 466. theophylline: inhibits conversion of cAMP to AMP
438. sucralfate: cannot be used with antacids or H2 blockers 467. thiabendazole: microtubule inhibitor
439. sulbactam: beta lactamase inhibitor 468. thiopental: ultra-short acting barbiturate used to induce
440. sulfamethoxazole: blocks dihydropteroate synthase surgical anesthesia
441. sulfinpyrazone: acts simliarly to probenecid 469. thioridazine: low potency dopamine receptor blocker
442. sulfonamides: stevens-johnson 470. thioridazine: side effects are retinal deposits, torsades,
postural hypotension, sedation, CNS depression
443. sulfonamides: G6PDH
471. ticarcillin: used against enterobacter and pseudomonas
444. sulfonamides: photosensitivity
472. ticlopidine: platelet antiaggregant
445. sulfonylureas: stimulate closure of potassium channels
473. ticlopidine: interferes with binding of fibrin to Gp2b/3a
446. sulfonylureas: glyburide and glipizide
receptor on platelets
447. sulfonylureas: cause release of preformed insulin
474. TMP-SMX: blocks folate synthesis
448. sumatriptan: binds the serotonin 1D receptor
475. TMP-SMX: can cause megaloblastic anemia
449. sumatriptan: causes vasoconstriction of cerebral
vasculature

9
476. TMP-SMX: do not give to pts with G6PDH deficiency 504. zolpidem: hypnotic drug that is not a benzodiazepine
477. tranylcypromine: MAOI
478. trastuzumab: binds to receptor tyrosine kinase Erb-B2
(HER-2)
479. trastuzumab: used for HER-2 positive breast cancer
480. trimethoprim: blocks DHFR
481. troglitazone: hepatotoxic
482. tubocurarine: nondepolarizing neuromuscular ganglionic
blockers
483. valproic acid: causes neural tube defects
484. valproic acid: used to treat all kinds of seizures, as well as
bipolar disorder
485. valproic acid: massive hepatic necrosis
486. vancomycin: used to treat MRSA
487. vancomycin: used to treat c. difficile
488. vancomycin: rapid IV infusion causes red man syndrome
489. vancomycin: bactericidal
490. vancomycin: causes cutaneous flushing
491. vancomycin: mildly ototoxic and nephrotoxic
492. vasopressin: used to treat esophageal varices
493. vasopression: V1 and V2 agonist
494. vincristine: M phase inhibitor
495. vincristine: blocks microtubule polymerization and spindle
formation
496. vincristine: used for lymphomas, wilms tumor, and
choriocarinomas
497. vincristine: microtubule inhibitor
498. warfarin: interferes with vitamin K dependent clotting
factors
499. zidovudine: inhibits viral reverse transcriptase
500. zidovudine: chain terminator
501. zidovudine: given to prevent transmission of HIV to
neonates
502. zileutin: inhibits leukotriene synthesis
503. zolpidem: binds benzodiazepine receptors, antagonized by
flumazenil

10