Optimal Imaging conditions for C-

C-PETplus
The ADAC C-PETplus PET-scanner acquires all data in full 3D mode (no septa) which
results in a very high sensitivity. Therefore the scanner requires less activity to be injected in
a patient than a 2D-PET-scanner with septa. For whole body oncologic studies, we
recommend to follow the injected dose levels outlined in the table below. This will ensure the
optimal imaging conditions for the scanner and result in best image quality. Since the count
rate of the scanner depends on the activity concentration in the patient it is important to inject
depending on body weight. We provide injection values for uptake times of 60 min. and 90
min., the latter are recommended in literature for most oncologic applications. These dose
values have been proved to lead to very good image quality at other C-PET sites. Shorter
uptake times than listed below will lead to higher activity concentrations in the patient and
therefore to decreased image quality. Longer uptake times have a lesser impact, however, for
to long uptake times (>2.5 h) the statistics in the images will be reduced. For physical reasons
there is no further increase of the injected dose needed for patients > 90 kg.

Patient Body Weight Recommended injection of Resulting activity

FDG in mCi concentration
kg lbs 60 min 90 min mCi/kg
uptake uptake at time of scan
40 88 1.8-2.2 2.2-2.7 0.035
45 99 2.0-2.5 2.4-3.0 0.035
50 110 2.2-2.8 2.7-3.3 0.035
55 121 2.5-3.0 3.0-3.6 0.035
60 132 2.7-3.3 3.3-4.0 0.035
65 143 2.9-3.6 3.5-4.3 0.035
70 154 3.1-3.8 3.8-4.6 0.035
75 165 3.4-4.1 4.1-5.0 0.035
80 176 3.6-4.4 4.3-5.3 0.035
85 187 3.8-4.7 4.6-5.7 0.035
90 198 4.1-4.9 4.9-6.0 0.034
95 209 4.1-4.9 4.9-6.0 0.032
100 220 4.1-4.9 4.9-6.0 0.031
105 231 4.1-4.9 4.9-6.0 0.029
110 242 4.1-4.9 4.9-6.0 0.028
115 253 4.1-4.9 4.9-6.0 0.027
120 264 4.1-4.9 4.9-6.0 0.026
125 275 4.1-4.9 4.9-6.0 0.025
130 286 4.1-4.9 4.9-6.0 0.024
135 297 4.1-4.9 4.9-6.0 0.023
Schematic of count rate curves as function of activity concentration
for C-PETplus