ECE 309 Biomedical Signal Processing and Analysis L T P C

3 0 0 3
Version No.: 2.00
Prerequisite: ECE205 Electrical and Electronic Measurements
Objectives:
Explain the human anatomy and physiology and the systems related to human body
Describe the electrical model of different bio electrodes used to capture electrical signals and
design of amplifiers with high gain and high isolation used for bio- applications.
Introduce new technologies in diagnostic and clinical applications.
Expected Outcome:
Student will be able to:
Design amplifiers circuits with high gain and high isolation used for bio applications.
Design an instrument system for electro physiological applications
Troubleshoot the shortcomings of electro physiological instruments.
Comprehend the operation of various bio-medical instruments
Unit I Concept of Medical Instrumentation
The origin of biopotentials, Measurement of biopotentials, Examples of biopotential electrodes
and signals, Microelectrodes, Biopotential amplifiers. Random noise, structured noise, and
physiological interference, Stationary versus nonstationary process, Noise in event related
potential

Unit II Cardiovascular Measurement

Measurements of Blood Pressure- Diastolic & Systolic measurement by invasive and non
invasive methods - Ultra sound, Spygmomanometer Automated methods - direct methods.
Blood flow: Electro-magnetic, Ultrasound, Blood cell counters. Blood flow, Doppler flow
measurement, Cardiac output. Electrocardiography, Phonocardiography, Plethysmography,
Cardiac pacemaker & Computer applications.

Unit III Noises in ECG & Filters at Treatment

High frequency noise, motion artifact in ECG, Power-line interference in ECG, Maternal
interference in fetal ECG, Muscle Contraction interference in VAG Signals, Time domain
filters- Synchronized averaging, Moving-average filters, Frequency domain filters Removal of
high frequency noise: Butterworth LPF, Removal of low frequency noise: Butterworth HPF. The
P, QRS, and T waves in the ECG, Derivative-based methods for QRS detection, The Pan-
Tompkins algorithm for QRS detection.

Unit IV Adaptive Filters & Noise Canceling

Optimal filtering- The Wiener filter, the adaptive noise canceller, The least-mean squares
adaptive filter, The recursive least square adaptive filter, Selecting an Appropriate filter,
Application: Maternal Fetal ECG. Noise Canceling Method to Enhance ECG Monitoring.
Fetal ECG Monitoring.

Unit V Measurement of Electrical activities

Electroencephalograph, Electromyography & their Interpretation, Detection of EEG rhythms,
Template matching for EEG spike and wave detection, Detection of EEG Spike and wave
complexes using Matched filter, Homomorphism filtering.
Frequency analysis of murmurs to diagnose valvular defects, The Fourier Spectrum, Estimation
of Power Spectral Density Function, Estimation of autocorrelation function, Synchronized
averaging of PCG Spectra, Moments of PSD functions, Spectral Power Ratios.

Proceedings of the 29th Academic Council [26.4.2013] 357

Textbooks
1. Rangaraj M. Rangayyan, Biomedical Signal Analysis A case study Approach, John Wiley & Sons,
2002.

Reference Books
1. Khandpur R.S., Handbook of Biomedical Instrumentation, Tata McGraw Hill, 1990.
2. Harry E. Thomas, Handbook of Automated Electronic Clinical Analysis, Reston Publishing
Company, Virginia, 1979.
3. Richard A. Normann, Principles of BioInstrumentation, John Wiley, 1988.
4. Richard Aston, Principles of Biomedical Instrumentation, Merrill Publishing, 1991.
5. Joseph J. Carr & John M. Brown, Introduction to Biomedical Equipment Technology, 3/e,
Prentice Hall.
6. Leslie Cromwell, Weibell, Erich A. Pfeiffer, Biomedical Instrumentation and Measurements, 2/e,
Prentice Hall of India, 2002.
7. D. C. Reddy, Biomedical Signal Processing- Principles and Techniques, Tata McGraw-Hill,
2005.

Mode of Evaluation: CAT- I & II, Assignments/ other tests, Term End Examination.

Proceedings of the 29th Academic Council [26.4.2013] 358