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Cronin et al.
MR Small-Bowel Follow-Through in Pediatric Patients
Pediatric Imaging
Original Research
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MR Small-Bowel Follow-Through
FOCUS ON:
S
follow-through (SBFT), pediatric patients, small-bowel mall-bowel pathology is not rare absent ionizing radiation exposure may have
disease in both pediatric and adult popu- significant implications on future patient
lations. Several entities, including care [1].
DOI:10.2214/AJR.08.1183
Crohns disease, celiac disease, MR small-bowel follow-through (SBFT)
Received May 6, 2008; accepted after revision the polyposis syndromes, intestinal malrota- offers a number of distinct advantages over
August 1, 2008. tion, luminal stenosis, and atresia, may mani- its projectional and cross-sectional alterna-
1
fest in childhood. Furthermore, many of these tives, including absence of associated ioniz-
All authors: Department of Radiology, University College
Hospital, Newcastle Rd., Galway, Ireland. Address
conditions require frequent, repetitive imaging ing radiation exposure, multiplanar imaging
correspondence to C. G. Cronin for diagnosis, assessment of response to treat- capabilities, superb contrast and temporal
(carmelcronin2000@hotmail.com). ment, and surveillance. Because the cumula- resolution, facilitation of sequential imag-
tive lifetime radiation exposure for patients ing over prolonged periods of time, and ob-
AJR 2009; 192:12391245 in this age group may culminate in a very viation of potentially nephrotoxic contrast
0361803X/09/19251239
real risk of cancer induction, any technique medium administration. Although MR
that combines high sensitivity for detection SBFT has proven efficacy in imaging the
American Roentgen Ray Society of soft-tissue abnormalities with limited or small bowel in the adult population [16],
reports describing the feasibility and suc- Materials and Methods September 2003 to January 2008, 280 MR SBFT
cess of this technique in pediatric patients Subjects examinations were performed at a single institute.
are extremely limited, hence the purpose of Institutional review board approval was These examinations included 17 children who
this study. obtained for this study. During the period from underwent MR SBFT (19 examinations) using a
standardized technique for evaluation of known or mixture [24]. Each phase of imaging involved Data Analysis
clinically suspected small-bowel abnormality. coronal and axial 2D acquisitions from the Retrospective chart analysis was also perform
Specific indications are outlined in Table 1. diaphragm to the symphysis pubis in craniocaudal ed, gathering information regarding patient symp
The currently analyzed pediatric group is from a extent and the entire abdominal cavity in the toms, indication for the MR SBFT examination,
similar database from previous articles [24, 7], transverse plane. Delayed repeat imaging was preexisting conditions, and correlating investiga
but the patients are unique. There is overlap of two performed as required until the contrast bolus had tional results. The amount of ingested oral
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patients with McKenna et al. [6]; however, this passed to the colon, in accordance with the image contrast agent is routinely noted immediately
research effort is unique in its objective. The acquisition algorithm suggested by Lohan et al. [7]. after the examination as part of departmental
images obtained were retrospectively evaluated on Examination completion was defined as the pres policy and was used in our study to score patient
a PACS. ence of contrast material in the cecum or further tolerance: poor (< 300 mL), moderate (300600
distally, having achieved prior diagnostic-quality mL), and well (> 600 mL). Total and average
Technique distention of the small bowel throughout its length. numbers of visits to the MR table, derived from
All patients were instructed to fast from the Patients were brought to the MR table only for information available on the PACS system, were
preceding midnight. No bowel preparation, image acquisition and remained in the preparation also noted, as was the total time spent on the MR
medications to promote gastric emptying or bowel room between sequential phases of imaging. One table (table time).
relaxation, or paramagnetic contrast agents were parent was allowed to remain in the scanning room
administered before imaging. Bowel distention with the patient if so desired after full safety Image Analysis
was achieved using a single packet of polyethylene screening of the parent involved. Earplugs were Each of the MR SBFT examinations was
glycol (PEG) solution (Klean Prep, Norgine) provided to prevent acoustic discomfort or trauma blindly and independently reviewed by two con
diluted in 1,000 mL of water and a small amount to the accompanying parent. No sedation of any sultant radiologists with an interest in MRI and
of orange flavoring added to render the mixture kind, either oral or IV, was used to improve gastrointestinal disease. For the purpose of image
more palatable [24]. Patients were instructed to acceptance or success of the MR examination. assessment, the small bowel was considered as
consume at least 600 mL of the 1,000 mL solution Patients were imaged in the supine position comprising five distinct segments: the duodenum,
over a 10- to 15-minute period, as permitted by because neither the supine nor prone position has jejunum, proximal ileum, distal ileum, and
individual patient tolerance [5, 8]. PEG is a high- been shown to be superior to the other in terms of terminal ileum [2]. Images were blindly and
osmolarity, nonabsorbed, nonfermented contrast lesion detection on prior comparative studies [2]. qualitatively evaluated with regard to degree of
medium that provides exquisite intraluminal All examinations were performed on a Symphony small-bowel distention using a visual assessment
contrast and luminal distention (PEG macrogol 1.5-T MRI system (Siemens Medical Solutions) grading scale that ranged from 1 to 3, as validated
3350, 59.0 g; anhydrous sodium sulfate, 5.685 g; equipped with high-performance gradient coils, in prior studies [24]. A score of 1 was taken to
sodium bicarbonate, 1.685 g; sodium chloride, characterized by a maximum gradient amplitude represent poor; 2, moderate; and 3, excellent
1.465 g; potassium chloride, 0.7425 g). All patients of 52 mT/m and a slew rate of 125 T/m/s. Large small-bowel distention. Scores of 2 or 3 were
and their parents were provided with an flexible surface coils were used in addition for taken to indicate an examination of diagnostic
information sheet detailing the procedure and the optimal signal reception. True fast imaging with quality. In assigning scores to each anatomic
potential risk of diarrhea due to PEG before steady-state free precession (SSFP) acquisitions segment, observers were requested to determine
commencement of the examination. was obtained during suspended inspiration, the the adequacy of small-bowel distention according
field of view encompassing from the diaphragm to to visibility of the bowel lumen, endoluminal
MR Protocol the symphysis pubis with the following imaging folds, and bowel wall. Jejunal loops were
Initial images were obtained 20 minutes after parameters: TR/TE, 4.72/2.36 and section distinguished from ileal loops both by their
commencement of contrast ingestion, irrespective thickness, 8-mm axial (distance factor, 20%) and respective locations and by the configuration of
of the patients ability to consume the entire contrast 5-mm coronal (distance factor, 0%). their folds (i.e., more closely packed, jejunum;
sparse, ileum) [2]. The number and location of
intraluminal, mural, and extraluminal pathologic
lesions depicted at each segment were recorded
and compared for each observer. Differences in
mean examination durations were assessed using
the unpaired Students t test. Interobserver
agreement with regard to small-bowel distention
scores assigned was assessed using the kappa
coefficient, with = 0 indicating poor agreement;
= 0.010.20, slight agreement; = 0.210.40,
fair agreement; = 0.410.60, moderate
agreement; = 0.610.80, substantial agreement;
Fig. 1Axial MR small- and = 0.811.00, excellent agreement.
bowel follow-through
image in 13-year-old boy Results
who had normal small
Seventeen children (11 boys and six girls;
bowel shows moderate
small-bowel distention age range, 617 years; mean age, 13.8 years)
(arrow). underwent 19 MR SBFT examinations. Two
children underwent follow-up MR SBFT ex- TABLE 2: Mean Distention Score per Small-Bowel Segment for
aminations, one for acute symptomatic exac- Each Observer
erbation of Crohns disease and the second
Observer Duodenum Jejunum Proximal Ileum Distal Ileum Terminal Ileum
for progressive Crohns disease.
Oral contrast material was ingested and 1 2.3 2.3 2.5 2.7 2.6
subsequent imaging was possible in all pa- 2 2.3 2.1 2.5 2.6 2.6
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tients. No significant adverse effects were en- NoteSmall-bowel distention was scored using a visual assessment grading scale that ranged from 1 to 3. A
countered after contrast ingestion. In 16 score of 1 was taken to represent poor; 2, moderate; and 3, excellent small-bowel distention.
(84.2%) of 19 examinations, the oral contrast
agent was well tolerated, whereas patients in Overall bowel distention was excellent in 15.8%. The reliable degree of segmental
three (15.8%) of 19 examinations had a mod- 16 (84.2%) of 19 patients and moderate in small-bowel distention provided facilitates vi-
erate ability to tolerate contrast ingestion. Two three (15.8%) of 19 examinations (Table 1 and sualization of luminal, mural, and extramural
children experienced nausea and one, vomit- Figs. 1 and 2). Mean distention scores as- disease without the need for duodenojejunal
ing during the ingestion process; these symp- signed to the duodenum, jejunum, proximal intubation (as is the case during enteroclysis)
toms limited oral contrast consumption to ileum, distal ileum, and terminal ileum were a traumatic process that bypasses and thus
58% of the recommended amount in one pa- 2.3, 2.3, 2.5, 2.7, and 2.6, respectively, for ob- precludes evaluation of the duodenum because
tient (350 mL) and 66% of recommended server 1 and 2.3, 2.1, 2.5, 2.6, and 2.6, respec-
amount in two children (400 mL). This inabil- tively, for observer 2 (Table 2). Interobserver
ity to comply with contrast instructions result- agreement was substantial ( = 0.73).
ed in moderate distention in these three cases No morphologic abnormalities were de-
(mean distention scores of 1.4, 1.6, and 1.8). tected in nine (47%) of 19 examinations,
The mean number of visits to the MR ta- whereas pathologic lesions were identified in
ble was 1.3 (range, 13 visits). Of our 19 pa- 10 (53%) of 19 examinations (Table 1). De-
tients, 31.6% (6/19) underwent delayed im- tailed information regarding the abnormali-
aging: 26.3% (5/19) underwent one delayed ties detected is provided in Table 3 and some
study and 5.3% (1/19) underwent two de- are illustrated in Figures 38.
layed studies. The mean duration for com-
plete small-bowel evaluation was 25 minutes Discussion
(range, 2060 minutes). No significant dif- The current study shows that MR SBFT us-
ference was identified between mean exami- ing PEG as an oral contrast agent is feasible in
nation duration in patients with negative children with suspected small-bowel abnor-
studies and those with positive findings (p > malities, providing examinations within the
0.05, Students t test). All patients tolerated diagnostic range in the majority of cases. The
Fig. 2Coronal MR small-bowel follow-through
the MRI study time, the table time ranging oral contrast medium was well tolerated in image in 6-year-old boy who had normal small bowel
from 2 to 4 minutes. 84.2% of studies and moderately tolerated in shows excellent small-bowel distention.
A B
Fig. 316-year-old girl with Crohns disease.
A and B, Excellent ileal distention is visualized at MR small-bowel follow-through (SBFT). Pathologically, MR SBFT shows concentric, thickened small-bowel walls with
attenuated valvulae conniventes (straight arrows). There is fibrofatty proliferation resulting in separation of bowel loops (white arrowheads, B) and free fluid in pelvis
(black arrowhead, B). Comb sign seen in B is due to inflammatory hyperemia of mesenteric vasculature, which suggests active disease (curved arrows, A).
Psoas
100
100
100
100
120
90
90
90
90
90
flexure [4]. The potential for duodenal evalua-
tion represents a significant advantage of MR
SBFT over enteroclysis techniques, resulting
200
200
200
220
160
180
190
180
170
170
in a significantly less traumatic experience in
a young patient [4].
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Abscess or
Sacroiliitis,
Phlegmon,
No
No
No
No
No
No
No
No
No
No
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Separation, fibrofatty
Extraluminal
proliferation
proliferation
proliferation
proliferation
proliferation
lesions
dren because they have a significantly short-
None
None
No
No
No
No
No
No
No
No
No
No
Yes
Yes
No
No
No
No
No
No
No
No
Attenuated Superficial
Attenuated Superficial
Attenuated Superficial
Attenuated Superficial
Attenuated Superficial
Attenuated Superficial
Ulcers
Fold
Circumferential
Circumferential
Circumferential
Circumferential
Circumferential
Circumferential
Circumferential
Mural
5 x 6 mm mass thickening
thickening
thickening
thickening
thickening
thickening
thickening
thickening
> 35 1 cm
12 5 mm
25 1 cm
3.5 x 3 mm
10 x 6 mm,
12 x 3 mm,
5 x 6 mm,
Size
6 x 2 mm
9 mm
adhesions, ileum
ilium
ilium
ilium
13
17
17
16
17
13
16
17
15
15
F
F
F
F
8
3
5
2
2
1
(34/373) of patients undergoing in excess of patients with inflammatory bowel disease, bowel abnormality. We show that MR SBFT
five CT examinations and 3% (11/373), more with the potential for overall reduction in cu- is feasible in the pediatric population because
than 10 CT examinations. The availability of mulative lifetime radiation exposure. it has the capability of rapidly providing stud-
a reproducible, accurate, sensitive technique In conclusion, MR SBFT is an emerging ies of high diagnostic quality without the need
without the need for ionizing radiation expo- technique that is of proven benefit in evaluat- for duodenojejunal intubation, patient seda-
sure may have huge implications for pediatric ing the adult patient with suspected small- tion, or ionizing radiation exposure.
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A B
A B
A B
Fig. 7MR small-bowel follow-through (SBFT) Fig. 816-year-old girl with history of Crohns disease who presented with exacerbation.
image of 16-year-old girl with Crohns disease shows A and B, Coronal MR small-bowel follow-through (SBFT) images show thickening of terminal ileum best seen in
thickening of ileum, located in center of pelvis (long A (curved arrows). There is inflammatory phlegmon adjacent to small-bowel disease (straight arrows), which is
arrows). Loops of small bowel proximal to this lesion seen on both coronal MR SBFT images. These images show moderate small-bowel distention at MR SBFT.
are dilated. Further thickening is seen in nondistended
loop of sigmoid colon (skip lesion), located in left side
of pelvis (short arrow). These images show moderate
small-bowel distention at MR SBFT.
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2. Cronin CG, Lohan DG, Mhuircheartaigh JN, et al. 5. Laghi A, Paolantonio P, Catalano C, et al. MR im- diol 2007; 62:804807
MRI small-bowel follow-through: prone versus su- aging of the small bowel using polyethylene gly- 8. Laghi A, Borrelli O, Paolantonio P, et al. Contrast-
pine patient positioning for best small-bowel disten- col solution as an oral contrast agent in adults and enhanced magnetic resonance imaging of the ter-
tion and lesion detection. AJR 2008; 191:502506 children with celiac disease: preliminary obser- minal ileum in children with Crohns disease. Gut
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Murphy JM. MR enterography of small-bowel 6. McKenna DA, Roche CJ, Murphy JM, McCarthy 9. Jaffe TA, Gaca AM, Delaney S, et al. Radiation
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subtype and the presence of underlying celiac dis- trast agent for MRI of the small bowel in a patient dominopelvic MDCT in Crohns disease. AJR
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