1. Inflammation. 2017 Nov 22. doi: 10.1007/s10753-017-0699-x.

[Epub ahead of print]

Cardioprotective Effects of Morroniside in Rats Following Acute Myocardial

Infarction.

Yu B(1), Wang W(2).

Author information:
(1)Department of Experimental
University, Beijing, People's
(2)Department of Experimental
University, Beijing, People's
Animal Centre, XuanWu Hospital of Capital Medical
Republic of China.
Animal Centre, XuanWu Hospital of Capital Medical
Republic of China. 2678516356@qq.com.

The aim of this study is to investigate the cardioprotective effects of

morroniside in rats following acute myocardial infarction. An acute myocardial
infarction (AMI) was induced by ligating the anterior descending coronary artery
(LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h
at doses of 45, 90, and 180 mg/kg, respectively. Biomarkers such as creatine
kinase (CK-MB), lactate dehydrogenase (LDH), -hydroxybutyrate dehydrogenase
(-HBDH), and aspartate aminotransferase (AST) activities in AMI rats in the
serum were detected with commercial kits [2]. Following AMI, morroniside was
administered intragastrically for 72 h at doses of 45, 90, and 180 mg/kg/d,
respectively. The expression of nuclear factor kappa B (NF-B) in cardiac
myocardium was detected by western blotting analysis. Meanwhile, cardiac function
was measured by echocardiography. We observed morroniside decreased the levels of
CK-MB, LDH, -HBDH, and AST activities in AMI rats after 24 h. We also found that
morroniside reduced the expression of NF-B in cardiac myocardium at 72 h post
AMI rats. Further, cardiac function was improved by administration of
morroniside. Collectively, our findings demonstrated that morroniside had
cardioprotective effects in rats following acute myocardial infarction.
Attenuation of inflammation might contribute to the cardioprotective effects of
morroniside.

DOI: 10.1007/s10753-017-0699-x
PMID: 29168080