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Respiratory Failure
Respiratory failure is not a disease per se but a consequence of the problems
that interfere with the ability to breathe. The term refers to the inability to perform
adequately the fundamental functions of respiration: to deliver oxygen to the
blood and to eliminate carbon dioxide from it.
Respiratory failure has many causes and can come on abruptly (acute
respiratory failure)when the underlying cause progresses rapidlyor slowly
(chronic respiratory failure)when it is associated over months or even years
with a progressive underlying process. Typically, respiratory failure initially
affects the ability either to take up oxygen (referred to as oxygenation failure) or
to eliminate carbon dioxide (referred to as ventilatory failure). Eventually, both
functions cease when the respiratory failure becomes severe enough. This
chapter will focus mainly on ventilatory failure; oxygenation failure is discussed
in more detail in Chapter 2, which examines the acute respiratory distress
syndrome (ARDS).
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Oxygenation Pneumonia
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Case study
Comment
This scenario is typical of patients who develop chronic respiratory failure
in the face of a slowly progressive neuromuscular condition. Despite the
bout with polio 58 years earlier, the patient had been able to function
normally until the aging process deteriorated his remaining motor nerves to
the point where he could no longer sustain a normal level of breathing.
Because the condition occurred so insidiously, his body had time to adapt
and rendered him unaware of any breathing difficulty at rest. Shortness of
breath at rest is a much bigger problem when respiratory failure is acute,
such as that brought on by an asthma attack, pneumonia, or ARDS.
Morning headaches are common because the rise in carbon dioxide at
night causes a reflex widening of blood vessels in the brain, increasing the
pressure of the fluid bathing the brain.
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and deeply we breathe. Depressed function of the respiratory center can con-
tribute to respiratory failure. This condition is most often related to drugs, like
narcotics, that blunt respiratory drive. Inadequate respiratory drive can also be
inherited or acquired as a consequence of processes that damage neurons,
such as strokes, severe trauma, or tumors, but this cause is rare.
The signal to breathe is carried to the muscles via nerves that can be para-
lyzed abruptly by conditions such as the autoimmune GuillainBarr syndrome
or an overwhelming infection throughout the body, such as sepsis (see Chap-
ter22); less rapidly by conditions like ALS; or, as in the case of the patient previ-
ously described, very slowly by post-polio syndrome and other conditions. High
spinal cord injury, such as that suffered by the actor Christopher Reeves, causes
respiratory failure because all muscles below the level of the injury are para-
lyzed, including the respiratory muscles. Interestingly, patients with low neck
fractures can still breathe because the nerves supplying the diaphragm arise
from the mid-neck.
The nerve signal is then conveyed to the muscles via the myoneural junction.
Antibodies to elements of the myoneural junction can cause severe weakness or
paralysis, a chronic disease called myasthenia gravis. A spectrum of diseases
affect the muscles themselves, including muscular dystrophy or acquired illnesses
like polymyositis, in which the bodys immune defense mechanisms attack the
muscles, causing inflammation and weakness. All these conditions impair the abil-
ity to move air in and out.
The first principle in managing patients at risk for respiratory failure is to prevent
progression of the underlying disease. Obviously, smoking cessation is an
extremely important component of preventive therapy, as are influenza and pneu-
mococcal vaccines. Pneumonia and asthma, for example, have specific therapies
that include antibiotics and bronchodilators that should be instituted promptly.
Simultaneously, the respiratory failure must be addressed. If it is acute and
severe, it is a medical emergency. Oxygen levels must be normalized as quickly
as possible by providing supplemental oxygen. Patients with high carbon diox-
ide levels need ventilatory support, so they receive pressurized gas from devices
(ventilators) that increase pressure when triggered by the patients inspiratory
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Nick Hill
effort or by a timer. The pressurized gas can be delivered via a plastic tube
inserted into the trachea (invasive ventilation) or via a mask strapped over the
nose and mouth or just the nose (noninvasive ventilation). Some patients may
be given noninvasive ventilation only at night. This treatment allows a better
quality of sleep so that symptoms of fatigue and daytime somnolence resolve.
Not all respiratory failure has a dire outlook. People may live functional lives
at home for many years with chronic respiratory failure, and patients with acute
respiratory failure can be ventilated until the acute disease is successfully
treated. They may then return to a normal life. Nevertheless, all respiratory fail-
ure is serious and has potential life-threatening consequences.
During the past few decades, clinical and scientific research has resulted in
greater understanding of respiratory failure and improved treatment. The iron
lung, which assisted breathing by inducing an intermittent negative pressure
around the body, was developed to cope with the respiratory failure that
accompanied the polio epidemic in the 1950s. As intensive care units were
developed to treat patients with acute respiratory failure during the 1960s,
positive pressure ventilators that forced gas into endotracheal tubes became
popular. Ventilators became increasingly sophisticated to enable patients to
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Iron lungs were the first ventilators used on a wide basis for the polio
epidemic in the 1950s. They created an intermittent negative pressure around
the chest so the lungs would expand and breathe.
trigger breaths so that they synchronized with the patients own breathing
pattern to enhance effectiveness and comfort. Over the past 15 years, better
ventilators, better delivery of air to patients, and noninvasive ventilation have
improved outcomes (3). Techniques to wean patients from invasive ventilation
more quickly and safely have also been developed, cutting down on complica-
tions and costs in intensive care units (4).
Noninvasive ventilation has been an important advance in the treatment of
acute respiratory failure. It reduces airway injury and the risk of pneumonia that
occurs because bacteria otherwise track into the lungs through the endotracheal
tube. It must, however, be used selectively, mainly for patients with COPD or
heart failure. In heart failure, blood cannot be pumped adequately, causing fluid
to back up in the lungs and interfere with oxygenation (pulmonary edema).
Often, noninvasive ventilation can support the patient until the excess fluid is
removed (3). Noninvasive ventilation has also been an important advance for
patients with chronic respiratory failure, such as the patient described in the
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case study (5). It has also led to an appreciation of the important role that abnor-
mal breathing during sleep plays in the progression of the respiratory failure (6).
For patients with chronic respiratory failure, noninvasive ventilation is much
easier and less expensive to administer than invasive ventilation, which requires
a tube to be placed surgically into the trachea but often enables patients to live
at home rather than in a long-term care institution.
RESPIRATORY CENTER
Depressed due to
strokes, drugs
PHRENIC NERVES
Amyotrophic lateral sclerosis
AIRWAYS
Obstructed due to
constriction, thickening,
mucus, COPD, asthma
PARENCHYMA
MYONEURAL JUNCTION
Inflammation, ARDS,
MUSCLE Myasthenia gravis
stiffness, fibrosis
Myopathy
Muscular dystrophy
Several possible defects contribute to respiratory failure. The signal to breathe originates in the
respiratory center and is sent by nerves via the myoneural junction to the respiratory muscles (such as
the diaphragm). Respiratory function also depends on the integrity of the airways, lung structure, and
blood vessels within the lungs. A few examples of diseases arising from the different defects are listed.
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References
1. Carson SS, Cox CE, Holmes GM, Howard A, Carey TS. The changing epidemiology of
mechanical ventilation: a population-based study. J Intensive Care Med 2006;21:173182.
2. Mason R, Broaddus V, Murray J, Nadel J, eds. Murray & Nadels Textbook of Respiratory
Medicine. 4th edition. Amsterdam, The Netherlands: Elsevier Health Sciences; 2005.
Chapters 85 and 86.
3. Nava S, Hill N. Non-invasive ventilation for acute respiratory failure. Lancet 2009;
374:250259.
4. Girard TD, Ely EW. Protocol-driven ventilator weaning: reviewing the evidence. Clin Chest
Med 2008;29:241252.
5. Ozsancak A, DAmbrosio C, Hill NS. Nocturnal noninvasive ventilation. Chest
2008;133:12751286.
6. Perrin C, DAmbrosio C, White A, Hill NS. Sleep in restrictive and neuromuscular respiratory
disorders. Semin Respir Crit Care Med 2005;26:117130.
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