BIO201: Flow of Genetic Information

Nagarjun Vijay

nagarjun@iiserb.ac.in
 Lectures
Course outline
15 major themes *
No attendance
Quizzes 2
Counts toward total grade
Informed in advance & no negative marks
Written examination
30 objective + 3 long essay type no negative marks
Mid term (30% of total grade)
Final term (50% of total grade)
Wild card quiz
Counts toward total grade surprise quiz
Analytical questions - has negative marks for wrong answers
Also counts towards O grade
* means important for exams & quizzes
 Course outline
Each theme

Keyword discussion (for self study hour) *

Discovery assignment (for self study hour)
Research/review paper reading (for self study hour)

OPTIONAL (counts only towards O grade) one of the following

Register your choice with TA before August 31st

Group presentation
Group/individual research presentation
Group/individual research proposal (max 1 page, excluding references)
Individual Wikipedia editing assignment
 Major Themes
1. Concept of central dogma of life and variations (Francis Crick)
2. Macromolecules and their organizations- DNA, RNA, Protein- Structure, conformation and
organization (Rosalind Franklin)
3. Chromatin structure and nucleosomes
4. Genes and genome organization (Sydney Brenner)
5. Plasmids and extra chromosomal DNA (Joshua Lederberg)
6. Transposons (Barbara McClintock)
7. Gene regulation (Jacques Monod)
8. DNA replication in prokaryotes (Tsuneko Okazaki)
9. DNA replication in eukaryotes
10. Mechanism of transcription in prokaryotes
11. Mechanism of transcription in eukaryotes (Roger D. Kornberg)
12. Translation: Genetic code, and its degeneracy, regulation of translation process (Marshall Warren
Nirenberg)
13. Concept of RNA world (Walter Gilbert)
14. RNA replication and processing: capping, polyadenylation
15. Introduction to gene silencing, epigenetics (Andrew Fire)
What is Inheritance?
How does inheritance work?
 Particles of heredity

https://en.wikipedia.org/wiki/Robert_Feulgen
Griffiths experiment

"transforming principle"
AveryMacLeodMcCarty experiment
The Hershey-Chase Experiment
Flow of genetic information
Theme image
 Theme 1: Central dogma of life
The Central Dogma. This states that once information
has passed into protein it cannot get out again. In more
detail, the transfer of information from nucleic acid to
nucleic acid, or from nucleic acid to protein may be
possible, but transfer from protein to protein, or from
protein to nucleic acid is impossible. Information means
here the precise determination of sequence, either of
bases in the nucleic acid or of amino acid residues in the
protein.

Francis Crick, 1958

 Keywords 1
(for self study hour)

1. Inheritance
2. Gregor Mendel
3. Feulgen stain
4. Griffiths experiment
5. Transforming principle
6. Hershey-Chase experiment
7. DNAse
8. Protease
9. AveryMacLeodMcCarty (AMM) experiment
10. Genetic information