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PATHOPHYSIOLOGY

CONTRIBUTIN
PRECIPITATIN PREDISPOSIN
G
GFACTORS GFACTORS
- Age : 77 years FACTORS
old -Stress
NSAIDs use -Diet: spicy
food, coffee
addict

Elicit their effects on


the cyclooxygenase-
1
Impaired mucosal
defense to acid

Disruption of mucous
barrier

Inflammatory effect Neutrophils: .86%


on gastric mucosa

Ulcer burrows deep

Weakening and
necrosis of arterial
wall
Development of
pseudoaneurysms

Peripheral Weakened wall


vasoconstriction raptures leading to
hemorrhage

Pale nail
beds and UPPER GASTROINTESTINAL
conjuctiva BLEEDING

- Generalized BP: 130/70


Body RR: 21
Weakness CR: 80
- Dizziness