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TO ESTIMATE SURVIVAL FROM NEWLY DIAGNOSED BRAIN METASTASES (Sperduto PW et al., 2012)
Prognostic Factor 0 0,5 1,0 Patient Score
Non-small-cell Age, years >60 50-60 <50
and small-cell KPS <70 70-80 90-100
Lung cancer Extracranial MTX Present - Absent
No. of BM >3 2-3 1
Median survival (months): 0 - 1.0 = 3.0 / 1,5-2,0=5,5 / 2,5-3,0=9,4 / 3,5-4,0 = 14,8 Total:
Prognostic Factor 0 1,0 2,0 Patient Score
Melanoma KPS < 70 70-80 90-100
No. of BM >3 2-3 1
Median survival (months): 01,0 = 3,4 / 1,52,0 = 7,7 / 2,5 3,0 = 15,1 / 3,5 4,0 = 25,3 Total:
Prognostic factor 0 1,0 2,0 Patient Score
Renal cell
KPS < 70 70-80 90-100
carcinoma
No. of BM >3 2-3 1
Median survival (months): 0-1,0 = 3,3 / 1,5-2,0 = 7,3 / 2,5 - 3,0 = 11,3 / 3,5 - 4,0 = 14,8 Total:
Prognostic Factor 0 1 2 3 4 Patient Score
GI cancers
KPS <70 70 80 90 100
Median survival (months): 0 1,0 = 3,1 / 2,0 = 4,4 / 3,0 = 6,9 / 4,0 = 13,5 Total:
Prognostic Factor 0 0,5 1,0 1,5 2,0 Patient Score
KPS 50 60 70-80 90-100 n/a
Breast cancer
Subtype Basal n/a LumA HER2 LumB
Age, years 60 < 60 n/a n/a n/a
Median survival (months): 0-1,0 = 3,4 / 1,5 2,0 = 7,7 / 2,5 3,0 = 15,1 / 3,5 4,0 = 25,3 Total:
Breast cancer subtype denitions: Basal: triple [ - ] / LumA: ER / PR [+], (HER2) [ - ] / LumB: triple [+] / HER2: ER / PR [ - ], (HER2) [+].
VERSO
UNIVERSIDADE FEDERAL FLUMINENSE
HOSPITAL UNIVERSITRIO ANTNIO PEDRO
DEPARTAMENTO DE NEUROCIRURGIA
FRENTE