Session O9. Neuropharmacology
Neuropsychology
637
Lower Vitamin B6 Levels Are Associated with
Inflammation Among Migraine Patients
Shaik Munvar M., Tan Huay L., Gan Siew H.
Human Genome Centre, Kubang Kerian, Malaysia
Objective: Vitamin B6 availability plays a critical role in both
the innate and adaptive immune responses. A variety of disease
conditions have repeatedly been found to be associated with low
levels of vitamin B6. The aim of the study is to compare serum
levels of tumor necrosis factor-alpha (TNF-α) and vitamin
B6 among migraineurs when compared to healthy controls.
Methods: This hospital-based study was conducted in Hospital
Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia,
between January and December 2013. Migraine was diagnosed at
the Neurology Clinic as per criteria of the International Headache
Society. Inclusion criteria include: the patients between 1560
years old and diagnosed with migraine for more than 1 year.
Exclusion criteria include: pregnant women, migraine patients
with any neurological, cardiovascular diseases and history of
trauma. Serum was collected from a total of 129 female migraine
cases and 129 non-migraine female volunteers. Vitamin B6 and
TNF-α levels were measured using an enzyme-linked
immunosorbent assay.
Results: Females with migraine had significantly lower vitamin
B6 scores (10.9 vs 20.2 ng/ml, p< 0.001) but higher TNF-&#945;
scores (20.5 vs 3.9 pg/ml, p< 0.001) when compared with healthy
controls. The significant Spearmans correlation (0.42, p< 0.001)
determined the moderate correlation between serum levels of
vitamin B6 and TNF-&#945; among migraine patients.
Conclusions: This study clearly indicates lower vitamin levels
and higher TNF-&#945; among migraineurs suggesting that
inflammation may lead to lower levels of vitamin B6. Future stud-
ies should focus on intake of vitamin B6 and its effect on inflam-
mation among migraine patients.
92 Neuroepidemiology 2014;43:71113
Session O10.
634
Analysis the Mental Task Performance While Listen to
Music Using EEG Signal
Balasubramaniam G.1, Adalarasu K.2, Rajasekaran R.3,
Pravinkumar S.4
1
Rajiv Gandhi Salai; 2PSNA College of Engineering and
Technology; 3SBST, VIT University; 4SSN college of Engineering,
Kalavakkam, India
Objectives: Music becomes an integral part of every humans.
Research has shown that both the psychological and physiological
health of an individual improves following music therapy. Music
has an influence on the nervous system and enhances the glumate
neurotransmission, which plays an important role in learning.
Each frequency band of an EEG rhythm relates to a specific brain
function; i.e., the frontal midline theta rhythm (Fm theta) often
appears on an EEG during consecutive mental tasks. The measure
of theta synchronization and alpha de-synchronization in particu-
lar electrode location reflects the good task performance. The
objective of this study is to analysis the effects of subject preferred
like and dislike musics on task performance using EEG signal and
Psytask.
Methods: Eight healthy volunteers aged between 1920 years
participated in this study. To avoid cross contamination of
musics experiment was performed on two different days. EEG
signal was recorded while listening to the subject, selective like/
dislike music with and without a task and compared the rest
condition using RMS EEG-32 Super Spec with a sampling fre-
quency of 256 Hz/channel. The mental task performances were
calculated by finding the Error of commission and Error of
omission during rest (No Music) and different music conditions.
EEG signal was pre-processed and the relative wavelet packet
energy in the particular bands was calculated in all electrode
locations using wavelet Packet Decomposition (WPD) tech-
niques.
Results: The nonparametric wilcoxon signed rank tests were
performed; the theta component energy was significantly (p<
0.05) high at parietal (P3, Pz and P4) and temporal (T4 and
T6) electrode locations while listening to like-music with men-
tal task performance when compared with the rest. The alpha
component energy was significantly (p < 0.05) decreased at
parietal and temporal lobe while listening to like-music with
task performance when compared with the rest. The Beta com-
ponent energy was significantly (p< 0.050) high only at frontal
(F8) electrode location while listening to dislike-music along
with task when compared with listening to dislike-music with-
out a task. There were no significant changes in alpha and theta
component energy throughout dislike-music listening and per-
forming tasks. The Error of Commission for No Go trials and
error of omission for Go trials was statistically significant p<
0.05) different between like and dislike music.
Conclusion: The theta synchronization and alpha de-synchro-
nization were appearing only in the cognitive processing elec-
37.48.66.67 - 11/6/2014 6:17:34 AM
4th International Congress on Neurology and
Epidemiology, Kuala Lumpur 2014
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