12/22/2014 ChemoregimenDosageforRenalDysfunction

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AnalCancer DosageforRenalDysfunction
BiliaryTractCancer
Alemtuzumab(Campath) Unknown
BladderCancer

BrainTumor Anastrozole(Arimidex) Nodosereduction(linktothereference)

BreastCancer
LAsparaginase(Elspar) Nodosereduction(linktothereference)
CancerofUnknownPrimary
Bicalutamide(Casodex) Nodosereduction(linktothereference)
CarcinoidTumor

CervicalCancer Bendamustine(Treanda) IfCrCl<40mL/min,donotuse(linktothereference)

ColorectalCancer Bleomycin(Blenoxane) IfCrCl1050mL/min,reducedoseby25%

IfCrCl<10mL/min,reducedoseby50%(linktothereference)
EndometrialCancer

EsophagealCancer
Bortezomib(Velcade) Nodosereduction(linktothereference)
GastricCancer
Busulfan(Myleran) Nodosereduction
GastrointestinalStromalTumor

HeadandNeckCancer Capecitabine(Xeloda) IfCrCl3050mL/min,reducedoseby25%

HepatocellularCancer IfCrCl<30mL/min,donotuse(linktothereference)

KaposiSarcoma Carboplatin(Paraplatin) DosingbasedonAUC(linktothereference)

Leukemia Carmustine(BCNU) IfCrCl<60mL/min,donotuse

LungCancer Chlorambucil(Leukeran) Nodosereduction
Lymphoma
Cisplatin(CDDP) IfCrCl3060mL/min,reducedoseby50%
Melanoma IfCrCl<30mL/min,donotuse

Mesothelioma Cyclophosphamide(Cytoxan) IfCrCl1050mL/min,reducedoseby25%

MultipleMyeloma IfCrCl<10mL/min,reducedoseby50%

OvarianCancer Dacarbazine(DTIC) IfCrCL1050mL/min,reducedoseby25%

IfCrCl<10mL/min,reducedoseby50%
PancreaticCancer

ProstateCancer Dasatinib(Sprycel) Unknown.<4%excretedbykidney(linktothereference)

RenalCellCancer
Daunorubicin(Daunomycin) IfCr>3mg/dL,reducedoseby50%
Sarcoma
Docetaxel(Taxotere) Nodosereduction(linktothereference)
TesticularCancer

Thymoma Doxorubicin(Adriamycin) Nodosereduction(linktothereference)

MyelodysplasticSyndrome Doxil(Pegylatedliposomal Nodosereduction(linktothereference)

doxorubicin)
DosageforHepaticDysfunction

DosageforRenalDysfunction Erlotinib(Tarceva) Nodosereduction(linktothereference)

CalculationofCarboplatinDose
Etoposide(VP16) IfCrCl1050mL/min,reducedoseby25%
IfCrCl<10mL/min,reducedoseby50%

Exemestane(Aromasin) Nodosereduction(linktothereference)

Fludarabine(Fludara) IfCrCl3070mL/min,reducedoseby20%
IfCrCl<30mL/min,donotuse(linktothereference)

Fluorouracil(5FU) Nodosereduction(linktothearticle)

Fulvestrant(Faslodex) Nodosereduction(linktothereference)

Gemcitabine(Gemzar) Nodosereduction(linktothereference)

Goserelin(Zoladex) Nodosereduction(linktothereference)

Hydroxyurea(Hydrea) IfCrCl1050mL/min,reducedoseby50%
IfCrCl<10mL/min,reducedoseby80%

Idarubicin(Idamycin) IfCrCl<10mL/min,reducedoseby25%(linktothereference)

Imatinib(Gleevec) Nodosereduction(linktothereference)

Interferonalpha Nodosereduction

Interleukin2 IfCr>44.5mg/dL,donotuse

Irinotecan(Camptosar,CPT11) Nodosereduction(nodosereduction)

Ixabepilone(Ixempra) IfCrCl>30mL/min,nodosereduction(linktothereference)

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12/22/2014 ChemoregimenDosageforRenalDysfunction

Lapatinib(Tykerb) Notstudied.Only2%eliminatedbykidneys(linktothereference)

Lenalidomide(Revlimid) Substantiallyexcretedbykidney.Trialsexcludedpatientswithrenalinsufficiency(linktothe
reference)

Letrozole(Femara) IfCrCl>10mL/min,nodosereduction(linktothereference)

Leucovorin(LV) Nodosereduction

Lomustine(CCNU) IfCrCl<60mL/min,donotuse

Melphalan(Alkeran) PO:ifCrCl<30mL/min,considerdosereduction(linktothereference)
IV:ifBUN>30mg/dL,reducedoseby50%

Methotrexate(MTX) IfCrCl3060mL/min,reducedoseby50%
IfCrCl<30mL/min,donotuse

MitomycinC(Mutamycin) IfCrCl1060mL/min,reducedoseby25%
IfCrCl<10mL/min,reducedoseby50%

Mitoxantrone(Novantrone) Nodosereduction

Nilotinib(Tasigna) Nottested.Notrenallyexcreted(linktothereference)

Nilutamide(Nilandron) Nodosereduction

Paclitaxel(Taxol) Nodosereduction

Pemetrexed(Alimta) IfCrCl>45mL/min,nodosereduction
IfCrCl<45mL/min,donotuse(linktothereference)

Procarbazine(Matulane) IfCrCl<30mL/min,donotuse

Sorafenib(Nexavar) Nodosereduction(linktothereference)

Streptozocin(Zanosar) IfCrCl<60mL/min,donotuse

Sunitinib(Sutent) IfCrCl>42mL/min,nodosereduction(linktothereference)

Tamoxifen(Nolvadex) Nodosereduction

Temsirolimus(Torisel) Nodosereduction(linktothereference)

Topotecan(Hycamtin) IfCrCl>40mL/min,nodosereduction
IfCrCl2039mL/min,reduceto0.75mg/m2(linktothereference)

UFT Nodosereduction

Vinblastine(Velban) Nodosereduction(linktothereference)

Vincristine(Oncovin,VCR) Nodosereduction(linktothereference)

Vinorelbine(Navelbine) Nodosereduction

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