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INTRA-UTERIN
DAN
GANGGUAN YANG MUNGKIN TIMBUL
Rahmatina B. Herman
Bagian Fisiologi
STAGE
TIME PERIOD
PRINCIPAL EVENTS
Fertilized
egg
12-24 hours
following ovulation
Cleavage
Morula
Blastocyst
Gastrula
- The fetal stage begins at the end of the 8th week - lasts until birth
Fertilization
of germ cells
Meiotic division
of germ cells
Haploid Ovum
Haploid Sperm
Fertilization
Mitosis
Offspring of diploid somatic cells
Ovum with X sex chromosome
Fertilized by
Embryo with XY sc
Embryo with XX sc
Genetic sex
Sex-determining region
of Y chr (SRY) stimulates
Production of H-Y antigen
In plasma membrane of
undifferentiated gonad
H-Y antigen directs
differentiation
No Y chr, so no SRY
undifferentiated gonads
Gonadal
sex
Testosterone
Promotes development of
undifferentiated external
sex
Mullerian-inhibiting factor
Dihydrotestosterone
(DHT)
Converted to
Degeneration of
Mullerian ducts
seminal vesicle)
Absence of testosterone
Undifferentiated external
genitalia along female lines
(e.g. clitoris. labia)
Ovaries does not secrete hormone and factor
Phenotype
sex
Absence of Mullerian-
inhibiting factor
Degeneration of
Wolfian ducts
- storing up glycogen
By day 12:
- decidual tissue
HORMONES FUNCTION
1. Human chorionic
gonadotropin
(hCG)
2. Estrogen
3. Progesterone
HORMONES
FUNCTION
4. Human Chorionic
Somatomammo
tropin (hCS)
similar to GH and
prolactin
5. Relaxin
6. Placental PTHrp
(Parathyroid
Hormone-related
peptide)
Theory I:
Theory II:
Theory III:
- At 12 weeks : 10 cm
- At 20 weeks : 25 cm
Heart:
Blood cells:
- Acid-base balance
End of
Month Size / Weight
Representative Changes
0.6 cm
3 cm / 1 g
- Ossifications begins
End of
Month
Size / Weight
Representative Changes
7.5 cm / 30 g
18 cm / 100 g
End of
Month
Size / Weight
Representative Changes
25 - 30 cm /
200 - 450 g
27 - 35 cm /
550 - 800 g
End of
Month
Size / Weight
Representative Changes
32 - 42 cm /
1100 - 1350 g
41 - 45 cm /
2000 - 2300 g
50 cm / 3200 -
3400 g
- Lanugo shed
- Iron
- Some vitamins
Metabolism of Calcium and Phosphate
During the earlier part of fetal life, fetal bones are relatively
unossified and have mainly cartilagous matrix until 4th
month of pregnancy
Total amount of calcium and phosphate needed during
gestation represent only 1/50 quantities of these
substances in mothers bone . minimal drain from mother
A much greater drain occurs after birth during lactation
Metabolism of Iron