S-101 S-105

S-117

S-102
P-8 / AF-102
S-116 Air filtration
S-103

S-104 S-106
P-1 / V101
Blending / storage medium S-111 P-4 / ST-101 S-112 S-150 S-151
P-3 / MX-101 Heat sterilization
Mixing
S-107 S-109 S-110
S-118
S-119 P-20 / RVF-101 S-152 P-21 / HX-101
Biomass removal Cooling
S-108
P-7 / V103 S-153
Fermentation P-9 / V-106
P-2 / V-102 S-115 Storage
Blending / storage glucose

S-113 P-6 / AF-101 S-163

S-114 Air filtration S-160 S-155
P-22 / MX-102
P-5 / G-101 Acidification S-154
S-157
Gas compression
S-159 P-23 / CX-101
S-174 S-166 Centrifugal extraction
S-176 S-165 S-162

P-24 / MX-104
S-156
S-164 P-25 / V-104 S-161 Neutralization S-158
Re-extraction and crystallization
S-175
P-26 / BCF-101
P-30 / FBDR-101 S-167 S-173 Basket centrifugation S-172
S-177 Fluid-bed drying
S-171 P-29 / MX-103
Mixing

P-27 / CSP-101 S-168

Component Splitting S-170
S-169 P-28 / MX-105
P-31 / V-105 S-178 Neutralization
Storage penicillin sodium salt

Figure 10.1 Process flow diagram of the penicillin V production model. Reproduced by permission of John Wiley & Sons Inc.