DNA VIRUS

PARVOVIRUS POLYOMAVIRUS PAPILLOMAVIRUS ADENOVIRUS HEPADNAVIRUS HERPESVIRUS POXVIRUS

 Icosahedral  Icosahedral  Icosahedral  Icosahedral  42nm  dsDNA  dsDNA
 ssDNA  dsDNA  dsDNA  dsDNA  dsDNA  Enveloped  Enveloped –
 No enveloped  No enveloped  No enveloped  No enveloped  Enveloped multiple layer
8 virus Had been
Parvovirus B19 BK virus Warts Respiratory tract Hepatitis B eradicated
 Erythema  Haemorrhage  Skin warts,  Acute resp dz  Acute -> chronic
infectiosum cystitis in bone plantar warts, - Hepatocellular
- 5th dz marrow flat warts Eye carcinoma
- Slap cheek transplant pts  Mild
 Polyarthralgia Cancer “swimming
JC virus  Cervix cancer pool
 Progressive -hpv-16 conjunctivitis
multifocal -hpv-18
leukoencephalop GIT
athy (PML) in  Infantile
brain tumor pts gastroenteritis

HERPESVIRUS
HSV 1 / 2 HHV3 HHV4 HHV5 HHV 6/7 HHV8
HSV 1 VARICELLA ZOSTER EPSTEIN BARR VIRUS CYTOMEGALOVIRUS Roseolla infantum  in AIDS pts,
 oropharyngeal VIRUS (EBV) (CMV)  acute high fever  Kaposi Sarcoma
lesion  Rash, successive  Infectious  asymptomatic and often febrile
crops of lesion mononucleosis infection seizure
HSV 2  Rxtivation –  Infect B cells  produces mild flu-like  a rapid
 genital herpes (STD) posttherpetic  Transmit : symptom defeverescence
neuralgia - body secretion  latent thru/out life and occur
vesicular rash  Latent in nerve  burkitt’s lymphoma may rxtivate  a morbilization rash
 hodgkin’s  in immunocomprom appear
lymphoma - mononucleosis
 high risk for pregnant
mom
- congenital CMV
infection
 POXVIRUS
STRUCTURE EPIDEMIOLOGY PATHOGENESIS CLINICAL MANIFEST LAB DIAGNOSIS TREAT&PREVENT
 dsDNA, linear  Smallpox – variola 1. Enter mucous  Incubation period : Direct examination :  Immunoglobulins of
 Multiple membrane virus membrane of upper 10-14 days  Skin lesion vaccinated person
enveloped  Highly contagious RT  Sudden onset, fever  E microscopy  Prophylaxis :
 Largest  Transmit : direct 2. Multiply in lymphoid & malaise 1-5 days methisazone
 Most complex contact and tissue  Rash PCR :  Vaccination
 Resist inactivation airborne 3. Transient viraemia - Macules >  Specific
 V encoded proteins  Vanished 4. Infects Res papules >
immune syst.  Have vaccination 5. 2ndary vesicles > Virus isolation :
multiplication pustules  Culture in chicken
6. Severe viraemia  Skin crusts fall off 2 embryo
7. Clinical disease weeks – pink scar
8. Immune response  Lesion on face more Serology :
activated than trunk  Antibody after 1
9. Macs activated  Severe : week
move to all body haemorrhagic rash  ELISA, IF, HI
parts
10. Skin lesion regress
11. Pathogens clear