Cebu Normal University

College of Nursing

DRUG STUDY

Name of Patient: N/A Age: N/A Height: N/A

Diagnosis: N/A Sex: N/A Weight: N/A
Doctor: N/A Date of Admission: N/A Body Built: N/A

DRUG DATA CLASSIFICATI MECHANISM OF INDICATION CONTRAINDICATIO ADVERSE NURSING

ON ACTION S NS REACTIONS RESPONSIBILITIES
• Generic name: • Pharmacologic >Relaxes vascular smooth >hypertension Drug-drug: >CNS: dizziness, Before:
muscle, thereby reducing blood >heart failure >antihypertensives, nitrates: drowsiness, headache, >Assess patient for hypersensititvity to
hydralazine Class pressure, decreasing peripheral >eclampsia additive hypotension peripheral neuritis drug and any of its components
hydrochloride peripheral vasodilator vascular resistance, and >beta-adrenergic blockers: >CV: tachycardia, angina, >use cautiously for patients with
increasing heart rate, stroke decreased risk of hydralazine- orthostatic hypotension, hepatic, and renal impairment, and
• Trade name: volume, amd cardiac output induced tachycardia arrythmias breastfeeding mothers.
Apo-Hydralazine, Pharmacodynamics: >epinephrine: reduced pressor >EENT: lacrimation, nassal >tell patient to take tablets with food
Apersoline, Novo- Route Onset Peak response to epinephrine congestion >assess for the baseline vital signs
Hyalazin, Nu-Hydral Duration >metropolol, propanolol: >GI: nausea, vomiting, >observe the 15 rights in drug
P.O. 45 min 2hr 3-8hr increased blood levels of both diarrhea, constipation, administration.
• Therapeutic I.V. 10-20min 15-20min 3-8hr drugs anorexia During:
• Minimum dose: Class I.M. 10-30min 1hr 3-8hr >MAOI: increased hypotension >metabolic: sodium >administer oral form with food
5 mg IV antihypertensive Pharmacokinetics: >NSAID: decreased retention >inject I.V. form slowly over 1 min.
rapidly absorbed after oral hypertensive response >musculoskeletal: joint pain, >monitor blood pressure response
administration, and peak plasma Drug-diagnostic tests: arthritis continuously
• Maximum dose levels are reached at 1-2 hours. >Coomb’s test: positive result >Skin: rash, blisters, fever, >draw up and use parenteral drug
20 mg IV Plasma levels decline with a half- >Granulocytes, hemoglobin, lymphadenopathy, edema, immediately
life of 3-7 hours. Binding to neutrophils, platelets, RBC, lupuslike syndrome >be aware that sol’n changes color
human plasma protein is 87%. WBC: decreased levels after coming in contact with metal
• Content • Pregnancy Plasma levels of hydralazine Drug-behaviors: needle.
hydralazine Risk Category vary widely among individuals. >Alcohol use: additive After:
hydrochloride Hydralazine is subject to hypotensive response >watch for peripheral neuritis
C polymorphic acetylation; slow >monitor complete blood count, lupus
acetylators generally have higher erythematous cell studies
• Availability plasma levels of hydralazine and >monitor blood pressure, PR, RR, and
injection: 20mg/mL require lower doses to maintain weight daily
>tablets: 10mg, 25mg, control of blood pressure. >instruct patient to move slowly when
50mg Hydralazine undergoes extensive sitting up or standing to avoid dizziness
hepatic metabolism; it is excreted >watch for s/sx of lupus like syndrome.
mainly in the form of metabolites
in the urine.Administration of
• Routes of hydralazine with food results in
Administration higher levels of the drug in
IV plasma.

Source: Source: Source: www.DrugGuide.com Source: Source: www.DrugGuide.com Source: www.DrugGuide.com Source: www.DrugGuide.com
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