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Karen Van Proeyen1, Karolina Szlufcik1, Henri Nielens2, Koen Pelgrim1, Louise
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Tunstall RJ, et al. Fasting activates the gene expression of UCP3 independent of
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ANABOLISMO ACENTUADO

Bouhlel E1, Zaouali M, Miled A, Tabka Z, Bigard X, Shephard R. Ramadan fasting and
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Louise Deldicque, Katrien De Bock, Michael Maris, Monique Ramaekers, Henri

Nielens, Marc Francaux, Peter Hespel. Increased p70s6k phosphorylation during
intake of a protein–carbohydrate drink following resistance exercise in the fasted state.
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BENEFÍCIOS A SAÚDE
CÂNCER

Gehrig JJ, Ross J, Jamison RL. Effect of long-term, alternate day feeding on renal
function in aging conscious rats. Kidney international. 1988;34(5):620-630.
Lee C, Longo VD. Fasting vs. dietary restriction in cellular protection and cancer
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Lizzia Raffaghello,#2 Fernando Safdie,#1 Giovanna Bianchi,2 Tanya Dorff,5 Luigi
Fontana,3,4 and Valter D Longo 1 Fasting and differential chemotherapy protection in
patients Cell Cycle. Nov 15, 2010; 9(22): 4474–4476
Raffaghello L, et al. Fasting and differential chemotherapy protection in patients. Cell
Cycle 2010 9: 4474 – 4476.
Thomas JA, Antonelli JA, Lloyd JC, Masko EM, Poulton SH, Phillips TE, et al. Effect of
intermittent fasting on prostate cancer tumor growth in a mouse model. Prostate cancer
and prostatic diseases. 2010;13(4):350-355.
Varady KA, Roohk DJ, Bruss M, Hellerstein MK. Alternate-day fasting reduces global
cell proliferation rates independently of dietary fat content in mice. Nutrition (Burbank,
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Varady KA, Roohk DJ, McEvoy-Hein BK, Gaylinn BD, Thorner MO, Hellerstein MK.
Modified alternate-day fasting regimens reduce cell proliferation rates to a similar
extent as daily calorie restriction in mice. The FASEB journal official publication of the
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ANTI-ENVELHECIMENTO

Goodrick C, Ingram D, Reynolds M, Freeman J, Cider N. Effects of intermittent feeding

upon body weight and lifespan in inbred mice: interaction of genotype and age.
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Moroi-Fetters SE, Mervis RF, London ED, Ingram DK. Dietary restriction suppresses
age-related changes in dendritic spines. Neurobiology of aging. 1989;10(4):317-322.
HORMESE

Ben Salem L1, Bchir S, Bouguerra R, Ben Slama C. [Cortisol rhythm during the month
of Ramadan]. East Mediterr Health J. 2003 Sep-Nov;9(5-6):1093-8
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glucocorticoid receptor expression in the hippocampus and cerebral cortex of rats.
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Annual review of nutrition. 2005;25:237–260.

ANALGESIA

Santos-Arteaga M, Sierra-Domínguez S a, Fontanella GH, Delgado-García JM, Carrión

AM. Analgesia induced by dietary restriction is mediated by the kappa-opioid system.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
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SISTEMA DIGESTÓRIO

Goldszmid RS, Trinchieri G. Nature Immunology 13, 932–938 (2012) Published online
18 September 2012

CÉREBRO

Anson RM, Guo Z, De Cabo R, Iyun T, Rios M, Hagepanos A, et al. Intermittent fasting
dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal
resistance to injury from calorie intake. Proceedings of the National Academy of
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Arumugam T, Phillips T, Cheng A. Age and energy intake interact to modify cell stress
pathways and stroke outcome. Annals of neurology. 2010;67(1):41-52
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damage and improves behavioral outcome following excitotoxic and metabolic insults.
Annals of neurology. 1999;45(1):8-15.
Bruce-Keller AJ, Umberger G, McFall R, Mattson MP. Food restriction reduces brain
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neurodegeneration in animal models of excitotoxicity. Brain research. 2004;1002(1-
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glucose metabolism and BDNF levels, slows disease progression, and increases
survival in huntingtin mutant mice. Proceedings of the National Academy of Sciences.
2003;100(5):2911.
Duan W, Guo Z, Mattson MP. Brain-derived neurotrophic factor mediates an
excitoprotective effect of dietary restriction in mice. Journal of neurochemistry.
2001;76(2):619-626.
Duan W, Mattson MP. Dietary restriction and 2‐deoxyglucose administration improve
behavioral outcome and reduce degeneration of dopaminergic neurons in models of
Parkinson’s disease. Journal of Neuroscience Research. 1999;57(2):195-206.
Fontán-Lozano A, Sáez-Cassanelli JL, Inda MC, de los Santos-Arteaga M, Sierra-
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Lee J, Duan W, Long JM, Ingram DK, Mattson MP. Dietary restriction increases the
number of newly generated neural cells, and induces BDNF expression, in the dentate
gyrus of rats. Journal of molecular neuroscience : MN. 2000;15(2):99-108.
Mattson MP, Duan W, Guo Z. Meal size and frequency affect neuronal plasticity and
vulnerability to disease: cellular and molecular mechanisms. Journal of neurochemistry.
2003;84(3):417-31. - See more at: http://www.lift-heavy.com/intermittent-
fasting/#sthash.EH3aP24d.dpuf

Moroi-Fetters SE, Mervis RF, London ED, Ingram DK. Dietary restriction
suppresses age-related changes in dendritic spines. Neurobiology of aging.
1989;10(4):317-322.
Sharma S, Kaur G. Neuroprotective potential of dietary restriction against kainate-
induced excitotoxicity in adult male Wistar rats. Brain research bulletin. 2005;67(6):482-
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ischemic brain damage and improve behavioral outcome: evidence for a
preconditioning mechanism. Journal of neuroscience research. 1999;57(6):830-839.
Zhu H, Guo Q, Mattson MP. Dietary restriction protects hippocampal neurons against
the death-promoting action of a presenilin-1 mutation. Brain research.
1999;842(1):224-229.

CORAÇÃO

Ahmet I, Wan R, Mattson MP, Lakatta EG, Talan M. Cardioprotection by intermittent

fasting in rats. Circulation. 2005;112(20):3115-21.
Denzel MS, Scimia MC, Zumstein PM, Walsh K, Ruiz-Lozano P, Ranscht B. T-cadherin
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Gandhi H, Upaganlawar A, Balaraman R. Adipocytokines: The pied pipers. Journal of
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Katare RG, Kakinuma Y, Arikawa M, Yamasaki F, Sato T. Chronic intermittent fasting
improves the survival following large myocardial ischemia by activation of
BDNF/VEGF/PI3K signaling pathway. Journal of molecular and cellular cardiology.
2009;46(3):405-412.
Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, et al. Caloric
restriction and intermittent fasting alter spectral measures of heart rate and blood
pressure variability in rats. The FASEB journal : official publication of the Federation of
American Societies for Experimental Biology. 2006;20(6):631-637.
Thomas JA, Antonelli JA, Lloyd JC, Masko EM, Poulton SH, Phillips TE, et al. Effect of
intermittent fasting on prostate cancer tumor growth in a mouse model. Prostate cancer
and prostatic diseases. 2010;13(4):350-355.
Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. Intermittent fasting prevents
the progression of type I diabetic nephropathy in rats and changes the expression of
Sir2 and p53. FEBS letters. 2007;581(5):1071-1078.
Varady KA, Allister CA, Roohk DJ, Hellerstein MK. Improvements in body fat
distribution and circulating adiponectin by alternate-day fasting versus calorie
restriction. The Journal of nutritional biochemistry. 2010;21(3):188-195
Wan R, Ahmet I, Brown M, Cheng A, Kamimura N, Talan M, et al. Cardioprotective
effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.
The Journal of nutritional biochemistry. 2010;21(5):413–417.
Wan R, Camandola S, Mattson MP. Intermittent food deprivation improves
cardiovascular and neuroendocrine responses to stress in rats. The Journal of nutrition.
2003;133(6):1921-1929 –
Wan R, Camandola S. Intermittent fasting and dietary supplementation with 2-deoxy-D-
glucose improve functional and metabolic cardiovascular risk factors in rats. Faseb
Journal. 2003;17(9):1133-1134.

DIABETES

Anson RM, Guo Z, De Cabo R, Iyun T, Rios M, Hagepanos A, et al. Intermittent fasting
dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal
resistance to injury from calorie intake. Proceedings of the National Academy of
Sciences of the United States of America. 2003;100(10):6216.
Arumugam T, Phillips T, Cheng A. Age and energy intake interact to modify cell stress
pathways and stroke outcome. Annals of neurology. 2010;67(1):41-52.
Science daily. Mediterranean diet without breakfast best choice for diabetics.
November 28, 2013
Thomas JA, Antonelli JA, Lloyd JC, Masko EM, Poulton SH, Phillips TE, et al. Effect of
intermittent fasting on prostate cancer tumor growth in a mouse model. Prostate cancer
and prostatic diseases. 2010;13(4):350-355.
Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. Intermittent fasting prevents
the progression of type I diabetic nephropathy in rats and changes the expression of
Sir2 and p53. FEBS letters. 2007;581(5):1071-1078.
Wan R, Ahmet I, Brown M, Cheng A, Kamimura N, Talan M, et al. Cardioprotective
effect of intermittent fasting is associated with an elevation of adiponectin levels in rats.
The Journal of nutritional biochemistry. 2010;21(5):413–417.
Wan R, Camandola S. Intermittent fasting and dietary supplementation with 2-deoxy-
D-glucose improve functional and metabolic cardiovascular risk factors in rats. Faseb
Journal. 2003;17(9):1133-1134.

SÍNDROME METABÓLICA

Halberg N, Henriksen M, Söderhamn N, Stallknecht B, Ploug T, Schjerling P, et al.

Effect of intermittent fasting and refeeding on insulin action in healthy men. Journal of
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Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E. Alternate-day fasting in
nonobese subjects: effects on body weight, body composition, and energy metabolism.
The American journal of clinical nutrition. 2005;81(1):69-73.
Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, et al. Alternate day
calorie restriction improves clinical findings and reduces markers of oxidative stress
and inflammation in overweight adults with moderate asthma. Free Radical Biology and
Medicine. 2007;42(5):665–674.
Louiza Belkacemi,1 Ghalem Selselet-Attou,1 Emeline Hupkens,2 Evrard
Nguidjoe,3 Karim Louchami,2 Abdullah Sener,2 and Willy J. Malaisse2 Intermittent
Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected. International
Journal of Endocrinology
Volume 2012 (2012), Article ID 962012, 12 pages
Varady KA, Bhutani S, Church EC, Klempel MC. Short-term modified alternate-day
fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults.
The American journal of clinical nutrition. 2009;90(5):1138.

AUTOFAGIA
Alirezaei M1, Kemball CC, Flynn CT, Wood MR, Whitton JL, Kiosses WB. Short-term
fasting induces profound neuronal autophagy. Autophagy. 2010 Aug;6(6):702-10. Epub
2010 Aug 14

Watson JP, Giuliano V. Autophagy – the housekeeper in every cell that fights aging.
Posted on 19. April 2013

MITOS

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IF E MULHERES
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Michael E. Holmstrup Christopher M. Owens Timothy J. Fairchild Jill A. Kanaley
Effect of meal frequency on glucose and insulin excursions over the course of a day
.Department of Exercise Science, Human Performance Laboratory, Syracuse
University, Syracuse, NY, United States Received: July 7, 2010; Accepted: October 5,
2010; Published Online: October 25, 2010

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CATABOLISMO

Anson RM, Guo Z, De Cabo R, Iyun T, Rios M, Hagepanos A, et al. Intermittent

fasting dissociates beneficial effects of dietary restriction on glucose metabolism and
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Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, et al. Alternate day
calorie restriction improves clinical findings and reduces markers of oxidative stress
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CAFÉ DA MANHÃ É A REFEIÇÃO MAIS IMPORTANTE DO DIA?

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