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Surgical prophylaxis aims to prevent surgical site and healthcare-associated infections, thereby
reducing surgical morbidity (and mortality). Growing evidence indicates that aspects of
prescribing practice are also associated with health care associated infections, notably Extended
Spectrum B-lactamase (ESBL) and C. difficile infection with cephalosporin use. It is therefore
crucial that antibiotic prophylaxis is given judiciously and where indicated. Antimicrobial surgical
prophylaxis should:
• be undertaken only in operations where there is evidence that prophylaxis has a beneficial
effect on the incidence of post operative infection;
• target only the few major pathogens which are most relevant in terms of prevention of
infection and takes into account local antimicrobial susceptibility patterns;
• use a narrow spectrum agent that targets these pathogens and is not an important
therapeutic agent;
• be used only short term for the period of time in which (normally sterile) body tissues are
exposed to contamination during the operation.
All surgical prophylaxis should be fully documented in the patient’s records, preferably within the
“once-only medication” section of the treatment chart. All relevant details should be written,
including:
• Antibiotic name, dose and mode of administration
• Exact time of administration
• Clear statement of once-only dosage (or clear indication of no longer than 24 hour
duration, where indicated in the guidelines)
1
Summary of guideline implementation:
1. Antibiotic prophylaxis should be administered where medical evidence suggests that they
either recommended in all instances or should be considered in specific high risk
circumstances.
2. Timing of antibiotic(s):
a. Optimum timing is ≤30 minutes prior to skin incision (usually in anaesthetic room at
induction of anaesthesia),
b. Sub-optimal administration occurs if given to >1 hour prior to skin incision or post-skin
incision.
3. Recording of antibiotic: In the “once only” section of drug prescription on form. This is
preferred to recording in the anaesthetic record.
4. Choice of agent:
a. Appropriate narrow spectrum agent(s) that target the likely most important pathogens
should be adopted whenever possible. Agents used for treatment of life threatening
infections such as carbapenems, ceftazidime, tigecycline and piperacillin-tazobactam
should not be used for prophylaxis.
b. If documented beta-lactam allergy is present, alternatives should be utilised
c. Prophylactic gentamicin dosing is based on patient height (see gentamicin tables in
guidelines) and approximates to 3mg/kg/ideal body weight, capped at 300mg. This
allows bolus administration in anaesthetic room.
5. Frequency of administration: Antibiotic prophylaxis is generally indicated as a single do se
only. The exceptions to this recommendation would be instances of surgery involving
potentially high contamination such as large bowel intervention or alternatively the insertion
of prostheses. In these circumstances, 24 hour coverage would be warranted.
However, in all operations, if extensive blood loss occurs intraoperatively or the operation is
significantly prolonged, a second dose may be needed as follows:
a. More than 1.5 litre intra-operative blood loss:
Re-dose following fluid replacement giving same dose for all agents except
gentamicin (give half dose) and teicoplanin (do not redose).
b. Operation prolonged:
i. > 4 hours (re-dose flucloxacillin)
ii. >8 hours (re-dose flucloxacillin, co-amoxiclav, metronidazole and,
if eGFR>60ml/min, administer another full dose of gentamicin.
iii. Do not redose, teicoplanin or clarithromycin.
6. De-colonise MRSA positive patients prior to surgery unless risk of postponing the operation
is deemed too high; in such circumstances and in the case of complex individual prophylaxis
issues, discussed with infection control pre-operatively.
2
Discuss with infection control (4528) if patient is MRSA positive or has a
history of MRSA infection / colonisation in the previous twelve months, or
has been in hospital for more than a week before operation
Antibiotic
Operation Standard prophylaxis Documented penicillin allergy
prophylaxis
Antibiotic choice & dose Additional Antibiotic choice & dose Additional
administer ≤30 min before post-op administer ≤30 min before post-op
operation doses operation doses
2 OPHTHALMIC SURGERY
Clindamycin 6-hrly
600mg IV x 3 doses
Amoxicillin-clavulanate 8-hrly
3.3 Intraoral bone grafting procedures Recommended
1.2g IV x 2 doses
Gentamicin
IV per dosing schedule none
Flucloxacillin 8-hrly
Facial plastic surgery Should be 2g IV x 2 doses Teicoplanin
4.2 none
(with implant) considered Gentamicin 400mg IV
IV per dosing schedule none
Head and neck surgery
4.3 Not recommended Not applicable
(clean, benign)
Ear surgery
4.8 Not recommended Not applicable
(clean/clean-contaminated)
ABDOMINAL SURGERY
6 Likely organisms: Staphylococci; where applicable - coliforms
(NON-GASTROINTESTINAL)
Hernia repair
6.1 Not recommended Not applicable
(without mesh )
Hernia repair Consider in
6.2
(with mesh ) high risk
High risk: obesity, diabetes, immunosuppression or
co-existing infection at other sites Flucloxacillin Clindamycin
none none
Open/laparoscopic surgery with mesh (eg Consider in 2g IV 600mg IV
6.3
gastric band / rectoplexy) high risk
High risk: obesity, diabetes, immunosuppression or co-existing infection
at other sites
Highly
7.12 Appendicectomy
recommended
Metronidazole 8-hrly Metronidazole 8-hrly
Highly 500mg IV x 2 doses 500mg IV x 2 doses
7.13 Colorectal surgery
recommended Gentamicin Gentamicin
IV per dosing schedule none IV per dosing schedule none
Teicoplanin
Flucloxacillin 6-hrly
400mg IV
Arthroplasty 2g IV x 3 doses
Highly none
8.1 and any surgery involving Gentamicin
recommended Gentamicin
insertion of implant IV per dosing schedule none
IV per dosing schedule
Antibiotic-loaded cement (1 gram of tobramycin to 40 grams of powder) is
recommended as an adjunct to intravenous antibiotics
8.2 Surgery (without implant ) Not recommended
Not applicable
8.3 Arthroscopy Not recommended
Flucloxacillin Clindamycin
8.4 Soft tissue surgery of the hand Recommended none none
2g IV 600mg IV
Highly
8.5 Hip fracture repair
recommended Flucloxacillin 6-hrly Teicoplanin
Highly 2g IV x 3 doses 400mg IV
8.6 Hemiarthroplasty
recommended none
Open reduction with Highly Gentamicin Gentamicin
8.7
internal fixation recommended IV per dosing schedule none IV per dosing schedule
Highly
8.8 Open fracture
recommended Grade 3 fractures: treat for 72 hours or until soft tissue coverage of wound.
Highly
9.5 Caesarean section
recommended
Consider in
9.6 Perineal tear
high risk Amoxicillin-clavulanate Clindamycin
none none
1.2g IV 600mg IV
High risk: third/fourth degree perineal tears involving the anal
sphincter/rectal mucosa
Consider in
10.13 Percutaneous nephrolithotomy
high risk Ciprofloxacin 500mg 12-hrly
orally for one week preoperatively
High risk: patients with stone ≥ 20mm or with pelvicalyceal dilation
Consider in
12.1 Cosmetic surgery
high risk
Flucloxacillin Clindamycin
none none
2g IV 600mg IV
High risk: procedures on the lower extremities or groin, for wedge
excisions of the lip and ear, skin flaps on the nose, skin grafts, extensive
inflammatory skin disease
Clindamycin
Clean-contaminated procedures Amoxicillin-clavulanate 600mg IV
12.1 Recommended none none
(where no specific evidence is available ) 1.2g IV Gentamicin
IV per dosing schedule
Flucloxacillin 8-hrly
Insertion of a prothetic device or implant 2g IV x 2 doses Teicoplanin
12.2 Recommended none
(where no specific evidence is available ) Gentamicin 400mg IV
IV per dosing schedule none
• non-tunnelled central
13.1 Not recommended
venous catheter (CVC)
Not applicable
13.2 • tunnelled CVC Not recommended
Recommended for:
* Dental procedures involving manipulation of gingival tissue or the
periapical region or incision/perforation of oral mucosa
* Respiratory tract procedures involving incision or biopsy of the
respiratory tract mucosa e.g. tonsillectomy
in patients with:
Prosthetic cardiac valve or prosthetic material used for cardiac
Amoxicillin oral Clindamycin oral
valve repair
2 grams (adult); 600 mg (adult);
Previous IE
50 mg/kg (children) 20 mg/kg (children)
Congenital heart disease (CHD):
or none or none
– Unrepaired cyanotic CHD, including palliative shunts and Amoxicillin IV Clindamycin IV
conduits. 1 gram (adult); 600 mg (adult);
50 mg/kg (children) 20 mg/kg (children)
– Completely repaired congenital heart defect with prosthetic
material or device, during the first 6 months after the procedure.