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Please cite this article in press as Gurleen kaur and G. Gananarajan., A Review Article on Oral Jellies for
Pediatrics, Indo Am. J. P. Sci, 2018; 05(01).
FUNCTIONS OF ORAL MUCOSA It includes from the mouth to anus and it is divided
Protection into two parts:
Sensation 1. Upper GIT
Secretion 2. Lower GIT
Thermal regulation It’s about 9mtr(30feet) it releases various hormones
Permeability and absorption to regulate the digestive process.
For all the tissue saliva act as, protective fluid and it
protects from abrasion buy rough materials and from
chemicals. Saliva (aqueous fluid) it mainly contains
1% organic and inorganic materials. The major
framework is the flow rate which mainly depends
upon the type of stimulus and degree of stimulation.
The salivary pH ranges from 5.6 to 7.9 it depends
upon the flow rate. [4]
TASTE MASKING
In oral administration the taste is the important
parameter, the desirable taste is the better choice for
paediatrics it is one of the pharmaceutical parameter.
Taste buds plays the role of taste and they are around
10,000. The chemoreceptors pass signals to brain for
the perception of taste. As most of the pharmaceutical
drugs are bitter in taste so, taste masking is an
important parameter in designing the dosage form
and it is mainly done by adding sweetener and
flavours.
Key aspects involve the development of (novel) using pectin, guar gum, and gellan gum. Asian
dosage forms such as jelly formulations, the safety of Journal of Pharmaceutics. 2014 Oct 1:241.
excipients, child acceptability and the importance of 3.Hooda R, Tripathi M, Kapoor K. A review on oral
suitable dosing devices. The acquired knowledge is mucosal drug delivery system. The pharma
useful to formulation scientists as well as to doctors, innovation. 2012 Mar 1;1(1).
pharmacists and caregivers when prescribing, 4.Tabak, L.A., Levine, M.J., Mandel, I.D. and
compounding, dispensing or administering medicines Ellison, S.A., Role of salivary mucins in the
to children. protection of the oral cavity, J. Oral Pathol.,
1982;11:1-17.
CONCLUSION: 5.College open stax Anatomy & Physiology (Jun
There are several methods adopted and utilised for 9;2013) Connexions Website.
the taste masking of bitter drugs. In respect to https://commons.wikimedia.org/wiki/File%3A2401_
pediatric age group medicated jellies has the potential Components_of_the_Digestive_System.jpg
to evolve as one of the most popular dosage form. Its 6.Steemit.com. (2017). Available at:
unique properties help us to improve better patient https://steemit.com/science/@timsaid/life-explorers-
compliant in respect to pediatric group. It also able to the-human-senses-part-iv-taste.
provide prominent therapeutic effectiveness by early 7.Sharma V., Chopra H. Role of taste and taste
onset of action as having quick absorption and masking of bitter drugs in pharmaceutical industries
dissolution of drug. Oral jellies are alternative to an overview. Int J Pharm Pharm Sci. 2010;2(4):123-
solid dosage form as they possess both liquid and 5.
solid property and its having ease administration 8. Biologyboom.com. (2017). Write a note on taste
without ingestion of water. Therefore, the oral buds | Biology Boom. Available at:
medicated jellies are an accepted technology. http://biologyboom.com/write-a-note-on-taste-buds/
9.Thoke SB, Gayke A, Dengale R, Patil P, Sharma Y.
REFERENCES: Review on: taste masking approaches and evaluation
1.Eisert.W and Gruber.P, “US 6,015,577 B1: of taste masking. International Journal of
Pharmaceutical compositions containing Pharmaceutical Sciences. 2012;4(2):1895-907.
dipyridamole or mopidamol and acetylsalicylic acid 10.Bio1152.nicerweb.com. (2017). taste.html
or the physiologically acceptable salts thereof; 50_13SweetReceptor-L.jpg. Available at:
processes for www.ondrugdelivery.com Copyright © http://bio1152.nicerweb.com/Locked/media/ch50/tast
2011 Frederick Furness Publishing preparing them e.html
and their use in treating clot formation”, assigned to 11.Bhalerao K, Gambhire S, Singh S. Taste masking
Dr. Karl Thomae GbH. to improve compliance. Int. Res. J. Pharm. App. Sci.
2.Prakash K, Satyanarayana V, Nagiat H, Fathi A, 2013;3: 224-37.
Shanta A, Prameela A. Formulation development and 12.Roy G.M. Taste masking in oral pharmaceuticals.
evaluation of novel oral jellies of carbamazepine Pharm. Tech 1994; 18, 84-99.
13.Tripathi A, Parmar D, Patel U, Patel G, Daslaniya 16.Chiappetta DA, Hocht C, Sosnik A. A highly
D, Bhimani B. Taste masking: a novel approach for concentrated and taste-improved aqueous formulation
bitter and obnoxious drugs. JPSBR. 2011;1(3):36- of efavirenz for a more appropriate pediatric
142. management of the anti-HIV therapy. Current HIV
14.Panda BP, Dey NS, Rao ME. Development of research. 2010 Apr 1;8(3):223-31.
innovative orally fast disintegrating film dosage 17.Cardoz MR, Ravikumar P. Design, Development
forms: a review. International Journal of and Evaluation of Novel Oral Medicated Jellies. Indo
Pharmaceutical Sciences and Nanotechnology. American Journal of Pharmaceutical Sciences. 2017
2012;5(2):1666-74. Jun 1;4(6):1746-54.
15.Mehta RM. Pharmaceutics – II Vallabh
Prakashan. Second Edition; 2003: 168-172.