DAFTAR ISI

HALAMAN JUDUL .............................................................................................. i

DAFTAR ISI ......................................................................................................... ii
DAFTAR GAMBAR ............................................................................................. 1
DAFTAR TABEL ................................................................................................. 2
BAB 1 PENDAHULUAN ..................................................................................... 3
1.1 Latar Belakang ......................................................................................... 3
1.2 Rumusan Masalah .....................................................................................5
1.3 Tujuan ....................................................................................................... 6
1.3.1 Tujuan Umum ................................................................................... 6
1.3.2 Tujuan Khusus .................................................................................. 6
1.4 Manfaat Penelitian .................................................................................... 7
1.4.1 Manfaat Bagi Masyarakat ................................................................. 7
1.4.2 Manfaat Bagi Rumah Sakit ............................................................... 7
1.4.3 Manfaat Ilmiah .................................................................................. 7
1.4.4 Manfaat Bagi Peneliti ........................................................................ 7
BAB 2 TINJAUAN PUSTAKA ............................................................................ 8
2.1 Sistem Limfatik ........................................................................................ 8
2.1.1 Pembuluh Limfe ..................................................................................... 9
2.1.2 Cairan Limfe ......................................................................................... 11
2.1.3 Nodus Limfe ..........................................................................................11
2.1.4 Limfosit ..................................................................................................12
2.2 Fungsi Sistem Limfatik .......................................................................... 13
2.3 Limfoma ................................................................................................. 14
2.3.1 Patogenesis Limfoma .............................................................................14
2.3.2 Lokasi Limfoma .....................................................................................16
2.3.3 Stadium Limfoma ..................................................................................17
2.4 Limfoma Non Hodgkin .......................................................................... 20
2.4.1 Etiologi dan Faktor Risiko Limfoma Non Hodgkin ..............................20
2.4.2 Klasifikasi Limfoma Non Hodgkin ......................................................24
2.4.3 Formulasi Kerja Limfoma Non Hodgkin untuk Penggunaan Klinis .....25

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 2.4.3.1 Limfoma Non Hodgkin Derajat Rendah .......................................25
2.4.3.1.1 Limfoma Limfositik Sel Kecil ...............................................26
2.4.3.1.2 Limfoma Folikuler dengan Small Claved Cell .......................26
2.4.3.1.3 Limfoma Folikuler Campuran ...............................................27
2.4.3.2 Limfoma Non Hodgkin Derajat Sedang ........................................28
2.4.3.2.1 Limfoma Folikuler Sel Besar ................................................28
2.4.3.2.2 Limfoma Difus dengan Small Cleaved Cell ..........................28
2.4.3.3.3 Limfoma Difus Campuran ....................................................28
2.4.3.2.4 Limfoma Difus Sel Besar ......................................................28
2.4.3.3 Limfoma Non Hodgkin Derajat Tinggi .........................................29
2.4.3.3.1 Limfoma Imunoblastik Sel Besar ..........................................29
2.4.3.3.2 Limfoma Limfoblastik ...........................................................30
2.4.3.3.3 Limfoma dengan Small Non Cleaved Cell (Limfoma Burkitt
dan Non Burkitt .......................................................................31
2.4.4 Subtipe Lain ..........................................................................................32
2.4.4.1 Limfoma Terkait AIDS .................................................................32
2.4.4.2 Limfoma Sel T Kulit ......................................................................32
2.4.4.3 Limfoma/Leukemia Sel T Dewasa (ATLL) ..................................33
2.4.4.4 Limfadenopati Angio-Imunoblastik ..............................................33
2.4.4.5 Limfoma Monositoid Sel B ...........................................................34
2.4.4.6 Histiositosis Maligna/Sindrom Hemofagositik .............................34
2.4.5 Gambaran Klinis ...................................................................................35
2.4.6 Pendekatan Diagnostik ..........................................................................37
2.4.7 Temuan Laboratorium Klinis pada Limfoma Non Hodgkin ................38
2.4.8 Terapi ....................................................................................................39
2.5 Limfoma Hodgkin ................................................................................. 39
2.5.1 Etiologi dan Faktor Risiko Limfoma Hodgkin .....................................39
2.5.2 Klasifikasi Limfoma Hodgkin ..............................................................41
2.5.2.1 Limfoma Hodgkin Nodular Limfosit Predominan (NLPHL) .......42
2.5.2.2 Limfoma Hodgkin Klasik (CHL) ..................................................43
2.5.2.2.1 Limfoma Hodgkin Klasik Kaya Limfosit (LRCHL) .............44
2.5.2.2.2 Limfoma Hodgkin Nodular Sklerosis (NSHL) .....................45

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 2.5.2.2.3 Limfoma Hodgkin Sel Campuran (MCHL) ..........................47
2.5.2.2.4 Limfoma Hodgkin Deplesi Limfosit (LDHL) .......................48
2.5.3 Gambaran Klinis ...................................................................................49
2.5.4 Pendekatan Diagnostik Limfoma Hodgkin ...........................................50
2.5.5 Temuan Laboratorium Limfoma Hodgkin ............................................51
2.5.6 Terapi Limfoma Hodgkin .....................................................................52
2.6 CD20 (Cluster of Differentiation) ......................................................... 52
BAB 3 KERANGKA KONSEP.......................................................................... 55
BAB 4 METODOLOGI PENELITIAN ............................................................ 56
4.1 Desain Penelitian .................................................................................... 56
4.2 Lokasi dan Waktu Penelitian .................................................................. 56
4.3 Data dan Instrumen Penelitian ............................................................... 56
4.3.1 Data Penelitian ................................................................................ 56
4.3.2 Instrumen Penelitian........................................................................ 56
4.4 Populasi dan Sampel .............................................................................. 56
4.4.1 Populasi ........................................................................................... 56
4.4.2 Sampel ............................................................................................. 57
4.4.3 Besar Sampel ................................................................................... 57
4.5 Variabel Penelitian ................................................................................. 57
4.6 Definisi Operasional ............................................................................... 57
4.7 Prosedur Penelitian ................................................................................. 60
4.8 Pengolahan Data ..................................................................................... 61
4.9 Kerangka Penelitian ............................................................................... 61
4.10 Jadwal Penelitian .................................................................................... 62
DAFTAR PUSTAKA .......................................................................................... 63

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