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Nama Jurnal internasional : …………
Quartile : Q1/Q2/Q3/Q4 Biaya submit : ……… dolar/........? 5 artikel yang terbit tahun 2016 - 2017
No Judul artikel Hasil penelitian Kesimpulan
1 Auramine O, an Our study revealed that AuO is the major water- In conclusion, we found that incense smoke soluble component of IBC. AuO has no apparent AuO, an ingredient of ingredient, effect on malignant transformation; but, it incense smoke, significantly promotes dramatically promotes lung cancer malignancy. increases the metastatic lung cancer AuO accumulates in the nucleus and binds DNA abilities and stemness malignancy of lung tumor cells. These results point out the characters of lung tumor nuclear translocation capability and DNA cells through the activation binding ability of AuO, especially in lung tumor of ALDH1A1, which is cells. AuO Induces the autophagy activity in known to be associated with lung tumor cells. In comparison to normal poor outcome and culture condition, BEAS-2B cells do not have progression of lung cancer. remarkably morphological change under AuO- For public health, reducing containing culture condition. However, AuO or avoiding the use of AuO treatment leads to the granular structures at the in incense is recommended. surface of A549 cells. We speculated that the granular structures might be AuO-induced autophagosomes.
To determine the effect of AuO on lung cell
transformation, BEAS-2B cells were treated with various doses of AuO, and the result showed that AuO at 0.5 mM (the maximal concentration) does not dramatically affect cell viability. AuO significantly enhances migration and invasive abilities and the in vitro and in vivo stemness features of lung tumor cells through activating the expression of aldehyde dehydrogenase family 1 member A1 (ALDH1A1), and ALDH1A1 knockdown attenuates AuO-induced autophagy activity and blocks AuO-induced lung tumor malignancy. 2 Pharmacokinetic According to pkCSM in silico prediction, zinc The cytotoxic effect of the and gluconate is poorly absorbed and consequently zinc gluconate-based Toxicological presents low distribution volume and is product, Evaluation of chemically inert to CYP isoenzymes. Infertile, is an important a Zinc LAZARprediction suggested carcinogenic effect factor, considering its use as Gluconate- of zinc gluconate in rodents in general and to a canine sterilization agent. Based Chemical mice and rats separately. The maximum Cell death mechanism would Sterilant Using tolerated dose in humans and the toxicity to have to be apoptosis, since In Vitro and In fathead minnows were predicted in the same necrotic processes are Silico range using both strategies. According to potentially carcinogenic. Approaches LAZAR’s prediction, the carcinogenicity Although Infertile is propensity of Infertile was determinant to the licensed for use on animals, following investigation of the genetic its genotoxic and cytotoxic toxicological profile of this compound. A study effects, shown in the in vitro in Galapagos Islands showed that some animals toxicological evaluation, treated with the zinc gluconate procedure demonstrate that the highest presented tissue necrosis. These complications dose (60mM) presents a risk were attributed to improper injection techniques for animal health by necrosis or inaccurate after-treatment management, induction. Studies must be besides the intrinsic characteristics of the local continued in order to clarify environment. Necrosis has a crucial role in the activity on cells and inflammatory response. tissues involved in the sterilant activity of Infertile There is evidence that Infertile is a clastogenic and the cell damage induced, or aneugenic compound, because, at 12mM, in order to better understand almost 10% of the cells were found with the pathophysiological micronucleus. At 30 and 60 mM, the increased mechanisms of this drug. rate of necrosis and apoptosis suggests high cytotoxicity. Once cellular disruption occurs, several damage associated molecular patterns (DAMPs) are released, such asmitochondrial DNA (mtDNA), which exerts immunogenic function and can recruit neutrophils to the area of necrosis. A chronic necrotic-induced inflammatory environment causes the emergence of DNA damage induced by oxidative stress. This phenomenon can be mediated by ROS, such as superoxide radicals (O2−) and RNS, derived from nitric oxide radicals (NO∙). 3 Slight The results of the study showed the stability of hypercalcemia the test item in the vehicle at room temperature is not associated was demonstrated over a period of 3 days. The with positive test item was also stable at 4 °C for 5 days. The responses in the accuracy results of all samples were within 8.2% Comet of their mean and individual theoretical Assay in male concentrations. That mild increases in serum rat liver calcium concentration (up to 1.4 times above the concurrent control) and increased urinary calcium concentration (up to 27.8 times above the concurrent control) results in clinical signs like mild tremor, faster respiration rate and decreased activity in a few animals. On Day 4, calcium gluconate at 4000 mg/kg/day was associated with tremors and a faster respiratory rate in one male and decreased activity level (with eyes partly closed) in another one.
The test item and the positive control had no
influence on the macroscopic appearance of the liver. No test item- or positive controlrelated microscopic findings were noted. Mild increased hepatocellular mitoses were noted in 2 positive control animals. However, under the conditions of the study, no increase in the %Tail DNA in the Comet assay and no indication of liver damage as determined by histopathological means were observed. Thus, mild increases in plasma calcium did not lead to positive results in a genotoxicity assessment by the Comet assay in the rat liver. This result is important as it confirms the reliability of this assay for regulatory evaluation of safety. 4 5