University of Medical Sciences &Technology

Faculty of Engineering

Semester (8)
Final _ Examinations
Batch (8) Department of Biomedical Engineering
Biological System Modeling

Date: 06/ 07/2013 Time 3 hours Time 11:45 – 02:45

Answer All Questions

Q1: Define the following terms:

1. A valid model.
2. Non holonomic system.
3. Identifiablity problem.
4. Kinetic homogeneity.
5. Inherent regulatory.
Q2: Read the following statements carefully and write down ( T ) for
true ones and ( F ) for false ones. Then correct false one.
1. Yates suggested that complexity arises when one or more of four
attributes are found.
2. The black box model is based on the physiological knowledge that
it is proposed to have been represented by the model.

3. In order to complete the transformation from system to model, we

need to have specified the structure of the model and to have
partially determined all the parameters corresponding to that
structure.
4. Electrophysiological signals relating to brain, muscle or cardiac
function are obtained from intrinsic dynamics of the physiological
system.
5. The validation process takes place once the completed model is
available.
6. System modeling provides us with a means of representing the
variables which characterize physiological dynamics as captured by
the measurement process.

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 7. In the areas of electrophysiology and neurophysiology there is a
lack of knowledge of the underlying physiology.
8. The human stomach produces square-like waves of approximately
0.05 Hz.
9. The relationship between glucose and insulin is an example of
causal relationship between two variables.
10.The model formulation is a key driver of good modeling
methodology.

Q3: Answer the following questions

1. Define each parameters of the Fick’s equation below?

2. List the compartmental model purposes?

3. Mention one biological example for each of the following model types:
a) Linear
b) Dynamic
c) Static
d) Time invariant
e) Non linear

Q4:

A. With the aid of diagram only show the following:

1. Model identification.
2. Signal flow diagram for a simple enzymic reaction.
3. Trophic hormone action.
B. Build a Simulink model that solves the following differential
equation 2nd-order mass-spring-damper system zero ICs input
f(t) is a step with magnitude 3 parameters: m = 0.25, c = 0.5,
k=1

mx  cx  kx  f (t )
Good luck

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