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Technical Data:
CF 3 Orders
M.Wt: 407.31
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F N
Formula: C16H15F6N5O N enquiry@selleckchem.com
N N
Solubility: DMSO
Purity: 99% NH 2 O Tech Support
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Storage: at -20℃ 2 years F
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CAS No.: 486460-32-6 Synonyms: MK-0431, Januvia techbio@selleckchem.com
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Biological Activity
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Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are
important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after
a meal.Dipeptidyl-peptidase IV(DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as
well as that of other regulatory peptides.[1] Sitagliptin abolished sDPP-IV effects on splenic CD4+
T-cell migration whereas incretins decreased migration of lymph node, but not splenic, CD4+
T-cells. Sitagliptin decreases migration of splenic CD4 + T-cells through a pathway involving
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Rac1/VASP, whereas its inhibitory effects on the migration of lymph node CD4+ T-cells involve
incretin-activation of the NF-κB pathway.[2]It is eliminated renally, with a terminal half-life of
11.8-14.4 hours. [3]
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PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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