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Pathophysiology of Asthma

Predisposing Factor Causal Factor Contributing factor

 Atopy  Exposure to indoor and  Respiratory infections


 Female Gender outdoor allergies  Air pollution
 Occupational sensitizer  Active/passive smoking

a IgE stimulation

Neutrphils Eosinophils Mast Cells Degranulation Lymphocytes

Histamine Prostaglandins Bradykinins Leukotrienes

INFLAMMATION

Hyperresponsive of
airways

Increased blood flow Fluid leak from the


Vasoconstriction
vasculature

Attraction of white blood


Mucus Secretion
cells to the area Bronchospasm

Wheezing
Non-
productive/ Chest
productive SOB tightness
cough Peak Flow
Variability

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