Course name: Bioinorganic chemistry

Course No.: CH 517

Credits:
L T P C
3 0 0 4

Please do not use your cellular phones during the class

Credit distribution:

a. Class test*: 20%

b. Mid semester test: 30%
c. End semester test: 30%
d. Assignment: 20%

*Class test: Class tests will be conducted randomly after the end of some of the classes to
ensure the students are following the course materials properly. This will also aid the
students to improve their grade following a constant performance throughout the
semester.

Grades: Relative grading technique will be employed by the instructor.

Course materials:

Topics Details (expected timeline)

1. Basic Concepts of Biochemistry a. Building blocks of biology: Amino acids
(Dec.28-29, 2017)
2. Basic Concepts of Chemistry a. Metal-ligand interaction
b. Ligand field theory
c. Redox properties
d. Spectroscopy: Optical, CD, Mössbauer
(Dec.29, 2017 - January 9, 2018)
3. Metals in biology a. Metal-protein interactions
b. Metal based cofactors in biology
c. Transport and storage of metal ions in
biology (Iron)
(January 11-19, 2018)
4. Metals in medicine a. Anti-cancer agents
b. Contrast agents
(January 23-30, 2018)
5. Hydrolytic chemistry a. Carbonic anhydrase
b. Urease
c. Acotinase
(February 1-16, 2018)

1
6. Electron transfer in proteins a. Basic concepts
b. Fe-S clusters
c. Copper proteins
d. Photosynthesis and respiration
(March 6-16, 2018)
7. Chemistry of O2 a. Basic concepts
b. P450 enzymes
c. O2 transport
(March 20-April 12, 2018)
8. Special enzymes a. Hydrogenase
b. Nitrogenase
(April 12-20, 2018)

References:

1. Bioinorganic Chemistry, Bertini, Gray, Stiefel, Valentine, Eds, University Science

Books, 2007

2. Principles of Bioinorganic Chemistry, Lippard and Berg, University Science Books,

1994

Class notes and other required documents will be provided accordingly to the students.