Nama Maba : Novia Ayu Kusumaningrum

Nama Rasi : Ilmu Kesehatan gigi dan Mulut-Pencegahan

DELMOPINOL HYDROCHLORIDE

Delmopinol is paired with hydrochloride to form the International Non-

proprietary Name (INN) 3-(4-propylheptyl)-4-morpholinethanolwith a molecular
weight of 307.90 g/mol. This structure is paired with hydrochloride to create a
delmopinol hydrochloride salt, where a 1% (w/v) aqueous solution has a pH range
between 4 and 5. Delmopinol hydrochloride has low antimicrobial action of
delmopinol, noting that delmopinol has more potential as a surfactant than as a
bactericidal agent.1

Delmopinol at a concentration of 0.2% was shown to be better than controls for

reduction of plaque in a study that met American Dental Association (ADA) criteria
Streptococcus mutans, a gram- positive bacteria commonly associated with oral
bacterial flora, has been shown to be displaced when imbedded within a biofilm, where
a glass adhered biofilm treated with delmopinol observed under a transmission electron
microscope (TEM) exhibited and “empty of unordered matrix” between cells,
indicating poor biofilm development and notable removal of cells . As a result, it was
found that delmopinol reduced glucan-containing plaque,allowing for further removal
of bacteria through mechanical action.1,2

Dental plaque is probably the most studied example of a bacterial biofilm. It is

found naturally on tooth surfaces, where it forms part of the host defense by
suppressing overgrowth by opportunistic pathogenic species. However, if left
undisturbed, plaque can accumulate beyond levels compatible with oral health and shift
the balance of the microflora, which can lead to diseases such as caries, gingivitis and
periodontitis. These diseases can be treated and/or prevented with antimicrobial agents,
but, in accordance with generally accepted strategies, the aim of such agents should be
to control the accumulation of plaque rather than to eliminate it entirely.2

These include displacement of components from the pellicle, and interference

with the build-up and cohesion of plaque by reducing glucan synthesis and glucan
viscosity. Delmopinol may also reduce cell to cell adhesion by Changing the Colloidal
 Nama Maba : Novia Ayu Kusumaningrum
Nama Rasi : Ilmu Kesehatan gigi dan Mulut-Pencegahan

stability Of bacterial suspensions and by detaching or solubilising surface structures of

oral bacteria, and has been demonstrated to affect acid production in oral bacteria.3,4

The Food and Drug Administration (FDA) recently approved “Decapinol Oral
Rinse” on April 18, 2005. The rinse is approved for the prevention of gingivitis and
periodontitis, and due to the lack of information regarding use by children and pregnant
women, it is advised that pregnant women and children under twelve years old avoid
using the product (FDA, 2005). In the United States of America, a product containing
delmopinol is described as a “next-generation” oral rinse, advertising the reduction of
plaque, as well as the prevention of bleeding gums by 36%, as determined by data the
company has collected. Suggested use for plaque reduction overtime includes two daily
rinses with 10mL of the rinse for 30 seconds.1,2
 Nama Maba : Novia Ayu Kusumaningrum
Nama Rasi : Ilmu Kesehatan gigi dan Mulut-Pencegahan

DAFTAR PUSTAKA

1. Ewel, Ellen Sutton. 2013. Effect of Delmopinol Hydrochloride on the Prevention

and Removal of Listeria monocytogenes and Salmonella enterica Stainless Steel-
Adhered Biofilms. Virginia Polytechnic Institute and State University.

2. Sjodin T, Kristen N, Bigitta S, et al,. 2016. A clinical and microbiological study on

the enantiomers of delmopinol. Acta Odontologica Scandinavica: Sweden.

3. Neilands J., Ulrika J., et al. 2013. The effect of delmopinol and fluoride on acid
adaptation and acid production in dental plaque biofilms. Elsevier: Sweden.

4. Mehta P., Saini N., et al. 2014. A Surfactant - A New Line of Defense against Plaque.
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS): India.